Protein Alignment Dys and Actn2

DIOPT Version :9

• Sequence 1: NP_001036722.1
• Gene: Dys / 42327
• FlyBaseID: FBgn0260003
• Length: 3598
• Species: Drosophila melanogaster
• Sequence 2: NP_001163796.1
• Gene: Actn2 / 291245
• RGDID: 1308097
• Length: 894
• Species: Rattus norvegicus
• Alignment Length: 1068
• Identity: 227/1068 - (21%)
• Similarity: 428/1068 - (40%)
• Gaps: 263/1068 - (24%)

  Fly     1 MEPGI----LIDERQHI-------------------QKKTFTKWINSHLIDTQCTPVKDLFLDLR 42
            :|||:    :.||.:::                   |:||||.|.||||.... |.::::..|.|
  Rat     4 IEPGVQYNYVYDEDEYMIQEEEWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAG-TQIENIEEDFR 67

  Fly    43 DGHRLLALLSTLTQTNL-KPEKGRMRVHHINNLNKVITEIQQHGVKLVNISSDDIVGGNAKLTLG 106
            :|.:|:.||..::...| ||::|:||.|.|.|:||.:..|...|||||:|.:::||.||.|:|||
  Rat    68 NGLKLMLLLEVISGERLPKPDRGKMRFHKIANVNKALDYIASKGVKLVSIGAEEIVDGNVKMTLG 132

  Fly   107 LIWLIALEFNGQHLVKSHSSNGVEKSLLAWARQYTEPH-GLQLNDFSSSWSDGRAFLMILDAHVE 170
            :||.|.|.|..|.:  |......::.||.|.::.|.|: .:.:.:|.:||.||.....::..|..
  Rat   133 MIWTIILRFAIQDI--SVEETSAKEGLLLWCQRKTAPYRNVNIQNFHTSWKDGLGLCALIHRHRP 195

  Fly   171 ELNLQAAL-QQHALKRLHLAFDLAHRHFKIEKLLDAED-VHTHKPDNKSIQMYVMCLYHAMESMR 233
            :|...:.| :...:..::||.::|.:|..|.|:||||| |:|.|||.::|..||.|.|||.
  Rat   196 DLIDYSKLNKDDPIGNINLAMEIAEKHLDIPKMLDAEDIVNTPKPDERAIMTYVSCFYHAF---- 256

  Fly   234 TRQQEQEQDEGQDQDPGRVPCTSITDLDEVPLDNDQTSLGLYTSDSAGSME--QRSSGELKTHSM 296
                     .|.:|  .......|..:..|..:|::.            ||  :|.:.||.....
  Rat   257 ---------AGAEQ--AETAANRICKVLAVNQENERL------------MEEYERLASELLEWIR 298

  Fly   297 RPLSTATNASVEISGYQSALEAVLTLLLEDEQLLSQNLPDPQDFQ--------TAKLQFHENESF 353
            |.:....|.:.|                :..|.:.:.|.|.:|::        ..|.|...|.:.
  Rat   299 RTIPWLENRTPE----------------KTMQAMQKKLEDFRDYRRKHKPPKVQEKCQLEINFNT 347

  Fly   354 M---LKLTEHQEYVGEALEEGSNLINESQKAGAGLSQEDQNEVRQQMVLLNERWETLRLRALDVQ 415
            :   |:::....::.   .||..:   |..||| ..:.:|.|...:..||||      :|.|:
  Rat   348 LQTKLRISNRPAFMP---SEGKMV---SDIAGA-WQRLEQAEKGYEEWLLNE------IRRLE-- 397

  Fly   416 AKILMRLAEFQKQKLEQLRQFLTSVEDRISHMSDIGPTLEEAEKQLLEAQKLKADLSEQQELVDS 480
              .|..|||..:||......:....|..:........:|.|....|.:.:..::||:..|:.|:.
  Rat   398 --RLEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQDRVEQ 460

  Fly   481 LSSMVVIVNDTSGNFND---LEDRLSALGERWSHVVKWSDLRKEKLQQYKCI------------- 529
            ::::...:|:.  :::|   :.||...:.::|..:...:..|:|.|::.:.:
  Rat   461 IAAIAQELNEL--DYHDAVNVNDRCQKICDQWDRLGTLTQKRREALERTEKLLETIDQLHLEFAK 523

