Protein Alignment Dys and actn4

DIOPT Version :9

• Sequence 1: NP_001036722.1
• Gene: Dys / 42327
• FlyBaseID: FBgn0260003
• Length: 3598
• Species: Drosophila melanogaster
• Sequence 2: XP_017951705.1
• Gene: actn4 / 448522
• XenbaseID: XB-GENE-494339
• Length: 926
• Species: Xenopus tropicalis
• Alignment Length: 1152
• Identity: 251/1152 - (21%)
• Similarity: 403/1152 - (34%)
• Gaps: 415/1152 - (36%)

  Fly     5 ILID---ERQHIQKKTFTKWINSHLIDTQCTPVKDLFLDLRDGHRLLALLSTLTQTNL-KPEKGR 65
            :|:|   |:|  |:||||.|.||||.... |.::::..|.|||.:|:.||..::...| |||:|:
 Frog    35 LLLDPAWEKQ--QRKTFTAWCNSHLRKAG-TQIENIDEDFRDGLKLMLLLEVISGERLPKPERGK 96

  Fly    66 MRVHHINNLNKVITEIQQHGVKLVNISSDDIVGGNAKLTLGLIWLIALEFNGQHLVKSHSSNGVE 130
            ||||.|||:||.:..|...|||||:|.:::||.||.|:|||:||.|.|.|..|.:  |......:
 Frog    97 MRVHKINNVNKALDFIASKGVKLVSIGAEEIVDGNTKMTLGMIWTIILRFAIQDI--SVEETSAK 159

  Fly   131 KSLLAWARQYTEPH-GLQLNDFSSSWSDGRAFLMILDAHVEELNLQAALQQHALKR------LHL 188
            :.||.|.::.|.|: .:.:.:|..||.||.||..::..|..||     ::...|::      |:.
 Frog   160 EGLLLWCQRKTAPYKNVNVQNFHISWKDGLAFNALIHRHRPEL-----IEYDKLRKDDPVTNLNN 219

  Fly   189 AFDLAHRHFKIEKLLDAED-VHTHKPDNKSIQMYVMCLYHAMESMRTRQQEQEQDEGQDQDPGRV 252
            ||::|.|:..|.|:||||| |:|.:||.|:|..||...|||.
 Frog   220 AFEVAERYLDIPKMLDAEDIVNTARPDEKAIMTYVSSFYHAF----------------------- 261

  Fly   253 PCTSITDLDEVPLDNDQTSLGLYTSDSAGSMEQRSSGELKTHSMRPLSTATNASVEISGYQSALE 317
                                               ||..|.      .||.|...::.......|
 Frog   262 -----------------------------------SGAQKA------ETAANRICKVLAVNQENE 285

  Fly   318 AVLTLLLEDEQLLSQNLPDPQDFQTAKLQFHENESFMLKLTEHQEYVGEALEEGSNLINESQKAG 382
            .    |:||.:.|:.:|                          .|::...:....|.:.|.....
 Frog   286 H----LMEDYEKLASDL--------------------------LEWIRRTIPWLENRVPEKTMHD 320

  Fly   383 AGLSQEDQNEVR--------QQMVLLNERWETLRLRALDVQAKILMRLAEFQKQKLEQLRQFLTS 439
            .....||..:.|        |:...|...:.||:                 .|.:|.....|:.|
 Frog   321 MQQKLEDFRDYRRVHKPPKVQEKCQLEINFNTLQ-----------------TKLRLSNRPAFMPS 368

  Fly   440 VEDRISHMSDIGPTLEEAEK----QLLEAQKLKADLSEQQELVDSLSSMVVIVNDTSGNFNDLED 500
            ....:|.:::....||:|||    .||.|.:       :.|.:|.|:.               :.
 Frog   369 EGKMVSDINNGWQHLEQAEKGFEEWLLNAIR-------RLERLDHLAE---------------KF 411

  Fly   501 RLSAL-GERWSH----VVKWSDLRKEKLQQYKCISRWLDAREQDLKLMESRDVTDVGGITQRINE 560
            |..|| .|.|:.    ::|..|.....|...|.:.|..:|.|.||...:.| |..:..|.|.:||
 Frog   412 RQKALIHEAWTEGKEAMLKQKDYESATLADIKALIRKHEAFESDLAAHQDR-VEQIAAIAQELNE 475

