Protein Alignment Dys and ACTN1

DIOPT Version :9

• Sequence 1: NP_001036722.1
• Gene: Dys / 42327
• FlyBaseID: FBgn0260003
• Length: 3598
• Species: Drosophila melanogaster
• Sequence 2: XP_016877209.1
• Gene: ACTN1 / 87
• HGNCID: 163
• Length: 1106
• Species: Homo sapiens
• Alignment Length: 1019
• Identity: 219/1019 - (21%)
• Similarity: 359/1019 - (35%)
• Gaps: 351/1019 - (34%)

  Fly    16 KTFTKWINSHLIDTQCTPVKDLFLDLRDGHRLLALLSTLTQTNL-KPEKGRMRVHHINNLNKVIT 79
            :|||.|.||||.... |.::::..|.|||.:|:.||..::...| |||:|:||||.|:|:||.:.
Human    64 ETFTAWCNSHLRKAG-TQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALD 127

  Fly    80 EIQQHGVKLVNISSDDIVGGNAKLTLGLIWLIALEFNGQHLVKSHSSNGVEKSLLAWARQYTEPH 144
            .|...|||||:|.:::||.||.|:|||:||.|.|.|..|.:  |......::.||.|.::.|.|:
Human   128 FIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDI--SVEETSAKEGLLLWCQRKTAPY 190

  Fly   145 -GLQLNDFSSSWSDGRAFLMILDAHVEELNLQAALQQ-HALKRLHLAFDLAHRHFKIEKLLDAED 207
             .:.:.:|..||.||..|..::..|..||.....|:: ..|..|:.|||:|.::..|.|:|||||
Human   191 KNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAED 255

  Fly   208 -VHTHKPDNKSIQMYVMCLYHAMESMRTRQQEQEQDEGQDQDPGRVPCTSITDLDEVPLDNDQTS 271
             |.|.:||.|:|..||...|||.
Human   256 IVGTARPDEKAIMTYVSSFYHAF------------------------------------------ 278

  Fly   272 LGLYTSDSAGSMEQRSSGELKTHSMRPLSTATNASVEISGYQSALEAVLTLLLEDEQLLSQNLPD 336
                            ||..|.      .||.|...:          ||.:..|:|||:
Human   279 ----------------SGAQKA------ETAANRICK----------VLAVNQENEQLM------ 305

  Fly   337 PQDFQTAKLQFHENESFMLKLTEHQEYVGEALEEGSNLINESQKAGAGLSQEDQNEVR------- 394
             :|::  ||           .::..|::...:....|.:.|:.........||..:.|
Human   306 -EDYE--KL-----------ASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKPPK 356

  Fly   395 -QQMVLLNERWETLRLRALDVQAKILMRLAEFQKQKLEQLRQFLTSVEDRISHMSDIGPTLEEAE 458
             |:...|...:.||:                 .|.:|.....|:.|....:|.:::....||:.|
Human   357 VQEKCQLEINFNTLQ-----------------TKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVE 404

  Fly   459 K-----QLLEAQKLKADLSEQQELVDSLSSMVVIVNDTSGNFNDLEDRLSALGERWSHVVKWSDL 518
            |     .|.|.::|        |.:|.|:.          .|.    :.:::.|.|:..: |..|
Human   405 KGYEEWLLNEIRRL--------ERLDHLAE----------KFR----QKASIHEAWTDAM-WPSL 446

  Fly   519 RKEK-------------LQQYKCISRWLDAREQDLKLMESRDVTDVGGITQRINELNY------- 563
            ...|             |.:.|.:.:..:|.|.||...:.| |..:..|.|.:|||:|
Human   447 NPGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDR-VEQIAAIAQELNELDYYDSPSVN 510

  Fly   564 --CAKDLLELQRYLIDLRQMVAATLQDGDDKGERVLIQLESYEDRLDALKQIVEVQTVRIETKGF 626
              |.|        :.|....:.|..|...:       .||..|..|:.:.|:
Human   511 ARCQK--------ICDQWDNLGALTQKRRE-------ALERTEKLLETIDQL------------- 547

  Fly   627 NFGRDRASYDDSRVVRPEGWVDYQMIIRFGEDDSQEDDDEHDLASKKRKLRNADNFNALENHIME 691
                               :::|                          .:.|..||
Human   548 -------------------YLEY--------------------------AKRAAPFN-------- 559

  Fly   692 HFGYVQEVEQKLQQLQRQSLRQQCELLKELQAENSRRCGTLPELKKLYEVCELEDPSRNLLLE-E 755
                 ..:|..::.||...:....|.::.|...:.:...|||:          .|..|..:|. .
Human   560 -----NWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPD----------ADKERLAILGIH 609

  Fly   756 THIKQLEQRYANLSQKLSSQQSESHTLLAKEKYYNSLTGFKLVLADSRDWYKQHAGSASGNELEQ 820
            ..:.::.|.|              |..:|....|.::|                     ..|:..
Human   610 NEVSKIVQTY--------------HVNMAGTNPYTTIT---------------------PQEING 639

  Fly   821 RLSHMESLASEISEAKT---ATEELDDNLIEWKQDFGL---FYDSW--HDMKQALQALIQQRGGE 877
            :..|:..|.....:|.|   |.::.::.|   ::.||.   ....|  ..|::..:..|:..|
Human   640 KWDHVRQLVPRRDQALTEEHARQQHNERL---RKQFGAQANVIGPWIQTKMEEIGRISIEMHG-- 699

  Fly   878 SLSRQLKQIQDFVTKVSNQKVRVSNLEVMQEQQHFLNQLLDEMESLRLTYDNIPKHLIGEELQTA 942
            :|..||..::.:...:.|.|.::..|    |..|   ||:.|    .|.:||...:...|.::..
Human   700 TLEDQLSHLRQYEKSIVNYKPKIDQL----EGDH---QLIQE----ALIFDNKHTNYTMEHIRVG 753

  Fly   943 WNRLPEQLNERVIKQTTAIEN--------------LNHFAAEYN 972
            |    |||...:.:....:||              :|.|.|.:|
Human   754 W----EQLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFN 793

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dys	NP_001036722.1	CH	13..111	CDD:278723	46/95 (48%)
		CH	129..225	CDD:278723	36/98 (37%)
		SPEC	312..525	CDD:238103	41/238 (17%)
		SbcC	<325..957	CDD:223496	115/675 (17%)
		Smc	<816..1591	CDD:224117	38/179 (21%)
		SPEC	1174..1365	CDD:238103
		SPEC	1289..1485	CDD:295325
		SPEC	2369..2576	CDD:238103
		SPEC	2477..2714	CDD:238103
		WW	2852..2882	CDD:238122
		EF-hand_2	2883..2997	CDD:286194
		EF-hand_3	3001..3100	CDD:286195
		ZZ_dystrophin	3110..3158	CDD:239074
ACTN1	XP_016877209.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910