DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dys and Sptbn2

DIOPT Version :9

Sequence 1:NP_001036722.1 Gene:Dys / 42327 FlyBaseID:FBgn0260003 Length:3598 Species:Drosophila melanogaster
Sequence 2:XP_008758314.1 Gene:Sptbn2 / 29211 RGDID:3751 Length:2395 Species:Rattus norvegicus


Alignment Length:2975 Identity:606/2975 - (20%)
Similarity:1053/2975 - (35%) Gaps:921/2975 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 LIDERQHIQKKTFTKWINSHLIDTQCTPVKDLFLDLRDGHRLLALLSTLT-QTNLKPEKGRMRVH 69
            |.|||:.:||||||||:||||....|. |.||:.|||||..||.||..|: :|..||.|||||:|
  Rat    58 LQDEREAVQKKTFTKWVNSHLARVTCR-VGDLYSDLRDGRNLLRLLEVLSGETLPKPTKGRMRIH 121

  Fly    70 HINNLNKVITEIQQHGVKLVNISSDDIVGGNAKLTLGLIWLIALEFNGQHLVKSHSSNGVEKS-- 132
            .:.|::|.:..:::..|.|.|:.|.|||.||.:|||||:|.|.|.|..|.:......|..:||  
  Rat   122 CLENVDKALQFLKEQKVHLENMGSHDIVDGNHRLTLGLVWTIILRFQIQDISVETEDNKEKKSAK 186

  Fly   133 --LLAWARQYTEPH-GLQLNDFSSSWSDGRAFLMILDAHVEE-LNLQAALQQHALKRLHLAFDLA 193
              ||.|.:..|..: .:.:::|::||.||.||..|:..|..: |:.::..:.:|...|..||:||
  Rat   187 DALLLWCQMKTAGYPNVNVHNFTTSWRDGLAFNAIVHKHRPDLLDFESLKKCNAHYNLQNAFNLA 251

  Fly   194 HRHFKIEKLLDAEDVHTHKPDNKSIQMYVMCLYHAMESMRTRQQEQEQDEGQDQDPGRVPCTSIT 258
            .:...:.||||.|||:..:||.|||..||...||....|:                         
  Rat   252 EKELGLTKLLDPEDVNVDQPDEKSIITYVATYYHYFSKMK------------------------- 291

  Fly   259 DLDEVPLDNDQTSLGLYTSDSAGSMEQRSSGELKTHSMRPLSTATNASVEISGYQSALEAVL--- 320
                                 |.::|.:..|::..|:|       .|...:..|:|....:|   
  Rat   292 ---------------------ALAVEGKRIGKVLDHAM-------EAEHLVEKYESLASELLQWI 328

  Fly   321 ---TLLLEDEQLLS-----QN-LPDPQDFQTAKL--QFHENESFMLKLTEHQEYVGEALEEGSNL 374
               .:.|.|.||.:     || |.....::|.:.  :|.|..:..:.|...|          |.|
  Rat   329 EQTIVTLNDRQLANSLSGVQNQLQSFNSYRTVEKPPKFTEKGNLEVLLFTIQ----------SKL 383

  Fly   375 INESQKA-----GAGLSQEDQNEVRQQMVLLNERWETLRLRALDVQAKILMRLAEFQKQKLEQL- 433
            ...:||.     |..:|.            :|:.||  ||...:.:.::.:|....:::||||| 
  Rat   384 RANNQKVYTPREGRLISD------------INKAWE--RLEKAEHERELALRTELIRQEKLEQLA 434

  Fly   434 ---------RQFLTSVEDRISHMSDIGPTLEEAEKQLLEAQKLKADL---SEQQELVDSLSSMVV 486
                     |:...|...|:....:.|..|...|..:.:.:.::.|:   |.:.:.||::::.: 
  Rat   435 ARFDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDIVAYSGRVQAVDAVAAEL- 498

  Fly   487 IVNDTSGNFNDLEDRLSALGERWSHVVK-WSDLRKEKLQQYKCISRWLDAREQDLKLMESRDVTD 550
                .:.:::|:: |::|   |.::|.: |..||:           .:.||.:.|.|        
  Rat   499 ----AAEHYHDIK-RIAA---RQNNVARLWDFLRE-----------MVAARRERLLL-------- 536

