DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dys and Sptbn1

DIOPT Version :9

Sequence 1:NP_001036722.1 Gene:Dys / 42327 FlyBaseID:FBgn0260003 Length:3598 Species:Drosophila melanogaster
Sequence 2:NP_787030.2 Gene:Sptbn1 / 20742 MGIID:98388 Length:2363 Species:Mus musculus


Alignment Length:2980 Identity:593/2980 - (19%)
Similarity:1073/2980 - (36%) Gaps:936/2980 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 LIDERQHIQKKTFTKWINSHLIDTQCTPVKDLFLDLRDGHRLLALLSTLTQTNL-KPEKGRMRVH 69
            |.|||:.:||||||||:||||....|. :.||:.|||||..|:.||..|:...| ||.|||||:|
Mouse    48 LADEREAVQKKTFTKWVNSHLARVSCR-ITDLYTDLRDGRMLIKLLEVLSGERLPKPTKGRMRIH 111

  Fly    70 HINNLNKVITEIQQHGVKLVNISSDDIVGGNAKLTLGLIWLIALEFNGQHLVKSHSSNGVEKS-- 132
            .:.|::|.:..:::..|.|.|:.|.|||.||.:|||||||.|.|.|..|.:......|..:||  
Mouse   112 CLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLTLGLIWTIILRFQIQDISVETEDNKEKKSAK 176

  Fly   133 --LLAWARQYTEPH-GLQLNDFSSSWSDGRAFLMILDAHVEEL-NLQAALQQHALKRLHLAFDLA 193
              ||.|.:..|..: .:.:::|::||.||.||..::..|..:| :.....:.:|...|..||:||
Mouse   177 DALLLWCQMKTAGYPNVNIHNFTTSWRDGMAFNALIHKHRPDLIDFDKLKKSNAHYNLQNAFNLA 241

  Fly   194 HRHFKIEKLLDAEDVHTHKPDNKSIQMYVMCLYHAMESMRTRQQEQEQDEGQDQDPGRVPCTSIT 258
            .:|..:.||||.||:....||.|||..||:..||....|:....|.::       .|:|      
Mouse   242 EQHLGLTKLLDPEDISVDHPDEKSIITYVVTYYHYFSKMKALAVEGKR-------IGKV------ 293

  Fly   259 DLDEVPLDNDQTSLGLYTSDSAGSMEQRSSGELKTHSMRPLSTATNASVEISGYQSALEAVL--- 320
                  |||                      .::|..|            |..|:|....:|   
Mouse   294 ------LDN----------------------AIETEKM------------IEKYESLASDLLEWI 318

  Fly   321 --TLLLEDEQLLSQNLPDPQD----FQTAKL-----QFHENESFMLKLTEHQEYVGEALEEGSNL 374
              |:::.:.:..:.:|...|.    |.|.:.     :|.|..:..:.|...|          |.:
Mouse   319 EQTIIILNNRKFANSLVGVQQQLQAFNTYRTVEKPPKFTEKGNLEVLLFTIQ----------SKM 373

  Fly   375 INESQKA-----GAGLSQEDQNEVRQQMVLLNERWETLRLRALDVQAKILMRLAEFQKQKLEQL- 433
            ...:||.     |..:|.            :|:.||  ||...:.:.::.:|....:::||||| 
Mouse   374 RANNQKVYMPREGKLISD------------INKAWE--RLEKAEHERELALRNELIRQEKLEQLA 424

  Fly   434 ---------RQFLTSVEDRISHMSDIG---PTLEEAEKQLLEAQKLKADLSEQQELVDSLSSMVV 486
                     |:...|...|:....:.|   |.:|.|.|   :.:.::.|::..:|.|   .::|.
Mouse   425 RRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATK---KHEAIETDIAAYEERV---QAVVA 483

