DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Dys and jbug

DIOPT Version :9

Sequence 1:NP_001036722.1 Gene:Dys / 42327 FlyBaseID:FBgn0260003 Length:3598 Species:Drosophila melanogaster
Sequence 2:NP_001261140.1 Gene:jbug / 43997 FlyBaseID:FBgn0028371 Length:2990 Species:Drosophila melanogaster


Alignment Length:2715 Identity:493/2715 - (18%)
Similarity:850/2715 - (31%) Gaps:880/2715 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    13 IQKKTFTKWINSHLIDTQCTPVKDLFLDLRDGHRLLALLSTLTQTNLKPEKGRM---RVHHINNL 74
            ||..||..|:|.||.:|. ..|.|...|..||..|.||:..|....|||...|.   :.|::.|.
  Fly    60 IQANTFRNWVNEHLRETG-MQVHDWATDFCDGTCLCALVENLQTRPLKPSWNRRPANQHHYLENA 123

  Fly    75 NKVITEIQQHGVKLVNISSDDIVGGNAKLTLGLIWLIALEFNGQHLVKSHSSNGVEKSLLAWARQ 139
            ...:..|:...:|||||.:.|||.||.||.|||||.:.:.:.     ...|.....|.:|||. |
  Fly   124 TTALKSIEADHIKLVNIGNVDIVNGNIKLILGLIWSLIVRYQ-----IGRSKFPPRKLMLAWL-Q 182

  Fly   140 YTEPHGLQLNDFSSSWSDGRAFLMILD-------AHVEELNLQAALQQHALKRLHLAFDLAHRHF 197
            ...| ..::.:.::.|:.|.....:||       .|...|:     ...:::....|.|||.|.|
  Fly   183 AALP-DCRITNLTTDWNSGVNLAALLDYCQPGLFPHWRSLD-----PSQSVRNCTQAMDLAQREF 241

  Fly   198 KIEKLLDAEDVHTHKPDNKSIQMYVMCL-------YHA-MESMRTRQQEQEQDEGQDQDPGRVPC 254
            .:.|:|:.|.:.:...|..|...|:...       |:| |..:.|:.::..::...|.:.|||.|
  Fly   242 GVPKVLEPEYLASPWLDELSGMTYLSYFMKPGGPGYNATMRWVNTQVKDPVKNFTTDWNDGRVMC 306

  Fly   255 TSITDLDEVPLDNDQTSLGLYTSDSAGSMEQRSSGELKTHS-------------MRPLSTA---T 303
            ..|..|                ..||.:.|:.|:......:             ::|:.||   .
  Fly   307 EIIKGL----------------GGSAPAPEKLSTDPFHYENNIRKAVDAGARLGVQPILTAKDMA 355

  Fly   304 NASVE---ISGYQSALEAV---------LTLLLEDE------------QLLSQNL---------- 334
            |..||   |..|.:.|:.|         :::.||..            .::|:::          
  Fly   356 NPEVEHLGIMAYAAHLQWVPPRPPLSDLVSVYLESTSGRVGEPTHFRIDVMSRDISLSSVRCHVV 420

  Fly   335 -PDPQDFQTAKLQFHENESFMLKLTEHQEYVGEALEEGSNLINESQKAGAGLSQEDQNEVRQQMV 398
             |..|..|..:|..|....|:.:.....|.|.|        |.|....|        :..|....
  Fly   421 PPSGQPGQPVRLNAHGEGVFVPERYGMHEIVVE--------IGEDSLGG--------HFFRALPR 469

  Fly   399 LLNERWETLRLRALDVQAKILMRLAEFQKQKLEQLRQFLTSVEDR-ISHMSDIGPTLEEAEKQLL 462
            ||......:...||....::|:...  ...|.|.:  .:|:|... |||...: ..::|....:.
  Fly   470 LLQVAPPGMAPCALGSLVEVLVNAT--GAPKTEDI--LVTAVSPTGISHNCPL-KKIDEGHSAIF 529

  Fly   463 ---EAQKLKADLSEQQELVDSLSSMVVIVNDTSG-NFNDLEDRLSALGERWSHVVKWSDLRKEKL 523
               ||...:..::.|...:.. ......|.|.|| :.:.|:..:              .||....
  Fly   530 KPDEAGIWEIAITYQGRHIQG-GPFTCAVFDASGVSVHGLDGAM--------------PLRAHTF 579

