DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MET and Met

DIOPT Version :9

Sequence 1:	XP_011514525.1	Gene:	MET / 4233	HGNCID:	7029	Length:	1409	Species:	Homo sapiens
Sequence 2:	NP_113705.1	Gene:	Met / 24553	RGDID:	3082	Length:	1382	Species:	Rattus norvegicus

Alignment Length:	1383	Identity:	1226/1383 - (88%)
Similarity:	1305/1383 - (94%)	Gaps:	3/1383 - (0%)

- Green bases have known domain annotations that are detailed below.

Human    20 MKAPAVLAPGILVLLFTLVQRSNGECKEALAKSEMNVNMKYQLPNFTAETPIQNVILHEHHIFLG 84
            ||||..||||||:||.||.|||:|||||||.||||||||||||||||||||||||:||.|||:||
  Rat     1 MKAPTALAPGILLLLLTLAQRSHGECKEALVKSEMNVNMKYQLPNFTAETPIQNVVLHGHHIYLG 65

Human    85 ATNYIYVLNEEDLQKVAEYKTGPVLEHPDCFPCQDCSSKANLSGGVWKDNINMALVVDTYYDDQL 149
            |||||||||::|||||:|:|||||:||||||||||||||||:||||||||:||||:|||||||||
  Rat    66 ATNYIYVLNDKDLQKVSEFKTGPVVEHPDCFPCQDCSSKANVSGGVWKDNVNMALLVDTYYDDQL 130

Human   150 ISCGSVNRGTCQRHVFPHNHTADIQSEVHCIFSPQIEEPS-QCPDCVVSALGAKVLSSVKDRFIN 213
            |||||||||||||||.|.::.|||||||||:|||..||.| |||||||||||||||.|.||||||
  Rat   131 ISCGSVNRGTCQRHVLPPDNAADIQSEVHCMFSPLAEEESGQCPDCVVSALGAKVLLSEKDRFIN 195

Human   214 FFVGNTINSSYFPDHPLHSISVRRLKETKDGFMFLTDQSYIDVLPEFRDSYPIKYVHAFESNNFI 278
            |||||||||||.||:.||||||||||||:|||.|||||||||||.||||||||||:||||||:||
  Rat   196 FFVGNTINSSYPPDYSLHSISVRRLKETQDGFKFLTDQSYIDVLGEFRDSYPIKYIHAFESNHFI 260

Human   279 YFLTVQRETLDAQTFHTRIIRFCSINSGLHSYMEMPLECILTEKRKKRSTKKEVFNILQAAYVSK 343
            ||||||:|||||||||||||||||::|||||||||||||||||||:||||::|||||||||||||
  Rat   261 YFLTVQKETLDAQTFHTRIIRFCSVDSGLHSYMEMPLECILTEKRRKRSTREEVFNILQAAYVSK 325

Human   344 PGAQLARQIGASLNDDILFGVFAQSKPDSAEPMDRSAMCAFPIKYVNDFFNKIVNKNNVRCLQHF 408
            |||.||:|||||..||||:||||||||||||||:|||:|||||||||||||||||||||||||||
  Rat   326 PGANLAKQIGASPYDDILYGVFAQSKPDSAEPMNRSAVCAFPIKYVNDFFNKIVNKNNVRCLQHF 390

Human   409 YGPNHEHCFNRTLLRNSSGCEARRDEYRTEFTTALQRVDLFMGQFSEVLLTSISTFIKGDLTIAN 473
            |||||||||||||||||||||.|.||||||||||||.||||||:.:.||||||||||||||||||
  Rat   391 YGPNHEHCFNRTLLRNSSGCEVRSDEYRTEFTTALQAVDLFMGRLNHVLLTSISTFIKGDLTIAN 455

Human   474 LGTSEGRFMQVVVSRSGPSTPHVNFLLDSHPVSPEVIVEHTLNQNGYTLVITGKKITKIPLNGLG 538
            ||||||||||||:||:...|||||||||||||||||||||..||||||||:||||||||||||||
  Rat   456 LGTSEGRFMQVVLSRTAHFTPHVNFLLDSHPVSPEVIVEHPSNQNGYTLVVTGKKITKIPLNGLG 520

Human   539 CRHFQSCSQCLSAPPFVQCGWCHDKCVRSEECLSGTWTQQICLPAIYKVFPNSAPLEGGTRLTIC 603
            |.||||||||||||.|:||||||::||.|.||.||||||:|||||:|||||.||||||||.||||
  Rat   521 CGHFQSCSQCLSAPYFIQCGWCHNRCVHSNECPSGTWTQEICLPAVYKVFPTSAPLEGGTMLTIC 585

Human   604 GWDFGFRRNNKFDLKKTRVLLGNESCTLTLSESTMNTLKCTVGPAMNKHFNMSIIISNGHGTTQY 668
            ||||||::||||||:||:||||||||||||||||.|||||||||||::|||:|:|:||...||||
  Rat   586 GWDFGFKKNNKFDLRKTKVLLGNESCTLTLSESTTNTLKCTVGPAMSEHFNVSVIVSNSRETTQY 650

Human   669 STFSYVDPVITSISPKYGPMAGGTLLTLTGNYLNSGNSRHISIGGKTCTLKSVSNSILECYTPAQ 733
            |.|||||||||||||:|||.||||||||||.|||||||||||||||||||||||:||||||||..
  Rat   651 SAFSYVDPVITSISPRYGPHAGGTLLTLTGKYLNSGNSRHISIGGKTCTLKSVSDSILECYTPGH 715

