DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Dys and Sptbn1

DIOPT Version :9

Sequence 1:NP_001036722.1 Gene:Dys / 42327 FlyBaseID:FBgn0260003 Length:3598 Species:Drosophila melanogaster
Sequence 2:NP_001013148.1 Gene:Sptbn1 / 305614 RGDID:727922 Length:2358 Species:Rattus norvegicus


Alignment Length:3067 Identity:596/3067 - (19%)
Similarity:1029/3067 - (33%) Gaps:1103/3067 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 LIDERQHIQKKTFTKWINSHLIDTQCTPVKDLFLDLRDGHRLLALLSTLTQTNL-KPEKGRMRVH 69
            |.|||:.:||||||||:||||....|. :.||:.|||||..|:.||..|:...| ||.|||||:|
  Rat    48 LADEREAVQKKTFTKWVNSHLARVSCR-ITDLYTDLRDGRMLIKLLEVLSGERLPKPTKGRMRIH 111

  Fly    70 HINNLNKVITEIQQHGVKLVNISSDDIVGGNAKLTLGLIWLIALEFNGQHLVKSHSSNGVEKS-- 132
            .:.|::|.:..:::..|.|.|:.|.|||.||.:|||||||.|.|.|..|.:......|..:||  
  Rat   112 CLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLTLGLIWTIILRFQIQDISVETEDNKEKKSAK 176

  Fly   133 --LLAWARQYTEPH-GLQLNDFSSSWSDGRAFLMILDAHVEEL-NLQAALQQHALKRLHLAFDLA 193
              ||.|.:..|..: .:.:::|::||.||.||..::..|..:| :.....:.:|...|..||:||
  Rat   177 DALLLWCQMKTAGYPNVNIHNFTTSWRDGMAFNALIHKHRPDLIDFDKLKKSNAHYNLQNAFNLA 241

  Fly   194 HRHFKIEKLLDAEDVHTHKPDNKSIQMYVMCLYHAMESMRTRQQEQEQDEGQDQDPGRVPCTSIT 258
            .:|..:.||||.||:....||.|||..||:..||....|:....|.::       .|:|      
  Rat   242 EQHLGLTKLLDPEDISVDHPDEKSIITYVVTYYHYFSKMKALAVEGKR-------IGKV------ 293

  Fly   259 DLDEVPLDNDQTSLGLYTSDSAGSMEQRSSGELKTHSMRPLSTATNASVEISGYQSALEAVL--- 320
                  |||                      .::|..|            |..|:|....:|   
  Rat   294 ------LDN----------------------AIETEKM------------IEKYESLASDLLEWI 318

  Fly   321 --TLLLEDEQLLSQNLPDPQD----FQTAKL-----QFHENESFMLKLTEHQEYVGEALEEGSNL 374
              |:::.:.:..:.:|...|.    |.|.:.     :|.|..:..:.|...|          |.:
  Rat   319 EQTIIILNNRKFANSLVGVQQQLQAFNTYRTVEKPPKFTEKGNLEVLLFTIQ----------SKM 373

  Fly   375 INESQKA-----GAGLSQEDQNEVRQQMVLLNERWETLRLRALDVQAKILMRLAEFQKQKLEQL- 433
            ...:||.     |..:|.            :|:.||  ||...:.:.::.:|....:::||||| 
  Rat   374 RANNQKVYMPREGKLISD------------INKAWE--RLEKAEHERELALRNELIRQEKLEQLA 424

  Fly   434 RQFLTSVEDRISHMSDIGPTLEEAEKQLLEAQKLKADLSEQQELV--DSLSSMVVIVNDTSGNFN 496
            |:|     ||.:.|.:..                   |||.|.||  |:....:..|...:....
  Rat   425 RRF-----DRKAAMRETW-------------------LSENQRLVSQDNFGFDLPAVEAATKKHE 465

  Fly   497 DLEDRLSALGERWSHVV---------KWSDLRKEKLQQYKCISRWLDAREQDLKLMESRDVTDVG 552
            .:|..::|..||...||         .:.|:::...::...|..|    |..|:|:.:|      
  Rat   466 AIETDIAAYEERVQAVVAVARELEAESYHDIKRITARKDNVIRLW----EYLLELLRAR------ 520

