DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Dys and Sptbn4

DIOPT Version :9

Sequence 1:NP_001036722.1 Gene:Dys / 42327 FlyBaseID:FBgn0260003 Length:3598 Species:Drosophila melanogaster
Sequence 2:XP_006540500.1 Gene:Sptbn4 / 80297 MGIID:1890574 Length:2580 Species:Mus musculus


Alignment Length:2563 Identity:502/2563 - (19%)
Similarity:866/2563 - (33%) Gaps:902/2563 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 LIDERQHIQKKTFTKWINSHLIDTQCTPVKDLFLDLRDGHRLLALLSTLTQTNL-KPEKGRMRVH 69
            |.|||:.:||||||||:||||....| .:.||:.|||||..|..||..|:...| :|.:||||:|
Mouse    75 LADEREAVQKKTFTKWVNSHLARVGC-HIGDLYADLRDGFVLTRLLEVLSGEQLPRPTRGRMRIH 138

  Fly    70 HINNLNKVITEIQQHGVKLVNISSDDIVGGNAKLTLGLIWLIALEFNGQHLVK-----SHSSNGV 129
            .:.|::|.:..:::..|.|.|:.|.|||.||.:|||||:|.|.|.|..| ::|     :..:...
Mouse   139 SLENVDKALQFLKEQRVHLENVGSHDIVDGNHRLTLGLVWTIILRFQIQ-VIKIETEDNRETRSA 202

  Fly   130 EKSLLAWARQYTEPH-GLQLNDFSSSWSDGRAFLMILDAHVEEL-NLQAALQQHALKRLHLAFDL 192
            :.:||.|.:..|..: .:.:.:|::||.||.||..::..|..:| :|....:.:|...|..||..
Mouse   203 KDALLLWCQMKTAGYPEVNIQNFTTSWRDGLAFNALIHRHRPDLVDLSKLTKSNANYNLQRAFRT 267

  Fly   193 AHRHFKIEKLLDAEDVHTHKPDNKSIQMYVMCLYHAMESMRTRQQEQEQDEGQDQDPGRVPCTSI 257
            |.:|..:.:|||.|||:...||.|||..||:..||....|:....|.::       .|:|     
Mouse   268 AEQHLGLARLLDPEDVNMEAPDEKSIITYVVSFYHYFSKMKALAVEGKR-------IGKV----- 320

  Fly   258 TDLDEVPLDNDQTSLGLYTSDSAGSMEQRSSGELKTHSMRPLSTATNASV--EISGYQSALEAVL 320
              ||:| |:.|:. :..|         :..:.||.....|.:...:|...  .:||.|..|:|..
Mouse   321 --LDQV-LEVDKI-IERY---------EELAAELLAWIHRTVDLISNQKFANSLSGVQQQLQAFT 372

  Fly   321 TLLLEDEQLLSQNLPDPQDFQ------------TAKLQFHENESFMLKLTEHQEYVGEALEEGSN 373
            ...         .|..|..||            .:||:.|....|:.:             ||..
Mouse   373 AYC---------TLEKPVKFQEKGNLEVLLFSIQSKLRAHNRRLFVPR-------------EGCG 415

  Fly   374 LINESQKAGAGLSQEDQNEVRQQMVLLNERWETLRLRALDVQAKILMRLAEFQKQKLEQLRQFLT 438
            :.:..:..|.....|.:.|...:..|:  |.|.|.|.|.....|:.||.:...:.:         
Mouse   416 IWDIDKAWGELEKAEHEREAALRAELI--RQEKLELLAQRFDHKVAMRESWLNENQ--------- 469

  Fly   439 SVEDRISHMSDIGPTLEEAEKQLLEAQKLKADLSEQQELVDSLSSMVVIVNDTSGNFNDLEDRLS 503
                |:....:.|..|...|..:.:.:.::||::..:|.|..::              :|...|:
Mouse   470 ----RLVSQDNFGYELPAVEAAMKKHEAIEADIAAYEERVQGVA--------------ELAQALA 516

  Fly   504 ALG---------ERWSHVVKWSDL------RKEKLQQYKCISR----------WLD-------AR 536
            |.|         :|.|.:.:|:.|      |:.:|:|...:.:          |::       :|
Mouse   517 AEGYYDARRVAAQRDSVLRQWALLTGLVGARRTRLEQNLALQKVFQEMVYMVDWMEEMQTQLLSR 581