  Fly   524 QQYKCISRWLDAREQDLKLMESRDVTDVGGITQRINELN----------YCAKDLLELQRYLIDL 578
            :        :|||.           ..|.|      ||:          .|:.:.:...:|.:  
  Fly   580 E--------VDARG-----------VGVSG------ELHVDIVHDKHSLVCSVEKIVENKYRV-- 617

  Fly   579 RQMVAATLQDGDDKGERVLIQLESYEDRLDALKQIVEVQTVRIETKGFNFGRDRAS-YDDSRVVR 642
                  |.....:...||.|....|:.:....       .:|:.||| ..|:.|:| ..||:...
  Fly   618 ------TFMPRQNGKYRVYIYFNGYDVKGSPF-------IMRVGTKG-RSGKTRSSPLHDSKHRS 668

  Fly   643 PEGWVDYQMIIRFGEDDSQEDD-DEHDLASKKR--------KLRNADNFNAL---------ENHI 689
            ....:.:........:|.:... ..|:.|.:..        ||...|..::.         |||.
  Fly   669 ESPSMHFVSTTNTRHNDYRNSSLSRHNTAERTNSYSPQYSPKLDTTDYHSSSSRYYKRESEENHA 733

  Fly   690 -----------MEHFGYVQEVEQKLQQL---------QRQSLRQQCELLKELQAENSRRCGTLPE 734
                       .....|:...:...:.|         ...|.:......||.:..:.||..|.|:
  Fly   734 TPPPAPPPASGSPTVKYLNSADLYTETLNGRRDSKTSNSSSTKNDYYYDKENELYSQRRAVTKPK 798

  Fly   735 LKKLYEVCELEDPSRNLLLEETHIKQLEQRYANL-------------SQKLSSQQSESHTLLAKE 786
            |....|..||...:..     :.....:||:..|             |..|:::.||.||     
  Fly   799 LTPPREERELTSTTNT-----SSSSSFQQRHQQLATSTLTRSLSPIPSPTLNTRSSEVHT----- 853

  Fly   787 KYYNSLTGFKLVLADSRDWYKQHAGSASGNELEQRLSHMESLASEISEAKTATEELDDNLIEWKQ 851
              ::.||      ..:.:.|:....:.:.:.....:|.::..:...:...|||            
  Fly   854 --HSPLT------IKTSNQYESSTRNITSSPRHASVSPVQRYSPNSAYITTAT------------ 898

  Fly   852 DFGLFYDSWHDMKQALQALIQQRGGESLSRQLKQIQDFVTK---VSNQKVRVS-NLEVMQEQ--- 909
                     |.|...|.:.:.:.|.|| ||.:::...:.:.   |::..:|.| :|....|:   
  Fly   899 ---------HRMGSPLTSPVSKNGYES-SRTVEKSSTYKSTSNYVTDSNIRASPSLYGTAERLRR 953

  Fly   910 --------QHFLNQLLDEME---SLRLTYD--NIPKHLIG-EELQTAWNRLPEQLNERVIKQTTA 960
                    .|..|..:..|:   :.|.::|  |..||::. ..|::..|...:|||..:......
  Fly   954 TGSPEPRIDHSSNVRVSSMKPASARRDSWDVINKTKHMLSHNSLESLANMTEKQLNTELQYNRPD 1018

  Fly   961 IENLNHFAAEYN--AIIAMLRSAADSKLNGSDGASSQDLRKLEIDVISARNFSEILIKEAEPAQK 1023
            :::..|...:||  |:....:..:|.:.:..|     |..:.:...|:.::.|.           
  Fly  1019 LDHETHRNTQYNKFALHKQQQQQSDYRRDSPD-----DGERYKPSAITVKSHSN----------- 1067

  Fly  1024 ESLQSQIRALNTLYDQVEQVHREKKEQQTVLQSHIDLIQLRLKETDQWLTDLESN----TPKSGI 1084
                      ||..|:.....:..||.    ..|:             :|  |||    :|..|.
  Fly  1068 ----------NTYTDKSGGYTKTVKES----SEHV-------------VT--ESNGHGPSPGYGY 1103