  Fly   553 GITQRINELNYCAKDLLELQRYLID-LRQMVAATLQDGDDKGERVLIQLESYEDRLD--ALKQI- 613
              .||: |:|...:.:.:...|::| :.:|....|  ..|.|:.:|    ..||.|.  ||.:. 
  Rat   521 --RQRL-EMNLGLQKIFQEMLYIMDWMDEMKVLLL--SQDYGKHLL----GVEDLLQKHALVEAD 576

  Fly   614 VEVQTVRIETKGFN-----FGRDRASYD--DSRVVRPEGWVDYQMIIRFGEDDSQEDDDEHDLAS 671
            :.:|..|:  :|.|     |..|...|.  |.:|:|..                           
  Rat   577 IAIQAERV--RGVNASAQKFATDGEGYKPCDPQVIRDR--------------------------- 612

  Fly   672 KKRKLRNADNFNALENHIMEHFGYVQEVEQKLQQLQRQSLRQQCELLKELQA--ENSRRCGTLPE 734
                                    |..:|...|:|        |:|..|.:|  |.|||.     
  Rat   613 ------------------------VAHMEFCYQEL--------CQLAAERRARLEESRRL----- 640

  Fly   735 LKKLYEVCELEDPSRNLLLEETHIKQLEQRYANLSQKLSSQQSESHTLLAKEKYYNSLTGFKLVL 799
            .|..:|:.|          ||..|::.|:                  :|:.:.|...||....:|
  Rat   641 WKFFWEMAE----------EEGWIREKEK------------------ILSSDDYGKDLTSVMRLL 677

  Fly   800 ADSRDWYKQHAGSASGNELEQRLSHMESLASEISEAKTATEELDDNLIEWKQDFGLFYDSWHDMK 864
            :..|         |..:|:..|..|.|                                      
  Rat   678 SKHR---------AFEDEMSGRSGHFE-------------------------------------- 695

  Fly   865 QALQALIQQRGGESLSRQLKQIQDFVTKVSNQKVRVSNLEVMQEQQHFLNQLLDEMESLRLTYDN 929
                            :.:|:.:|.:.                 ::||.::.:.|    |::|  
  Rat   696 ----------------QAIKEGEDMIA-----------------EEHFGSEKIRE----RISY-- 721

  Fly   930 IPKHLIGEELQTAWNRLPEQLNERVIKQTTAIENLNHFAAEYNAIIA----MLRSAADSKLNGSD 990
                     ::..|..| |||:....|:......|:.|.|:.:.|.|    :|:..:.:.: |.|
  Rat   722 ---------IREQWANL-EQLSAIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSNDV-GHD 775

  Fly   991 GASSQDLRKLEIDVI----SARNFSEILIKEA-----EPAQKESLQSQIRALNTLYDQVEQVHRE 1046
            ..|:|.|.|...||.    :.|...:.|.::|     ..|:...::.::..:...|.:|.::.|.
  Rat   776 EYSTQSLVKKHKDVAEEISNYRPTIDTLHEQAGALPQAHAESPDVKGRLAGIEERYKEVAELTRL 840

  Fly  1047 KKE--QQTV----LQSHIDLIQLRLKETDQWLTDLESNTPKSGISDIVNSNELFQSKSRFQTLKE 1105
            :|:  |.|:    :.|..|..:|.:.|.:|||.:::       |.:.:...|:.|  .||::|:.
  Rat   841 RKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQ-------IPEKLEDLEVIQ--HRFESLEP 896

  Fly  1106 TCERETTQFRDLNERGGELLLQMDELQDQDRESRYGSLAKQFTRINARWTEVTELV-YAKTALLE 1169
            ....:.::...:|:...:|   |......::|.|     .|..::|.||::..||| ..|.|||.
  Rat   897 EMNNQASRVAVVNQIARQL---MHSGHPSEKEIR-----AQQDKLNTRWSQFRELVDRKKDALLS 953

  Fly  1170 HISTQ-----LGEFKKFMVSETGYLDKLENKIRNTPENAADAEEIMEELDDLENVLRSHSEEWLD 1229
            .:|.|     ..|.|.::..:|                     :::|...||.|.|..       
  Rat   954 ALSIQNYHLECNETKSWIREKT---------------------KVIESTQDLGNDLAG------- 990

