DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment MET and PlexA

DIOPT Version :9

Sequence 1:XP_011514525.1 Gene:MET / 4233 HGNCID:7029 Length:1409 Species:Homo sapiens
Sequence 2:NP_524637.2 Gene:PlexA / 43832 FlyBaseID:FBgn0025741 Length:1945 Species:Drosophila melanogaster


Alignment Length:1780 Identity:356/1780 - (20%)
Similarity:596/1780 - (33%) Gaps:660/1780 - (37%)


- Green bases have known domain annotations that are detailed below.


Human    57 NMKYQLPNFTA-ETPIQNVILH--EHHIFLGATNYIYVLNEEDLQKVAEYKTGPVLEHPDCFPCQ 118
            |:...:.|..| :|.:.::::.  ...:|:|..|.:|.|: .||:.....||||..:..:| ...
  Fly    60 NLNSTITNVAAFDTKLNHLLVDTITGRVFVGGVNRLYQLS-PDLELSETVKTGPQNDSVEC-SIL 122

Human   119 DCSSKANLSGGVWKDNINMALVVDTYYDDQLISCGSVNRGTCQ----------RHVFPHNHTA-D 172
            ||...|..|.   .||.|..|::|. ...:||:|||:.:|||.          .|..|....| |
  Fly   123 DCPLNAVRSP---TDNYNKVLLIDR-ATSRLIACGSLFQGTCTVRNLQNVSIIEHEVPDAVVAND 183

Human   173 IQSEVHCIFSPQIEEPSQCPDCVVSALGAKVLSSVKDRFINFFVGNTINSSYFPDHPLHSISVRR 237
            ..|......:|   .|.|.|...|..:|               |..|.||.|..:.|  :::.|.
  Fly   184 ANSSTVAFIAP---GPPQHPVTNVMYVG---------------VTYTNNSPYRSEIP--AVASRS 228

Human   238 LKETKDGFMFLTDQSYID------VLPEFRDSYPIKYVHAFESNNFIYFLTVQ---RETLDAQTF 293
            |::||   ||....|.:.      :....|::|.:.||:.|.|..|.||||.|   ......:.:
  Fly   229 LEKTK---MFQIASSAVTTGTRTFINSYARETYFVNYVYGFSSERFSYFLTTQLKHSHHSSPKEY 290

Human   294 HTRIIRFCSINSGLHSYMEMPLECILTEKRKKRSTKKEVFNILQAAYVSKPGAQLARQIGASLND 358
            .|:::|.|..:|..:||.|:|:|||   ...:..||   ||::||.::.||.:.||:.:|.|:.|
  Fly   291 ITKLVRICQEDSNYYSYTEIPVECI---SDAQGGTK---FNLVQAGFLGKPSSDLAQSLGISIQD 349

Human   359 DILFGVFAQSKPDSAEPMDRSAMCAFPIKYVNDFFNKIVNKNNVRCLQHFYGPNHEHCFNRTLLR 423
            |:||.||  ||.:...|.:.||:|.:.:|.:...|.:                |.:.|||.:.:|
  Fly   350 DVLFAVF--SKGEGNTPTNNSALCIYSLKSIRRKFMQ----------------NIKSCFNGSGMR 396

Human   424 N------SSGCEARR-----DEY-----------RTEFTTALQRVDLFMGQFSEVLLTSISTFIK 466
            .      |..|...:     :::           .|..|:.  .|.:|..:.:.|..||.|.:  
  Fly   397 GLDFISPSMPCVLTKLQTIGEDFCGLDVNSPLGGETPITSV--PVAMFNTKLTSVAATSTSGY-- 457

Human   467 GDLTIANLGTSEGRFMQVVVSRSGPSTPHVNFLLDSHPVSPEVIVEHTL-NQNGYTLVITGKKIT 530
               |:..:|||:|...:||:..|..:..:.:|.:|   :..|:..:... |||.|..|::..|::
  Fly   458 ---TVVFVGTSDGFLKKVVIESSSIANEYASFAVD---LGSEINRDMQFDNQNLYIYVMSKTKVS 516

