DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7333 and Slc22a3

DIOPT Version :9

Sequence 1:	NP_650814.2	Gene:	CG7333 / 42334	FlyBaseID:	FBgn0038715	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_035525.1	Gene:	Slc22a3 / 20519	MGIID:	1333817	Length:	551	Species:	Mus musculus

Alignment Length:	580	Identity:	143/580 - (24%)
Similarity:	255/580 - (43%)	Gaps:	73/580 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 FSQVLDKCGNYGRFQVMILLLYGYTNILGSLHYFSQTLITFTPE-HWCFHADLNGLSVEGIRSVY 66
            |.|.|.|.|.:||||..:.||...|.:..:..:.....:...|: :||.......|:.....|..
Mouse     4 FDQALRKAGEFGRFQRRVFLLLCLTGVTFAFLFVGVVFLGSQPDYYWCRGPRATALAERCAWSPE 68

  Fly    67 E-----------------------------NISAS-SCTPLLGVVNGTG-VVSTNRKCRNWIFNR 100
            |                             |.|:. ||.||....|.:. :||.:   .:|.:
Mouse    69 EEWNLTTPELHVPAERRGQGHCHRYLLEATNTSSELSCDPLTAFPNRSAPLVSCS---GDWRY-- 128

  Fly   101 ESGYESITTELKWVCDKSHHPAVGQSFFFMGSVVGTIIFGYLSDQVGRLPSLLMATL-CGATGDF 164
            ...:.:|.::...||..:....:.|:...:|.:.|....||.:|:.|||...|::.. .|.|| .
Mouse   129 VETHSTIVSQFDLVCSNAWMLDLTQAILNLGFLAGAFTLGYAADRYGRLIIYLISCFGVGITG-V 192

  Fly   165 ITSFVHTLPWFAFSRFMSGLSTDTMYYLMYILVFEYLSPKSRTFGLNIILAVFYCFGLMTSPWAA 229
            :.:|......|...||:.|:.....:...:::|.|.:..|.|.. :.|::.:|:..|::..|..|
Mouse   193 VVAFAPNFSVFVIFRFLQGVFGKGAWMTCFVIVTEIVGSKQRRI-VGIVIQMFFTLGIIILPGIA 256

  Fly   230 IWIGNWRRYLWLASLPALGVLIYPFLICESAQWLLTKRKYDDAVICLKKVAKFNRRHVEESVFDE 294
            .:..:|:......|||:...|:|.:::.||.:||:|:::.:.|:..|::|||.|.:|:..:
Mouse   257 YFTPSWQGIQLAISLPSFLFLLYYWVVPESPRWLITRKQGEKALQILRRVAKCNGKHLSSN---- 317

  Fly   295 FVKYYRERELQDYKLNSHEDTFLAMFLTPRLRRFTLTLL----VKSVI---ITLSCDVINRNMEG 352
                |.|..:.|.::::  .:.|.:..||::|:.||.|:    ..:|:   :.:...:|..|:
Mouse   318 ----YSEITVTDEEVSN--PSCLDLVRTPQMRKCTLILMFAWFTSAVVYQGLVMRLGLIGGNL-- 374

  Fly   353 LGTSPFKLFSFTSIVYLPAGVAILLLQNKIGRKGMACTALFVGGLITTATGFMIAHLDPTENALL 417
                 :..|..:.:|.||..:.|||...::||:.....:..|.|:....|.|:     |.....|
Mouse   375 -----YIDFFISGLVELPGALLILLTIERLGRRLPFAASNIVAGVSCLVTAFL-----PEGIPWL 429

  Fly   418 LAIMVGLGRFGATVSYDAEIQYAAEIIPTSVRGQAVSNIHVIGLASSSLAFYVIY-LAQYYKPLP 481
            ...:..|||.|.|::::......:|:.||::|...||....:......:|.:::: ||..:..||
Mouse   430 RTTVATLGRLGITMAFEIVYLVNSELYPTTLRNFGVSLCSGLCDFGGIIAPFLLFRLAAIWLELP 494

  Fly   482 SIFISCLMFFGAGLCLTLPETLNKKLPETLADGEKFALNESFLYFPCFSRKEKNVRTESV 541
            .|....|.....||.:.||||....||||:.|.||  |..|.|: .|..:|:..|.|..|
Mouse   495 LIIFGILASVCGGLVMLLPETKGIALPETVEDVEK--LGSSQLH-QCGRKKKTQVSTSDV 551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7333	NP_650814.2	2A0119	11..510	CDD:273328	126/539 (23%)
CG7333	NP_650814.2	MFS	126..499	CDD:119392	92/381 (24%)
Slc22a3	NP_035525.1	2A0119	12..523	CDD:273328	126/539 (23%)
Slc22a3	NP_035525.1	MFS	145..513	CDD:119392	93/391 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844075
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.950