DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7333 and Slc22a5

DIOPT Version :9

Sequence 1:	NP_650814.2	Gene:	CG7333 / 42334	FlyBaseID:	FBgn0038715	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_035526.1	Gene:	Slc22a5 / 20520	MGIID:	1329012	Length:	557	Species:	Mus musculus

Alignment Length:	559	Identity:	149/559 - (26%)
Similarity:	233/559 - (41%)	Gaps:	89/559 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DFSQVLDKCGNYGRFQVMILLLYGYTNILGSLHYFSQTLITFTPEHWCF-------------H-- 51
            |:.:|....|.:|.||.:|..|...:.|....:..|...:..||||.|.             |
Mouse     3 DYDEVTAFLGEWGPFQRLIFFLLSASIIPNGFNGMSIVFLAGTPEHRCLVPHTVNLSSAWRNHSI 67

  Fly    52 ----------------------ADLNGLSVEGIRSV-YENISASSCTPLLGVVNGTGVVSTNRKC 93
                                  |:.:.|.:|..|.| .|.:...||      ::|
Mouse    68 PLETKDGRQVPQKCRRYRLATIANFSELGLEPGRDVDLEQLEQESC------LDG---------- 116

  Fly    94 RNWIFNRESGYESITTELKWVCDKSHHPAVGQSFFFMGSVVGTIIFGYLSDQVGRLPSLLMATLC 158
              |.::::....:|.||...||.......:..|.||:|.::|:.|.|.|||:.|| .::|..|:.
Mouse   117 --WEYDKDVFLSTIVTEWDLVCKDDWKAPLTTSLFFVGVLMGSFISGQLSDRFGR-KNVLFLTMG 178

  Fly   159 GATG-DFITSFVHTLPWFAFSRFMSGLSTDTMYYLMYILVFEYLSPKSRTFGLNIILAVFYCFGL 222
            ..|| .|:..|......|.....:.|:...:.|...::|..|.||...|.....:.:.:||.||.
Mouse   179 MQTGFSFLQVFSVNFEMFTVLFVLVGMGQISNYVAAFVLGTEILSKSIRIIFATLGVCIFYAFGF 243

  Fly   223 MTSPWAAIWIGNWRRYLWLASLPALGVLIYP--FLICESAQWLLTKRKYDDAVICLKKVAKFNRR 285
            |..|..|.:|.:||..|...::|  |||...  :.|.||.:||:::.:..:|.:.::|.||.|..
Mouse   244 MVLPLFAYFIRDWRMLLLALTVP--GVLCGALWWFIPESPRWLISQGRIKEAEVIIRKAAKINGI 306

  Fly   286 HVEESVFDEFVKYYRERELQDYKLNSHEDTFLAMFLTPRLRRFTLTLLVKSVIITLSCDV----- 345
            ....::||       ..||||  |||.:.....::...|.|...: :.:.|:|:.|:..|
Mouse   307 VAPSTIFD-------PSELQD--LNSTKPQLHHIYDLIRTRNIRV-ITIMSIILWLTISVGYFGL 361

  Fly   346 --INRNMEG-LGTSPFKLFSFTSIVYLPAGVAILLLQNKIGRKGMACTALFVGGLITTATGFMIA 407
              ...|:.| :..:.|.|    :.|.:||.|...||...:.|:.....|||:||.:     .:..
Mouse   362 SLDTPNLHGDIYVNCFLL----AAVEVPAYVLAWLLLQYLPRRYSISAALFLGGSV-----LLFM 417

  Fly   408 HLDPTENALLLAIMVGLGRFGATVSYDAEIQYAAEIIPTSVRGQAVSNIHVIGLASSSLAFYVIY 472
            .|.|:|...|...:|.:|:||.|.:|.....|.||:.||.||...|..........|.|:.|.:|
Mouse   418 QLVPSELFYLSTALVMVGKFGITSAYSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVY 482

  Fly   473 LAQYYKPLPSIFISCLMFFGAGLCLTLPETLNKKLPETL 511
            |..|.:.||.|.:..|....|.|.|..||:....||:|:
Mouse   483 LGAYDRFLPYILMGSLTILTAILTLFFPESFGVPLPDTI 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7333	NP_650814.2	2A0119	11..510	CDD:273328	146/547 (27%)
CG7333	NP_650814.2	MFS	126..499	CDD:119392	113/383 (30%)
Slc22a5	NP_035526.1	2A0119	12..520	CDD:273328	146/547 (27%)
Slc22a5	NP_035526.1	MFS	123..510	CDD:119392	118/408 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843872
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.950