  Fly   487 IVNDTSG-NFNDLEDRLSALGERWSHVVKWSDLRKEKLQQYKCISRWLDAREQDLKLMESRDVTD 550
            :..:... |::|:: |::|              ||:.:     |..|    |..|:|:.:|    
Mouse   484 VARELEAENYHDIK-RITA--------------RKDNV-----IRLW----EYLLELLRAR---- 520

  Fly   551 VGGITQRINELNYCAKDLLELQRYLID-LRQMVAATLQDGDDKGERVLIQLESYEDRLD--ALKQ 612
                .||: |:|...:.:.:...|::| :.:|....|  ..|.|:.:|    ..||.|.  ||.:
Mouse   521 ----RQRL-EMNLGLQKIFQEMLYIMDWMDEMKVLLL--SQDYGKHLL----GVEDLLQKHALVE 574

  Fly   613 I-VEVQTVRIETKGFN-----FGRDRASYD--DSRVVRPEGWVDYQMIIRFGEDDSQEDDDEHDL 669
            . :.:|..|:  :|.|     |..|...|.  |.:|:|..                         
Mouse   575 ADIAIQAERV--RGVNASAQKFATDGEGYKPCDPQVIRDR------------------------- 612

  Fly   670 ASKKRKLRNADNFNALENHIMEHFGYVQEVEQKLQQLQRQSLRQQCELLKELQA--ENSRRCGTL 732
                                      |..:|...|:|        |:|..|.:|  |.|||.   
Mouse   613 --------------------------VAHMEFCYQEL--------CQLAAERRARLEESRRL--- 640

  Fly   733 PELKKLYEVCELEDPSRNLLLEETHIKQLEQRYANLSQKLSSQQSESHTLLAKEKYYNSLTGFKL 797
              .|..:|:.|          ||..|::.|:                  :|:.:.|...||....
Mouse   641 --WKFFWEMAE----------EEGWIREKEK------------------ILSSDDYGKDLTSVMR 675

  Fly   798 VLADSRDWYKQHAGSASGNELEQRLSHMESLASEISEAKTATEELDDNLIEWKQDFGLFYDSWHD 862
            :|:..|         |..:|:..|..|.|                                    
Mouse   676 LLSKHR---------AFEDEMSGRSGHFE------------------------------------ 695

  Fly   863 MKQALQALIQQRGGESLSRQLKQIQDFVTKVSNQKVRVSNLEVMQEQQHFLNQLLDEMESLRLTY 927
                              :.:|:.:|.:.                 ::||.::.:.|    |:.|
Mouse   696 ------------------QAIKEGEDMIA-----------------EEHFGSEKIRE----RIIY 721

  Fly   928 DNIPKHLIGEELQTAWNRLPEQLNERVIKQTTAIENLNHFAAEYNAIIA----MLRSAADSKLNG 988
                       ::..|..| |||:....|:......|:.|.|:.:.|.|    :|:..:.:.: |
Mouse   722 -----------IREQWANL-EQLSAIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSNDV-G 773

  Fly   989 SDGASSQDLRKLEIDV----ISARNFSEILIKEAEP-----AQKESLQSQIRALNTLYDQVEQVH 1044
            .|..|:|.|.|...||    .:.|...:.|.::|..     |:...::.::..:.....::.::.
Mouse   774 HDEYSTQSLVKKHKDVAEEITNYRPTIDTLHEQASALPQAHAESPDVKGRLAGIEERCKEMAELT 838

  Fly  1045 REKKE--QQTV----LQSHIDLIQLRLKETDQWLTDLESNTPKSGISDIVNSNELFQSKSRFQTL 1103
            |.:|:  |.|:    :.|..|..:|.:.|.:|||.:::       |.:.:...|:.|  .||::|
Mouse   839 RLRKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQ-------IPEKLEDLEVIQ--HRFESL 894

