DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Dys and ACTN2

DIOPT Version :9

Sequence 1:NP_001036722.1 Gene:Dys / 42327 FlyBaseID:FBgn0260003 Length:3598 Species:Drosophila melanogaster
Sequence 2:NP_001094.1 Gene:ACTN2 / 88 HGNCID:164 Length:894 Species:Homo sapiens


Alignment Length:1076 Identity:230/1076 - (21%)
Similarity:422/1076 - (39%) Gaps:279/1076 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MEPGI----LIDERQHI-------------------QKKTFTKWINSHLIDTQCTPVKDLFLDLR 42
            :|||:    :.||.:::                   |:||||.|.||||.... |.::::..|.|
Human     4 IEPGVQYNYVYDEDEYMIQEEEWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAG-TQIENIEEDFR 67

  Fly    43 DGHRLLALLSTLTQTNL-KPEKGRMRVHHINNLNKVITEIQQHGVKLVNISSDDIVGGNAKLTLG 106
            :|.:|:.||..::...| ||::|:||.|.|.|:||.:..|...|||||:|.:::||.||.|:|||
Human    68 NGLKLMLLLEVISGERLPKPDRGKMRFHKIANVNKALDYIASKGVKLVSIGAEEIVDGNVKMTLG 132

  Fly   107 LIWLIALEFNGQHLVKSHSSNGVEKSLLAWARQYTEPH-GLQLNDFSSSWSDGRAFLMILDAHVE 170
            :||.|.|.|..|.:  |......::.||.|.::.|.|: .:.:.:|.:||.||.....::..|..
Human   133 MIWTIILRFAIQDI--SVEETSAKEGLLLWCQRKTAPYRNVNIQNFHTSWKDGLGLCALIHRHRP 195

  Fly   171 ELNLQAAL-QQHALKRLHLAFDLAHRHFKIEKLLDAED-VHTHKPDNKSIQMYVMCLYHAMESMR 233
            :|...:.| :...:..::||.::|.:|..|.|:||||| |:|.|||.::|..||.|.|||.    
Human   196 DLIDYSKLNKDDPIGNINLAMEIAEKHLDIPKMLDAEDIVNTPKPDERAIMTYVSCFYHAF---- 256

  Fly   234 TRQQEQEQDEGQDQDPGRVPCTSITDLDEVPLDNDQTSLGLYTSDSAGSME--QRSSGELKTHSM 296
                     .|.:|  .......|..:..|..:|::.            ||  :|.:.||.....
Human   257 ---------AGAEQ--AETAANRICKVLAVNQENERL------------MEEYERLASELLEWIR 298

  Fly   297 RPLSTATNASVEISGYQSALEAVLTLLLEDEQLLSQNLPDPQDFQ--------TAKLQFHENESF 353
            |.:....|.:.|                :..|.:.:.|.|.:|::        ..|.|...|.:.
Human   299 RTIPWLENRTPE----------------KTMQAMQKKLEDFRDYRRKHKPPKVQEKCQLEINFNT 347

  Fly   354 M---LKLTEHQEYVGEALEEGSNLINESQKAGAGLSQEDQNEVRQQMVLLNERWETLRLRALDVQ 415
            :   |:::....::.   .||..:   |..||| ..:.:|.|...:..||||      :|.|:  
Human   348 LQTKLRISNRPAFMP---SEGKMV---SDIAGA-WQRLEQAEKGYEEWLLNE------IRRLE-- 397

  Fly   416 AKILMRLAEFQKQKLEQLRQFLTSVEDRISHMSDIGPTLEEAEKQLLEAQKLKADLSEQQELVDS 480
              .|..|||..:||......:....|..:........:|.|....|.:.:..::||:..|:.|:.
Human   398 --RLEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQDRVEQ 460

  Fly   481 LSSMVVIVNDTSGNFND---LEDRLSALGERWSHVVKWSDLRKEKLQQYKCI------------- 529
            ::::...:|:.  :::|   :.||...:.::|..:...:..|:|.|::.:.:             
Human   461 IAAIAQELNEL--DYHDAVNVNDRCQKICDQWDRLGTLTQKRREALERMEKLLETIDQLHLEFAK 523

