Protein Alignment Dys and jbug

DIOPT Version :10

• Sequence 1: NP_001036722.1
• Gene: Dys / 42327
• FlyBaseID: FBgn0260003
• Length: 3598
• Species: Drosophila melanogaster
• Sequence 2: NP_001261140.1
• Gene: jbug / 43997
• FlyBaseID: FBgn0028371
• Length: 2990
• Species: Drosophila melanogaster
• Alignment Length: 2715
• Identity: 493/2715 - (18%)
• Similarity: 850/2715 - (31%)
• Gaps: 880/2715 - (32%)

  Fly    13 IQKKTFTKWINSHLIDTQCTPVKDLFLDLRDGHRLLALLSTLTQTNLKPEKGRM---RVHHINNL 74
            ||..||..|:|.||.:|. ..|.|...|..||..|.||:..|....|||...|.   :.|::.|.
  Fly    60 IQANTFRNWVNEHLRETG-MQVHDWATDFCDGTCLCALVENLQTRPLKPSWNRRPANQHHYLENA 123

  Fly    75 NKVITEIQQHGVKLVNISSDDIVGGNAKLTLGLIWLIALEFNGQHLVKSHSSNGVEKSLLAWARQ 139
            ...:..|:...:|||||.:.|||.||.||.|||||.:.:.:.     ...|.....|.:|||. |
  Fly   124 TTALKSIEADHIKLVNIGNVDIVNGNIKLILGLIWSLIVRYQ-----IGRSKFPPRKLMLAWL-Q 182

  Fly   140 YTEPHGLQLNDFSSSWSDGRAFLMILD-------AHVEELNLQAALQQHALKRLHLAFDLAHRHF 197
            ...| ..::.:.::.|:.|.....:||       .|...|:     ...:::....|.|||.|.|
  Fly   183 AALP-DCRITNLTTDWNSGVNLAALLDYCQPGLFPHWRSLD-----PSQSVRNCTQAMDLAQREF 241

  Fly   198 KIEKLLDAEDVHTHKPDNKSIQMYVMCL-------YHA-MESMRTRQQEQEQDEGQDQDPGRVPC 254
            .:.|:|:.|.:.:...|..|...|:...       |:| |..:.|:.::..::...|.:.|||.|
  Fly   242 GVPKVLEPEYLASPWLDELSGMTYLSYFMKPGGPGYNATMRWVNTQVKDPVKNFTTDWNDGRVMC 306

  Fly   255 TSITDLDEVPLDNDQTSLGLYTSDSAGSMEQRSSGELKTHS-------------MRPLSTA---T 303
            ..|..|                ..||.:.|:.|:......:             ::|:.||   .
  Fly   307 EIIKGL----------------GGSAPAPEKLSTDPFHYENNIRKAVDAGARLGVQPILTAKDMA 355

  Fly   304 NASVE---ISGYQSALEAV---------LTLLLEDE------------QLLSQNL---------- 334
            |..||   |..|.:.|:.|         :::.||..            .::|:::
  Fly   356 NPEVEHLGIMAYAAHLQWVPPRPPLSDLVSVYLESTSGRVGEPTHFRIDVMSRDISLSSVRCHVV 420

  Fly   335 -PDPQDFQTAKLQFHENESFMLKLTEHQEYVGEALEEGSNLINESQKAGAGLSQEDQNEVRQQMV 398
             |..|..|..:|..|....|:.:.....|.|.|        |.|....|        :..|....
  Fly   421 PPSGQPGQPVRLNAHGEGVFVPERYGMHEIVVE--------IGEDSLGG--------HFFRALPR 469

  Fly   399 LLNERWETLRLRALDVQAKILMRLAEFQKQKLEQLRQFLTSVEDR-ISHMSDIGPTLEEAEKQLL 462
            ||......:...||....::|:...  ...|.|.:  .:|:|... |||...: ..::|....:.
  Fly   470 LLQVAPPGMAPCALGSLVEVLVNAT--GAPKTEDI--LVTAVSPTGISHNCPL-KKIDEGHSAIF 529

