DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7333 and Slc22a26

DIOPT Version :9

Sequence 1:	NP_650814.2	Gene:	CG7333 / 42334	FlyBaseID:	FBgn0038715	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	XP_017173677.1	Gene:	Slc22a26 / 236149	MGIID:	2385316	Length:	553	Species:	Mus musculus

Alignment Length:	570	Identity:	143/570 - (25%)
Similarity:	246/570 - (43%)	Gaps:	53/570 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDFSQVLDKCGNYGRFQVMILLLYGYTNILGSLHYFSQTLITFTPEHWCF-HA---DLNGLSVEG 61
            |.|..:|:..|::||||::.:......|::...|...:........|.|: |.   |.|..:..|
Mouse     1 MAFQDLLNLVGSHGRFQILQMAFLLICNVITMPHVILENFTAANLGHRCWVHIIDNDTNSNNNSG 65

  Fly    62 IRS----------VYENISASSC----TPLLGVVNGTGVVST-----NRKCRN-WIFNRESGYES 106
            |.|          :..|:....|    .|...::...|..|.     ...|.: |::::.:...:
Mouse    66 ILSQDDLLRISIPLDSNLRPEKCRRFVQPQWHLLQFNGSFSNMTEPDTEPCMDGWVYDQRTFLST 130

  Fly   107 ITTELKWVCDKSHHPAVGQSFFFMGSVVGTIIFGYLSDQVGRLPSLLMATLCGATGDFITSFVHT 171
            ..||...||......:|.:..|.:|.:.|..:.|:|||:.||......|.|..|.....|:...|
Mouse   131 TVTEWNLVCGSQELNSVAKFIFLIGVLAGHFVGGHLSDKFGRKLLFRCALLQMAITGTCTALAPT 195

  Fly   172 LPWFAFSRFMSGLSTDTMYYLMYILVFEYLSPKSRTFGLNIILAVFYCFGLMTSPWAAIWIGNWR 236
            ...:...||::||....:.....:|:.|:.|||::.....:.::..: ||.:.....|....||
Mouse   196 FFIYCLLRFLTGLCIIPINTNSVLLMLEWTSPKTQALVTTLSMSSHH-FGGLILAGLAFAFQNW- 258

  Fly   237 RYLWLASLPALGVLIYPF--LICESAQWLLTKRKYDDAVICLKKVAKFNR-RHVEESVFDEFVKY 298
            .:|.||....:.||:.|.  .:.|||:||:...|...|:..|:|||..|. ::.|:.:..|.|:.
Mouse   259 HHLQLAISVPIFVLLIPTSRWLTESARWLIVTNKPQKALQELRKVASKNGIKNSEDVLTMEVVRT 323

  Fly   299 YRERELQDYKLNSHEDTFLAMFLTPRLRRFTLTLLVKSVIITLSCDV-INRNMEGLGTSPFKLFS 362
            ..:.|:   .:...:.:...:|..|.||: .|.||.....:.:|..| ||.|::.|..:.|...|
Mouse   324 IMKDEI---AIPRTKPSLRDLFHMPNLRK-RLCLLCLLRFLQISPTVGINMNLQHLKGNVFLTQS 384

  Fly   363 FTSIVYLPAGVAILLLQNKIGRKGMACTALFVGGLITTATGFMIAHLD-PTENALLLAIMVGLGR 426
            .||...:||......|.|.|||:........:.|:      |:::.:. |.|...||.:::.|..
Mouse   385 LTSAFSIPATALGGFLLNYIGRRISQLLPCLLFGI------FLLSIVSVPQEMQTLLVVLITLAG 443

  Fly   427 FGATVSYDAEIQYAAEIIPTSVRGQAVSNIHVIGLASSSLAFYVIYLAQYYKPLPSIFISCLMFF 491
            ..:.:.|::.:.|::|::||.:|..|:..|.:.|...::|:..::.|..|...||.|....|...
Mouse   444 GSSAMIYNSNVLYSSELMPTVIRATALGVIGICGGVGAALSPLIMILTLYSASLPWIIYGVLSIL 508

  Fly   492 GAGLCLTLPETLNKKLPETLADGEKFALNESFLYFPCFSRKEKNVRTESV 541
            |..|.|.||||.|:.||:::.|.|            |.....|..:.|.|
Mouse   509 GGLLPLILPETKNQPLPDSIQDVE------------CGWESSKQKKEEDV 546

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7333	NP_650814.2	2A0119	11..510	CDD:273328	134/527 (25%)
CG7333	NP_650814.2	MFS	126..499	CDD:119392	100/377 (27%)
Slc22a26	XP_017173677.1	MFS	109..506	CDD:391944	103/408 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843993
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.030