DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Dys and alpha-Spec

DIOPT Version :9

Sequence 1:NP_001036722.1 Gene:Dys / 42327 FlyBaseID:FBgn0260003 Length:3598 Species:Drosophila melanogaster
Sequence 2:NP_001261286.1 Gene:alpha-Spec / 38231 FlyBaseID:FBgn0250789 Length:2457 Species:Drosophila melanogaster


Alignment Length:3032 Identity:548/3032 - (18%)
Similarity:1041/3032 - (34%) Gaps:863/3032 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   413 DVQAK---ILMRLAEF------QKQKLEQLRQFLTSVEDRISHMSDIGPTLEEA-EKQLLEAQKL 467
            |:|.:   :|.|..:|      :::|||..|:|.....|.....|.|...|:.| |:...:...|
  Fly    17 DIQERREQVLSRYNDFKIETRQKREKLEDSRRFQYFKRDADELESWIHEKLQAASEESYRDPTNL 81

  Fly   468 KADLSEQQEL---VDSLSSMVVIVNDTSGNF--------NDLEDRLSALGERWSHVVKWSDLRKE 521
            :|.:.:.|..   |.:.|:.:|.:::|....        ..::.||..|.:.|..::.....:..
  Fly    82 QAKIQKHQAFEAEVSAHSNAIVSLDNTGQEMINQQHFASESIQVRLDELHKLWELLLSRLAEKGL 146

  Fly   522 KLQQ--------YKC--ISRWLDAREQDLKLME-SRDVTDVGGITQRINELNYCAKDLLELQRYL 575
            ||||        .:|  :..|:..:|..:...| .:|:..|..:.::.:|..   ||:...:..:
  Fly   147 KLQQALVLVQFLRQCEEVMFWIKDKETFVTADEFGQDLEHVEVLQRKFDEFQ---KDMASQEYRV 208

  Fly   576 IDLRQMVAATLQDGDDKGERVLIQLESYEDRLDALKQIVEVQTVRI----ETKGFNFGRDRASYD 636
            .::.|:....:|||..:.:.:..:.|...:....|||:..|:..::    |.:.||  ||.    
  Fly   209 TEVNQLADKLVQDGHPERDTITKRKEELNEAWQRLKQLAIVRQEKLFGAHEIQRFN--RDA---- 267

  Fly   637 DSRVVRPEGWVDYQMIIRFGEDDSQEDDDEHDLASKKRKLRNADNFNALENHIMEHFGYVQEVEQ 701
            |..|    .|:..:.::      ...||...||||          ..||:.   :|.|    ||:
  Fly   268 DETV----AWIAEKDVV------LSSDDYGRDLAS----------VQALQR---KHEG----VER 305

  Fly   702 KLQQLQRQSLRQQCELLKELQAENSRRCGTLPELKKLYEVCELEDPSRNLLLEETHIKQLEQRYA 766
            .|..|:        :.:..|.||..|.|.                      :...|..|:..:.|
  Fly   306 DLAALE--------DKVSTLGAEAQRLCS----------------------IHADHSDQIRDKQA 340

  Fly   767 NLS---QKLSSQQSESHTLLAKEKYYNSLTGFKLVLADSRD---WYKQHAGSASGNELEQRLSHM 825
            .::   |.|:::..|....| .|.||  |..|   |||.||   |........|.:||.:.::..
  Fly   341 EIANYWQSLTTKARERKQKL-DESYY--LHRF---LADFRDLVSWINGMKAIISADELAKDVAGA 399

  Fly   826 ESLASEISEAKTATEELDDNLIEWKQDFGLFYDSWHDMKQALQALIQQRGGESLSRQ---LKQIQ 887
            |:|.....|.|...:..:|:.                      .|..:.|.:.|.|:   ..:||
  Fly   400 EALLERHQEHKGEIDAREDSF----------------------KLTTESGQKLLEREHYAAAEIQ 442

  Fly   888 DFVTKVSNQKVRVSNLEVMQEQQHFLNQLLDEMESLRLTYDNIPKHLIGEELQTAWNRLPEQLNE 952
            :.:..:.|.|  .|.|.:.::::....|.:|    |:|.|                 |..||.:.
  Fly   443 EKLAALENDK--SSLLSLWEDRRILYEQCMD----LQLFY-----------------RDTEQADT 484

  Fly   953 RVIKQTTAIENLNHFAAEYNAIIAMLRSAADSKLNGSDGASSQDLRKLEIDVISARNFSEILIKE 1017
            .:.||...:.|                               :||.. .:|.:      |.|||:
  Fly   485 WMAKQEAFLAN-------------------------------EDLGD-SLDSV------EALIKK 511