  Fly   561 LNY---------CAK--DLLELQRYLIDLRQMVAATLQDGDDKGERVLIQLESYEDRLDALKQIV 614
            |:|         |.|  |..:|...|...|:..                 ||..|.:|:|:.|:
 Frog   476 LDYYDSPSVNARCQKICDQWDLLGSLTHTRREA-----------------LEVTEKQLEAIDQL- 522

  Fly   615 EVQTVRIETKGFNFGRDRASYDDSRVVRPEGWVDYQMIIRFGEDDSQEDDDEHDLASKKRKLRNA 679
                                           :::|                          .:.|
 Frog   523 -------------------------------YLEY--------------------------AKRA 530

  Fly   680 DNFNALENHIMEHFGYVQEVEQKLQQLQRQSLRQQCELLKELQAENSRRCGTLPELKKLYEVCEL 744
            ..||             ..:|..::.||...:....|.::.|.|.:.:...|||:
 Frog   531 APFN-------------NWMEGAMEDLQDMFIVHTIEEIEGLIAAHEQFKSTLPD---------- 572

  Fly   745 EDPSRNLLLEETHIKQLEQRYANLSQKLSSQQSESHTLLAKEKYYNSLTGFKLVLADSRDWYK-- 807
            .|..|..:|          ...|.:||::..   ||..||....|.::|.   .:.:|: |.|
 Frog   573 ADREREAIL----------GIQNEAQKIADY---SHIKLASGNPYTTVTP---QIINSK-WEKVQ 620

  Fly   808 ----QHAGSASG-NELEQRLSHME----SLASEISEAKTATEELDDNLIEWKQDFGLFYDSWHDM 863
                :..|:..| ::.:|...|:.    |||:.:.              .|.|         ..|
 Frog   621 QLVPKRDGALKGEHDKQQSNEHLRLQFASLANVVG--------------PWIQ---------AKM 662

  Fly   864 KQALQALIQQRGGESLSRQLKQIQDFVTKVSNQKVRVSNLEVMQEQQHFLNQLLDEMESLRLTYD 928
            ::..:..|:..|  :|..|:..::.:...|.|.|..:..|    ||||   ||:.|    .|.:|
 Frog   663 EEIGRIAIELHG--TLEDQMTHLKQYEQSVINYKPNIDKL----EQQH---QLIQE----ALIFD 714

  Fly   929 NIPKHLIGEELQTAWNRLPEQLNERVIKQTTAIEN---------------------LNHF----- 967
            |...:...|.::..|    |.|...:.:.:..:||                     .|||
 Frog   715 NKHTNYTMEHIRVGW----EHLLTTIARTSNEVENQILTRDAKGISQEQMHEYRASFNHFDRDHT 775

  Fly   968 ----AAEYNAIIAMLRSAADSKLNGSDGASSQDLRKLEIDVISARNFSEILIK------EAEPAQ 1022
                ..|:.|.:..|            |...::.|:..|..:.|.:|..:||.      :||
 Frog   776 GALGPEEFKACLISL------------GYDVENDRQKRIGALDADDFRALLISTGYSLGDAE--- 825

  Fly  1023 KESLQSQIRALNTLYDQVEQVHREKKEQQTVLQSHIDLIQLRLKETD 1069
                          ::::..:...........|:.||.:.....:||
 Frog   826 --------------FNRIMAIVDPNNTGMVTFQAFIDFMSRETTDTD 858

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dys	NP_001036722.1	CH	13..111	CDD:278723	49/98 (50%)
		CH	129..225	CDD:278723	36/103 (35%)
		SPEC	312..525	CDD:238103	40/229 (17%)
		SbcC	<325..957	CDD:223496	124/670 (19%)
		Smc	<816..1591	CDD:224117	52/294 (18%)
		SPEC	1174..1365	CDD:238103
		SPEC	1289..1485	CDD:295325
		SPEC	2369..2576	CDD:238103
		SPEC	2477..2714	CDD:238103
		WW	2852..2882	CDD:238122
		EF-hand_2	2883..2997	CDD:286194
		EF-hand_3	3001..3100	CDD:286195
		ZZ_dystrophin	3110..3158	CDD:239074
actn4	XP_017951705.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910