  Fly   537 EQDLKLMESRDVT--------DVGGITQRINELNYCAKDLLELQRY------------------L 575
            |....|:|:.|:.        |:...::|:..||..|....:||.|                  |
Mouse   582 ECGQHLVEADDLLQKHGLLEGDIAAQSERVEALNAAALRFSQLQGYQPCDPQVICNRVNHVHGCL 646

  Fly   576 IDLRQMVA----------------------------------ATLQDGDDKG-----------ER 595
            .:|::..|                                  ||...|...|           .|
Mouse   647 SELQEQAARRRAELEASRSLWALLQELEEAESWARDKERLLEATSGSGGAAGTAGGAHDLSSTAR 711

  Fly   596 VLIQLESYEDRLDALKQIVEVQTVR----IETKGFNFG-----------RDRAS--------YDD 637
            :|.|.:..:..|...:.::: |.:|    :...|.:.|           .:||:        .::
Mouse   712 LLAQHKILQGELGGRRALLQ-QALRRGEELAAAGGSVGPGAEPLHLAGLAERAASARRRWQRLEE 775

  Fly   638 SRVVRPEGWVDYQMIIRFGED-----DSQED--------DDEHDLASKKRKLRNADNFNALENHI 689
            :...|.....:.:.:.:||.|     |...|        |..||.||.:|..|   ...||...:
Mouse   776 AAARRERRLQEARALHQFGADLDGLLDWLRDAYRLAAAGDFGHDEASSRRLAR---QHRALTGEV 837

  Fly   690 MEHFG---------------------------YVQEVEQ------KLQQLQRQSLR--------- 712
            ..|.|                           .|.|.||      ::..|:||.||         
Mouse   838 EAHRGPVGGLRRQLATLGGASGAGPLVVALQVRVVEAEQLFAEVTEVAALRRQWLRDALAVYRMF 902

  Fly   713 ---QQCEL---------------------------LKELQAENSRRCGTLPELKK-LYEVCELED 746
               ..|||                           .:.|..|.:...|.:.::.: :.|:.|...
Mouse   903 GEVHACELWIGEKEQWLLAMRVPDSLDDVEVVQHRFESLDQEMNSLMGRVLDVNQTVQELVEGGH 967

  Fly   747 PSRN-----------------------------LLLEETHIKQLEQRYANLSQKLSSQQS----- 777
            ||.:                             :||.|.|:.::.:..|.:.:|..:.:|     
Mouse   968 PSSDEVRSCQDHLNSRWNRIVELVEQRKEEMSAVLLVENHVLEVAEVRAQVREKRRAVESAPRAG 1032

  Fly   778 -------------------------ESHTLLAKEKY-----------------YNSLTGF----- 795
                                     |...||| |::                 :.:|.|.     
Mouse  1033 GALQWRLSGLEAALQALEPRQAALLEEAALLA-ERFPAQATRLHQGAEELGAEWGALAGAAQACG 1096

  Fly   796 KLVLADSR------------DWY---KQHAGSASG------NELEQRLSHMESLASEI------- 832
            :.|.|..|            ||.   ::.||:..|      .|.:..|:...:|..|:       
Mouse  1097 EAVAAAGRLQRFLRDLDTFLDWLVRAQEAAGAVEGPLPRSLEEADGLLARHAALKEEVDQREEDY 1161

  Fly   833 ------SEAKTATE--------ELDDNL----IEWKQDFGLFYDSWHDMKQAL------------ 867
                  |||..|:|        .||:.|    :.|.:..||    |.:.::||            
Mouse  1162 ARIVAASEALLASEGAELGPGLALDEWLPHLEVGWHKLLGL----WEERREALVQAHVYQLFLRD 1222

  Fly   868 --QALIQQRGG-------------ESLSRQLKQIQDFVT--KVSNQKVRVSNLEVMQEQQHFLNQ 915
              |||...|..             ||:...:|:.:||:|  :::.||::|:    :|..:..|.|
Mouse  1223 LCQALAVLRNQEVALSGAELPCTVESVEEAMKRHRDFLTTMELNQQKMQVA----VQAAESLLRQ 1283

  Fly   916 LLDEMESLRLTYDNIPKHLIGEELQTAWNRLPEQLNERVIKQTTAIEN------LNHFAAEYNAI 974
                            .:..||:.|.|..||.|:..|..::....::.      |.||..:.:.:
Mouse  1284 ----------------GNAYGEQAQEAVARLLEKSQENQLRAQQWMQKLLDQLVLQHFLRDCHEL 1332

