Protein Alignment Dys and MACF1

DIOPT Version :10

• Sequence 1: NP_001036722.1
• Gene: Dys / 42327
• FlyBaseID: FBgn0260003
• Length: 3598
• Species: Drosophila melanogaster
• Sequence 2: NP_001380991.1
• Gene: MACF1 / 23499
• HGNCID: 13664
• Length: 7555
• Species: Homo sapiens
• Alignment Length: 4018
• Identity: 772/4018 - (19%)
• Similarity: 1387/4018 - (34%)
• Gaps: 1175/4018 - (29%)

  Fly     2 EPGILIDERQHIQKKTFTKWINSHLIDTQCTPVKDLFLDLRD----------GHR---------- 46
            :||:|.::      ...||.:...|.:.| .||:.|....||          .||
Human  4028 DPGVLQEQ------LATTKQLQEELAEHQ-VPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSIL 4085

  Fly    47 --------LLALLSTLTQTNLKPEKGRMRVHHINNLNKVITEIQQH--GVKLVNISS---DDIVG 98
                    .||..|:|.|..:...:...  ..:.:|.:.|.|::|:  |.::.::||   .:.:.
Human  4086 SHFQSLSYSLAERSSLLQKAIAQSQSVQ--ESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALA 4148

  Fly    99 GNAKL--------------------------------TLGLIWLIALEFNGQHLVKSHSSNGVEK 131
            .|.||                                ..|.:..::..|....|.:....:.::|
Human  4149 TNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKK 4213

  Fly   132 SLLAWARQYTEPHGLQLNDFSSSWS-----------DGRAFLMILDAHVEELNLQAALQQHALKR 185
             ||..|..:....| :|..|..:.|           |...|..    .::||||:...||..|..
Human  4214 -LLPQAEMFEHLSG-KLQQFMENKSRMLASGNQPDQDITHFFQ----QIQELNLEMEDQQENLDT 4272

  Fly   186 L-HLAFDLAHRHFKIEKLLDAEDVHTHKPDNKSIQMYVMCLYHAMESMRTRQQE----QEQ-DEG 244
            | ||..:|:...|.::.....:.|...:.|...:|          ::::.|:::    ||| ||.
Human  4273 LEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQ----------KTVKEREKDASSCQEQLDEF 4327

  Fly   245 Q----------DQDPGRVPCTSITDLDEVPLDNDQTSLGLYTSD--SAGSMEQR----------- 286
            :          .:..|.:|.|. |.:....|:.....|.....|  |.|::.:.
Human  4328 RKLVRTFQKWLKETEGSIPPTE-TSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENL 4391

  Fly   287 --------SSGELKTHSMRPLSTATNASV-EISGY------------------------------ 312
                    |.|  ||.|:.|   :..:|| .::||
Human  4392 IMEITAPDSQG--KTGSILP---SVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHER 4451

  Fly   313 QSALEAVLTLLLE---------------DEQLLSQN-LPDPQDFQTAKLQFHENESFMLKLTEHQ 361
            |.:|:|:|..:.|               :|.|.|.: :..|...:|.|.|...|::|:.:
Human  4452 QESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAE----- 4511

  Fly   362 EYVGEALEEGSNLINESQKAGAGL------SQEDQN--EVRQQMVLLNERWE------TLRLRAL 412
                  ||:.|..|.:.::|.|||      |||.:|  :::::   ||.|||      ..|.|.|
Human  4512 ------LEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEE---LNSRWERATEVTVARQRQL 4567

  Fly   413 DVQAKILMRLAEFQKQKLEQLRQFLTSVEDRISHMS--DIGPTLEEAEKQLLE--AQKLKADLSE 473
            :..|.   .||.||..: .|||.:|...|..:..:.  .|.|.:..|:||.::  .::.:|...:
Human  4568 EESAS---HLACFQAAE-SQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQ 4628

  Fly   474 QQELVDSLSSMVVIVNDTSGNFNDLEDRLSALGERWSHVVKWSDLRKEKLQQYKCISRWLDAREQ 538
            .::|.::...::....|.|.:.:.::..|.::.::|..:....:.|..::.|....|.......|
Human  4629 HEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQ 4693

  Fly   539 DLKLMESRDVTDVG--------------GITQRINELNYCAKDLLELQRYLIDLRQMVAATLQD- 588
            ||    |..|..||              .:.|::.|.:....||.:|     |.....|.||.|
Human  4694 DL----SEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQL-----DHEVKEAQTLCDE 4749

