DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Dys and ACTN4

DIOPT Version :9

Sequence 1:NP_001036722.1 Gene:Dys / 42327 FlyBaseID:FBgn0260003 Length:3598 Species:Drosophila melanogaster
Sequence 2:XP_016882820.1 Gene:ACTN4 / 81 HGNCID:166 Length:933 Species:Homo sapiens


Alignment Length:929 Identity:213/929 - (22%)
Similarity:372/929 - (40%) Gaps:243/929 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 ILID---ERQHIQKKTFTKWINSHLIDTQCTPVKDLFLDLRDGHRLLALLSTLTQTNL-KPEKGR 65
            :|:|   |:|  |:||||.|.||||.... |.::::..|.|||.:|:.||..::...| |||:|:
Human    42 LLLDPAWEKQ--QRKTFTAWCNSHLRKAG-TQIENIDEDFRDGLKLMLLLEVISGERLPKPERGK 103

  Fly    66 MRVHHINNLNKVITEIQQHGVKLVNISSDDIVGGNAKLTLGLIWLIALEFNGQHLVKSHSSNGVE 130
            ||||.|||:||.:..|...|||||:|.:::||.||||:|||:||.|.|.|..|.:  |......:
Human   104 MRVHKINNVNKALDFIASKGVKLVSIGAEEIVDGNAKMTLGMIWTIILRFAIQDI--SVEETSAK 166

  Fly   131 KSLLAWARQYTEPH-GLQLNDFSSSWSDGRAFLMILDAHVEELNLQAALQQHALKR------LHL 188
            :.||.|.::.|.|: .:.:.:|..||.||.||..::..|..||     ::...|::      |:.
Human   167 EGLLLWCQRKTAPYKNVNVQNFHISWKDGLAFNALIHRHRPEL-----IEYDKLRKDDPVTNLNN 226

  Fly   189 AFDLAHRHFKIEKLLDAED-VHTHKPDNKSIQMYVMCLYHAMESMRTRQQEQEQDEGQDQDPGRV 252
            ||::|.::..|.|:||||| |:|.:||.|:|..||...|||....:..:                
Human   227 AFEVAEKYLDIPKMLDAEDIVNTARPDEKAIMTYVSSFYHAFSGAQKAE---------------- 275

  Fly   253 PCTSITDLDEVPLDNDQTSLGLYTSDSAGSMEQRSSGELKTHSMRPLSTATNASVEISGYQSALE 317
              |:...:.:|...|.:..                      |.|             ..|:....
Human   276 --TAANRICKVLAVNQENE----------------------HLM-------------EDYEKLAS 303

  Fly   318 AVLTLL------LEDE------QLLSQNLPDPQDFQTA--------KLQFHENESFM---LKLTE 359
            .:|..:      |||.      |.:.|.|.|.:|::..        |.|...|.:.:   |:|:.
Human   304 DLLEWIRRTIPWLEDRVPQKTIQEMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNTLQTKLRLSN 368

  Fly   360 HQEYV---GEALEEGSNLINESQKAGAGLSQEDQNEVRQQMVLLNERWETLRLRALDVQAKILMR 421
            ...::   |:.:.:.:|.....::|..|..:...||:|             ||..||       .
Human   369 RPAFMPSEGKMVSDINNGWQHLEQAEKGYEEWLLNEIR-------------RLERLD-------H 413

  Fly   422 LAEFQKQKLEQLRQFLTSVEDRISHMSDIGPTLEEAEKQLLEAQKLKADLSEQQELVDSLSSMVV 486
            |||..:||......:....|..:.|......||.:.:..:.:.:..::||:..|:.|:.::::..
Human   414 LAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQ 478

  Fly   487 IVND----TSGNFNDLEDRLSALGERWSHVVKWSDLRKEKLQ----QYKCI-------------- 529
            .:|:    .|.|.|   .|...:.::|..:...:..|:|.|:    |.:.|              
Human   479 ELNELDYYDSHNVN---TRCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQLHLEYAKRAAPF 540

  Fly   530 SRWLDAREQDLKLMESRDVTDVGGITQRINELNYCAKDLLELQRYLIDLRQMVAATLQDGDDKGE 594
            :.|:::..:||:.|         .|...|.|:           ..||.......:||.|.|.:.|
Human   541 NNWMESAMEDLQDM---------FIVHTIEEI-----------EGLISAHDQFKSTLPDADRERE 585

  Fly   595 RVL-IQLESYEDRLDALKQIVEVQTVRIETKGFNFGRDRASYDDSRVVRPEGWVDYQMII----- 653
            .:| |..|:        ::|.|...:::.      |.:..:....:::..: |...|.::     
Human   586 AILAIHKEA--------QRIAESNHIKLS------GSNPYTTVTPQIINSK-WEKVQQLVPKRDH 635

  Fly   654 RFGEDDSQEDDDEHDLASKKRKLRN--ADNFNALENHI---MEHFGYVQ-----EVEQKLQQLQR 708
            ...|:.|::..:||        ||.  |...|.:...|   ||..|.:.     .:|.:|..|::
Human   636 ALLEEQSKQQSNEH--------LRRQFASQANVVGPWIQTKMEEIGRISIEMNGTLEDQLSHLKQ 692

  Fly   709 QS------------LRQQCELLKELQAENSRRCGTLPELKKLYEVCELEDPSRNLLLEETHIK-Q 760
            ..            |.||.:|::                    |....::...|..:|  ||: .
Human   693 YERSIVDYKPNLDLLEQQHQLIQ--------------------EALIFDNKHTNYTME--HIRVG 735

  Fly   761 LEQRYANLSQKLSSQQSESHTLLAKEKYYNSLTGFKLVLADSRDWYKQHAGSASGNELEQRLSHM 825
            .||....:::.::..:::..|..||......:..|:   |....:.|.|.|:....|.:..|..:
Human   736 WEQLLTTIARTINEVENQILTRDAKGISQEQMQEFR---ASFNHFDKDHGGALGPEEFKACLISL 797

  Fly   826 ESLASEISEAKTATEELDD 844
            ........:.:|.:.:.||
Human   798 GYDVENDRQKQTGSMDSDD 816

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DysNP_001036722.1 CH 13..111 CDD:278723 50/98 (51%)
CH 129..225 CDD:278723 35/103 (34%)
SPEC 312..525 CDD:238103 48/246 (20%)
SbcC <325..957 CDD:223496 108/591 (18%)
Smc <816..1591 CDD:224117 5/29 (17%)
SPEC 1174..1365 CDD:238103
SPEC 1289..1485 CDD:295325
SPEC 2369..2576 CDD:238103
SPEC 2477..2714 CDD:238103
WW 2852..2882 CDD:238122
EF-hand_2 2883..2997 CDD:286194
EF-hand_3 3001..3100 CDD:286195
ZZ_dystrophin 3110..3158 CDD:239074
ACTN4XP_016882820.1 CH_ACTN_rpt1 47..151 CDD:409063 53/106 (50%)
CH_ACTN_rpt2 155..269 CDD:409065 40/120 (33%)
SPEC 296..517 CDD:238103 47/243 (19%)
SPEC 414..640 CDD:238103 46/263 (17%)
SPEC 532..754 CDD:238103 48/286 (17%)
PTZ00184 759..>890 CDD:185504 12/61 (20%)
EFhand_Ca_insen 863..929 CDD:400872
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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