  Fly  1230 KIQEIGNELIDNEFMADSIRRDIDETVQRWTQLQQQAKKRTELLEQKVSEAEQSEKCIVQFEKWL 1294
             :..:..:|...|       ||:.....:.:.||::|:|    ||                    
  Rat   991 -VMALQRKLTGME-------RDLVAIEAKLSDLQKEAEK----LE-------------------- 1023

  Fly  1295 TRVDDILSDHLDNDVTIVDQPEEFQRLAHEFVANEKNFKEISELIDEHTRNGKVGAANRLQEQLN 1359
                   |:|.|....|:.:..|...:..|.....||            |...:|.|::||:.|.
  Rat  1024 -------SEHPDQAQAILSRLAEISDVWEEMKTTLKN------------REASLGEASKLQQFLR 1069

  Fly  1360 LMEVRFKYCQAKLSKCTAIQHSYESRLNRAYTDLRNVERSTEVVDVASAGPNTVQTQYQKCLQIY 1424
            .::                  .::|.|:|..|.:.:.:.           |||: |:.:|.|..:
  Rat  1070 DLD------------------DFQSWLSRTQTAIASEDM-----------PNTL-TEAEKLLTQH 1104

  Fly  1425 RTLSEIKSEIESTIKTGRRVCEDRYTKSPKQLSQRIDALKHLYNTLGENVTQSKATLERLLTLAR 1489
               ..||:||::        .|:.|.|               ...:||.|||.:...:.:  ..|
  Rat  1105 ---ENIKNEIDN--------YEEDYQK---------------MRDMGEMVTQGQTDAQYM--FLR 1141

  Fly  1490 QLEECFDSADNLIRRFESPQEVHDRNSILLEFEDVLRRCEDHYNEYNKSCDQSCMVETRQRIDGL 1554
            |..:..|:.                                 :||.:|      |.|.||.:...
  Rat  1142 QRLQALDTG---------------------------------WNELHK------MWENRQNLLSQ 1167

  Fly  1555 KATYHK-----------LTSADIIKRLTEMKTTLQNLDNISLETLRAMEHDLKEINVPSNPEIEK 1608
            ...|.:           |.:.:.:...|||.|||:.                      :...|:|
  Rat  1168 SHAYQQFLRDTKQAEAFLNNQEYVLAHTEMPTTLEG----------------------AEAAIKK 1210

  Fly  1609 LQQQVIAIVVDVLKTRFNEATTLAARNTSSPDNDDTEIVVVSDTVRQRRARTPQSGESPSSAHTS 1673
              |:.....:|..:.:.| |.....|...|..|      :.||.::::       .:|....|..
  Rat  1211 --QEDFMTTMDANEEKIN-AVVETGRRLVSDGN------INSDRIQEK-------VDSIDDRHRK 1259

  Fly  1674 SSESPTKGVENSPGAVGDQVMPDLLPPQTFRLAESSTLFSQISLNPQKVTNTPPPKPAKTKRKAP 1738
            :.|:                              :|.|..::..|                    
  Rat  1260 NREA------------------------------ASELLMRLKDN-------------------- 1274

  Fly  1739 SSPAQVVEIRVKNIQNDKMSVQNIDLEPQQGEIVDTVNILESVEPFVPEYVETVQIVDLSEDSDS 1803
                       :::|......|.:.|                   ::.|.:.|.|  |:|.|   
  Rat  1275 -----------RDLQKFLQDCQELSL-------------------WINEKMLTAQ--DMSYD--- 1304

  Fly  1804 SVRVDSQGKEMRRSKSKHSLNETPLPKVSDNDE--DSAEQEEDLLRPSAENTSTPFLRVEKRRIS 1866
                     |.|...||...::..:.:::.|.|  |..|:|...|                  ||
  Rat  1305 ---------EARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQL------------------IS 1342

  Fly  1867 FDEKRKRVANERDILRDSEEEEPKTPDTPRAAQVSKPKRWRQLQPEMDALEPESPGRDSFYSPDK 1931
                                |:|:|....:.......|.|..|              :|......
  Rat  1343 --------------------EKPETEAVVKEKLTGLHKMWEVL--------------ESTTQTKA 1373