  Fly   589 -----GDD--------KGERVLIQLESYEDRLDALKQIVEVQTVRIETKGFNFGRDRASYDDSRV 640
                 |:.        :.|.|.:.|:..||.  |..:|..:|.....|:.|     :..:|:.|.
Human  4750 LSVLIGEQYLKDELKKRLETVALPLQGLEDL--AADRINRLQAALASTQQF-----QQMFDELRT 4807

  Fly   641 VRPEGWVDYQMIIRFGEDDSQEDDDEHDLASKKRKLRNADNFNALENHIMEHFGYVQEVEQKLQQ 705
                 |:          ||.|           .::.:|.                  .:..||::
Human  4808 -----WL----------DDKQ-----------SQQAKNC------------------PISAKLER 4828

  Fly   706 LQRQSLRQQCELLKELQAENSRRCGTLPELKKLYEVCELEDPSRNLLLE----------ETHIKQ 760
            ||.| |::..|..|.|...:..           |||...|..|  |||.          :..:.:
Human  4829 LQSQ-LQENEEFQKSLNQHSGS-----------YEVIVAEGES--LLLSVPPGEEKRTLQNQLVE 4879

  Fly   761 LEQRYANLSQKLSSQQSESHTLLAKEKYYNSLTGFKLVLADSRDWYKQHAGSASG---------- 815
            |:..:..||:|.:.:||.....:.|.:.|      :..:.|...|.:......|.
Human  4880 LKNHWEELSKKTADRQSRLKDCMQKAQKY------QWHVEDLVPWIEDCKAKMSELRVTLDPVQL 4938

  Fly   816 -----------NELEQRLSHMESLASEISEAKTATEELDDNLIEWKQDFGLFYDSWHDMKQALQA 869
                       ||:|:|.|.:|.|.|.......::|..:|.:.:.|.......|:   :.:.|||
Human  4939 ESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDA---VTEELQA 5000

  Fly   870 LIQQRGG-ESLSRQLKQIQD----FVTKVSNQKVRV-------------SNLEVMQEQQHFLNQL 916
               :.|. |.::::|::.|:    ...||...|.::             .|||.::.||..|..|
Human  5001 ---KTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQAL 5062

  Fly   917 LDEMESLRLTYDNIPKHLI---------------GEELQTAWNRLPEQLNERVIKQTTAIENLNH 966
            ..:::.||    |..:.|:               .|..|..:..:.:::|...:.....:|.:..
Human  5063 EPQVDYLR----NFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQ 5123

  Fly   967 FAAEYNAIIAMLRSAADSKLNGSDGASSQDLRKLEIDVISAR---NFSEILIKEAEPAQKE---- 1024
            |......:.:.| :..|.:|:|. ||..:|...|:..:...|   |...:|..:.|.::.|
Human  5124 FHCRVREMFSQL-ADLDDELDGM-GAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHM 5186

  Fly  1025 ----------SLQSQIRALNTLYDQVEQVHREKKEQQTVLQSHIDLIQLRLK------------E 1067
                      .|:.::.|||....::.:..:.::||..:....::....:||            |
Human  5187 LEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAE 5251

  Fly  1068 TDQWLTDLESNTPKSGISDIVNSNELFQSKSRFQTLKETCERETTQFRDLNERGGELLLQMDELQ 1132
            ..||:...|.......::|.    ::||        ||..:....:.:.:|..|..|      :|
Human  5252 ALQWVVGTEVEIINQQLADF----KMFQ--------KEQVDPLQMKLQQVNGLGQGL------IQ 5298

  Fly  1133 DQDRESRYGSLAKQFTRINARWTEVTELVYAKTALLEHISTQLGEFKKFMVSETGYLDKLENKIR 1197
            ...::.....|......|||||..:.:.|..:.|.|:......|:|:..:.....:|...|..|.
Human  5299 SAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIA 5363

  Fly  1198 NTPENAADAEEIMEELDD---LENVLRSHSEEWLDKIQEIGNELIDNEFMAD--SIRRDIDETVQ 1257
            |....:|:.:.:..::.:   |:.:| ...:..:|.:|..|..:..:..:||  .|...::....
Human  5364 NQKPPSAEYKVVKAQIQEQKLLQRLL-DDRKATVDMLQAEGGRIAQSAELADREKITGQLESLES 5427

