DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Dys and Sptbn4

DIOPT Version :9

Sequence 1:NP_001036722.1 Gene:Dys / 42327 FlyBaseID:FBgn0260003 Length:3598 Species:Drosophila melanogaster
Sequence 2:XP_008757363.1 Gene:Sptbn4 / 308458 RGDID:1304682 Length:2609 Species:Rattus norvegicus


Alignment Length:2562 Identity:502/2562 - (19%)
Similarity:870/2562 - (33%) Gaps:920/2562 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 LIDERQHIQKKTFTKWINSHLIDTQCTPVKDLFLDLRDGHRLLALLSTLTQTNL-KPEKGRMRVH 69
            |.|||:.:||||||||:||||....| .:.||:.|||||..|..||..|:...| :|.:||||:|
  Rat   104 LADEREAVQKKTFTKWVNSHLARVGC-HIGDLYADLRDGFVLTRLLEVLSGEQLPRPTRGRMRIH 167

  Fly    70 HINNLNKVITEIQQHGVKLVNISSDDIVGGNAKLTLGLIWLIALEFNGQHLVK-----SHSSNGV 129
            .:.|::|.:..:::..|.|.|:.|.|||.||.:|||||:|.|.|.|..| ::|     :..:...
  Rat   168 SLENVDKALQFLKEQRVHLENVGSHDIVDGNHRLTLGLVWTIILRFQIQ-VIKIETEDNRETRSA 231

  Fly   130 EKSLLAWARQYTEPH-GLQLNDFSSSWSDGRAFLMILDAHVEEL-NLQAALQQHALKRLHLAFDL 192
            :.:||.|.:..|..: .:.:.:|::||.||.||..::..|..:| :|....:.:|...|..||..
  Rat   232 KDALLLWCQMKTAGYPEVNIQNFTTSWRDGLAFNALIHRHRPDLVDLSKLTKSNANYNLQRAFRT 296

  Fly   193 AHRHFKIEKLLDAEDVHTHKPDNKSIQMYVMCLYHAMESMRTRQQEQEQDEGQDQDPGRVPCTSI 257
            |.:|..:.:|||.|||:...||.|||..||:..||....|:....|.::       .|:|     
  Rat   297 AEQHLGLARLLDPEDVNMEAPDEKSIITYVVSFYHYFSKMKALAVEGKR-------IGKV----- 349

  Fly   258 TDLDEVPLDNDQTSLGLYTSDSAGSMEQRSSGELKTHSMRPLSTATNASV--EISGYQSALEAVL 320
              ||:| |:.|:. :..|         :..:.||.....|.:...:|...  .:||.|..|:|..
  Rat   350 --LDQV-LEVDKI-IERY---------EELAAELLAWIHRTVDLISNQKFANSLSGVQQQLQAFT 401

  Fly   321 TLLLEDEQLLSQNLPDPQDFQ------------TAKLQFHENESFMLKLTEHQEYVGEALEEGSN 373
            ...         .|..|..||            .:||:.|....|:.:             ||..
  Rat   402 AYC---------TLEKPVKFQEKGNLEVLLFSIQSKLRAHNRRLFVPR-------------EGCG 444

  Fly   374 LINESQKAGAGLSQEDQNEVRQQMVLLNERWETLRLRALDVQAKILMRLAEFQKQKLEQLRQFLT 438
            :.:..:..|.....|.:.|...:..|:  |.|.|.|.|.....|:.||.:...:.:         
  Rat   445 IWDIDKAWGELEKAEHEREAALRAELI--RQEKLELLAQRFDHKVAMRESWLNENQ--------- 498

  Fly   439 SVEDRISHMSDIGPTLEEAEKQLLEAQKLKADLSEQQELVDSLSSMVVIVNDTSGNFNDLEDRLS 503
                |:....:.|..|...|..:.:.:.::||::..:|.|..::              :|...|:
  Rat   499 ----RLVSQDNFGYELPAVEAAMKKHEAIEADIAAYEERVQGVA--------------ELAQALA 545

  Fly   504 ALG---------ERWSHVVKWSDL------RKEKLQQYKCISR----------WLD-------AR 536
            |.|         :|.|.:.:|:.|      |:.:|:|...:.:          |::       :|
  Rat   546 AEGYYDARRVAAQRDSVLRQWALLTGLVGARRTRLEQNLALQKVFQEMVYMVDWMEEMQTQLLSR 610