  Fly   530 -----SRWLDAREQDLKLMESRDVTDVGGITQRINELNYCAKDLLELQRYLIDLRQMVAATLQDG 589
                 :.|::...:||:.|                   :....:.|:|. ||...:...|||.:.
Human   524 RAAPFNNWMEGAMEDLQDM-------------------FIVHSIEEIQS-LITAHEQFKATLPEA 568

  Fly   590 DDKGERVLIQ---------LESYEDRLDALKQIVEVQTVRIETKGFNFGRDRASYDDSRVVRPEG 645
            |  |||..|.         ::||..|:.:......|....:.||                     
Human   569 D--GERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTK--------------------- 610

  Fly   646 WVDYQMIIRFGEDDSQEDDDEHDLASKKRKLRNADNFNALENHIMEHFGYVQEVEQKLQQLQRQS 710
            |...:.::...:...||     :||.:....|....|.|..|.|...      ::.|::::.|.|
Human   611 WDKVKQLVPIRDQSLQE-----ELARQHANERLRRQFAAQANAIGPW------IQNKMEEIARSS 664

  Fly   711 LRQQCELLKELQAENSRRCGTLPELKKLYEVCELEDPSRNLLLEETHIKQLEQRYANLSQKLSSQ 775
            :               :..|.|.:     ::.:|:....|::..:.:|.:||..:..:.:.|.. 
Human   665 I---------------QITGALED-----QMNQLKQYEHNIINYKNNIDKLEGDHQLIQEALVF- 708

  Fly   776 QSESHTLLAKEKYYNSLTGFKLVLADSRDWYKQHAGSASGNELEQRLSHMESLASEISEAKTATE 840
             ...||....|   :...|::|:|...         :.:.||:|.::.        ..:||..|:
Human   709 -DNKHTNYTME---HIRVGWELLLTTI---------ARTINEVETQIL--------TRDAKGITQ 752

  Fly   841 ELDDNLIEWKQDFGLF-----------------YDSWHDMKQA----LQALIQQRGGESLSRQLK 884
            |   .:.|::..|..|                 ....:|:.:|    :..|:...|..:::    
Human   753 E---QMNEFRASFNHFDRRKNGLMDHEDFRACLISMGYDLGEAEFARIMTLVDPNGQGTVT---- 810

  Fly   885 QIQDFVTKVSNQKVRVSNLEVMQEQQHFLNQLLDEMESLRLTYDNIPKHLIGEELQTAWNRLPEQ 949
             .|.|:..::.:.......|.:             :.|.|:...:.| :::.|||:   ..||..
Human   811 -FQSFIDFMTRETADTDTAEQV-------------IASFRILASDKP-YILAEELR---RELPPD 857

  Fly   950 LNERVIKQTTAIENLNHF--AAEYNAIIAMLRSAAD 983
            ..:..||:..|.......  |.:|.|..:.|...:|
Human   858 QAQYCIKRMPAYSGPGSVPGALDYAAFSSALYGESD 893

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DysNP_001036722.1 CH 13..111 CDD:278723 45/117 (38%)
CH 129..225 CDD:278723 32/98 (33%)
SPEC 312..525 CDD:238103 44/226 (19%)
SbcC <325..957 CDD:223496 119/693 (17%)
Smc <816..1591 CDD:224117 33/191 (17%)
SPEC 1174..1365 CDD:238103
SPEC 1289..1485 CDD:295325
SPEC 2369..2576 CDD:238103
SPEC 2477..2714 CDD:238103
WW 2852..2882 CDD:238122
EF-hand_2 2883..2997 CDD:286194
EF-hand_3 3001..3100 CDD:286195
ZZ_dystrophin 3110..3158 CDD:239074
ACTN2NP_001094.1 Actin-binding 1..254 88/252 (35%)
SAC6 36..>299 CDD:227401 96/292 (33%)
Spectrin 1 281..391 25/144 (17%)
Spectrin 281..391 CDD:306853 25/144 (17%)
Spectrin 2 401..506 21/106 (20%)
SPEC 402..629 CDD:238103 46/276 (17%)
Spectrin 3 516..627 23/153 (15%)
Spectrin 4 637..740 24/142 (17%)
Spectrin 637..739 CDD:306853 24/141 (17%)
EFh_PEF 747..>851 CDD:330173 19/125 (15%)
EFhand_Ca_insen 824..890 CDD:312305 16/82 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.910

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