DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7333 and SLC22A24

DIOPT Version :9

Sequence 1:	NP_650814.2	Gene:	CG7333 / 42334	FlyBaseID:	FBgn0038715	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_001129978.2	Gene:	SLC22A24 / 283238	HGNCID:	28542	Length:	552	Species:	Homo sapiens

Alignment Length:	579	Identity:	146/579 - (25%)
Similarity:	252/579 - (43%)	Gaps:	76/579 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDFSQVLDKCGNYGRFQVMILLLYGYTNILGSLHYFSQTLITFTPEHWCF----------HADLN 55
            |.|..:||:.|..||||:.::..:..||||...:...:....|||.|.|:          ..|..
Human     1 MGFDVLLDQVGGMGRFQICLIAFFCITNILLFPNIVLENFTAFTPSHRCWVPLLDNDTVSDNDTG 65

  Fly    56 GLSVEGIRSVY----ENISASSCTPLL----------GVVNGTGVVSTNRKCRNWIFNRESGYES 106
            .||.:.:..:.    .|:....|...:          |....|....|......|:::|.|...:
Human    66 TLSKDDLLRISIPLDSNLRPQKCQRFIHPQWQLLHLNGTFPNTNEPDTEPCVDGWVYDRSSFLST 130

  Fly   107 ITTELKWVCDKSHHPAVGQSFFFMGSVVGTIIFGYLSDQVGRLPSLLMATLCG---ATGDFITSF 168
            |.||...||:.....::.||.|..||::|.:|:|:|||:|||   .::..||.   |..:...:|
Human   131 IVTEWDLVCESQSLKSMVQSLFMAGSLLGGLIYGHLSDRVGR---KIICKLCFLQLAISNTCAAF 192

  Fly   169 VHTLPWFAFSRFMSGLSTDTMYYLMYILVFEYLSPKSRTFGLNIILAVFYCFGLMTSPWAAIWIG 233
            ..|...:...||::|.||.|:....:||..|:..|:||:..:.::|. .|..|.|.....|..|.
Human   193 APTFLVYCILRFLAGFSTMTILGNTFILSLEWTLPRSRSMTIMVLLC-SYSVGQMLLGGLAFAIQ 256

  Fly   234 NWRRYLWLASLPALGVLIYPFLICESAQWLLTKRKYDDAVICLKKVAKFN-RRHVEESVFDEFVK 297
            :|.......|.|.:.:.:..:.:.|||:||:...:.|:.:..|::||..| :::.||::..|.|:
Human   257 DWHILQLTVSTPIIVLFLSSWKMVESARWLIINNQLDEGLKELRRVAHINGKKNTEETLTTELVR 321

  Fly   298 YYRERELQDYKLNSHEDTFLAMFLTPRLR---------RFTLTLLVKSVIITLSCDVINRNMEGL 353
            ...::||...::.:   :..::|..|:||         ||.:|:....:|:         |::.|
Human   322 STMKKELDAVRIKT---SIFSLFRAPKLRMRVFGLCFVRFAITVPFYGLIL---------NLQHL 374

  Fly   354 GTSPFKLFSFT--SIVYLPAGVAILLLQNKIGRKGMACTALFVGGLITTATGFMIAHLDPTENAL 416
            | |...||...  ::.:....|::|.| |.:||:.......|..||......|:     |.|..:
Human   375 G-SNVSLFQILCGAVTFTARCVSLLTL-NHMGRRISQILFTFPVGLFILVNTFL-----PQEMQI 432

  Fly   417 LLAIMVGLGRFGATVSYDAEIQYAAEIIPTSVRGQAVSNIHVIGLASSSLAFYVIYLAQYYKPLP 481
            |..::..||....:.:.::...:..|::||.:|........|.|...::||..::.|..|...||
Human   433 LRVVLATLGIGSVSAASNSASVHHNELVPTILRSTVAGINAVSGRTGAALAPLLMTLMAYSPHLP 497

  Fly   482 SIFISCLMFFGAGLCLTLPETLNKKLPETLADGEKFALNESFLYFPCFSRKE-KNVRTE 539
            .|...........:.|.||||.:..||.|:.|.|.             .||: :|::.|
Human   498 WISYGVFPILAVPVILLLPETRDLPLPNTIQDVEN-------------DRKDSRNIKQE 543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7333	NP_650814.2	2A0119	11..510	CDD:273328	135/537 (25%)
CG7333	NP_650814.2	MFS	126..499	CDD:119392	98/387 (25%)
SLC22A24	NP_001129978.2	MFS_OAT	109..516	CDD:340932	108/429 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153834
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.950