  Fly  1258 RWTQLQQQAKKRTELLEQKVSEAEQSEKCIVQFEKWLTRVDDILS---DHLDNDVTIVDQPEEFQ 1319
            |||:|..:|..|.:.||..:..|:       ||.:....:.|.||   ..|.|...:..|..:.|
Human  5428 RWTELLSKAAARQKQLEDILVLAK-------QFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQ 5485

  Fly  1320 R--LAHEFVANEKNFKEISELIDEHTRN----GKVGAA----------NRLQEQLNLMEVRFKYC 1368
            :  :.|         |.:.|.|:.|..:    .|:|.:          ..|.|:::.::.|:...
Human  5486 QQIIRH---------KALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEI 5541

  Fly  1369 QAKLSKCTAIQHSYESRLNRAYTDLR--------------NVERSTEVVDVASAGPNTVQTQYQK 1419
            |.:..:..|:       |::|.::.|              .||.....|.|.....:.:..|:..
Human  5542 QDRCCRKAAL-------LDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHAD 5599

  Fly  1420 CLQIYRTLSEIKSEIESTIKTGRRVCEDRYTKSPKQLSQRIDALKHLYNTLGENVTQSKATLERL 1484
            .|.:...:...|..::..||.|:.:.:....:....:.:::|.:|..|..:  .||.|||.  |.
Human  5600 HLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADI--TVTSSKAL--RT 5660

  Fly  1485 LTLARQLEECFDSADNLIRRFESPQEVHDRNSILLEFEDVLRRCEDHYNEYNKSCDQSCMVETRQ 1549
            |..|||          |..:|:|..|         |....||..|:   |...|..||   .|.:
Human  5661 LEQARQ----------LATKFQSTYE---------ELTGWLREVEE---ELATSGGQS---PTGE 5700

  Fly  1550 RIDGLKATYHKLTSADIIKRLTEMKTTLQNLDNISLETLRAMEHDLKEINVPSNPEIEKL---QQ 1611
            :|...:....:|.     |.:.|.:..|..::.:|...|..:....:|       .::||   ..
Human  5701 QIPQFQQRQKELK-----KEVMEHRLVLDTVNEVSRALLELVPWRARE-------GLDKLVSDAN 5753

  Fly  1612 QVIAIVVDVLKTRFNEATTLAARNTSSPDNDDTEIVVVSDTVRQRRARTPQSGESPSS------- 1669
            :...:|.|.:..|.:|......|:.......|.|:..|::|.|:..|..|...|...:
Human  5754 EQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQ 5818

  Fly  1670 ------------------AH------TSSSESPTKGVENSPGAVGDQVMPDLLPPQTF-RLAESS 1709
                              :|      |...|..|...|.:...:.......||..:.: ||..:.
Human  5819 KAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQ 5883

  Fly  1710 TLFSQI-----SLNP----QKVTNTPPPKPAKTKRKAPSSPAQVVEIRVKNIQNDKMSVQNI--- 1762
            .|.:|.     .|:|    .:......|.||....:......::.::| ::|...|..:..:
Human  5884 VLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLR-ESIAEHKPHIDKLLKI 5947

  Fly  1763 -----DLEPQQGEIVDTVNILESVEPFVPEYVETV--QIVDLSEDSDSSVRVDSQGKEMRRSKSK 1820
                 :|.|::||:|:  ...:..|....:..|.|  :.:.|.|....|.:...:.:.|..:...
Human  5948 GPQLKELNPEEGEMVE--EKYQKAENMYAQIKEEVRQRALALDEAVSQSTQFHDKIEPMLETLEN 6010

  Fly  1821 HS--LNETPLPKVSDNDEDSAEQEEDLLRPSAENTSTPFLRVEKRRISFDEKRKR---------- 1873
            .|  |...||          ...|.|.:|....:..:..:.:||.:.||:..::|
Human  6011 LSSRLRMPPL----------IPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQG 6065

  Fly  1874 -----VANE------------RDILRDSEEEEPKTPDTPRAAQVSKPKRWRQLQPEMDALEP--- 1918
                 .|.|            .||...:||.|.|..|....|:    |.|..:...:..::.
Human  6066 ADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAE----KFWYDMAALLTTIKDTQD 6126