  Fly  1085 SDI-----VNSNELFQSKSRFQTLKETCERETTQFRDLNERGG----ELLLQMDELQDQDRE--- 1137
            |.:     ::.|.......|.|.:.........:|.....|.|    |:|:....:....|.   
  Fly  1104 SSLSRFRPIDGNATGARAIRVQDIPNGSIGRPVEFEIDGSRAGSGNLEILVNGGRVTSSVRSLGG 1168

  Fly  1138 ---------SRYGSLAKQFTRINAR------W-------------TEVTELVYAKTALLEHI--- 1171
                     ..:|:...|.| .|..      |             .|.|.||.|.|..:..|   
  Fly  1169 QRFIASFTPHEHGTHTVQIT-FNGETVPGSPWHAEIMSSPGLTALGESTRLVPANTPAVFEILPP 1232

  Fly  1172 ---STQLGEFKKFMVSETGYLDKLENKIRNTPENAADAEEIMEELDDLENVLRSHSEEWLDKIQE 1233
               |...||....::  |....||..::.:...|.|...|.:.                    .|
  Fly  1233 PGQSLSKGECVATVL--TPSKSKLNARVTHEAANGAARIEFVP--------------------TE 1275

  Fly  1234 IGNELIDNEFMADS------IRRDIDETVQRWTQLQ-----QQAKKRTEL-------LEQKVSEA 1280
            :|..:||.......      |.:..|.::.:.|::.     |..:.|.:.       ||..::|.
  Fly  1276 VGTHVIDASINGTKIAGGPLIAKVYDSSLIQVTEVNGGVVGQACQFRVDASAAGEGQLEISINEG 1340

  Fly  1281 EQSE--------KCIVQFEKWLTRVDDILSDHLDNDVTIVDQPEEFQRLAHEFVANEKNFKEISE 1337
            |...        :|:|.|                       .||:.:                |.
  Fly  1341 EVPNHVQVVGGGRCLVSF-----------------------TPEQAK----------------SH 1366

  Fly  1338 LIDEHTRNGKVGAANRLQEQLNLMEVRFKYCQAKLSKC---TAIQHSYESRLNRAYTDLRNVER- 1398
            |||                        .|:....:..|   .|:..:....||.:..:|..|.| 
  Fly  1367 LID------------------------IKFNGETVRGCPFVCAVADTSRVLLNLSNLELIPVNRP 1407

  Fly  1399 STEVVDVASAGPNTVQTQY---QKCLQIYRTLSEI----KSEIESTIKTGRRVCEDRYTKSPKQ- 1455
            |:..:.|:..|...:....   |..|.: |...:|    .:|...|...|..: ...|.....| 
  Fly  1408 SSFHITVSGGGAAELAVSVRGPQGELPV-RVTGDIHAGFTAEFTPTTVGGHSI-NVEYNGFAVQG 1470

  Fly  1456 ---LSQRIDALKHLYNTLGENVTQSKATLERLLTLARQLEECFDSAD----NL-----IRRFESP 1508
               |::..||.|.:..::...            |:.|.::...|:.|    ||     .:....|
  Fly  1471 TPFLAKSYDASKVVVGSVSRG------------TMGRPVQFTVDAGDAGEGNLEITISAKGQNIP 1523

  Fly  1509 QEVHDRNSILLEFEDV-LRRCEDHYN-EYNKSCDQSCMVETR--------QRIDGLKATYHKLTS 1563
            .:||.:.|.......| ...||...| .:||.....|.:...        |...|.....|: |:
  Fly  1524 TQVHPQGSARFSVSFVPTESCEHTINVSFNKMPVPGCPITVSISGGVAGPQVSLGGPGPVHQ-TN 1587

  Fly  1564 ADIIK----RLTEMKTTLQNLDNISLETLRAMEHDLKE----------------INVPSN----- 1603
            :.:|.    ||.:::.   |::..:.:::.|..|...:                :||..|     
  Fly  1588 SFVINHNGGRLEDIEV---NVEGPAGQSVPAQVHQSADGVFKAEFVPRVVGEHRVNVTVNGLPTA 1649

  Fly  1604 --PEIEKLQQQVIAIVVDVLKTRFNEATT-LAARNTSSPDNDDTEIVVVSDTVRQRRARTPQSGE 1665
              |...|:.......|.:|......:|.| |...:.:.|.|  .|:.|             ..|.
  Fly  1650 GSPYAAKVYDVSAIKVKNVSSGTVGKAVTFLVETSQAGPGN--LEVTV-------------NGGR 1699