Human   734 TISTEFAVKLKIDLANRETSIFSYREDPIVYEIHPTKSFISGGSTITGVGKNLNSVSVPRMVINV 798
            |:|.||.||||||||:|.||.|||.|||.|.|||||||||||||||||:||||||||.|::||.|
  Rat   716 TVSAEFPVKLKIDLADRVTSSFSYGEDPFVSEIHPTKSFISGGSTITGIGKNLNSVSTPKLVIEV 780

Human   799 HEAGRNFTVACQHRSNSEIICCTTPSLQQLNLQLPLKTKAFFMLDGILSKYFDLIYVHNPVFKPF 863
            |:.|.|:||||||||:||||||||||||||:|||||||||||:|||||||:|||.|||:|:||||
  Rat   781 HDVGVNYTVACQHRSSSEIICCTTPSLQQLDLQLPLKTKAFFLLDGILSKHFDLTYVHDPMFKPF 845

Human   864 EKPVMISMGNENVLEIKGNDIDPEAVKGEVLKVGNKSCENIHLHSEAVLCTVPNDLLKLN-SELN 927
            |||||||||||||:||||:|||||||||||||||||||||:|.||||:|||||:|||||| .|||
  Rat   846 EKPVMISMGNENVVEIKGDDIDPEAVKGEVLKVGNKSCENLHWHSEALLCTVPSDLLKLNGGELN 910

Human   928 IEWKQAISSTVLGKVIVQPDQNFTGLIAGVVSISTALLLLLGFFLWLKKRKQIKDLGSELVRYDA 992
            ||||||:||||||||||||||||.|||.|.||||..:||:.|.||||:|||. ||||||||||||
  Rat   911 IEWKQAVSSTVLGKVIVQPDQNFAGLIIGAVSISVVVLLVSGLFLWLRKRKH-KDLGSELVRYDA 974

Human   993 RVHTPHLDRLVSARSVSPTTEMVSNESVDYRATFPEDQFPNSSQNGSCRQVQYPLTDMSPILTSG 1057
            ||||||||||||||||||||||||||||||||||||||||||||||:||||||||||:|||||||
  Rat   975 RVHTPHLDRLVSARSVSPTTEMVSNESVDYRATFPEDQFPNSSQNGACRQVQYPLTDLSPILTSG 1039

Human  1058 DSDISSPLLQNTVHIDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGK 1122
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||:|||
  Rat  1040 DSDISSPLLQNTVHIDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDSDGK 1104

Human  1123 KIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNF 1187
            |||||||||||||||.|||||||||||||||||||||||||||||||||||||||||||||||||
  Rat  1105 KIHCAVKSLNRITDIEEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNF 1169

Human  1188 IRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKE 1252
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat  1170 IRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKE 1234

Human  1253 YYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQ 1317
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||:||||
  Rat  1235 YYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITIYLLQ 1299

Human  1318 GRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRISAIFSTFIGEHYVHVNATYVNVKCVA 1382
            ||||||||||||.|||||||||||||||||||||||||||:||||||||||||||||||||||||
  Rat  1300 GRRLLQPEYCPDALYEVMLKCWHPKAEMRPSFSELVSRISSIFSTFIGEHYVHVNATYVNVKCVA 1364

Human  1383 PYPSLLSSEDNADDEVDT 1400
            ||||||.|:||.|.|.:|
  Rat  1365 PYPSLLPSQDNIDGEANT 1382

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MET	XP_011514525.1	Sema_MET	44..535	CDD:200539	431/491 (88%)
		PSI	538..580	CDD:214655	32/41 (78%)
		IPT_plexin_repeat1	582..675	CDD:238585	75/92 (82%)
		IPT_plexin_repeat2	676..759	CDD:238584	70/82 (85%)
		IPT_plexin_repeat3	761..856	CDD:238586	78/94 (83%)
		IPT	857..953	CDD:214657	84/96 (88%)
		Pkinase_Tyr	1097..1356	CDD:285015	254/258 (98%)
		PTKc_Met_Ron	1101..1362	CDD:270649	255/260 (98%)
Met	NP_113705.1	Sema	25..517	CDD:301699	431/491 (88%)
		PSI	520..562	CDD:214655	32/41 (78%)
		IPT_plexin_repeat1	564..657	CDD:238585	75/92 (82%)
		IPT_plexin_repeat2	658..739	CDD:238584	68/80 (85%)
		IPT	743..838	CDD:301692	78/94 (83%)
		IPT	839..>903	CDD:214657	55/63 (87%)
		Pkinase_Tyr	1079..1338	CDD:285015	254/258 (98%)
		PTKc_Met_Ron	1083..1344	CDD:270649	255/260 (98%)
		Interaction with RANBP9. /evidence=ECO:0000250	1213..1382		160/168 (95%)
		Interaction with MUC20. /evidence=ECO:0000250	1321..1360		37/38 (97%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83677290
Domainoid	1	1.000	785	1.000	Domainoid score	I2773
eggNOG	0	0.000	Not matched by this tool.
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H206
Inparanoid	1	1.050	2508	1.000	Inparanoid score	I804
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG44211
OrthoDB	1	1.010	-	-		D11245at9347
OrthoFinder	1	1.000	-	-		FOG0008065
OrthoInspector	1	1.000	-	-		oto131708
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	1	1.100	-	-	LDO	PTHR24416
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2994
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	16	16.410