  Fly   537 EQDLKLMESRDVT--------DVGGITQRINELNYCAKDLLELQRY------------------L 575
            |....|:|:.|:.        |:...::|:..||..|....:||.|                  |
  Rat   611 ECGQHLVEADDLLQKHGLLEGDIAAQSERVEALNAAALRFSQLQGYQPCDPQVICNRVNHVHGCL 675

  Fly   576 IDLRQMVA----------------------------------ATLQDGDDKG-----------ER 595
            .:|::..|                                  ||...|...|           .|
  Rat   676 SELQEQAARRRAELEASRSLWALLQELEEAESWARDKERLLEATSGSGGAAGTAGGAHDLSSTAR 740

  Fly   596 VLIQLESYEDRLDALKQIVEVQTVR----IETKGFNFG-----------RDRAS--------YDD 637
            :|.|.:..:..|...:.::: |.:|    :...|.:.|           .:||:        .::
  Rat   741 LLAQHKILQGELGGRRALLQ-QALRRGEELAAAGGSVGPGAEPLHLAGLAERAASARRRWQRLEE 804

  Fly   638 SRVVRPEGWVDYQMIIRFGED-----DSQED--------DDEHDLASKKRKLRNADNFNALENHI 689
            :...|.....:.:.:.:||.|     |...|        |..||.||.:|..|   ...||...:
  Rat   805 AAARRERRLQEARALHQFGADLDGLLDWLRDAYRLAAAGDFGHDEASSRRLAR---QHRALTGEV 866

  Fly   690 MEHFG---------------------------YVQEVEQ------KLQQLQRQSLR--------- 712
            ..|.|                           .|.|.||      ::..|:||.||         
  Rat   867 EAHRGPVGGLRRQLATLGGASGAGPLVVALQVRVVEAEQLFAEVTEVAALRRQWLRDALAVYRMF 931

  Fly   713 ---QQCEL---------------------------LKELQAENSRRCGTLPELKK-LYEVCELED 746
               ..|||                           .:.|..|.:...|.:.::.: :.|:.|...
  Rat   932 GEVHACELWIGEKEQWLLAMRVPDSLDDVEVVQHRFESLDQEMNSLMGRVLDVNQTVQELVEGGH 996

  Fly   747 PSRN-----------------------------LLLEETHIKQLEQRYANLSQKLSSQQS----- 777
            ||.:                             :||.|.|:.::.:..|.:.:|..:.:|     
  Rat   997 PSSDEVRSCQDHLNSRWNRIVELVEQRKEEMSAVLLVENHVLEVAEVRAQVREKRRAVESAPRAG 1061

  Fly   778 -------------------------ESHTLLAKEKY-----------------YNSLTGF----- 795
                                     |...||| |::                 :.:|.|.     
  Rat  1062 GALQWRLSGLEAALQALEPRQAALLEEAALLA-ERFPAQATRLHQGAEELGAEWGALAGAAQACG 1125

  Fly   796 KLVLADSR------------DWY---KQHAGSASG------NELEQRLSHMESLASEI------- 832
            :.|.|..|            ||.   ::.||:..|      .|.:..|:...:|..|:       
  Rat  1126 EAVAAAGRLQRFLRDLDTFLDWLVRAQEAAGAVEGPLPRSLEEADGLLARHAALKEEVDQREEDY 1190

  Fly   833 ------SEAKTATE--------ELDDNL----IEWKQDFGLFYDSWHDMKQAL------------ 867
                  |||..|::        .||:.|    :.|.:..||    |.:.::||            
  Rat  1191 ARIVAASEALLASDGAELGPGLALDEWLPHLEVGWHKLLGL----WEERREALVQAHVYQLFLRD 1251

  Fly   868 --QALIQQRGG-------------ESLSRQLKQIQDFVT--KVSNQKVRVSNLEVMQEQQHFLNQ 915
              |||...|..             ||:...:|:.:||:|  :::.||::|:    :|..:..|.|
  Rat  1252 LCQALAVLRNQEVALSGAELPCTVESVEEAMKRHRDFLTTMELNQQKMQVA----VQAAEGLLRQ 1312

  Fly   916 LLDEMESLRLTYDNIPKHLIGEELQTAWNRLPEQLNERVIKQTTAIEN------LNHFAAEYNAI 974
                            .:..||:.|.|..||.|:..|..::....::.      |.||..:.:.:
  Rat  1313 ----------------GNAYGEQAQEAVARLLEKSQENQLRAQQWMQKLLDQLVLQHFLRDCHEL 1361