Human   531 KI-------------------------------------------PL------------------ 534
            |:                                           ||                  
  Fly   517 KVKVFDCSDYKTCGDCLGARDPYCGWCSLENKCSPRSNCQDDANDPLYWVSYKTGKCTTITSVVP 581

Human   535 --------------------------------------------NGLGC---------------R 540
                                                        ||:.|               .
  Fly   582 HQLQRTTARTLELIIDHLPQLKENLICAFTTEDKALFTNATKKRNGVNCTTPRTDMLPQIEQGKH 646

Human   541 HF---------------------------QSCSQCLSA--------------------------- 551
            ||                           .||::|:|:                           
  Fly   647 HFTAKLSVRTRNGPDLVSTDFTFFDCSTHSSCTRCVSSEFPCDWCVEAHRCTHDTAENCRNDILV 711

Human   552 -------------PPF----------------------------------VQ------------- 556
                         |.|                                  ||             
  Fly   712 TGVSRIGPSYRSGPGFCPTINATGDGSEVLVAGGTSKSIKVKVHIIGQFIVQTRFVCQFNIEGRV 776

Human   557 ----------------------------------------------------------------- 556
                                                                             
  Fly   777 TSLNAQLLGDTIYCDSMEFQYTSRSPNLTATFAVIWGGSKPLDNPHNIHVVIYRCREMADSCGIC 841

Human   557 --------CGWCH--DKCVRSEECLSG-----TW--TQQIC-LPAIYKVFPNSAPLEGGTRLTIC 603
                    ||||.  :.|...|:|...     .|  ..:|| .|.|:...|.:.|.||||.:||.
  Fly   842 LALSEKYNCGWCSSTNTCEVEEQCNKNKEGKTDWLNRSEICPNPEIHTFQPKTGPWEGGTNITIR 906

Human   604 GWDFGFRRNNKFDLKKTRVLLGNESCTLTLSESTMNT--LKCTV-GPAMNKHFNMSIIISNG--H 663
            |.:.|...|:.:    :.|.:...:| :...:..::|  :.||| .|....:.|..|::..|  .
  Fly   907 GINLGKNYNDIY----SGVRIAGINC-MPFPQFYIDTKQIVCTVDSPGEQMYRNGKIVVQIGDYR 966

Human   664 GTTQYSTFSYVDPVITSISPKYGPMAGGTLLTLTGNYLNSGNSRHISIGGK-TCTLKSVSNSILE 727
            |.:: ..:.:|||.|...:||:||.:|||.:.:||.:||:|:....||... .|.:.|..:|...
  Fly   967 GESK-EDYEFVDPKILDFNPKFGPTSGGTEIHITGKHLNAGSRIQASINDHLPCKILSTDSSQAI 1030

Human   728 CYTPAQTISTEFAVKLKIDLANRETS--IFSYREDPIVY--------EIHPTKSFISGGSTITGV 782
            |.|.|.....|..:|:..|...||.:  .|.|..||.|.        :|...|...:||..|:..
  Fly  1031 CRTSASPGIIEGRLKMSFDNGPREFNDYNFKYVLDPTVEHVSSGPSGQIKVPKGIPAGGIRISVT 1095

Human   783 GKNLNSVSVPRMVINVHEAGRNFTVACQHRSNSEIICCTTPSL----QQLNLQLPLKTKAFFMLD 843
            |....|:..|.:.:..:  |..:...|:.:|::|:. |.:|.:    ..:..:.|:..:..|::|
  Fly  1096 GTQFTSIQNPNIYVVYN--GEMYASPCRVQSDTEME-CASPVVDVDSHVIEAERPILLEYGFLMD 1157

Human   844 GILSKYFDLIYVHNPVFKPFEKP------VMISMGNENVLEIKGNDIDPEAVKGEV-LKVGNKSC 901
            .:| :..:|..|||..|:.:..|      ..:.......|.|.|.::|....:.:| :|:||..|
  Fly  1158 NVL-RVQNLSKVHNNHFELYPNPEYFIFEERVKYFKSEYLTINGRNLDRACKESDVEVKIGNGFC 1221