  Fly  1018 AEPAQKESLQSQIRALNTLYDQVEQVHREKKEQQTVLQSHIDLIQLRLKETDQWLTDLESNTPKS 1082
            .|..:| ||.:|...:..|                      |:...:|.:...:..|        
  Fly   512 HEDFEK-SLAAQEEKIKAL----------------------DIFATKLIDGQHYAAD-------- 545

  Fly  1083 GISDIVNSNELFQSKSRFQTLKETCERETTQFRDLNERGGELLLQMDELQDQDRESRYGSLAKQF 1147
               |:....::..::      :...:.::::.|.|             |:|.:|       .:||
  Fly   546 ---DVAQRRQMLLAR------RAALQEKSSKRRQL-------------LEDSNR-------YQQF 581

  Fly  1148 TRINARWTEVTELVYAKTALLEHISTQLGEFKKFMVSETGYLDKLENKIRNTPENAADAEEIMEE 1212
            .|.                 .:.....:.|..|| .::..|||         |.|....   |::
  Fly   582 ERD-----------------CDETKGWISEKLKF-ATDDSYLD---------PTNLNGK---MQK 616

  Fly  1213 LDDLENVLRSHSEEWLDKIQEIGNELIDNE-FMADSIRRDIDETVQRW-TQLQQQAKKRTELLEQ 1275
            ..:.|:.|.::... ::.|..:|.|||:.: :.||.|...:.|.|..| |.:|...||.|:|.| 
  Fly   617 HQNFEHELNANKSR-IEDITNVGTELIEKQHYAADQINTRMQEIVVLWETLVQASDKKGTKLNE- 679

  Fly  1276 KVSEAEQSEKCIVQFEKWLTRVD-DILSDHLDNDVTIVDQPEEFQRLAH-EFVANEKNFKEISEL 1338
             ..:.:|..:.|...|.||:.:: .:||:....|:|.|...::...|.. :.:|::...:.|...
  Fly   680 -ACQQQQFNRTIEDIELWLSEIEGQLLSEDHGKDLTSVQNLQKKHALLEADVMAHQDRIESIKVA 743

  Fly  1339 IDEHTRNGKVGAANRLQEQLNLMEVRFKYCQAKLSKCTAIQHSYES-RLNRAYTDLRNVERSTEV 1402
            .::...:|...|.|...::.|| ..|:....|.:.:  ..||..:| ::.:.:.||.:.......
  Fly   744 ANKFIESGHFDADNIRNKEGNL-SARYAALAAPMGE--RKQHLLDSLQVQQLFRDLEDEAAWIRE 805

  Fly  1403 VDVASAGPNT------VQTQYQKCLQIYRTLSEIKSEIESTIKTGRRVCEDRYTKSPKQLSQRID 1461
            .:..:|..|.      ||...:|...:...::..::.:.:.|.:|..:.:|:...| ..:.||::
  Fly   806 KEPIAASTNRGRDLIGVQNLIKKHQAVLAEINNHEARLLNVISSGENMLKDQPFAS-DDIRQRLE 869

  Fly  1462 ALKHLYNTLGENVTQSKATLERLLTLARQLEECFDSADNLIRRFESPQEVHDRNSILLEFEDVLR 1526
            ||:..:|||.|..:|.|..|:..|    |..:.|..|             ::..|.:.|.|.:..
  Fly   870 ALQEQWNTLKEKSSQRKQDLDDSL----QAHQYFADA-------------NEAESWMREKEPIAT 917

  Fly  1527 RCEDHYNEYNKSCDQSCMVETRQRIDGLKATYHKLTSADIIKRLTEMKTTLQNLDNISLETLRAM 1591
            .     ::|.|..|                     :|..::|:...:.:.|:...|    |::|:
  Fly   918 G-----SDYGKDED---------------------SSEALLKKHEALVSDLEAFGN----TIQAL 952

  Fly  1592 EHDLKEINVPSNPEIEKLQQQVIAIVVDVLKTRFNEAT-----TLAARNTSSPDNDDTEIVVVSD 1651
            :...|.......|.::...::.:..:.|..:....|.:     .|...|:   :|.|...|.|:|
  Fly   953 QEQAKNCRQQETPVVDITGKECVVALYDYTEKSPREVSMKKGDVLTLLNS---NNKDWWKVEVND 1014