  Fly   551 VGGITQRIN-ELNYCAKDLLELQRYLIDLRQMVAATLQDGDDKGERVLIQLESYEDRLDALKQIV 614
                    | ||....:|||    ||:|....:...|| ..|.|:    .|...||.|. |.::|
  Rat   537 --------NLELQKVFQDLL----YLMDWMAEMKGRLQ-SQDLGK----HLAGVEDLLQ-LHELV 583

  Fly   615 E----VQTVRIETKGFNFGRDRASYDDSRVVRPEGWVDYQMIIRFGEDDSQEDDDEHDLASKKRK 675
            |    ||..|:                 |.|....       :||.:...:....:..|.|::  
  Rat   584 EADIAVQAERV-----------------RAVSASA-------LRFCDPGKEYRPCDPQLVSER-- 622

  Fly   676 LRNADNFNALENHIMEHFGYVQEVEQKLQQLQRQSLRQQCEL--LKELQAENSRRCGTLPELKKL 738
                                |..:||..:.|        |||  .:..:.|.|||.     .:.|
  Rat   623 --------------------VATLEQSYEAL--------CELAATRRARLEESRRL-----WRFL 654

  Fly   739 YEVCELEDPSRNLLLEETHIKQLEQRYANLSQKLSSQQSESHTLLAKEKYYNSLTGFKLVLADSR 803
            :||.|.|...|    |:.|:....:...:|:..|  :....||.|..| ....|...||.|...:
  Rat   655 WEVGEAEAWVR----EQQHLLASAETGRDLTGVL--RLLNKHTALRGE-MSGRLGPLKLTLEQGQ 712

  Fly   804 DWYKQ-HAG----SASGNELEQRLSHMESLASEISE--AKTATEELDDNLIEWKQDFGLFYDSWH 861
            ....: |.|    |....||:.:...:|:||.|.::  |:.|      :|.:::.|.. ..::| 
  Rat   713 QLVAEGHPGANQASTRAAELQAQWERLEALAEERAQRLAQAA------SLYQFQADAN-DMEAW- 769

  Fly   862 DMKQALQALIQQRGG------ESLSRQLKQIQDFVTKVSNQKVRVSNLEVMQEQQHFLNQLLDEM 920
             :..||:.:.....|      ::|:||.:.:::.:      :.....|:.::||...|...|...
  Rat   770 -LVDALRLVSSPEVGHDEFSTQALARQHRALEEEI------RAHRPTLDALREQAAALPPALSHT 827

  Fly   921 ESLRLTYDNIPKHLIGEELQTAWNRLPEQLNERVIKQTTAIENLNHFAAEYNAIIAMLRSAA--- 982
            ..::.....:.:|.             |:|..|..::..|:|     ||  .|...||..|.   
  Rat   828 PEVQGRVPTLEQHY-------------EELQARAGERARALE-----AA--LAFYTMLSEAGACG 872

  Fly   983 ------DSKLNGSDGASSQDLRKLEI------------DVISAR-----NFSEILIKEAEPAQKE 1024
                  :..|||.  |..:.|..||:            :.::||     :.:|.|:|.:.|.:..
  Rat   873 LWVEEKEQWLNGL--ALPERLEDLEVVQQRFETLEPEMNALAARVTAVSDIAEQLLKASPPGKDR 935

  Fly  1025 SLQSQIRALNTLYDQVEQVHREKKEQQTVLQSHIDLIQLRLKETDQWLTDLESNTPKSGISDIVN 1089
            .:.:| ..||..:.|...:...||...|...| |....|...||..|:.:               
  Rat   936 IIGTQ-EQLNQRWQQFRSLADGKKAALTSALS-IQNYHLECTETQAWMRE--------------- 983

  Fly  1090 SNELFQSKSRFQTLKETCERETTQFRDL-NERGGELLLQMDELQDQDRESRYGSLAKQFTRINAR 1153
                           :|...|:||  || |:..|.|.||. :|...:|:         ...|:||
  Rat   984 ---------------KTKVIESTQ--DLGNDLAGVLALQR-KLAGTERD---------LEAISAR 1021