  Fly  1919 -----ESPGRDSFYSPDKESGFDAEPLVFSDDEDIPRFSLEMTSTIDSDSDTSRIMTPST----- 1973
                 ||||.|              |.:.....:......|.|..:..:.:..||:....
Human  6127 IVHDLESPGID--------------PSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACG 6177

  Fly  1974 KNPNPFLSKVLESLSSPVDDSNVTLKSPISEEQPQNLDDRVR---EFDKQAKQMIYKLKLTKAKI 2035
            :...|.:.|.::.:::..::.|.|.|     |:.:.|:|.::   ::....:.|...|..|.
Human  6178 ETEKPEVRKSIDEMNNAWENLNKTWK-----ERLEKLEDAMQAAVQYQDTLQAMFDWLDNTV--- 6234

  Fly  2036 EQCHESEAEDLRLLIAPDAATLISQGDSLVLETHGRQGSISRLVMRTQIILREQFR-EVQQARSK 2099
                      ::|...|...|.::                   .::.|:...::|: ||.|
Human  6235 ----------IKLCTMPPVGTDLN-------------------TVKDQLNEMKEFKVEVYQ---- 6266

  Fly  2100 TSGSGAPAPPLDSVNIEELVTKGLRRINVLIEKTVD-------LKSSTDLEKRMEDINE----RH 2153
                       ..:.:|:|..:|    .::::|..|       .:..|:|:...|::.|    |.
Human  6267 -----------QQIEMEKLNHQG----ELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQ 6316

  Fly  2154 DDLQVIVSAIGK-------------------NAQM-----PKVTPLMMNEIEKTKNNLIAHADSI 2194
            ..|:..:.|:|:                   :||.     |||..:.:.:....||:::||..::
Human  6317 HKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATV 6381

  Fly  2195 ELSLTELRNGPRISNGKERPDASSAATMSCRSEYNNEPSGTGALAGSFDKSVLQISDWLTWEQNM 2259
            |   |..:.|..:.......||||   :..|.|..|:          ..:||||.:     |:..
Human  6382 E---TVNKAGNELLESSAGDDASS---LRSRLEAMNQ----------CWESVLQKT-----EERE 6425

  Fly  2260 IKIQSVL---------VDDGDAVRLAIEKQEKVLRELKMKKPQLNELVHTA-EVLKGDVK-RQQL 2313
            .::||.|         ::|   ..|.:.:.|.   :|...|| ...|..|| |.|...:: ..||
Human  6426 QQLQSTLQQAQGFHSEIED---FLLELTRMES---QLSASKP-TGGLPETAREQLDTHMELYSQL 6483

  Fly  2314 QEKELKQFSLAPHCSADLDYMRCCL--------------KVTRLREHWDETSQCVLQRAAQLKNM 2364
            :.||.....|       ||..|..|              .|..|.:.|...|..:.:|.::|:..
Human  6484 KAKEETYNQL-------LDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEA 6541

  Fly  2365 LSDSQRFEAKRLELEKWLARMEQRAERMGTIATTADILEAQQKEQKSFHAELHQNKQHFDIFNEL 2429
            |:.:..|:....|...||...||........:...:.:.:|.:|.|.|..|::.::......::.
Human  6542 LNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQT 6606

  Fly  2430 TQKLIAVYPNDDTTRIKKMTEVINQRYANLNSGVINRGKQLHAAVHSLQSFDRAMDQFLAFLSET 2494
            ..:|..:....|...||.:...:..|:..:....|.||:.|..|....:.|..|..:.:.:|.:.
Human  6607 GNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDA 6671

  Fly  2495 ETLCENAESDIERNP-------LMFKDLQSEIETHRVVYDRLDGTGRKLLGSLTSQEDAVMLQRR 2552
            |:..: :|.:|..:|       ...|:.|..:...:.|||....|||.|.......||:..|...
Human  6672 ESHLD-SELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNF 6735

  Fly  2553 LDEMNQRWNNLKSKSIAIRNRLESNSEHWNALLLS------LRELTEWVIRKDTELSTLGLGPVR 2611
            |.|:..:|:.:..||:..:::||      .|||.|      |:.|.:|:.:.:.:|:.  ..||.
Human  6736 LGEVRDKWDTVCGKSVERQHKLE------EALLFSGQFMDALQALVDWLYKVEPQLAE--DQPVH 6792