  Fly  1932 ESGFDAE--PLVFSDDEDIPRFSLEMTSTIDSDSDTSRIMTPSTKNPNPFLSKVLESLS------ 1988
            :..|||.  .|......|:.::...:.|.|.|| |..:.:|.|.:|      |||:..|      
  Rat  1374 QRLFDANKAELFTQSCADLDKWLHGLESQIQSD-DYGKDLTTSAQN------KVLDGASVFLLMY 1431

  Fly  1989 -----------------SPVDDSNVTLKSPISE------EQPQNL--DDRVREFDKQAKQMIY-- 2026
                             ..||...:|:::...|      |:..||  ...:.:|::..:..|.  
  Rat  1432 SCPPRCWRIRWKRGRAQMRVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWV 1496

  Fly  2027 --KLKLTKAKIEQCHESEAEDLRLLIAPDAATLISQGDSLVLETHGRQGSISRLVMRTQIILREQ 2089
              ::.|. ...:..|..:...|          ||.:..:|..|..|.|..|..:..|:|.|:.:.
  Rat  1497 GERMPLA-TSTDHGHNLQTVQL----------LIKKNQTLQKEIQGHQPRIDDIFERSQNIITDS 1550

  Fly  2090 FREVQQARSKTSGSGAPAPPLDSVNIEELVTK--GLRRI-NVLIEKTVDLKSSTDLEKRMEDINE 2151
                                 .|:|.|.:..:  .|::: .:|||:|         |||...:.|
  Rat  1551 ---------------------SSLNAEAIRQRLADLKQLWGLLIEET---------EKRHRRLEE 1585

  Fly  2152 RHDDLQVIVSAIGKNAQMPKVTPLMMNEIEKTKNNLIAHADSIELSLTELRNGPRISNGKERPDA 2216
            .|...|....|....|.|.:....||:| ||.|                              |.
  Rat  1586 AHKAQQYYFDAAEAEAWMSEQELYMMSE-EKAK------------------------------DE 1619

  Fly  2217 SSAATMSCRSEYNNEPSGTGALAGSFDKSVLQ--ISDWLTWEQNMIKIQSVLVDDGDAVRLAIEK 2279
            .||.:|..:.:                  :|:  :.|:......:.|....||.|...     |.
  Rat  1620 QSAVSMLKKHQ------------------ILEQAVEDYAETVHQLSKTSRALVADSHP-----ES 1661

  Fly  2280 QEKVLRELKMKK--PQLNELVHTAEVLKGDVKRQQLQEKELKQFSLAPHCSADLDYMRCCLKVTR 2342
            :...:|:.|:.|  ..|.:|        .:.:|.:|.|:                          
  Rat  1662 ERISMRQSKVDKLYAGLKDL--------AEERRGKLDER-------------------------- 1692

  Fly  2343 LREHWDETSQCVLQRAAQLKNMLSDSQRFEAKRLELEKWLARMEQRA--ERMGTIATTADILEAQ 2405
                         .|..||...:.|          ||:|:|..|..|  ..:|.......:|:.:
  Rat  1693 -------------HRLFQLNREVDD----------LEQWIAEREVVAGSHELGQDYEHVTMLQER 1734

  Fly  2406 QKEQKSFHAELHQNKQHFDIFNELTQKLIAVYPNDDTTRIKKMTEVINQRYANL------NSGVI 2464
            .:|.......:.|  :..|..|.:...||....:|..| |.:..:.:|:.:|:|      .:.::
  Rat  1735 FREFARDTGNIGQ--ERVDTVNHMADDLINSGHSDAAT-IAEWKDGLNEAWADLLELIDTRTQIL 1796

  Fly  2465 NRGKQLHAAVHSLQS-FDRAMDQFLAFLSE-------TETLCE---NAESDIERNPLMFKDLQSE 2518
            ....:||...|..:. |.|..|:......|       .|||..   ..|.||:......:.||.:
  Rat  1797 AASYELHKFYHDAKEIFGRIQDKHKKLPEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQED 1861

  Fly  2519 IETHRVVY--DRLDGTGRKLLGSLTSQEDAVMLQRRLDEMNQRWNNLKSKSIAIRNRLESNSEHW 2581
            ....:..|  |:.|.                 :|:|.:|:.:.|.:|.......|.||....:.:
  Rat  1862 AARLQAAYAGDKADD-----------------IQKRENEVLEAWKSLLDACEGRRVRLVDTGDKF 1909