  Fly   975 IAMLRSAADSKLNGSDGASSQDLRKLEIDVISARNFSEILIKEAEPAQKESLQSQIRALNTLYDQ 1039
            ...:.   :..|...|| :.:|..||....:..:.|.      ||.||.:               
  Rat  1362 DGWIH---EKMLMARDG-TREDSHKLHKRWLRHQAFM------AELAQNK--------------- 1401

  Fly  1040 VEQVHREKKEQQTVLQSHIDL---IQLRLKETDQWLTDLESNTPKSGISDIVNSNELFQSKSRFQ 1101
             |.:.:.::|.|.::|...:|   ::.:|.|..|...:|||.|.       ..:.:||::....|
  Rat  1402 -EWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQ-------AKARQLFEASKADQ 1458

  Fly  1102 TLKETCERETTQFRDLNERGGELLLQMD-ELQDQDRESRYGSLAKQFTRINA------RW-TEVT 1158
            .::        .|.:|::|    ||.|: :|||.|......::..|..::.:      .| .||.
  Rat  1459 LVQ--------SFAELDKR----LLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWCREVG 1511

  Fly  1159 ELVYAKTAL-LEHISTQLGEFKKFMVSE--TGYLDKLENKIRNTPENAADAEEIMEELDD----- 1215
            ||.....|| ||..|.:|...::..|.|  ...|:.|:.: |.....:.:..::..:|||     
  Rat  1512 ELQAQTAALPLEQASKELVGERQSAVGERLVRLLEPLQER-RRLLLASKELHQVAHDLDDELAWV 1575

  Fly  1216 ----------------------------LENVLRSHS---EEWLDKIQEIGNELIDNEFMADSIR 1249
                                        |...:::|.   ||.|::...:.: |...|  |:::|
  Rat  1576 QERLPLAMLTERGTGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGVLAS-LRSPE--AEAVR 1637

  Fly  1250 RDIDETVQRWTQLQQQAKKRTELLEQKVSEAEQSEKCIVQFEKWLTRVD---------------- 1298
            |..::....||.|::..::|.:.|: ...:.||....:.:.|.||...:                
  Rat  1638 RGQEQLQSAWTGLREATERRQQTLD-AAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTL 1701

  Fly  1299 DILSDHLDNDVTIVDQPEEFQRLAHEFVANEKNFKEISELIDEHTRNGKVGAANRLQEQLNLMEV 1363
            .:|..||..:..:.:..|...:|:.:..|..:.....||.|            :|.|.|::.:.|
  Rat  1702 QLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQI------------SRRQSQVDRLYV 1754

  Fly  1364 RFKYCQAKLSKCTAIQHSYESRLNRAYTDLRNVERSTEVVDVASAGPNTVQTQYQKCLQIYRTLS 1428
            ..|.. .:..:.:..|..:..:|:|...:|.:.....|||    ||...:...::....:....|
  Rat  1755 ALKEL-GEERRVSLEQQYWLYQLSRQVDELEHWIAEKEVV----AGSPELGQDFEHVSVLQEKFS 1814

  Fly  1429 EIKSEIESTIKTGRRVCEDRYTKSPKQLSQRIDALKHLYNTLGENVTQSK--------------A 1479
            |..||   |...||    :|..    .::|.:|.|....:|....:.:.|              .
  Rat  1815 EFASE---TGTAGR----ERLA----AVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMG 1868

  Fly  1480 TLERLLTLARQLEECFDSADNL----------IRRFESPQE---------------VHD------ 1513
            |..:||..:|:|.:.|..|..|          :.|..:|.|               .||      
  Rat  1869 TRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTAPPEPRPSASSMQRTLRAFEHDLQLLVS 1933

  Fly  1514 ---------------------------RNSILLEFEDVLRRCEDHYNEYNKSCDQSCMVETRQR- 1550
                                       ...:|..::::|..|||.....:.:.| :....::.| 
  Rat  1934 QVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWKELLAACEDARLHVSSTAD-ALRFHSQARD 1997

  Fly  1551 ----IDGLKA------------------TYHKLTSADIIKRLTEMKTTLQNLDNISLETLRAMEH 1593
                :||:..                  .||:....::..|:.|: |..|.|....|....||..
  Rat  1998 LLSWMDGIAGQIGAADKPRDVSSVEVLMNYHQGLKTELEARVPEL-TACQELGRSLLLNKSAMAD 2061