  Fly   463 ---EAQKLKADLSEQQELVDSLSSMVVIVNDTSG-NFNDLEDRLSALGERWSHVVKWSDLRKEKL 523
               ||...:..::.|...:.. ......|.|.|| :.:.|:..:              .||....
  Fly   530 KPDEAGIWEIAITYQGRHIQG-GPFTCAVFDASGVSVHGLDGAM--------------PLRAHTF 579

  Fly   524 QQYKCISRWLDAREQDLKLMESRDVTDVGGITQRINELN----------YCAKDLLELQRYLIDL 578
            :        :|||.           ..|.|      ||:          .|:.:.:...:|.:
  Fly   580 E--------VDARG-----------VGVSG------ELHVDIVHDKHSLVCSVEKIVENKYRV-- 617

  Fly   579 RQMVAATLQDGDDKGERVLIQLESYEDRLDALKQIVEVQTVRIETKGFNFGRDRAS-YDDSRVVR 642
                  |.....:...||.|....|:.:....       .:|:.||| ..|:.|:| ..||:...
  Fly   618 ------TFMPRQNGKYRVYIYFNGYDVKGSPF-------IMRVGTKG-RSGKTRSSPLHDSKHRS 668

  Fly   643 PEGWVDYQMIIRFGEDDSQEDD-DEHDLASKKR--------KLRNADNFNAL---------ENHI 689
            ....:.:........:|.:... ..|:.|.:..        ||...|..::.         |||.
  Fly   669 ESPSMHFVSTTNTRHNDYRNSSLSRHNTAERTNSYSPQYSPKLDTTDYHSSSSRYYKRESEENHA 733

  Fly   690 -----------MEHFGYVQEVEQKLQQL---------QRQSLRQQCELLKELQAENSRRCGTLPE 734
                       .....|:...:...:.|         ...|.:......||.:..:.||..|.|:
  Fly   734 TPPPAPPPASGSPTVKYLNSADLYTETLNGRRDSKTSNSSSTKNDYYYDKENELYSQRRAVTKPK 798

  Fly   735 LKKLYEVCELEDPSRNLLLEETHIKQLEQRYANL-------------SQKLSSQQSESHTLLAKE 786
            |....|..||...:..     :.....:||:..|             |..|:::.||.||
  Fly   799 LTPPREERELTSTTNT-----SSSSSFQQRHQQLATSTLTRSLSPIPSPTLNTRSSEVHT----- 853

  Fly   787 KYYNSLTGFKLVLADSRDWYKQHAGSASGNELEQRLSHMESLASEISEAKTATEELDDNLIEWKQ 851
              ::.||      ..:.:.|:....:.:.:.....:|.::..:...:...|||
  Fly   854 --HSPLT------IKTSNQYESSTRNITSSPRHASVSPVQRYSPNSAYITTAT------------ 898

  Fly   852 DFGLFYDSWHDMKQALQALIQQRGGESLSRQLKQIQDFVTK---VSNQKVRVS-NLEVMQEQ--- 909
                     |.|...|.:.:.:.|.|| ||.:::...:.:.   |::..:|.| :|....|:
  Fly   899 ---------HRMGSPLTSPVSKNGYES-SRTVEKSSTYKSTSNYVTDSNIRASPSLYGTAERLRR 953

  Fly   910 --------QHFLNQLLDEME---SLRLTYD--NIPKHLIG-EELQTAWNRLPEQLNERVIKQTTA 960
                    .|..|..:..|:   :.|.::|  |..||::. ..|::..|...:|||..:......
  Fly   954 TGSPEPRIDHSSNVRVSSMKPASARRDSWDVINKTKHMLSHNSLESLANMTEKQLNTELQYNRPD 1018

  Fly   961 IENLNHFAAEYN--AIIAMLRSAADSKLNGSDGASSQDLRKLEIDVISARNFSEILIKEAEPAQK 1023
            :::..|...:||  |:....:..:|.:.:..|     |..:.:...|:.::.|.
  Fly  1019 LDHETHRNTQYNKFALHKQQQQQSDYRRDSPD-----DGERYKPSAITVKSHSN----------- 1067

