Protein Alignment CG7333 and SV2C

DIOPT Version :10

• Sequence 1: NP_650814.2
• Gene: CG7333 / 42334
• FlyBaseID: FBgn0038715
• Length: 541
• Species: Drosophila melanogaster
• Sequence 2: NP_055794.3
• Gene: SV2C / 22987
• HGNCID: 30670
• Length: 727
• Species: Homo sapiens
• Alignment Length: 680
• Identity: 133/680 - (19%)
• Similarity: 218/680 - (32%)
• Gaps: 266/680 - (39%)

  Fly     3 FSQVLDKCGNYGRFQVMILLLYGYTNILGSLHYFSQTLITFTPEHWCFHADLNGLSVEGIRSVYE 67
            :..::.:|| :||||..:..:.|                      ....||  |:.|..:..|..
Human   138 YELIIQECG-HGRFQWALFFVLG----------------------MALMAD--GVEVFVVGFVLP 177

  Fly    68 NISASSCTPLLGVVNGTGVVSTNRKCRNWIFNRESGYESITTELKWVCDKSHHPAVGQSFFFMGS 132
            :.....|.|                      |..||         |:          .|..::|.
Human   178 SAETDLCIP----------------------NSGSG---------WL----------GSIVYLGM 201

  Fly   133 VVGTIIFGYLSDQVGRLPSLLMATLCGATGDFITSFVHTLPWFAFSRFMSGLSTDTMYYLMYILV 197
            :||...:|.|:|:|||..|||:.........|::|||....:|.|.|.:||.........::...
Human   202 MVGAFFWGGLADKVGRKQSLLICMSVNGFFAFLSSFVQGYGFFLFCRLLSGFGIGGAIPTVFSYF 266

  Fly   198 FEYLSPKSRTFGLNIILAVFYCFGLMTS--PWAAI----W---------IGNWRRYLWLASLPAL 247
            .|.|:.:.|...|:.:...:...|:..|  .||.|    |         ..:||.::.:.:||.:
Human   267 AEVLAREKRGEHLSWLCMFWMIGGIYASAMAWAIIPHYGWSFSMGSAYQFHSWRVFVIVCALPCV 331

  Fly   248 GVLIYPFLICESAQWLLTKRKYDDAVICLKKVAKFN--RRHVEESVF-----------DEFVK-- 297
            ..::....:.||.::||...|:|:|.:.||.:...|  .|...|.||           ||.::
Human   332 SSVVALTFMPESPRFLLEVGKHDEAWMILKLIHDTNMRARGQPEKVFTVNKIKTPKQIDELIEIE 396

  Fly   298 -----YYR------ERELQDYKLNSHEDTFLAMF------------------------------- 320
                 :||      ..||....|     ||:..|
Human   397 SDTGTWYRRCFVRIRTELYGIWL-----TFMRCFNYPVRDNTIKLTIVWFTLSFGYYGLSVWFPD 456

  Fly   321 ------------LTPRLRR-----FTLTLLVKSVIIT------------------------LSC- 343
                        ||..:.|     ||:...:::.|.|                        .||
Human   457 VIKPLQSDEYALLTRNVERDKYANFTINFTMENQIHTGMEYDNGRFIGVKFKSVTFKDSVFKSCT 521

  Fly   344 --DVIN-----RNMEGLGT--------------SPFKLFSF------------------------ 363
              ||.:     :|...:.|              |.||..||
Human   522 FEDVTSVNTYFKNCTFIDTVFDNTDFEPYKFIDSEFKNCSFFHNKTGCQITFDDDYSAYWIYFVN 586

  Fly   364 --TSIVYLPAGVAILLLQNKIGR----------KGMACTALFVGGLITTATGFMIAHLDPTENAL 416
              .::..||..:...||.::|||          .|::|..|:.|    |:...||.
Human   587 FLGTLAVLPGNIVSALLMDRIGRLTMLGGSMVLSGISCFFLWFG----TSESMMIG--------- 638

  Fly   417 LLAIMVGLGRFGATVS-YDAEIQYAAEIIPTSVRGQAVSNIHVIGLASSSLAFYVI-YLAQYYKP 479
            :|.:..||     |:| :::......|:.||..|......::.:..|::.|...:. .|....|.
Human   639 MLCLYNGL-----TISAWNSLDVVTVELYPTDRRATGFGFLNALCKAAAVLGNLIFGSLVSITKS 698

  Fly   480 LPSIFISCLMFFG--AGLCLTLPETLNKKL 507
            :|.:..|.::..|  .|||  ||:|..:.|
Human   699 IPILLASTVLVCGGLVGLC--LPDTRTQVL 726

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7333	NP_650814.2	2A0119	11..510	CDD:273328	132/672 (20%)
SV2C	NP_055794.3	synapt_SV2	1..727	CDD:130366	133/680 (20%)
		Interaction with SYT1. /evidence=ECO:0000250	1..57
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	24..84
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	109..128
		(Microbial infection) C.botulinum neurotoxin type A-binding. /evidence=ECO:0000269|PubMed:27294781	519..563		10/43 (23%)