DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dys and ain1

DIOPT Version :9

Sequence 1:	NP_001036722.1	Gene:	Dys / 42327	FlyBaseID:	FBgn0260003	Length:	3598	Species:	Drosophila melanogaster
Sequence 2:	NP_594295.1	Gene:	ain1 / 2542805	PomBaseID:	SPAC15A10.08	Length:	621	Species:	Schizosaccharomyces pombe

Alignment Length:	746	Identity:	182/746 - (24%)
Similarity:	293/746 - (39%)	Gaps:	211/746 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 QHIQKKTFTKWINSHLIDTQCTPVKDLFLDLRDGHRLLALLSTLTQTNL-----KPEKGRMRVHH 70
            |.:|.:|||||.|:.|.......|.||..||.||..|:.||..:...||     .|   |||||.
pombe     7 QSVQNRTFTKWFNTKLSSRDLPSVFDLRKDLSDGILLIQLLEIIGDENLGRYNRNP---RMRVHR 68

  Fly    71 INNLNKVITEIQQHGVKLVNISSDDIVGGNAKLTLGLIWLIALEFNGQHLVKSHSSNGV--EKSL 133
            :.|:||.:..|:..|:.|.||...|||.||.||.|||||.:.|.|.    :...:..|:  ::.|
pombe    69 LENVNKALEYIKSKGMPLTNIGPADIVDGNLKLILGLIWTLILRFT----IADINEEGLTAKEGL 129

  Fly   134 LAWARQYTEPH--GLQLNDFSSSWSDGRAFLMILDAHVEELNLQAALQQHALKR------LHLAF 190
            |.|.::.|..:  .:.:.||:.||::|.||..::..|..:|     |..:.|.:      :.|||
pombe   130 LLWCQRKTANYHPEVDVQDFTRSWTNGLAFCALIHQHRPDL-----LDYNKLDKKNHRANMQLAF 189

  Fly   191 DLAHRHFKIEKLLDAEDV-HTHKPDNKSIQMYVMCLYHAMESMRTRQQEQEQDEGQDQDPGRVPC 254
            |:|.:...|.:|::.||| ...:||.:||..||...:||..:
pombe   190 DIAQKSIGIPRLIEVEDVCDVDRPDERSIMTYVAEYFHAFST----------------------- 231

  Fly   255 TSITDLDEVPLDNDQTSLGLYTSDSAGSMEQRSSGELKTHSMRPLSTATNASVEISGYQSALEAV 319
                 ||:|             ..:|..:|:.:...:.||.|:            ..|:|.::.:
pombe   232 -----LDKV-------------ETAARRVERFTEVLMSTHDMK------------IDYESRMKRL 266

  Fly   320 LTLLLEDEQL-----LSQNLPDPQDFQTAKLQFHENESFMLKLTEHQEYVGEALEEGSNL--INE 377
            |..:...::.     ...|..|        ::.|.|.....|.||.:|:|.|.::..|.|  |..
pombe   267 LGSIARMQEYWHTVQFENNYTD--------VKSHSNNFAKFKATEKREWVKEKIDLESLLGTIQT 323

  Fly   378 SQKA--------GAGLSQED--------QNEVRQQMVLLN----ERWETLRLRALDVQAKILMRL 422
            :.|.        .|||...|        .:|...|..|:|    |..|::|:...|       |.
pombe   324 NLKTYQLRKYEPPAGLKIVDLERQWKDFLSEEANQSKLINTHMREIKESMRIAFAD-------RA 381

  Fly   423 AEFQKQKLEQLRQFLTSVE----DRISHM----SDIGPTLEEAEKQLLEAQKLKADLSEQQELVD 479
            ..|.|. |..:...:|:::    |::.|:    ..:||              |:.:|:..:.|.|
pombe   382 NSFSKM-LSTISNEITNLQGDWRDQLDHVEFLQEHLGP--------------LEVELASVKVLYD 431

  Fly   480 SLSSMVVIVND-TSGNFNDLEDRLSALGERWSHVVKWSDLRKEKLQQYKCISRWLDAREQDLKLM 543
            :.....:..|| |..::.|||..........::.:|:  |..|.|::.|   |.|..:|.|
pombe   432 NCFQAGIEENDYTMFSYEDLEHEFGITANIIANKIKY--LENELLEREK---RTLSKQELD---- 487

  Fly   544 ESRDVTDVGGIT--------QRINELN----YCAKDLLELQRYLIDLRQMV-----AATLQDGDD 591
                     |||        ::.|.||    |.|...|.|   :.|..:..     ||..::|..
pombe   488 ---------GITKVFRHFEKKKSNMLNEVEFYAALASLGL---VYDTEEGTALFHRAANSEEGVT 540

  Fly   592 KGERVLIQLESYEDRLDALKQIVEVQTVRIETKGFNF-----GRDRASYDD--SRVVRPEGWVDY 649
            ......|.:|..||| |:.:|::           :.|     |:...:.||  ...|||.
pombe   541 YERFTEIVMEELEDR-DSARQVL-----------YAFCDVADGKSYVTSDDLLRSQVRPN----- 588

  Fly   650 QMIIRFGEDDSQEDDDEHDLASKKRKLRNAD 680
              |::|.|.:..:..:..|..:..::|...|
pombe   589 --IVKFLECNMNKHSEGLDYLTWIKQLLAED 617

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dys	NP_001036722.1	CH	13..111	CDD:278723	46/102 (45%)
		CH	129..225	CDD:278723	31/106 (29%)
		SPEC	312..525	CDD:238103	52/248 (21%)
		SbcC	<325..957	CDD:223496	88/416 (21%)
		Smc	<816..1591	CDD:224117
		SPEC	1174..1365	CDD:238103
		SPEC	1289..1485	CDD:295325
		SPEC	2369..2576	CDD:238103
		SPEC	2477..2714	CDD:238103
		WW	2852..2882	CDD:238122
		EF-hand_2	2883..2997	CDD:286194
		EF-hand_3	3001..3100	CDD:286195
		ZZ_dystrophin	3110..3158	CDD:239074
ain1	NP_594295.1	SAC6	1..616	CDD:227401	181/743 (24%)
		CH	9..113	CDD:237981	47/106 (44%)
		CH	125..229	CDD:237981	32/108 (30%)
		EFhand_Ca_insen	554..615	CDD:285885	16/79 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11915
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100