  Fly  2612 GDAVSLQKQLDDHKAFRRQLEDKRPIVESNLTSGRQYIANEAAVSDTSDTEANHDSDSRYMSAEE 2676
            ||...:...:|.||.|:::|..:...|:....|||:.|                          |
Human  6793 GDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELI--------------------------E 6831

  Fly  2677 QSRELTRSIRREVGKLSEQWNNLIDRSDNWKHRLDEYMTKMRQFQKILEDLSSRVALAEQTK--T 2739
            .||:.|..::.::.:||.:|:.:...|.:.:.||::.:.:...|:..:..|...::.||||.  .
Human  6832 NSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFR 6896

  Fly  2740 SWLP------PSSVGEANEQMQQLQRLRDKMTTASALLD--------DC---------------- 2774
            ..||      .|.:....|.|::::..|..:.:|.|:.:        ||
Human  6897 GALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFE 6961

  Fly  2775 -------NEQQSFFTANQVLVPTPCLSKLEDLNT----------------------RMKLL---- 2806
                   ..||...||...||....|  ||:|..                      |:|.|
Human  6962 EVLTWAKQHQQRLETALSELVANAEL--LEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEH 7024

  Fly  2807 ----------QIAMDERQKVLCQAGAQQTH-----ENGDDGRTTSNSGTIGPLPNLGQS-VKPP- 2854
                      |..:|...|...:...:.||     ::...||.:.:..|..|:|.|.|| .|.|
Human  7025 QTFMEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEKSRSGGRKSLSQPTPPPMPILSQSEAKNPR 7089

  Fly  2855 -------WERATTAANVPYYIDHERETTHWDHPEMIELMKGLADLNEIRFSAYRTA-MKLRSVQK 2911
                   |::....|     ::.:|:..  |..:.:|.:|..|:.:   |..:|.. |:..:.:|
Human  7090 INQLSARWQQVWLLA-----LERQRKLN--DALDRLEELKEFANFD---FDVWRKKYMRWMNHKK 7144

  Fly  2912 RLALDRISMSTACESFDRHGLRAQNDKLIDIPDMTTVLHSLYVTIDKIDLTLMLDLAINWILNVY 2976
            ...:|          |.|...:.|:.|:.....:..:|.|.:.| .|:::|.:.|        ::
Human  7145 SRVMD----------FFRRIDKDQDGKITRQEFIDGILASKFPT-TKLEMTAVAD--------IF 7190

  Fly  2977 DSQRTGQIRVLSFKVGLVLLCKGHLEEKYRYLFRLVADTDRRADQRRLGLLLHDCIQVPRQLGEV 3041
            |....|.|....|...|         ...:..:|...|.|:..|            :|.||:.:.
Human  7191 DRDGDGYIDYYEFVAAL---------HPNKDAYRPTTDADKIED------------EVTRQVAQC 7234

  Fly  3042 AAFGGSNIEPSVRSCLEQAGISQ-EAIDGNQ---DISIELQHFL----------GWLQ------- 3085
            ..        :.|..:||.|.:: ....|||   ...:.|...|          ||:.
Human  7235 KC--------AKRFQVEQIGENKYRFFLGNQFGDSQQLRLVRILRSTVMVRVGGGWMALDEFLVK 7291

  Fly  3086 ------HEPQSLVWLPVLHRLAAAEAAKHQAKCNICKEYPIVGFRYRCLKCFNFDMCQKCFFF-- 3142
                  |.|.|.:             .:..:..:|..:.||...|      .|.::.:| |..
Human  7292 NDPCRVHHPGSKI-------------KRSDSSSSISSQSPIARGR------TNIELREK-FILPE 7336

  Fly  3143 ------------GRNAK------------------NHKLTHPMHEYCTTTTSTEDVRDFTRA--- 3174
                        ||.:|                  ||..|.......|..:.|:....|:|.
Human  7337 GASQGMTPFRSRGRRSKPSSRAASPTRSSSSASQSNHSCTSMPSSPATPASGTKTSLQFSRCYDK 7401

  Fly  3175 --LKNKFKSRKYFKKHPRVGYLPVQSVL--EGDALESPAPSPQHTTHQLQNDMHSRLEMYASRLA 3235
              |.|..........|.....||...|:  .|..|:.|.|:                 .::||.:
Human  7402 PWLVNSKAGTPIRDSHSPDLQLPTPEVIPSSGSKLKRPTPT-----------------FHSSRTS 7449

