DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7333 and Slc22a1

DIOPT Version :9

Sequence 1:	NP_650814.2	Gene:	CG7333 / 42334	FlyBaseID:	FBgn0038715	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_033228.2	Gene:	Slc22a1 / 20517	MGIID:	108111	Length:	556	Species:	Mus musculus

Alignment Length:	559	Identity:	145/559 - (25%)
Similarity:	233/559 - (41%)	Gaps:	70/559 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VLDKCGNYGRFQVMILLLYGYTNILGSLHYFSQTLITFTPEHWCFHADLNGLS------------ 58
            ||:..|.:|.||....||....:...:..|.....:.|||:|.|....:..||
Mouse     7 VLEHVGEFGWFQKQAFLLLCLISASLAPIYVGIVFLGFTPDHHCRSPGVAELSQRCGWSPAEELN 71

  Fly    59 --VEGIRSVYENISASSC--------TPLLGVVNGTGVVSTNRK------CRN-WIFNRESGYES 106
              |.|:.|..|....|.|        ...|..|:....::.||.      |.: |:::...  .|
Mouse    72 YTVPGLGSAGEASFLSQCMKYEVDWNQSTLDCVDPLSSLAANRSHLPLSPCEHGWVYDTPG--SS 134

  Fly   107 ITTELKWVCDKSHHPAVGQSFFFMGSVVGTIIFGYLSDQVGRLPSLLMATLCGATGDFITSFVHT 171
            |.||...||..:....:.||...:|..:|:::.||::|:.||...||:.||..:....:|:....
Mouse   135 IVTEFNLVCGDAWKVDLFQSCVNLGFFLGSLVVGYIADRFGRKLCLLVTTLVTSLSGVLTAVAPD 199

  Fly   172 LPWFAFSRFMSGLSTDTMYYLMYILVFEYL-SPKSRTFGLNIILAVFYCFGLMTSPWAAIWIGNW 235
            .......|.:.|:.:...:...|.|:.|:: |...||..  |:..|.:..||:.....|..|.:|
Mouse   200 YTSMLLFRLLQGMVSKGSWVSGYTLITEFVGSGYRRTTA--ILYQVAFTVGLVGLAGVAYAIPDW 262

  Fly   236 RRYLWL---ASLPALGVLIYPFLICESAQWLLTKRKYDDAVICLKKVAKFNRRHVEESVFDEFVK 297
            |   ||   .|||....|:|.:.:.||.:|||::::...||..::::|:.||:.....:
Mouse   263 R---WLQLAVSLPTFLFLLYYWFVPESPRWLLSQKRTTQAVRIMEQIAQKNRKVPPADL------ 318

  Fly   298 YYRERELQDYKLNSHEDTFLAMFLTPRLRRFTLTLLVKSVIITLSCDVINRNMEGL-------GT 355
              :...|::........:|..:|.||.||:.||.|:    .:..||.|:   .:||       |.
Mouse   319 --KMMCLEEDASERRSPSFADLFRTPSLRKHTLILM----YLWFSCAVL---YQGLIMHVGATGA 374

  Fly   356 SPFKLFSFTSIVYLPAGVAILLLQNKIGRKGMACTALFVGGLITTATGFMIAHLDPTENALLLAI 420
            :.:..|.::|:|..||...||:..::|||......:..|.|.......|:     |.|...|...
Mouse   375 NLYLDFFYSSLVEFPAAFIILVTIDRIGRIYPIAASNLVAGAACLLMIFI-----PHELHWLNVT 434

  Fly   421 MVGLGRFGATVSYDAEIQYAAEIIPTSVR--GQAVSNIHVIGLASSSLAFYVIYLAQYYKPLPSI 483
            :..|||.|||:.........||:.||.:|  |..|.:. :..|......|.|..|.:.::.||.|
Mouse   435 LACLGRMGATIVLQMVCLVNAELYPTFIRNLGMMVCSA-LCDLGGIFTPFMVFRLMEVWQALPLI 498

  Fly   484 FISCLMFFGAGLCLTLPETLNKKLPETLADGEKFALNES 522
            ....|......:.|.||||....||||:.:.|.....:|
Mouse   499 LFGVLGLSAGAVTLLLPETKGVALPETIEEAENLGRRKS 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7333	NP_650814.2	2A0119	11..510	CDD:273328	139/540 (26%)
CG7333	NP_650814.2	MFS	126..499	CDD:119392	100/385 (26%)
Slc22a1	NP_033228.2	2A0119	12..525	CDD:273328	139/540 (26%)
Slc22a1	NP_033228.2	MFS	125..515	CDD:119392	108/417 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843902
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.950