  Fly  1104 KETCERETTQFRDLNERGGELLLQMDELQDQDRESRYGSLAKQFTRINARWTEVTELV-YAKTAL 1167
            :.....:.::...:|:...:|   |......::|.|     .|..::|.||::..||| ..|.||
Mouse   895 EPEMNNQASRVAVVNQIARQL---MHNGHPSEKEIR-----AQQDKLNTRWSQFRELVDRKKDAL 951

  Fly  1168 LEHISTQ-----LGEFKKFMVSETGYLDK-------------LENKIRNTPENAADAEEIMEELD 1214
            |..:|.|     ..|.|.::..:|..::.             |:.|:.....   |...|..:|.
Mouse   952 LSALSIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMER---DLVAIEAKLS 1013

  Fly  1215 DLENVLRSHSEEWLDKIQEIGNELIDNEFMADSIRRDIDETVQRWTQLQQQAKKRTELLEQKVSE 1279
            ||:........|..|:.|.|.:.|.              |....|.:::...|.|...|.: .|:
Mouse  1014 DLQKEAEKLESEHPDQAQAILSRLA--------------EISDVWEEMKTTLKNREASLGE-ASK 1063

  Fly  1280 AEQSEKCIVQFEKWLTRVDD-ILSDHLDNDVTIVDQPEEFQRL--AHEFVANE--------KNFK 1333
            .:|..:.:..|:.||:|... |.|:.:.|.:|      |.::|  .||.:.||        :..:
Mouse  1064 LQQFLRDLDDFQSWLSRTQTAIASEDMPNTLT------EAEKLLTQHENIKNEIDNYEEDYQKMR 1122

  Fly  1334 EISELIDEHTRNGKVGA-----ANRLQ------EQLNLMEVRFKYCQAKLSKCTAIQHSYESRLN 1387
            ::.|::.:    |:..|     ..|||      .:|:.|   ::..|..||:    .|:|:..|.
Mouse  1123 DMGEMVTQ----GQTDAQYMFLRQRLQALDTGWNELHKM---WENRQNLLSQ----SHAYQQFLR 1176

  Fly  1388 RAYTDLRNVE---RSTEVVDVASAGPNTV---QTQYQKCLQIYRTLSEIKSEIESTIKTGRRVCE 1446
                |.:..|   .:.|.|...:..|.|:   :...:|......|:...:.:|.:.::||||:..
Mouse  1177 ----DTKQAEAFLNNQEYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVS 1237

  Fly  1447 DRYTKSPKQLSQRIDALKHLYNTLGENVTQSKATLERLLTLARQLEEC----------------- 1494
            |....|.: :.:::|::...:....|..::....|:....|.:.|::|                 
Mouse  1238 DGNINSDR-IQEKVDSIDDRHRKNREAASELLMRLKDNRDLQKFLQDCQELSLWINEKMLTAQDM 1301

  Fly  1495 -FDSADNLIRRF----------------------ESPQEVHDRNSILLEFEDVLRRCEDHYNEYN 1536
             :|.|.||..::                      |..|.:.::.    |.|.|::......::..
Mouse  1302 SYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKP----ETEAVVKEKLTGLHKMW 1362

  Fly  1537 KSCDQSCMVETRQRIDGLKATYHKLTSADIIKRLTEMKTTLQNLD--------NISLETLRAMEH 1593
            :..:.:...:.::..|..||.....:.||:.|.|..:::.:|:.|        ||.|:..:.:|:
Mouse  1363 EVLESTTQTKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLEN 1427

  Fly  1594 DLKEINVPSNPEIEKLQQQVIAIVVDVLKTRFNEATTLAARNTSSPDNDDTEIVVVSDTVRQRRA 1658
            .: |:.   ..|||:||.|..|:                                          
Mouse  1428 QM-EVR---KKEIEELQSQAQAL------------------------------------------ 1446

  Fly  1659 RTPQSGESPSSAHTSSSESPTKGVENSPGAVGDQVMPDLLPPQTFRLAESSTLFSQISLNPQKVT 1723
              .|.|:|.....:......||.:|             ||.|    |:|                
Mouse  1447 --SQEGKSTDEVDSKRLTVQTKFME-------------LLEP----LSE---------------- 1476