  Fly   975 IAMLRSAADSKLNGSDGASSQDLRKLEIDVISARNFSEILIKEAEPAQKESLQSQIRALNTLYDQ 1039
            ...:.   :..|...|| :.:|..||....:..:.|.      ||.||.:               
Mouse  1333 DGWIH---EKMLMARDG-TREDSHKLHKRWLRHQAFM------AELAQNK--------------- 1372

  Fly  1040 VEQVHREKKEQQTVLQSHIDL---IQLRLKETDQWLTDLESNTPKSGISDIVNSNELFQSKSRFQ 1101
             |.:.:.::|.|.::|...:|   ::.:|.|..|...:|||.|.       ..:.:||::....|
Mouse  1373 -EWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQ-------AKARQLFEASKADQ 1429

  Fly  1102 TLKETCERETTQFRDLNERGGELLLQMD-ELQDQDRESRYGSLAKQFTRINA------RW-TEVT 1158
            .::        .|.:|::|    ||.|: :|||.|......::..|..::.:      .| .||.
Mouse  1430 LVQ--------SFAELDKR----LLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWCREVG 1482

  Fly  1159 ELVYAKTAL-LEHISTQLGEFKKFMVSE--TGYLDKLENKIRNTPENAADAEEIMEELDD----- 1215
            ||.....|| ||..|.:|...::..|.|  ...|:.|:.: |.....:.:..::..:|||     
Mouse  1483 ELQAQTAALPLEQASKELVGERQSAVGERLVRLLEPLQER-RRLLLASKELHQVAHDLDDELAWV 1546

  Fly  1216 ----------------------------LENVLRSHS---EEWLDKIQEIGNELIDNEFMADSIR 1249
                                        |...:::|.   ||.|::...:.: |...|  |:::|
Mouse  1547 QERLPLAMQTERGTGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGVLAS-LRSPE--AEAVR 1608

  Fly  1250 RDIDETVQRWTQLQQQAKKRTELLEQKVSEAEQSEKCIVQFEKWLTRVD---------------- 1298
            |..::....||.|::.|::|.:.|: ...:.||....:.:.|.||...:                
Mouse  1609 RGQEQLQSAWTGLREAAERRQQTLD-AAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTL 1672

  Fly  1299 DILSDHLDNDVTIVDQPEEFQRLAHEFVANEKNFKEISELIDEHTRNGKVGAANRLQEQLNLMEV 1363
            .:|..||..:..:.:..|...:|:.:..|..:.....||.|            :|.|.|::.:.|
Mouse  1673 QLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQI------------SRRQSQVDRLYV 1725

  Fly  1364 RFKYCQAKLSKCTAIQHSYESRLNRAYTDLRNVERSTEVVDVASAGPNTVQTQYQKCLQIYRTLS 1428
            ..|.. .:..:.:..|..:..:|:|...:|.:.....|||    ||...:...::....:....|
Mouse  1726 ALKEL-GEERRVSLEQQYWLYQLSRQVDELEHWIAEKEVV----AGSPELGQDFEHVSVLQEKFS 1785

  Fly  1429 EIKSEIESTIKTGRRVCEDRYTKSPKQLSQRIDALKHLYNTLGENVTQSK--------------A 1479
            |..||   |...||    :|..    .::|.:|.|....:|....:.:.|              .
Mouse  1786 EFASE---TGTAGR----ERLA----AVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMG 1839

  Fly  1480 TLERLLTLARQLEECFDSADNL----------IRRFESPQE---------------VHD------ 1513
            |..:||..:|:|.:.|..|..|          :.|..:|.|               .||      
Mouse  1840 TRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTAPPEPRPSASSMQRTLRAFEHDLQLLVS 1904

  Fly  1514 ---------------------------RNSILLEFEDVLRRCEDHYNEYNKSCDQSCMVETRQR- 1550
                                       ...:|..::::|..|||.....:.:.| :....::.| 
Mouse  1905 QVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWKELLAACEDARLHVSSTAD-ALRFHSQARD 1968

  Fly  1551 ----IDGLKA------------------TYHKLTSADIIKRLTEMKTTLQNLDNISLETLRAMEH 1593
                :||:..                  .||:....::..|:.|: .|.|.|....|....||..
Mouse  1969 LLSWMDGIAGQIGAADKPRDVSSVEVLMNYHQGLKTELEARVPEL-ATCQELGRSLLLNKSAMAD 2032

