DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7333 and Slc22a1

DIOPT Version :9

Sequence 1:	NP_650814.2	Gene:	CG7333 / 42334	FlyBaseID:	FBgn0038715	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_036829.1	Gene:	Slc22a1 / 24904	RGDID:	3224	Length:	556	Species:	Rattus norvegicus

Alignment Length:	568	Identity:	142/568 - (25%)
Similarity:	235/568 - (41%)	Gaps:	88/568 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VLDKCGNYGRFQVMILLLYGYTNILGSLHYFSQTLITFTPEHWCFHADLNGLS------------ 58
            ||::.|.:|.||....||....:...:..|.....:.|||.|:|.:..:..||
  Rat     7 VLEQVGEFGWFQKQAFLLLCLISASLAPIYVGIVFLGFTPGHYCQNPGVAELSQRCGWSQAEELN 71

  Fly    59 --VEGIRSVYENISASSC--------TPLLGVVNGTGVVSTNRK------CRN-WIFNRESGYES 106
              |.|:....|....|.|        ...|..|:....:..||.      |.: |:::...  .|
  Rat    72 YTVPGLGPSDEASFLSQCMRYEVDWNQSTLDCVDPLSSLVANRSQLPLGPCEHGWVYDTPG--SS 134

  Fly   107 ITTELKWVCDKSHHPAVGQSFFFMGSVVGTIIFGYLSDQVGRLPSLLMATLCGATGDFITSFVHT 171
            |.||...||..:....:.||...:|..:|:::.||::|:.||...||:.||..:....:|:....
  Rat   135 IVTEFNLVCGDAWKVDLFQSCVNLGFFLGSLVVGYIADRFGRKLCLLVTTLVTSVSGVLTAVAPD 199

  Fly   172 LPWFAFSRFMSGLSTDTMYYLMYILVFEYL-SPKSRTFGLNIILAVFYCFGLMTSPWAAIWIGNW 235
            .......|.:.|:.:...:...|.|:.|:: |...||..  |:..:.:..||:.....|..|.:|
  Rat   200 YTSMLLFRLLQGMVSKGSWVSGYTLITEFVGSGYRRTTA--ILYQMAFTVGLVGLAGVAYAIPDW 262

  Fly   236 RRYLWL---ASLPALGVLIYPFLICESAQWLLTKRKYDDAVICLKKVAKFNRR---------HVE 288
            |   ||   .|||....|:|.:.:.||.:|||::::...||..::::|:.|.:         .:|
  Rat   263 R---WLQLAVSLPTFLFLLYYWFVPESPRWLLSQKRTTRAVRIMEQIAQKNGKVPPADLKMLCLE 324

  Fly   289 ESVFDEFVKYYRERELQDYKLNSHEDTFLAMFLTPRLRRFTLTLLVKSVIITLSCDVINRNMEGL 353
            |...::                 ...:|..:|.||.||:.|:.|:    .:..||.|:   .:||
  Rat   325 EDASEK-----------------RSPSFADLFRTPNLRKHTVILM----YLWFSCAVL---YQGL 365

  Fly   354 -------GTSPFKLFSFTSIVYLPAGVAILLLQNKIGRKGMACTALFVGGLITTATGFMIAHLDP 411
                   |.:.:..|.::|:|..||...||:..::|||    ...:....|:|.|...::..: |
  Rat   366 IMHVGATGANLYLDFFYSSLVEFPAAFIILVTIDRIGR----IYPIAASNLVTGAACLLMIFI-P 425

  Fly   412 TENALLLAIMVGLGRFGATVSYDAEIQYAAEIIPTSVR--GQAVSNIHVIGLASSSLAFYVIYLA 474
            .|...|...:..|||.|||:.........||:.||.:|  |..|.:. :..|......|.|..|.
  Rat   426 HELHWLNVTLACLGRMGATIVLQMVCLVNAELYPTFIRNLGMMVCSA-LCDLGGIFTPFMVFRLM 489

  Fly   475 QYYKPLPSIFISCLMFFGAGLCLTLPETLNKKLPETLADGEKFALNES 522
            :.::.||.|....|......:.|.||||....||||:.:.|.....:|
  Rat   490 EVWQALPLILFGVLGLTAGAMTLLLPETKGVALPETIEEAENLGRRKS 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7333	NP_650814.2	2A0119	11..510	CDD:273328	136/549 (25%)
CG7333	NP_650814.2	MFS	126..499	CDD:119392	98/394 (25%)
Slc22a1	NP_036829.1	2A0119	12..525	CDD:273328	136/549 (25%)
Slc22a1	NP_036829.1	MFS	125..515	CDD:119392	106/426 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347310
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.950