  Fly  1154 WTEVTE----LVYAKTALLEHISTQLGEFKKFMVSETGYLDKLENKIRNTPENAADA---EEIME 1211
            ..|:|:    |.....|....|:|:|||.      :||:.| |...:|...|:..:|   ::.:.
  Rat  1022 VGELTQEANALAAGHPAQAPAINTRLGEV------QTGWED-LRATMRRREESLGEARRLQDFLR 1079

  Fly  1212 ELDDLE----------------------------------NVLRSHSEEWLDKIQEIGNELIDNE 1242
            .|||.:                                  .|.|:.||  ..:::.:|.|:..::
  Rat  1080 SLDDFQAWLGRTQTAVASEEGPATLPEAEALLAQHAALRGEVERAQSE--YSRLRTLGEEVTRDQ 1142

  Fly  1243 FMADS----IRRDIDETVQRWTQLQQQAKKRTELLEQK------VSEAEQSEKCIVQFEKWLTRV 1297
              ||.    :|:.::.....|.:|.:..:.|...|.|.      :.:|.|:|..:...|..|:..
  Rat  1143 --ADPQCLFLRQRLEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVLSSQEYVLSHT 1205

  Fly  1298 D--------DILSDHLDNDVTIVDQPEEFQRLAHEFVANEKNFKEISELIDEHTRNGKVGAANRL 1354
            :        |.....|::.::.:|             ||.:..:.:.|...:....|.: .|.::
  Rat  1206 EMPGTLQAADAAIKKLEDFMSTMD-------------ANGERIRGLLEAGRQLVSKGNI-HAEKI 1256

  Fly  1355 QEQLNLMEVRFKYCQAKLSKCTA-----------IQHSYESRLNRAYTDLRNVERSTEVVDVASA 1408
            ||:.:.:|.|.:..|..:.:...           :|...|.:|   :.|    |:.....||:..
  Rat  1257 QEKADSIEKRHRKNQEAVQQLLGRLRDNREQQHFLQDCQELKL---WID----EKMLTAQDVSYD 1314

  Fly  1409 GPNTVQTQYQKCLQIYRTLSEIKSEIESTIKTGRRVCEDRYTKSPK---QLSQRIDALKHLYNTL 1470
            ....:.|::||.......|:..|..::...|.||.:..::    |:   .:|::::.|...::.|
  Rat  1315 EARNLHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEK----PELKVLVSEKLEDLHRRWDEL 1375

  Fly  1471 GENVTQSKATLERLLTLARQLEECFDSADNLIRRFESPQEVHDRNSILLEFEDVLRRCEDHYNEY 1535
             |..||:|         ||.|   ||:  |....|.                             
  Rat  1376 -ETTTQAK---------ARSL---FDA--NRAELFA----------------------------- 1396

  Fly  1536 NKSCDQSCMVETRQRIDGLKATYHKLTSADIIKRLTEMKTTLQNLDNISLETLRAMEHDLKEINV 1600
                 |||.. ....::.|:|..|   |.|..|.||.:        ||.|:..:.:|.::    .
  Rat  1397 -----QSCSA-LESWLESLQAQLH---SDDYGKDLTSV--------NILLKKQQMLEREM----A 1440

  Fly  1601 PSNPEIEKLQQQVIAIVVDVLKTRFNEATTLAA----RNTSSPDNDDTEIVVVSDTVRQRRARTP 1661
            ....|:|.:|.|..|:..:.......|.|:.|.    |....|..|              |.|..
  Rat  1441 VREKEVEAIQAQAKALAQEDQSAGEVERTSRAVEEKFRALCQPMKD--------------RCRRL 1491

  Fly  1662 QSGESPSSAHTSSSESPTKGVENSPGAVGDQVMPDLLPPQTFRLAESSTLFSQISLNPQKVTNTP 1726
            |:.......|....:......|..|.|...:...| ||.....:.::.||..:|..:..::.:. 
  Rat  1492 QASREQHQFHRDVEDEILWVTERLPMASSLEHGKD-LPSVQLLMKKNQTLQKEIQGHEPRIADL- 1554

  Fly  1727 PPKPAKTKRKAPSSP------------AQVVEIRVKNIQNDKMSVQNI-----DLEPQQGEIVDT 1774
             .:..:|...|.:.|            :..:|:|.|.:: :.:..|..     :.|...||    
  Rat  1555 -KERQRTLGTAAAGPELAELQEMWKRLSHELELRGKRLE-EALRAQQFYRDAAEAEAWMGE---- 1613