  Fly  1652 TVRQRRARTPQSGESPSSAHTSSSESPTKGVENSPGAVGDQVMPDLLPPQTFRLAESSTLFSQIS 1716
                |:...|.:......|..|:|:.                          .|.::.::     
  Fly  1015 ----RQGFVPAAYIKKIDAGLSASQQ--------------------------NLVDNHSI----- 1044

  Fly  1717 LNPQKVTNTPPPKPAKTKRKAPSSPAQVVEIRVKNIQNDKMSVQNIDLEPQQGEIVDTVNILESV 1781
                          ||.:.:.             |.|.|.:...   ...:|.::.:||.     
  Fly  1045 --------------AKRQNQI-------------NSQYDNLLAL---ARERQNKLNETVK----- 1074

  Fly  1782 EPFVPEYVETVQIVDLSEDSDSSVRVDSQGKEMRRSKSKHSLNETPLPKVSDNDEDSAEQEEDLL 1846
                 .||...:..||:              :..|.|..|:       :::|...:..|:.|.| 
  Fly  1075 -----AYVLVREAADLA--------------QWIRDKENHA-------QIADVVGEDLEEVEVL- 1112

  Fly  1847 RPSAENTSTPFLRVEKRRISFDEKRK----RVANERDILRDSEEEEPKTPDTPRAAQVSKP---- 1903
                          :|:...|::..|    |:||..:|    ..:......|..|.::...    
  Fly  1113 --------------QKKFDDFNDDLKANEVRLANMNEI----AVQLTSLGQTEAALKIQTQMQDL 1159

  Fly  1904 -KRWRQLQPEMDALEPESPGRDSFYSPDKESGFDAEPLVFSDDEDIPRFSLEMTSTIDSDSDTSR 1967
             ::|..||    .|..|...:                  .....::.||..::..|.|..::.:.
  Fly  1160 NEKWNNLQ----TLTAEKASQ------------------LGSAHEVQRFHRDIDETKDWIAEKAN 1202

  Fly  1968 IMTPSTKNPNPFLSKVLESLSSPVDDSNVTLKSPISEEQPQNLDDRVREFDKQAKQMIYK----L 2028
            .:.      |..|.|.|.|:.:      :..|....|.....|.|::|:.|:.|.:::..    .
  Fly  1203 ALN------NDDLGKDLRSVQT------LQRKHEGVERDLAALRDKIRQLDETANRLMQSHPDTA 1255

  Fly  2029 KLTKAKIEQCHE--------SEAEDLRLLIAPDAATLISQGDSLVLETHGRQGSISRLVMRTQII 2085
            :.|.||.::.:|        |.|...:||.:.|....:|....|:...:.....::...:...:.
  Fly  1256 EQTYAKQKEINEMWDQIITKSTARKEKLLDSYDLQRFLSDYRDLLAWINSMMSLVTSDELANDVT 1320

  Fly  2086 LREQFREVQQARSKTSG-----SGAPAPPLDSVNI------EELVTKGLRRI----------NVL 2129
            ..|...|..|||....|     |.||.....:.:|      ||..|:...|.          |.|
  Fly  1321 GAEALIERHQARRAEIGFTLGISSAPGAAASTSSIASPSGDEEHRTEIDARAGTFGAFEQFGNEL 1385

  Fly  2130 IEKTVDLKSSTDLEKRMEDINERHDDLQVIVSAIGKNAQMPKVTPLMMNEIEKTKNNLIA----- 2189
            ::  .:..:|.::::::||:.:..:||:...:......:......|.|.:.|..::.:.|     
  Fly  1386 LQ--ANHYASPEIKEKIEDLAKAREDLEKAWTERRLQLEQNLDLQLYMRDCELAESWMSAREAFL 1448

  Fly  2190 HAD-------SIELSLTELRNGPRISNGKERPDASSAATMSCRSEYNNEPSGTGALAGSFDKSVL 2247
            :||       ::|..:.:..:..:..||.|:..|:...........|:..|.   |.....|.||
  Fly  1449 NADDDANAGGNVEALIKKHEDFDKAINGHEQKIAALQTVADQLIAQNHYASN---LVDEKRKQVL 1510

  Fly  2248 QISDWLTWEQNMIKIQSVLVD---------DGDAVRLAIEKQEKVLRELKMKKPQLNELVHTAEV 2303
            :  .|...::.:|:.:|.|.|         |.|.:...|.::.::..|...|.|...:..|    
  Fly  1511 E--RWRHLKEGLIEKRSRLGDEQTLQQFSRDADEIENWIAEKLQLATEESYKDPANIQSKH---- 1569