  Fly  1594 DL-----------KEINVPSNPEIEKLQQQV-------IAIVVDVLKTRFNEATTLAARNTSSPD 1640
            ::           :|::...:...|.|||.:       .|:|.|...|.  :...|.:|...|..
  Rat  2062 EIQAQLDKLGSRKEEVSEKWDRHWEWLQQMLEVHQFAQEAVVADAWLTA--QEPLLQSRELGSSV 2124

  Fly  1641 NDDTEIVVVSDTVRQRRA------------------RTPQSGESPS------------------- 1668
            ::..:::...:..|:..|                  :..||.:.|:                   
  Rat  2125 DEVEQLIRRHEAFRKAAAAWEERFSSLRRLTTIEKLKAEQSKQPPTPLLGRKFFGDPTELAAKAA 2189

  Fly  1669 ------------------SAHTSSSESPTKGVENSPGAVGDQVMPDLLPPQTFRLAESSTLFSQI 1715
                              ::.|.|:|     |....|.|..::.|:.|.|:..||.|:|      
  Rat  2190 PLLRPGGYDRGLEPLARRASDTLSAE-----VRTRVGYVRQELKPERLQPRIDRLPETS------ 2243

  Fly  1716 SLNPQKVTNTPPPKPAKTKRKAPSSPAQVVEIRVKNIQNDKMSVQNIDLEPQQGEIVDTVNILES 1780
                .||....|...|......|.:||...::|.:               |::.|:.|....|  
  Rat  2244 ----GKVEPAAPTAAALDTTDTPGTPAVTEQVRPR---------------PERQELADRAEEL-- 2287

  Fly  1781 VEPFVPEYVETVQIVDLSEDSDSSVRVDSQGKEMRRSKSKHSLNETPLPKVSDNDEDSAEQEEDL 1845
                                           ...|||:.:.|         :|..|::|.:....
  Rat  2288 -------------------------------PRRRRSERQES---------TDQPEEAARRRRPE 2312

  Fly  1846 LRPSAEN------TSTPFLRVEKRRISFDEKRKRVANERDILRDSEEEEPKTPDTPRAAQVSKPK 1904
            .:.||::      |...:.::|:||    |:|     ||.|    |.:|....:||...::.|.|
  Rat  2313 RQESADHEGPHSLTLGRYEQMERRR----ERR-----ERRI----ERQESSEQETPTRGELVKGK 2364

  Fly  1905 RW-----RQLQ-----PEMDALEPESP 1921
            ..     .|||     |.:.|..|..|
  Rat  2365 ATLADIVEQLQEKEAGPGLPAAVPSLP 2391

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DysNP_001036722.1 CH 13..111 CDD:278723 48/98 (49%)
CH 129..225 CDD:278723 33/97 (34%)
SPEC 312..525 CDD:238103 43/239 (18%)
SbcC <325..957 CDD:223496 171/1011 (17%)
Smc <816..1591 CDD:224117 186/995 (19%)
SPEC 1174..1365 CDD:238103 42/244 (17%)
SPEC 1289..1485 CDD:295325 40/225 (18%)
SPEC 2369..2576 CDD:238103
SPEC 2477..2714 CDD:238103
WW 2852..2882 CDD:238122
EF-hand_2 2883..2997 CDD:286194
EF-hand_3 3001..3100 CDD:286195
ZZ_dystrophin 3110..3158 CDD:239074
Sptbn4XP_008757363.1 CH 111..214 CDD:237981 50/103 (49%)
CH 230..333 CDD:237981 35/102 (34%)
SPEC 361..584 CDD:238103 51/282 (18%)
SPEC 479..693 CDD:238103 40/240 (17%)
SPEC 819..1031 CDD:238103 35/214 (16%)
SPEC 1135..1239 CDD:197544 20/107 (19%)
SPEC 1245..1453 CDD:238103 52/260 (20%)
SPEC 1351..1558 CDD:238103 56/252 (22%)
SPEC 1560..1771 CDD:238103 38/227 (17%)
SPEC 1666..1878 CDD:238103 44/239 (18%)
Spectrin 1878..1977 CDD:278843 13/98 (13%)
SPEC 1987..>2154 CDD:238103 28/170 (16%)
PH 2464..2566 CDD:278594
PH_beta_spectrin 2466..2570 CDD:269975
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

Return to query results.
Submit another query.