  Fly  2582 NALLLSLRELTEW---VIRKDTELSTLGLGPVRGDAVSLQKQLDDHKAFRRQLEDKRPIVESNLT 2643
            ....: :|:|..|   |||:      :.......|..|::..:::|:..:.:::.:.....:.:.
  Rat  1910 RFFSM-VRDLMLWMEDVIRQ------IEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTACIE 1967

  Fly  2644 SGRQYIANEAAVSDTSDTEANHDSDSRYMSAE--EQSRELTRSIRREVGKLSEQWN--NLI---- 2700
            .|:..:|.:                 .|.|.|  |:..:||...:..:.|..::|.  .||    
  Rat  1968 LGKALLARK-----------------HYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVH 2015

  Fly  2701 ----DRS--DNWKHRLDEYMTKMRQFQKI--LEDLSSRVALAEQTKTSWLPPSSVGEANEQMQQL 2757
                |.|  :.|....:.|::.....|.:  :|.|..|....|::..:|         :|:...|
  Rat  2016 QFSRDASVAEAWLLGQEPYLSSREIGQSVDEVEKLIKRHEAFEKSAATW---------DERFSAL 2071

  Fly  2758 QRLRDKMTTASALLDDCNEQQSFFTANQVLVPTPCLSKLEDLNTRM-------KLLQIAMDERQK 2815
            :||     |...||:...:|:......:...|.|.....|:..::.       ::.|..:...|.
  Rat  2072 ERL-----TTLELLEVRRQQEEEERKRRPPSPEPSAKVSEEAESQQWDTSKGDQVSQNGLPAEQG 2131

  Fly  2816 VLCQAGAQQTHE--NG-DDGRTTSNSGTIGPLPNLGQSVKP--PWERATT---------AANVPY 2866
            ....||..:|.|  || .:.||:|...:..|.|...:..|.  |.:.|.|         ||.:..
  Rat  2132 SPRMAGTMETSEMVNGAAEQRTSSKESSPVPSPTSDRKAKSALPAQSAATLPARTLETPAAQMEG 2196

  Fly  2867 YIDHERETTHWD 2878
            :::.:.|   |:
  Rat  2197 FLNRKHE---WE 2205

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DysNP_001036722.1 CH 13..111 CDD:278723 51/98 (52%)
CH 129..225 CDD:278723 35/101 (35%)
SPEC 312..525 CDD:238103 48/243 (20%)
SbcC <325..957 CDD:223496 118/670 (18%)
Smc <816..1591 CDD:224117 144/810 (18%)
SPEC 1174..1365 CDD:238103 33/195 (17%)
SPEC 1289..1485 CDD:295325 36/195 (18%)
SPEC 2369..2576 CDD:238103 46/227 (20%)
SPEC 2477..2714 CDD:238103 47/266 (18%)
WW 2852..2882 CDD:238122 8/38 (21%)
EF-hand_2 2883..2997 CDD:286194
EF-hand_3 3001..3100 CDD:286195
ZZ_dystrophin 3110..3158 CDD:239074
Sptbn1NP_001013148.1 CH 55..158 CDD:237981 53/103 (51%)
CH 174..277 CDD:237981 36/102 (35%)
Spectrin 302..412 CDD:278843 24/145 (17%)
Spectrin 422..525 CDD:278843 30/139 (22%)
SPEC 530..743 CDD:238103 65/408 (16%)
SPEC 642..849 CDD:238103 54/331 (16%)
SPEC 851..1061 CDD:238103 59/305 (19%)
SPEC 958..1169 CDD:238103 65/386 (17%)
SPEC 1171..1380 CDD:238103 55/392 (14%)
SPEC 1276..1587 CDD:238103 79/443 (18%)
SPEC 1588..1800 CDD:238103 53/325 (16%)
SPEC 1801..2022 CDD:238103 48/261 (18%)
Spectrin 2012..>2070 CDD:278843 11/66 (17%)
PH 2194..2301 CDD:278594 2/15 (13%)
PH_beta_spectrin 2194..2299 CDD:269975 2/15 (13%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

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