  Fly  2304 LKGDVKRQQLQEKELK------QFSLA--------PHCSADLDYMRCCLKVTRLREHWDETSQCV 2354
                 ::.|..|.||.      |..||        ..||...|.::  .::|::.:.|:..:...
  Fly  1570 -----QKHQAFEAELAANADRIQSVLAMGGNLIDKKQCSGSEDAVQ--KRLTQIADQWEYLTHKT 1627

  Fly  2355 LQRAAQLKNMLSDSQR-FEAKRLELEKWLARMEQRAERMGTIATTAD------ILEAQQKEQKSF 2412
            .:::.:||.  ::.|| :.|...:|:.||..:|       ::.||.|      .::...|:.:..
  Fly  1628 TEKSLKLKE--ANKQRTYIAAVKDLDFWLGEVE-------SLLTTEDSGKDLASVQNLMKKHQLV 1683

  Fly  2413 HAELHQNKQHFDIFNELTQKLIAVYPNDDTTRIKKMTEVINQRYANLNSGVINRGKQLHAAVHSL 2477
            .|::..::......|.....|:. ....||..|::..:.||:||..:.:...:|..:|:.|: :|
  Fly  1684 EADIVAHEDRIKDMNNQADSLVE-SGQFDTAGIQEKRQSINERYERICNLAAHRQARLNEAL-TL 1746

  Fly  2478 QSFDRAMDQFLAFLSETETLCENAE-----SDIERNPLMFKDLQSEIETHRVVYDRLDGTGRKLL 2537
            ..|.|.:....:::.|.:.|..:.:     :.::......|.|::|:.:|......:...|.||:
  Fly  1747 HQFFRDIADEESWIKEKKLLVGSDDYGRDLTGVQNLKKKHKRLEAELGSHEPAIQAVQEAGEKLM 1811

  Fly  2538 GSLTSQEDAVMLQRRLDEMNQRWNNLKSKSIAIRNRLESNSEHWNALLLSLRELTEWVIRKDTEL 2602
            .  .|......:::||..:||.|..||:.: |.|.:....|..:...|..:.|...|:..|...|
  Fly  1812 D--VSNLGVPEIEQRLKALNQAWAELKNLA-ATRGQKLDESLTYQQFLAQVEEEEAWITEKQQLL 1873

  Fly  2603 STLGLGPVRGDAVSLQKQLDDHKAF---------------------------------------R 2628
            |....|   ....::|..|..|.||                                       |
  Fly  1874 SVEDYG---DSMAAVQGLLKKHDAFETDFTAHKDRCSLICDQGSELVEAKNHHGESIAQRCQQLR 1935

  Fly  2629 RQLED-----------------------KRPIVESNLTSGRQYIANEAAVSDTSDTE---ANHDS 2667
            .:|::                       |..:|||.:.....|:.::....|.|..:   ...::
  Fly  1936 LKLDNLSALAARRKGALLDNSAYLQFMWKADVVESWIDDKENYVRSDEFGRDLSTVQTLLTKQET 2000

  Fly  2668 DSRYMSAEEQ----------------SRELTRSIRREVGKLSEQWNNLIDRSDNWKHRLDEYMTK 2716
            ....::|.||                |...:.:|.:..|.:..:|..|.|.|:..|.||   :..
  Fly  2001 FDAGLNAFEQEGIHNITALKDQLINASHAQSPAILKRHGDVIARWQKLRDASNTRKDRL---LAM 2062

  Fly  2717 MRQFQKILEDLSSRVALAEQTKTSWLPPSSVGEANEQM---------QQLQRLRDKMTTASALLD 2772
            ..||::| |:|....|.......||..     .|.|.:         ::::.|||......|.|.
  Fly  2063 QEQFRQI-EELYLTFAKKASAFNSWFE-----NAEEDLTDPVRCNSIEEIRALRDAHAQFQASLS 2121

  Fly  2773 DCNEQQSFFTANQVLV------PTP-CLSKLEDLNTRMKLLQIAMDERQKVLCQAGAQQTHENGD 2830
            ..........|....:      |.| ....:|.|....:.||..::||...|.:...:|  |..|
  Fly  2122 SAEADFKALAALDQKIKSFNVGPNPYTWFTMEALEETWRNLQKIIEERDGELAKEAKRQ--EEND 2184