  Fly  3236 QVEYGGTGSNSTPDSDDEHQLIAQYCQALPGTSNGSAPKSPVQVMAAMDAEQREELEAIIRDLEE 3300
            ..  |.|.::|:|.|..     |:..:|.|..| .|.|.|.....|...|..|...:|...||
Human  7450 LA--GDTSNSSSPASTG-----AKTNRADPKKS-ASRPGSRAGSRAGSRASSRRGSDASDFDL-- 7504

  Fly  3301 ENANLQAEYQQLCSKEQSGMPEDSNGMQHSSSSMTGLSGQGEQGQDMMAEAKL 3353
                  .|.|..||             ..|.||..|  |||...:.:...:|:
Human  7505 ------LETQSACS-------------DTSESSAAG--GQGNSRRGLNKPSKI 7536

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dys	NP_001036722.1	CH_DMD-like_rpt1	12..118	CDD:409035	28/170 (16%)
		CH_SF	129..229	CDD:469584	25/111 (23%)
		SPEC	312..525	CDD:238103	57/276 (21%)
		PRK03918	<716..1238	CDD:235175	115/617 (19%)
		SMC_prok_B	<995..1279	CDD:274008	60/317 (19%)
		SPEC	1174..1365	CDD:238103	42/214 (20%)
		SPEC	1289..1485	CDD:413338	43/228 (19%)
		SPEC	2369..2576	CDD:238103	46/213 (22%)
		SPEC	2477..2714	CDD:238103	58/249 (23%)
		WW	2852..2882	CDD:238122	6/37 (16%)
		EFh_DMD_like	2919..3085	CDD:320000	33/179 (18%)
		EF-hand-like motif	2919..2958	CDD:320000	7/38 (18%)
		EF-hand-like motif	2961..2995	CDD:320000	7/33 (21%)
		EF-hand-like motif	3001..3037	CDD:320000	5/35 (14%)
		EF-hand-like motif	3050..3085	CDD:320000	11/48 (23%)
		ZZ_dystrophin	3110..3158	CDD:239074	13/79 (16%)
MACF1	NP_001380991.1	CH_PLEC-like_rpt1	40..176	CDD:409037
		CH_MACF1_rpt2	187..293	CDD:409089
		SPEC	581..675	CDD:197544
		SPEC	677..866	CDD:238103
		SH3_10	852..918	CDD:407754
		Spectrin_like	953..1030	CDD:465730
		SPEC	1159..1338	CDD:413338
		Plectin	1574..1612	CDD:459901
		Plectin	1651..1689	CDD:459901
		Plectin	1765..1800	CDD:459901
		Plectin	1803..1841	CDD:459901
		Plectin	<1850..1879	CDD:459901
		Plectin	2287..2325	CDD:459901
		Plectin	2363..2401	CDD:459901
		Plectin	2401..>2432	CDD:459901
		Plectin	2497..2535	CDD:459901
		Plectin	2576..2607	CDD:459901
		Plectin	2683..2721	CDD:459901
		SMC_prok_B	<3408..3750	CDD:274008
		SMC_prok_B	3581..>4345	CDD:274008	64/341 (19%)
		SPEC	3878..4106	CDD:238103	19/84 (23%)
		SPEC	4323..4570	CDD:238103	56/266 (21%)
		SPEC	4463..4682	CDD:238103	53/236 (22%)
		SPEC	4688..4902	CDD:238103	58/287 (20%)
		SMC_prok_B	4877..5807	CDD:274008	198/1030 (19%)
		SPEC	5343..5556	CDD:238103	45/236 (19%)
		SPEC	5778..5990	CDD:238103	36/214 (17%)
		SPEC	5888..6104	CDD:238103	42/228 (18%)
		SPEC	6106..6323	CDD:238103	43/290 (15%)
		SPEC	6326..6542	CDD:238103	54/250 (22%)
		SPEC	6547..6761	CDD:238103	47/220 (21%)
		SPEC	6766..6978	CDD:238103	47/239 (20%)
		SPEC	6988..7112	CDD:197544	24/128 (19%)
		FRQ1	<7146..7216	CDD:444056	16/97 (16%)
		GAS2	7221..7296	CDD:128539	16/94 (17%)
		PHA03307	7379..>7553	CDD:223039	46/206 (22%)