DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dys and Dyb

DIOPT Version :9

Sequence 1:	NP_001036722.1	Gene:	Dys / 42327	FlyBaseID:	FBgn0260003	Length:	3598	Species:	Drosophila melanogaster
Sequence 2:	NP_001097287.1	Gene:	Dyb / 36362	FlyBaseID:	FBgn0033739	Length:	816	Species:	Drosophila melanogaster

Alignment Length:	758	Identity:	183/758 - (24%)
Similarity:	297/758 - (39%)	Gaps:	197/758 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly  2889 LADLNEIRFSAYRTAMKLRSVQKRLALDRISMSTACESFDRHGLRA-QNDKLIDIPDMTTVLHSL 2952
            |...:.|||::||||.|||.:||...|..:.:....|:|..:||.. :....:.:..:.|::.||
  Fly    15 LQTFDSIRFASYRTASKLRYIQKSTNLHLVDIWNVIEAFRENGLNTLEPQSEVSVARLETLVSSL 79

  Fly  2953 YVTIDK-------IDLTLMLDLAINWILNVYDSQRTGQIRVLSFKVGLVLLCKGHLEEKYRYLFR 3010
            |..::|       :.:.....|.:||:|..|.|..:|:|||.|.||.|..:|.|.|.:|.||:|.
  Fly    80 YHNLNKRLPTAQQVPVDSKAGLLLNWLLAAYTSDNSGKIRVFSIKVALATMCSGKLVDKLRYIFS 144

  Fly  3011 LVADTDRRADQRRLGLLLHDCIQVPRQLGEVAAFGGSNIEPSVRSCLEQAGISQEAIDGNQDISI 3075
            .::|...:....:||..|.:.:.:|..:.|...|.            .:.|:.:|.......:::
  Fly   145 QISDGAGQLVAWKLGEFLREVLALPAAVYESPTFH------------YKEGLEEEIFPAENKVTV 197

  Fly  3076 ELQHFLGWLQHE--PQSLVWLPVLHRLAAAEAAKHQAKCNICKEYPIVGFRYRCLKCFNFDMCQK 3138
              ..|:..|..|  |..|||||::||||..|...|...|::|.:....||||||.:|..:.:||:
  Fly   198 --NDFMATLMSEPGPSCLVWLPLVHRLATVETIVHPTVCSVCHKENFTGFRYRCQRCHAYQLCQE 260

  Fly  3139 CFFFGRNAKNHKLTHPMHEYCTTTTSTEDVRDFTRALKNKFK--SRKYFKKHPRVGYLPVQSVLE 3201
            ||:.|:.:.||:..|.:.||.:..:.::.:   ..:|:..|:  ..|..:..||....| :..|.
  Fly   261 CFWHGKTSLNHQNDHEVKEYSSYKSPSKQI---GHSLRKSFRCVPEKTVQVLPRFPDQP-EKTLN 321

  Fly  3202 GDALESPAPSPQHT---------------------THQLQNDMHSRLEMYASRLAQVEYGGTGSN 3245
            ...:..|:|.|.|.                     .|.| .|..|.|:..|:..:.....||...
  Fly   322 LSHIVPPSPLPSHNGFSDPSGLVHGHHGPHPGLPGQHGL-FDRSSTLDSRATGRSLDSASGTAGT 385

  Fly  3246 ------STPDSDDEHQLIAQYCQAL--PGTSNGSAPKSPVQVMAAMDAEQREELEAIIRDLEEEN 3302
                  :...:|:||:|||:|...|  ...:..:.|.:...:.......|||    :|..||.:|
  Fly   386 TMSRVAAASANDEEHRLIARYAARLAQENRAPSNLPDNATPIGTDNSRAQRE----LIAQLESKN 446

  Fly  3303 ANLQAEYQQLCSKEQSGMPEDSNGMQHSSSSMTGLSGQGEQGQDMMAEAKLLRQHKGRLEARMQI 3367
            ..:..|..:|..::::......|                   ..::.|.:.|||.||.||..:..
  Fly   447 KEIMREIARLRRQQETEQMAPEN-------------------PALINELRALRQRKGELEGHLGA 492

  Fly  3368 LEDHNRQLEAQLQRLRQLLDEPNGGGSSATSSGLPSAPGSALNSKPNTLQTRSVTASQLNTDSPA 3432
            |:|..|||..||:.|.::|.      :..|:|     |.|..||.|
  Fly   493 LQDSRRQLMEQLEGLMRMLK------NQQTAS-----PRSTPNSSP------------------- 527

  Fly  3433 KMNQQNGHYEHNSKGIMLPGMNSEIQQQHAQLASLAAKHHQHQLSGA-------LNALHQQQQQQ 3490
                      .:.|...:||                         ||       ::|||   .||
  Fly   528 ----------RSGKSPPMPG-------------------------GAGILGTSPMSALH---AQQ 554

  Fly  3491 LQQQPPQQQRSMMTGNGGMDISGGMQTSGGYLGDDGRPPPPPHSSLMQQQHQQHLNENSSGLVTV 3555
            :||.|               ::||::.|              ...|:|||.||......
  Fly   555 MQQHP---------------MAGGVRAS--------------QQQLLQQQQQQAHGHGP------ 584

  Fly  3556 ITEQELESINDDLEDSSSSNTTNTTTT----TTTTATTEKTCV 3594
            .::.:||.:|....|..|:...|.:.|    .|||||...:.:
  Fly   585 FSQSQLEQLNQISSDMRSAFAANGSATPPPMRTTTATANVSAI 627

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dys	NP_001036722.1	CH	13..111	CDD:278723
		CH	129..225	CDD:278723
		SPEC	312..525	CDD:238103
		SbcC	<325..957	CDD:223496
		Smc	<816..1591	CDD:224117
		SPEC	1174..1365	CDD:238103
		SPEC	1289..1485	CDD:295325
		SPEC	2369..2576	CDD:238103
		SPEC	2477..2714	CDD:238103
		WW	2852..2882	CDD:238122
		EF-hand_2	2883..2997	CDD:286194	37/115 (32%)
		EF-hand_3	3001..3100	CDD:286195	24/100 (24%)
		ZZ_dystrophin	3110..3158	CDD:239074	17/47 (36%)
Dyb	NP_001097287.1	EF-hand_2	7..131	CDD:286194	37/115 (32%)
		EF-hand_3	135..223	CDD:286195	25/101 (25%)
		ZZ_dystrophin	232..280	CDD:239074	17/47 (36%)
		Ribosomal_L29	436..482	CDD:279204	12/68 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45439895
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840