  Fly  2831 DGRTTSNSGTIGPLPNLGQSVKPPWERATTAANVPYYIDHERETTHWDHPEMIELMKGLADLNEI 2895
            ..|.     ......||...    |...|..    |.:.:.|:.|        .:|:|...|.: 
  Fly  2185 KLRK-----EFAKHANLFHQ----WLTETRY----YMLGYNRQGT--------SMMEGSGSLEQ- 2227

  Fly  2896 RFSAYRTAMKLRSVQKRLALDRISMSTACESFDRHGLRAQNDKLIDIPDMTTVLHSLYVTIDKID 2960
                ...|:::::.:                     :||:...|..|.::..:|....:..::..
  Fly  2228 ----QLEALRVKATE---------------------VRARRVDLKKIEELGALLEEHLILDNRYT 2267

  Fly  2961 LTLMLDLAINWILNVYDSQRTGQIRVLSFKVGLVLLCKGHLEEKYRYLFRLVADTD--------- 3016
            ....:.||..|          .|:..||.::      :.:||::.:.........|         
  Fly  2268 EHSTVGLAQQW----------DQLDQLSMRM------QHNLEQQIQARNHSGVSEDSLKEFSMMF 2316

  Fly  3017 RRADQRRLGLLLH----DCIQVPRQLG-EVAAFGGSNIEPSVRSCLEQAGISQEAIDGNQDISIE 3076
            :..|:.:.|.|.|    .|:   |.|| ::........:|...:.|       :.:|.|:|..:.
  Fly  2317 KHFDKDKSGKLNHQEFKSCL---RALGYDLPMVEEGQPDPEFEAIL-------DVVDPNRDGYVS 2371

  Fly  3077 LQHFLGWL----QHEPQSLVWLPVLHR-LAAAE---AAKHQAKCNICKEYPIVGFRYRCLKCFNF 3133
            ||.::.::    ....||...:....| :.||:   ..|.:..||:.|                 
  Fly  2372 LQEYIAFMISKETENVQSYEEIENAFRAITAADRPYVTKEELYCNLTK----------------- 2419

  Fly  3134 DMCQKCFFFGRNAKNHKLTHPMHEYCTTTTSTEDVRDFTRAL 3175
            ||...|....:.....:...|:.:       ..|..||||.|
  Fly  2420 DMADYCVQRMKPFSEPRSGQPIKD-------ALDYIDFTRTL 2454

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DysNP_001036722.1 CH 13..111 CDD:278723
CH 129..225 CDD:278723
SPEC 312..525 CDD:238103 29/132 (22%)
SbcC <325..957 CDD:223496 120/588 (20%)
Smc <816..1591 CDD:224117 142/788 (18%)
SPEC 1174..1365 CDD:238103 47/194 (24%)
SPEC 1289..1485 CDD:295325 43/204 (21%)
SPEC 2369..2576 CDD:238103 46/218 (21%)
SPEC 2477..2714 CDD:238103 57/322 (18%)
WW 2852..2882 CDD:238122 5/29 (17%)
EF-hand_2 2883..2997 CDD:286194 15/113 (13%)
EF-hand_3 3001..3100 CDD:286195 21/117 (18%)
ZZ_dystrophin 3110..3158 CDD:239074 7/47 (15%)
alpha-SpecNP_001261286.1 SH3_Alpha_Spectrin 974..1026 CDD:212742 11/58 (19%)
SPEC 1074..1287 CDD:238103 49/296 (17%)
SPEC 1182..1425 CDD:238103 48/256 (19%)
SPEC 1426..1638 CDD:238103 43/229 (19%)
SPEC 1533..1744 CDD:238103 44/231 (19%)
SPEC 1646..1850 CDD:238103 43/215 (20%)
SPEC 1852..2062 CDD:238103 34/215 (16%)
SPEC 1958..2176 CDD:238103 45/226 (20%)
SPEC 2072..2296 CDD:238103 49/293 (17%)
EFh 2311..2379 CDD:238008 15/77 (19%)
EFhand_Ca_insen 2386..2456 CDD:400872 19/93 (20%)
SPEC 48..258 CDD:238103 40/212 (19%)
SPEC 154..364 CDD:238103 53/276 (19%)
SPEC 261..470 CDD:238103 63/301 (21%)
SPEC 471..680 CDD:238103 64/360 (18%)
SPEC 682..893 CDD:238103 45/214 (21%)
Spectrin 893..>961 CDD:395348 17/114 (15%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45439920
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - P PTHR11915
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
22.030

Return to query results.
Submit another query.