  Fly  1594 DL-----------KEINVPSNPEIEKLQQQV-------IAIVVDVLKTRFNEATTLAARNTSSPD 1640
            ::           :|::...:...|.|||.:       .|:|.|...|.  :...|.:|...|..
Mouse  2033 EIQAQLDKLGSRKEEVSEKWDRHWEWLQQMLEVHQFAQEAVVADAWLTA--QEPLLQSRELGSSV 2095

  Fly  1641 NDDTEIVVVSDTVRQRRA------------------RTPQSGESPS------------------- 1668
            ::..:::...:..|:..|                  :..||.:.|:                   
Mouse  2096 DEVEQLIRRHEAFRKAAAAWEERFSSLRRLTTIEKLKAEQSKQPPTPLLGRKFFGDPTELAAKAA 2160

  Fly  1669 ------------------SAHTSSSESPTKGVENSPGAVGDQVMPDLLPPQTFRLAESSTLFSQI 1715
                              ::.|.|:|     |....|.|..::.|:.|.|:..||.|:|......
Mouse  2161 PLLRPGGYDRGLEPLARRASDTLSAE-----VRTRVGYVRQELKPERLQPRIDRLPETSGKVEPA 2220

  Fly  1716 SLNPQKVTNTPPP-KPAKTKRKAPSSPAQVVEIRVKNIQNDKMSVQNIDLEPQQGEIVDTVNILE 1779
            :.....:..|..| .||.|:...|.|..|.:..|.:.:...:.|                     
Mouse  2221 APTAAALDTTDTPGTPAATELVRPRSERQELADRAEELPRRRRS--------------------- 2264

  Fly  1780 SVEPFVPEYVETVQIVDLSEDSDSSVRVDSQGKEMRRSKSKHSLNETPLPKVSDNDEDSAEQEED 1844
                      |..:.||..|::....|.:.|  |....:..|||.   |.:....:.....:|..
Mouse  2265 ----------ERQESVDQPEETARRRRPERQ--ESADHEGPHSLT---LGRYEQMERRRERRERR 2314

  Fly  1845 LLRPSAENTSTPFLRVEKRRISFDEKRKRVANERDILRDSEEEE--------------PK----- 1890
            :.|..:....||         :..|..|..|...||:...:|:|              |:     
Mouse  2315 IERQESSEQETP---------TRGELVKGKATLADIVEQLQEKEAGPGIPAGVPSLPQPRELPPG 2370

  Fly  1891 -------------TPDTPRAAQVSKPKR 1905
                         .||.|||....||:|
Mouse  2371 RLPNGLEPPERTPRPDRPRARDRPKPRR 2398

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DysNP_001036722.1 CH 13..111 CDD:278723 48/98 (49%)
CH 129..225 CDD:278723 33/97 (34%)
SPEC 312..525 CDD:238103 43/239 (18%)
SbcC <325..957 CDD:223496 172/1011 (17%)
Smc <816..1591 CDD:224117 188/995 (19%)
SPEC 1174..1365 CDD:238103 43/244 (18%)
SPEC 1289..1485 CDD:295325 40/225 (18%)
SPEC 2369..2576 CDD:238103
SPEC 2477..2714 CDD:238103
WW 2852..2882 CDD:238122
EF-hand_2 2883..2997 CDD:286194
EF-hand_3 3001..3100 CDD:286195
ZZ_dystrophin 3110..3158 CDD:239074
Sptbn4XP_006540500.1 SAC6 75..>423 CDD:227401 121/396 (31%)
SPEC 450..664 CDD:238103 40/240 (17%)
SPEC 790..1002 CDD:238103 35/214 (16%)
SPEC 1106..1210 CDD:197544 21/107 (20%)
SPEC 1216..1424 CDD:238103 52/260 (20%)
SPEC 1322..1529 CDD:238103 56/252 (22%)
SPEC 1531..1742 CDD:238103 39/227 (17%)
SPEC 1637..1849 CDD:238103 44/239 (18%)
Spectrin 1849..1948 CDD:334073 13/98 (13%)
SPEC 1958..>2125 CDD:238103 28/170 (16%)
PH_beta_spectrin 2437..2541 CDD:269975
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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