  Fly  1666 SPSSAHTSSSESPTKGVENSPGAVGDQVMPDLLPPQTFRLAESSTLFSQISLNPQKVTNTPPPKP 1730
            .|:||......  |..:..:|                 |.|||.|:  ::..|.|.|..:|    
  Fly  1700 VPTSAQAQGQH--TYAISFTP-----------------REAESHTV--ELRFNSQDVPGSP---- 1739

  Fly  1731 AKTKRKAPSSPAQVVEIRVKNIQNDKMSVQNIDLEPQQGEIVDTVNILESVEPFVPEYVETVQIV 1795
             .|.|.|.::..|..|..      ||:||..:.....:.:...||.:|......||..::.:...
  Fly  1740 -FTCRVAAAARIQSPETM------DKVSVGRLFEFVVESDTKPTVEVLGPARRSVPVKIDALGSS 1797

  Fly  1796 DLS--------EDSDSSVRVDSQG-------KEMRRSKSKHSLNETPL------PKVS---DNDE 1836
            .|.        |..|.||.|...|       ..:.::.|...:..|.:      ..||   :..:
  Fly  1798 TLGYNVKFEPMEVGDHSVEVRLPGGGHVEGSPFLLKAYSAEKVIVTDIRAGVVNKSVSFGINASQ 1862

  Fly  1837 DSAEQEEDLLRPSAENTSTPFLRVE-KRRISFDEKRKRVANERDILRDSEEEEPKTP-------- 1892
            ..|...|.::..:.:|... |::.| ..|...:.|....|.....:|.:....|.:|        
  Fly  1863 AGAGNLEIIVAVNGKNVPN-FVQSEGNARFKVNFKPTEAATHSLSVRFNGHPVPGSPFSCHIAAA 1926

  Fly  1893 ------DTPRAAQVSKPKRWRQLQPE-------MDALEPE----SPGRDSFY------------- 1927
                  ..|||..:.:..:...::.:       .|.:||:    ||..|:.:             
  Fly  1927 AASPSMGLPRAMAMGECLKQAAVKMDNTFELEGFDGVEPQIFVTSPSGDNEHCQLSQHDGGSYSA 1991

  Fly  1928 -----------------------SPDKESGFDAE------------------PLVFS-DDEDIPR 1950
                                   ||...:.||..                  |:.|| |......
  Fly  1992 SFRPTTVGRHLISVTANDQHINGSPFSCNVFDVSRVSISGLEQQYGPANLGVPVTFSVDAAGAGE 2056

  Fly  1951 FSLEMTSTIDSDSDTSRIM-----------TPSTKNP--------------NPFLSKV------- 1983
            .:||:..:.||.:..:.::           .|.:..|              :||...:       
  Fly  2057 GTLELVVSTDSSTVKAEVVACARGLYDVTFVPQSTEPHYVNITFNEVAVDGSPFRVDIQQHTQHI 2121

  Fly  1984 ----LESLSSPVDDSNVTLKSPISEEQPQNLDDRVREF-------------DKQAKQMIYK---- 2027
                |.::..|.||..|.:.||..:..|.:::.:..||             |::.:|.|..    
  Fly  2122 QIGSLAAIDFPADDQIVEIFSPDQKSVPYSINRQTAEFRTHMTGNYTLRFIDRETRQHIGSRTLC 2186

  Fly  2028 ------LKLTKAKIEQCHESEAEDLRLLIAPDAATLISQGDSLVLETHGRQGSISRLVMRTQIIL 2086
                  :|:|:.....||..                .|.|.||   ....||.:|.||       
  Fly  2187 VFDPTLVKITEVSEAFCHRP----------------ASIGVSL---NEAGQGDLSALV------- 2225

  Fly  2087 REQFREVQQARSKTSGSGAPAPPLDSVNIEELVTKGLR----RINVLI-EKTVDLKSSTDLEKRM 2146
            |....||.......|.:|          :.|:|.:..|    :|::|. |..:.||..       
  Fly  2226 RCGATEVPHTIRGPSKTG----------VYEIVYQPTRVAPHKISILFNEVPISLKPL------- 2273

