DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7333 and Slc22a8

DIOPT Version :9

Sequence 1:	NP_650814.2	Gene:	CG7333 / 42334	FlyBaseID:	FBgn0038715	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_001158106.1	Gene:	Slc22a8 / 19879	MGIID:	1336187	Length:	537	Species:	Mus musculus

Alignment Length:	537	Identity:	142/537 - (26%)
Similarity:	227/537 - (42%)	Gaps:	55/537 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDFSQVLDKCGNYGRFQVMILLLYGYTNILG-SLHYFSQTLITFTPEHWCF---HADL------- 54
            |.||::||:.|:.|.||.:.:.|.... ||| :.|...|.....||:|.|.   :|.|
Mouse     1 MTFSEILDRVGSMGPFQYLHVTLLALP-ILGIANHNLLQIFTATTPDHHCRPPPNASLEPWVLPL 64

  Fly    55 --NGLSVEGIRSVYENISASSCTPLLGVVNGTGVVSTNRKCRN-WIFNRESGYESITTELKWVCD 116
              ||...:.:|.|:        .|...:.|.|  ......|.: ||:|  |..::|.||...||.
Mouse    65 GPNGKPEKCLRFVH--------LPNASLPNDT--QGATEPCLDGWIYN--STRDTIVTEWDLVCG 117

  Fly   117 KSHHPAVGQSFFFMGSVVGTIIFGYLSDQVGRLPSLLMATLCGATGDFITSFVHTLPWFAFSRFM 181
            .:....:.||.|..|.:||..:||.|||:.||.|.|..:.|..|......:|..:|..:...||:
Mouse   118 SNKLKEMAQSVFMAGILVGGPVFGELSDRFGRKPILTWSYLLLAASGSSAAFSPSLTVYMIFRFL 182

  Fly   182 SGLSTDTMYYLMYILVFEYLSPKSRTFGLNIILAVFYCF--GLMTSPWAAIWIGNWRRYLWLASL 244
            .|.|...:.....||..|::...:|.....   .:.||:  |....|..|..:..||   ||...
Mouse   183 CGCSISGISLSTIILNVEWVPTSTRAISST---TIGYCYTIGQFILPGLAYAVPQWR---WLQLS 241

  Fly   245 PALGVLIYPFL---ICESAQWLLTKRKYDDAVICLKKVAKFNRRHVE-ESVFDEFVKYYRERELQ 305
            .:....|:..|   :.||.:||:...|:..|:..|::||.||.:..| |.:..|.:|:..::::.
Mouse   242 VSAAFFIFSLLSWWVPESIRWLVLSGKFSKALKTLQRVATFNGKKEEGEKLTVEELKFNLQKDIT 306

  Fly   306 DYKLN-SHEDTFLAMFLTPRLRRFTLTLLVKSVIITLSCDVINRNMEGLGTSPFKLFSFTSIVYL 369
            ..|:. ...|    :|....|||.|..|.:.......:...:...:|..|.:.:.|......|.:
Mouse   307 SAKVKYGLSD----LFRVSILRRVTFCLSLAWFATGFAYYSLAMGVEEFGVNIYILQIIFGGVDI 367

  Fly   370 PAGVAILLLQNKIGRKGMACTALFVGGLITTATGFMIAHLDPTENALLLAIMVGLGRFGATVSYD 434
            ||....:|..:.:||:......|.:.|:...|..|:     .:|..||...:...|:...:.|:.
Mouse   368 PAKFITILSISYLGRRITQGFLLILAGVAILALIFV-----SSEMQLLRTALAVFGKGCLSGSFS 427

  Fly   435 AEIQYAAEIIPTSVR--GQAVSNIHV-IGLASSSLAFYVIYLAQYYKPLPSIFISCLMFFGAGLC 496
            ....|.:|:.||.:|  |..:|||.. :|   |.:|..|....:....:|::....:...|....
Mouse   428 CLFLYTSELYPTVLRQTGMGISNIWARVG---SMIAPLVKITGELQPFIPNVIFGTMTLLGGSAA 489

  Fly   497 LTLPETLNKKLPETLAD 513
            ..|.||||:.||||:.|
Mouse   490 FFLLETLNRPLPETIED 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7333	NP_650814.2	2A0119	11..510	CDD:273328	134/522 (26%)
CG7333	NP_650814.2	MFS	126..499	CDD:119392	93/382 (24%)
Slc22a8	NP_001158106.1	2A0119	11..503	CDD:273328	134/522 (26%)
Slc22a8	NP_001158106.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	513..537
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844024
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.950