  Fly  1024 ESLQSQIRALNTLYDQVEQVHREKKEQQTVLQSHIDLIQLRLKETDQWLTDLESN----TPKSGI 1084
                      ||..|:.....:..||.    ..|:             :|  |||    :|..|.
  Fly  1068 ----------NTYTDKSGGYTKTVKES----SEHV-------------VT--ESNGHGPSPGYGY 1103

  Fly  1085 SDI-----VNSNELFQSKSRFQTLKETCERETTQFRDLNERGG----ELLLQMDELQDQDRE--- 1137
            |.:     ::.|.......|.|.:.........:|.....|.|    |:|:....:....|.
  Fly  1104 SSLSRFRPIDGNATGARAIRVQDIPNGSIGRPVEFEIDGSRAGSGNLEILVNGGRVTSSVRSLGG 1168

  Fly  1138 ---------SRYGSLAKQFTRINAR------W-------------TEVTELVYAKTALLEHI--- 1171
                     ..:|:...|.| .|..      |             .|.|.||.|.|..:..|
  Fly  1169 QRFIASFTPHEHGTHTVQIT-FNGETVPGSPWHAEIMSSPGLTALGESTRLVPANTPAVFEILPP 1232

  Fly  1172 ---STQLGEFKKFMVSETGYLDKLENKIRNTPENAADAEEIMEELDDLENVLRSHSEEWLDKIQE 1233
               |...||....::  |....||..::.:...|.|...|.:.                    .|
  Fly  1233 PGQSLSKGECVATVL--TPSKSKLNARVTHEAANGAARIEFVP--------------------TE 1275

  Fly  1234 IGNELIDNEFMADS------IRRDIDETVQRWTQLQ-----QQAKKRTEL-------LEQKVSEA 1280
            :|..:||.......      |.:..|.::.:.|::.     |..:.|.:.       ||..::|.
  Fly  1276 VGTHVIDASINGTKIAGGPLIAKVYDSSLIQVTEVNGGVVGQACQFRVDASAAGEGQLEISINEG 1340

  Fly  1281 EQSE--------KCIVQFEKWLTRVDDILSDHLDNDVTIVDQPEEFQRLAHEFVANEKNFKEISE 1337
            |...        :|:|.|                       .||:.:                |.
  Fly  1341 EVPNHVQVVGGGRCLVSF-----------------------TPEQAK----------------SH 1366

  Fly  1338 LIDEHTRNGKVGAANRLQEQLNLMEVRFKYCQAKLSKC---TAIQHSYESRLNRAYTDLRNVER- 1398
            |||                        .|:....:..|   .|:..:....||.:..:|..|.|
  Fly  1367 LID------------------------IKFNGETVRGCPFVCAVADTSRVLLNLSNLELIPVNRP 1407

  Fly  1399 STEVVDVASAGPNTVQTQY---QKCLQIYRTLSEI----KSEIESTIKTGRRVCEDRYTKSPKQ- 1455
            |:..:.|:..|...:....   |..|.: |...:|    .:|...|...|..: ...|.....|
  Fly  1408 SSFHITVSGGGAAELAVSVRGPQGELPV-RVTGDIHAGFTAEFTPTTVGGHSI-NVEYNGFAVQG 1470

  Fly  1456 ---LSQRIDALKHLYNTLGENVTQSKATLERLLTLARQLEECFDSAD----NL-----IRRFESP 1508
               |::..||.|.:..::...            |:.|.::...|:.|    ||     .:....|
  Fly  1471 TPFLAKSYDASKVVVGSVSRG------------TMGRPVQFTVDAGDAGEGNLEITISAKGQNIP 1523

  Fly  1509 QEVHDRNSILLEFEDV-LRRCEDHYN-EYNKSCDQSCMVETR--------QRIDGLKATYHKLTS 1563
            .:||.:.|.......| ...||...| .:||.....|.:...        |...|.....|: |:
  Fly  1524 TQVHPQGSARFSVSFVPTESCEHTINVSFNKMPVPGCPITVSISGGVAGPQVSLGGPGPVHQ-TN 1587

  Fly  1564 ADIIK----RLTEMKTTLQNLDNISLETLRAMEHDLKE----------------INVPSN----- 1603
            :.:|.    ||.:::.   |::..:.:::.|..|...:                :||..|
  Fly  1588 SFVINHNGGRLEDIEV---NVEGPAGQSVPAQVHQSADGVFKAEFVPRVVGEHRVNVTVNGLPTA 1649