  Fly  1775 VNILESVEPFVPEYVETVQIVDLSEDSDSSVRVDSQGKEMRRSKSKHSLNETPLPKVSDNDEDSA 1839
                              |.:.:.....:...:.:|.:     ..||.:.|..|...:...:..|
  Rat  1614 ------------------QELHMMGQEKAKDELSAQAE-----VKKHQVLEQALADYAQTIKQLA 1655

  Fly  1840 EQEEDLL---RPSAENTSTPFLRVEKRRISFDEKRKRVANERDILRDSEEEEPKTPDTPRAAQVS 1901
            ...:|::   .|.:...:....:|:|.....    |.:|.||   |:..:|.             
  Rat  1656 ASSQDMIDHEHPESTRLTIRQAQVDKLYAGL----KELAGER---RERLQEH------------- 1700

  Fly  1902 KPKRWRQLQPEMDALEPESPGRDSFYSPDKESGFDAEPLVFSDDEDIPRFSLEMTSTIDSDSDTS 1966
              .|..||:.|:|.||.....|: ..:...|.|.|.|.:....|: ...||.: ||||..:.   
  Rat  1701 --LRLCQLRRELDDLEQWIQERE-VVAASHELGQDYEHVTMLRDK-FREFSRD-TSTIGQER--- 1757

  Fly  1967 RIMTPSTKNPNPFLSKVLESLSSPVDDSNVTLKSPISEEQPQNLDDRVREFDKQAKQMIYKLKLT 2031
                                    ||.:|......|:.             ...|:..:.:.|  
  Rat  1758 ------------------------VDSANALANGLIAG-------------GHAARATVAEWK-- 1783

  Fly  2032 KAKIEQCHESEAEDLRLLIAPDAATLISQGDSLVLETHGRQGSISRLVMRTQIILREQFREVQQA 2096
                :..:|:.|:.|.||  .....:::....|....||.:.:::|:..:.|.:.....|::..|
  Rat  1784 ----DSLNEAWADLLELL--DTRGQVLAAAYELQRFLHGARQALARVQHKQQQLPDGTGRDLNAA 1842

  Fly  2097 RSKTSGSGAPAPPLD--SVNIEELVTKGLRRINVLIEKTVDLKSSTDLEKRMEDINERHDDLQVI 2159
            .:......|....:.  |..::::...|||     ::|......:.::.:.|:.:.|....||  
  Rat  1843 EALQRRHCAYEHDIQALSTQVQQVQDDGLR-----LQKAYAGDKAEEIGRHMQAVAEAWAQLQ-- 1900

  Fly  2160 VSAIGKNAQMPKVTPLMMNEIEKTK-----NNLIAHADSIELSLTELRNGPRISNGKERP-DASS 2218
                |.:|...:   |:::..:|.:     ..|:...|.|.|.:          :.:||| |.||
  Rat  1901 ----GSSAARRQ---LLLDTTDKFRFFKAVRELMLWMDGINLQM----------DAQERPRDVSS 1948

  Fly  2219 AATMSCRSEYNNEPSGTGALAGSFDKSVLQISDWLTWEQNMIKIQ--------SVLVDDGDAVRL 2275
            |                               |.:...|..||.:        |..:|.|..:  
  Rat  1949 A-------------------------------DLVIKNQQGIKAEIEARADRFSACIDMGQEL-- 1980

  Fly  2276 AIEKQEKVLRELKMKKPQLNELVHTAEVLKGDVKRQQLQEKELKQFSLAPHCSADLDYMRCCLKV 2340
             :.:......|:..|..||..            :||:..||..::          :|:::..|:|
  Rat  1981 -LARNHYAAEEISEKLSQLQS------------RRQETAEKWQEK----------MDWLQLVLEV 2022

  Fly  2341 ------TRLREHW-----------------DETSQCVLQRAAQLKNMLSDSQRFEAKRLELEKWL 2382
                  ..:.|.|                 ||....:.:..|..|:.::..:||.|    |||..
  Rat  2023 LVFGRDAGMAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEAFQKSAVAWEERFSA----LEKLT 2083