  Fly  2147 EDINERHDDLQVIVSAIGKNAQMPKVTPLMMNEIEKTKNNLIAHADSIELSLTE---LRNGP--- 2205
                    ::.|:.::.||...:..: .|..:.:.||.:..|   |:::....|   :.:||   
  Fly  2274 --------EINVLPASAGKEISVSGL-GLYQSRVGKTTSFAI---DTVKRPAREFDVVVSGPGGQ 2326

  Fly  2206 -------RISNGKERPDASSAATMSCRSE--YNNEP-SGTGALAGSFDKS 2245
                   :..||..:.:.:......|..|  :.::| .|:.....|||.|
  Fly  2327 ALPVRCYQTKNGHLQAEFTINKPGQCVIEVLHQSKPLPGSPFTCESFDSS 2376

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DysNP_001036722.1 CH 13..111 CDD:278723 42/100 (42%)
CH 129..225 CDD:278723 24/102 (24%)
SPEC 312..525 CDD:238103 42/249 (17%)
SbcC <325..957 CDD:223496 125/742 (17%)
Smc <816..1591 CDD:224117 153/911 (17%)
SPEC 1174..1365 CDD:238103 30/216 (14%)
SPEC 1289..1485 CDD:295325 31/210 (15%)
SPEC 2369..2576 CDD:238103
SPEC 2477..2714 CDD:238103
WW 2852..2882 CDD:238122
EF-hand_2 2883..2997 CDD:286194
EF-hand_3 3001..3100 CDD:286195
ZZ_dystrophin 3110..3158 CDD:239074
jbugNP_001261140.1 CH 60..165 CDD:237981 42/105 (40%)
CH 172..269 CDD:278723 24/103 (23%)
CH 281..371 CDD:278723 21/105 (20%)
IG_FLMN 468..560 CDD:214720 17/97 (18%)
Filamin 468..554 CDD:279024 16/91 (18%)
Filamin 557..644 CDD:279024 21/140 (15%)
IG_FLMN 560..648 CDD:214720 20/141 (14%)
Filamin 1116..1200 CDD:279024 12/84 (14%)
IG_FLMN 1119..1198 CDD:214720 12/79 (15%)
Filamin 1210..1294 CDD:279024 20/105 (19%)
Filamin 1299..1383 CDD:279024 19/146 (13%)
IG_FLMN 1310..1389 CDD:214720 18/141 (13%)
Filamin 1386..1473 CDD:279024 17/88 (19%)
IG_FLMN 1399..1480 CDD:214720 16/82 (20%)
Filamin 1477..1563 CDD:279024 20/97 (21%)
IG_FLMN 1480..1569 CDD:214720 19/100 (19%)
Filamin 1570..1653 CDD:279024 13/86 (15%)
IG_FLMN 1575..1659 CDD:214720 14/87 (16%)
Filamin 1657..1741 CDD:279024 24/124 (19%)
IG_FLMN 1661..1747 CDD:214720 27/126 (21%)
Filamin 1756..1830 CDD:279024 16/79 (20%)
Filamin 1834..1919 CDD:279024 14/85 (16%)
IG_FLMN 1837..1926 CDD:214720 14/89 (16%)
IG_FLMN 1936..2023 CDD:214720 10/86 (12%)
Filamin 1941..2017 CDD:279024 7/75 (9%)
Filamin 2021..2111 CDD:279024 13/89 (15%)
IG_FLMN 2025..2114 CDD:214720 12/88 (14%)
Filamin 2187..2268 CDD:279024 24/116 (21%)
Filamin 2279..2369 CDD:279024 16/93 (17%)
IG_FLMN 2285..2375 CDD:214720 16/93 (17%)
Filamin 2372..2459 CDD:279024 4/5 (80%)
IG_FLMN 2376..2465 CDD:214720 1/1 (100%)
IG_FLMN 2474..2561 CDD:214720
Filamin 2474..2555 CDD:279024
IG_FLMN 2657..2751 CDD:214720
Filamin 2657..2745 CDD:279024
Filamin 2755..2840 CDD:279024
IG_FLMN 2756..2847 CDD:214720
Filamin 2847..2937 CDD:279024
IG_FLMN 2850..2944 CDD:214720
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45439921
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
21.840

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