  Fly  1604 --PEIEKLQQQVIAIVVDVLKTRFNEATT-LAARNTSSPDNDDTEIVVVSDTVRQRRARTPQSGE 1665
              |...|:.......|.:|......:|.| |...:.:.|.|  .|:.|             ..|.
  Fly  1650 GSPYAAKVYDVSAIKVKNVSSGTVGKAVTFLVETSQAGPGN--LEVTV-------------NGGR 1699

  Fly  1666 SPSSAHTSSSESPTKGVENSPGAVGDQVMPDLLPPQTFRLAESSTLFSQISLNPQKVTNTPPPKP 1730
            .|:||......  |..:..:|                 |.|||.|:  ::..|.|.|..:|
  Fly  1700 VPTSAQAQGQH--TYAISFTP-----------------REAESHTV--ELRFNSQDVPGSP---- 1739

  Fly  1731 AKTKRKAPSSPAQVVEIRVKNIQNDKMSVQNIDLEPQQGEIVDTVNILESVEPFVPEYVETVQIV 1795
             .|.|.|.::..|..|..      ||:||..:.....:.:...||.:|......||..::.:...
  Fly  1740 -FTCRVAAAARIQSPETM------DKVSVGRLFEFVVESDTKPTVEVLGPARRSVPVKIDALGSS 1797

  Fly  1796 DLS--------EDSDSSVRVDSQG-------KEMRRSKSKHSLNETPL------PKVS---DNDE 1836
            .|.        |..|.||.|...|       ..:.::.|...:..|.:      ..||   :..:
  Fly  1798 TLGYNVKFEPMEVGDHSVEVRLPGGGHVEGSPFLLKAYSAEKVIVTDIRAGVVNKSVSFGINASQ 1862

  Fly  1837 DSAEQEEDLLRPSAENTSTPFLRVE-KRRISFDEKRKRVANERDILRDSEEEEPKTP-------- 1892
            ..|...|.::..:.:|... |::.| ..|...:.|....|.....:|.:....|.:|
  Fly  1863 AGAGNLEIIVAVNGKNVPN-FVQSEGNARFKVNFKPTEAATHSLSVRFNGHPVPGSPFSCHIAAA 1926

  Fly  1893 ------DTPRAAQVSKPKRWRQLQPE-------MDALEPE----SPGRDSFY------------- 1927
                  ..|||..:.:..:...::.:       .|.:||:    ||..|:.:
  Fly  1927 AASPSMGLPRAMAMGECLKQAAVKMDNTFELEGFDGVEPQIFVTSPSGDNEHCQLSQHDGGSYSA 1991

  Fly  1928 -----------------------SPDKESGFDAE------------------PLVFS-DDEDIPR 1950
                                   ||...:.||..                  |:.|| |......
  Fly  1992 SFRPTTVGRHLISVTANDQHINGSPFSCNVFDVSRVSISGLEQQYGPANLGVPVTFSVDAAGAGE 2056

  Fly  1951 FSLEMTSTIDSDSDTSRIM-----------TPSTKNP--------------NPFLSKV------- 1983
            .:||:..:.||.:..:.::           .|.:..|              :||...:
  Fly  2057 GTLELVVSTDSSTVKAEVVACARGLYDVTFVPQSTEPHYVNITFNEVAVDGSPFRVDIQQHTQHI 2121

  Fly  1984 ----LESLSSPVDDSNVTLKSPISEEQPQNLDDRVREF-------------DKQAKQMIYK---- 2027
                |.::..|.||..|.:.||..:..|.:::.:..||             |::.:|.|..
  Fly  2122 QIGSLAAIDFPADDQIVEIFSPDQKSVPYSINRQTAEFRTHMTGNYTLRFIDRETRQHIGSRTLC 2186

  Fly  2028 ------LKLTKAKIEQCHESEAEDLRLLIAPDAATLISQGDSLVLETHGRQGSISRLVMRTQIIL 2086
                  :|:|:.....||..                .|.|.||   ....||.:|.||
  Fly  2187 VFDPTLVKITEVSEAFCHRP----------------ASIGVSL---NEAGQGDLSALV------- 2225