Human   902 ENIHLHSEAVLCTVPND------------LLKLNSELNIEWKQAISSTVLGKVIVQPDQNFTGLI 954
            ....|..:.:.|..|::            ::::.:.|  |::..|.|.....:|:...:|   :|
  Fly  1222 NITSLSRQQLTCRPPSEATATKSMNGPEVIVRIGTSL--EYRIGILSYESSNIILDWGEN---VI 1281

Human   955 AGVVSISTALLLLLGFFLWLKKRKQIKDLGSELVRYDARVHTPHLDRLVSARSVSPTTEMVSNES 1019
            ..|  |:|.::|||.|...|...|:.....|.::| :.:.....|:..|:|              
  Fly  1282 FAV--IATIVILLLIFVALLVAYKKKSSESSRVLR-NMQEQMDILELRVAA-------------- 1329

Human  1020 VDYRATFPEDQFPNSSQNGSCRQVQYPLTDMSPILTSGDSDISSPLL------------QNTVHI 1072
             :.:..|.|              :|..:||::..||||    ..|.|            .:..||
  Fly  1330 -ECKEAFAE--------------LQTEMTDLTGDLTSG----GIPFLDYRSYAMKILFPNHEDHI 1375

Human  1073 DLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDI 1137
            .|....|||::..:.:.|        |.::|....|..::..||             ..||...:
  Fly  1376 VLQWERPELLRKEKGLRI--------FGQLIMNKTFLLLFIRTL-------------ESNRYFSM 1419

Human  1138 GEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKH------GDL-RNFIRNETHNP 1195
            .|               ..||.||:.:.|:|:      |.|...      ||| ...|..::|  
  Fly  1420 RE---------------RVNVASLIMVTLQSK------LEYCTDILKTLLGDLIEKCIEGKSH-- 1461

Human  1196 TVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKT 1260
                                .|..:.|..:....||...||..:..|  .::...:..|.:....
  Fly  1462 --------------------PKLLLRRTESVAEKMLSAWFTFLLYKF--LKECAGEPLYMLFRAV 1504

Human  1261 GAKL---PVKWMALE---SLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGR 1319
            ..::   ||.....|   ||..:|...:|                    .|....::...::|  
  Fly  1505 KGQVDKGPVDACTHEARYSLSEEKLIRQS--------------------IDFRPMNVYASIIQ-- 1547

Human  1320 RLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRISAIFSTFIGEHYVHVNATYVNVKCVAP- 1383
               ||.:|.:             .:|.||.:|.|| :..:....||:         |..||:.. 
  Fly  1548 ---QPIFCNN-------------LDMLPSHTENVS-VKVLDCDTIGQ---------VKEKCLETI 1586

Human  1384 YPSLLSSEDNADDEVDTRPASFWET 1408
            |.::.||:....|::|..    |.|
  Fly  1587 YRNIPSSQRPRKDDLDLE----WRT 1607

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
METXP_011514525.1 Sema_MET 44..535 CDD:200539 141/628 (22%)
PSI 538..580 CDD:214655 19/252 (8%)
IPT_plexin_repeat1 582..675 CDD:238585 24/97 (25%)
IPT_plexin_repeat2 676..759 CDD:238584 29/85 (34%)
IPT_plexin_repeat3 761..856 CDD:238586 21/106 (20%)
IPT 857..953 CDD:214657 21/114 (18%)
Pkinase_Tyr 1097..1356 CDD:285015 47/271 (17%)
PTKc_Met_Ron 1101..1362 CDD:270649 46/273 (17%)
PlexANP_524637.2 Sema_plexin_like 75..520 CDD:200497 135/507 (27%)
PSI 522..574 CDD:279745 2/51 (4%)
PSI 671..>699 CDD:279745 4/27 (15%)
PSI 830..883 CDD:279745 9/52 (17%)
IPT_plexin_repeat1 885..977 CDD:238585 24/97 (25%)
IPT_plexin_repeat2 978..1063 CDD:238584 28/84 (33%)
IPT 1078..1177 CDD:301692 23/102 (23%)
IPT_PCSR 1196..>1255 CDD:238337 12/58 (21%)
Plexin_cytopl 1353..1916 CDD:285529 68/373 (18%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3610
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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