  Fly  2383 ARMEQRAERMGTIATTADILEAQQKEQKSFHAELHQNKQHFDIFNELTQKLIAVYPNDDTTRIKK 2447
            |                  ||.::.|||....|..:.||      ..|.:.:|..|         
  Rat  2084 A------------------LEERENEQKRKREEEERRKQ------PPTSEPMASQP--------- 2115

  Fly  2448 MTEVINQRYANLNSGVINRGKQLHAAVHSLQSFDRAMDQFLAFLSET------ETLCENAESDIE 2506
                         .|.:..|:::         .|.|.|...:.|..:      ..:|.:.||.  
  Rat  2116 -------------EGSLVDGQRV---------LDTAWDGTQSKLPPSTQAPSINGVCTDTESS-- 2156

  Fly  2507 RNPLMFKDLQSEIETHRVVYDRLDGTGRKLLGSLTSQE-------DAVMLQRRLDEMNQRWNNLK 2564
             .||:   .|..:|...|......|||.:..|....::       .:.|.|.|..|      :..
  Rat  2157 -QPLL---EQQRLEQSNVPEGPGSGTGDESSGPRGERQTLPRGPAPSPMPQSRSSE------SAH 2211

  Fly  2565 SKSIAIRNRLESNSEHWNALLLSLREL---------TEW-----VIR-------KDTELSTLGLG 2608
            ..::..|....|..|.....|...:|:         ..|     |:|       ||...::.|: 
  Rat  2212 VATLPARGAELSAQEQMEGTLCRKQEMEAFNKKAANRSWQNVYCVLRRGSLGFYKDARAASAGV- 2275

  Fly  2609 PVRGDA-VSLQKQLDDHKAFRRQLEDKRPIVESNLTSGRQYI---ANEAAVSD----------TS 2659
            |..|:. |||.: .....||  ....::.:.:..|..|::|:   .:||.:|.          |:
  Rat  2276 PYHGEVPVSLAR-AQGSVAF--DYRKRKHVFKLGLQDGKEYLFQAKDEAEMSSWLRVVNAAIATA 2337

  Fly  2660 DTEANHDSDSRYMSAEEQSRELTRSIRREVGKLSEQWNNLIDRSDNWKHR 2709
            .:.:....:....||   ||.|||::  .:..:|:...:::.||.:.:.|
  Rat  2338 SSASGEPEEPVVPSA---SRGLTRAM--TMPPVSQPEGSIVLRSKDGRER 2382

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DysNP_001036722.1 CH 13..111 CDD:278723 52/98 (53%)
CH 129..225 CDD:278723 36/101 (36%)
SPEC 312..525 CDD:238103 50/245 (20%)
SbcC <325..957 CDD:223496 137/678 (20%)
Smc <816..1591 CDD:224117 171/882 (19%)
SPEC 1174..1365 CDD:238103 43/245 (18%)
SPEC 1289..1485 CDD:295325 38/217 (18%)
SPEC 2369..2576 CDD:238103 41/219 (19%)
SPEC 2477..2714 CDD:238103 56/281 (20%)
WW 2852..2882 CDD:238122
EF-hand_2 2883..2997 CDD:286194
EF-hand_3 3001..3100 CDD:286195
ZZ_dystrophin 3110..3158 CDD:239074
Sptbn2XP_008758314.1 CH 68..166 CDD:214479 51/98 (52%)
CH 184..287 CDD:237981 37/102 (36%)
Spectrin 312..421 CDD:278843 26/132 (20%)
Spectrin 436..529 CDD:278843 18/112 (16%)
SPEC 541..753 CDD:238103 65/287 (23%)
SPEC 756..965 CDD:238103 46/240 (19%)
SPEC 968..1179 CDD:238103 53/263 (20%)
SPEC 1181..1390 CDD:238103 46/248 (19%)
SPEC 1391..1595 CDD:238103 46/271 (17%)
SPEC 1596..1808 CDD:238103 51/311 (16%)
SPEC 1809..2017 CDD:238103 48/287 (17%)
SPEC 2025..>2082 CDD:197544 11/60 (18%)
PH_beta_spectrin 2228..2331 CDD:269975 21/106 (20%)
PH 2249..2331 CDD:278594 19/85 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

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