  Fly  2087 REQFREVQQARSKTSGSGAPAPPLDSVNIEELVTKGLR----RINVLI-EKTVDLKSSTDLEKRM 2146
            |....||.......|.:|          :.|:|.:..|    :|::|. |..:.||..
  Fly  2226 RCGATEVPHTIRGPSKTG----------VYEIVYQPTRVAPHKISILFNEVPISLKPL------- 2273

  Fly  2147 EDINERHDDLQVIVSAIGKNAQMPKVTPLMMNEIEKTKNNLIAHADSIELSLTE---LRNGP--- 2205
                    ::.|:.::.||...:..: .|..:.:.||.:..|   |:::....|   :.:||
  Fly  2274 --------EINVLPASAGKEISVSGL-GLYQSRVGKTTSFAI---DTVKRPAREFDVVVSGPGGQ 2326

  Fly  2206 -------RISNGKERPDASSAATMSCRSE--YNNEP-SGTGALAGSFDKS 2245
                   :..||..:.:.:......|..|  :.::| .|:.....|||.|
  Fly  2327 ALPVRCYQTKNGHLQAEFTINKPGQCVIEVLHQSKPLPGSPFTCESFDSS 2376

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dys	NP_001036722.1	CH_DMD-like_rpt1	12..118	CDD:409035	42/107 (39%)
		CH_SF	129..229	CDD:469584	26/114 (23%)
		SPEC	312..525	CDD:238103	42/249 (17%)
		PRK03918	<716..1238	CDD:235175	106/607 (17%)
		SMC_prok_B	<995..1279	CDD:274008	57/351 (16%)
		SPEC	1174..1365	CDD:238103	30/216 (14%)
		SPEC	1289..1485	CDD:413338	31/210 (15%)
		SPEC	2369..2576	CDD:238103
		SPEC	2477..2714	CDD:238103
		WW	2852..2882	CDD:238122
		EFh_DMD_like	2919..3085	CDD:320000
		EF-hand-like motif	2919..2958	CDD:320000
		EF-hand-like motif	2961..2995	CDD:320000
		EF-hand-like motif	3001..3037	CDD:320000
		EF-hand-like motif	3050..3085	CDD:320000
		ZZ_dystrophin	3110..3158	CDD:239074
jbug	NP_001261140.1	CH_jitterbug-like_rpt1	57..166	CDD:409076	42/111 (38%)
		CH_jitterbug-like_rpt2	170..274	CDD:409078	24/110 (22%)
		CH_jitterbug-like_rpt3	275..373	CDD:409034	24/113 (21%)
		IG_FLMN	468..560	CDD:214720	17/97 (18%)
		IG_FLMN	560..648	CDD:214720	20/141 (14%)
		IG_FLMN	1119..1198	CDD:214720	12/79 (15%)
		IG_FLMN	1220..1302	CDD:214720	17/103 (17%)
		IG_FLMN	1310..1389	CDD:214720	18/141 (13%)
		IG_FLMN	1399..1480	CDD:214720	16/82 (20%)
		IG_FLMN	1480..1569	CDD:214720	19/100 (19%)
		IG_FLMN	1575..1659	CDD:214720	14/87 (16%)
		IG_FLMN	1661..1747	CDD:214720	27/126 (21%)
		IG_FLMN	1757..1837	CDD:214720	16/79 (20%)
		IG_FLMN	1837..1926	CDD:214720	14/89 (16%)
		IG_FLMN	1936..2023	CDD:214720	10/86 (12%)
		Filamin	2021..2111	CDD:395505	13/89 (15%)
		IG_FLMN	2198..2280	CDD:214720	25/132 (19%)
		IG_FLMN	2285..2375	CDD:214720	16/93 (17%)
		IG_FLMN	2376..2465	CDD:214720	1/1 (100%)
		Filamin	2474..2555	CDD:395505
		IG_FLMN	2657..2751	CDD:214720
		IG_FLMN	2756..2847	CDD:214720
		IG_FLMN	2850..2944	CDD:214720