  Fly   530 -----SRWLDAREQDLKLMESRDVTDVGGITQRINELNYCAKDLLELQRYLIDLRQMVAATLQDG 589
                 :.|::...:||:.|                   :....:.|:|. ||...:...|||.:.
  Rat   524 RAAPFNNWMEGAMEDLQDM-------------------FIVHSIEEIQS-LITAHEQFKATLPEA 568

  Fly   590 DDKGERVL-IQLESYEDRLDALKQIVEVQTVRIETKGFNFGRDRASYDDSRVVRPEGWVDYQMII 653
            |.:.:.:| ||.|        ::::::..::||.:..   .....:.|:.|    ..|...:.::
  Rat   569 DGERQSILAIQNE--------VEKVIQSYSIRISSSN---PYSTVTMDELR----NKWDKVKQLV 618

  Fly   654 RFGEDDSQEDDDEHDLASKKRKLRNADNFNALENHIMEHFGYVQEVEQKLQQLQRQSLRQQCELL 718
            ...:...||     :||.:....|....|.|..|.|...      ::.|::::.|.|:
  Rat   619 PVRDQSLQE-----ELARQHANERLRRQFAAQANAIGPW------IQNKMEEIARSSI------- 665

  Fly   719 KELQAENSRRCGTLPELKKLYEVCELEDPSRNLLLEETHIKQLEQRYANLSQKLSSQQSESHTLL 783
                    :..|.|.:     ::.:|:....|::..:.:|.:||..:..:.:.|..  ...||..
  Rat   666 --------QITGALED-----QMNQLKQYEHNIINYKNNIDKLEGDHQLIQEALVF--DNKHTNY 715

  Fly   784 AKEKYYNSLTGFKLVLADSRDWYKQHAGSASGNELEQRLSHMESLASEISEAKTATEELDDNLIE 848
            ..|   :...|::|:|...         :.:.||:|.::.        ..:||..|:|   .:.|
  Rat   716 TME---HIRVGWELLLTTI---------ARTINEVETQIL--------TRDAKGITQE---QMNE 757

  Fly   849 WKQDFGLF-----------------YDSWHDMKQA----LQALIQQRGGESLSRQLKQIQDFVTK 892
            ::..|..|                 ....:|:.:|    :..|:...|..:::     .|.|:..
  Rat   758 FRASFNHFDRRKNGLMDHEDFRACLISMGYDLGEAEFARIMTLVDPNGQGTVT-----FQSFIDF 817

  Fly   893 VSNQKVRVSNLEVMQEQQHFLNQLLDEMESLRLTYDNIPKHLIGEELQTAWNRLPEQLNERVIKQ 957
            ::.:.......|.:             :.|.|:...:.| :::.|||:   ..||....:..||:
  Rat   818 MTRETADTDTAEQV-------------IASFRILASDKP-YILAEELR---RELPPDQAQYCIKR 865

  Fly   958 TTAIENLNHF--AAEYNAIIAMLRSAAD 983
            ..........  |.:|.|..:.|...:|
  Rat   866 MPPYSGPGSVPGALDYTAFSSALYGESD 893

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dys	NP_001036722.1	CH	13..111	CDD:278723	45/117 (38%)
		CH	129..225	CDD:278723	32/98 (33%)
		SPEC	312..525	CDD:238103	44/226 (19%)
		SbcC	<325..957	CDD:223496	117/685 (17%)
		Smc	<816..1591	CDD:224117	32/191 (17%)
		SPEC	1174..1365	CDD:238103
		SPEC	1289..1485	CDD:295325
		SPEC	2369..2576	CDD:238103
		SPEC	2477..2714	CDD:238103
		WW	2852..2882	CDD:238122
		EF-hand_2	2883..2997	CDD:286194
		EF-hand_3	3001..3100	CDD:286195
		ZZ_dystrophin	3110..3158	CDD:239074
Actn2	NP_001163796.1	CH_ACTN_rpt1	35..139	CDD:409063	46/104 (44%)
		CH_ACTN_rpt2	143..257	CDD:409065	38/128 (30%)
		Spectrin	281..391	CDD:395348	25/144 (17%)
		SPEC	402..629	CDD:238103	44/268 (16%)
		Spectrin	637..739	CDD:395348	24/141 (17%)
		PTZ00184	747..>851	CDD:185504	19/125 (15%)
		EFhand_Ca_insen	824..890	CDD:400872	15/82 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000