  Fly  1724 NTPPPKPAKTKRKAPSSPAQVVEIRVKNIQNDKMSVQ-NIDLEPQQGEIVDTVNILESVEPFVPE 1787
                                    |..|:...|...| |.|:|.:...:.:.:.:..|.     :
Mouse  1477 ------------------------RKHNLLASKEIHQFNRDVEDEILWVGERMPLATST-----D 1512

  Fly  1788 YVETVQIVDLSEDSDSSVRVDSQGKEMRRSKSKHSLNETPLPKVSDNDEDSAEQEEDLLRPSAEN 1852
            :...:|.|.|....:.:::.:.||.:               |::    :|..|:.::::..|:. 
Mouse  1513 HGHNLQTVQLLIKKNQTLQKEIQGHQ---------------PRI----DDIFERSQNIITDSSS- 1557

  Fly  1853 TSTPFLRVEKRRISFDEKRKRVANERD----ILRDSEEEEPKTPDTPRAAQVSKPKRWRQLQPEM 1913
                        ::.:..|:|:|:.:.    ::.::|:...:..:..:|.|.           ..
Mouse  1558 ------------LNAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHKAQQY-----------YF 1599

  Fly  1914 DALEPES-PGRDSFYSPDKESGFDAEPLV--FSDDEDIPRFSLEMTSTIDSDSDTSRIMTPSTKN 1975
            ||.|.|: ......|...:|...|.:..|  ....:.:.:...:...|:...|.|||.:. :..:
Mouse  1600 DAAEAEAWMSEQELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALV-ADSH 1663

  Fly  1976 PNPFLSKVLESLSSPVDDSNVTLKSPISEEQPQNLDDRVREFDKQAKQMIYKLKLTKAKIEQCHE 2040
            |.   |:.:....|.||.....||. ::||:...||:|.|.|           :|.:        
Mouse  1664 PE---SERISMRQSKVDKLYAGLKD-LAEERRGKLDERHRLF-----------QLNR-------- 1705

  Fly  2041 SEAEDLRLLIAPDAATLISQGDSLVLETHGRQGSISRLVMRTQIILREQFREVQQARSKTSGSGA 2105
             |.:||...||.         ..:|..:|........:.|     |:|:|||.  ||. |...|.
Mouse  1706 -EVDDLEQWIAE---------REVVAGSHELGQDYEHVTM-----LQERFREF--ARD-TGNIGQ 1752

  Fly  2106 PAPPLDSVN--IEELVTKGLRRINVLIE------------------KTVDLKSSTDLEKRMEDIN 2150
            ..  :|:||  .:||:..|......:.|                  :|..|.:|.:|.|...|..
Mouse  1753 ER--VDTVNNMADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAK 1815

  Fly  2151 ERHDDLQVIVSAIGKNAQMPKVTPLMMNEIEKTKNNLIAHADSIELSLTELRNGPRISNGKERPD 2215
            |....:|      .|:.::|:......|.:|..:.........|:...|::|   ::.....|..
Mouse  1816 EIFGRIQ------DKHKKLPEELGRDQNTVETLQRMHTTFEHDIQALGTQVR---QLQEDAARLQ 1871

  Fly  2216 ASSAATMSCRSEYNNEPSGTGALAGSFDKSVLQISDWLTWEQNMIKIQS---VLVDDGD------ 2271
            |:.|                |..|....|...::.:  .|:..:...:.   .|||.||      
Mouse  1872 AAYA----------------GDKADDIQKRENEVLE--AWKSLLDACEGRRVRLVDTGDKFRFFS 1918

  Fly  2272 AVRLAIEKQEKVLRELK-MKKPQ----LNELVHTAEVLKGDVKRQQLQEKELKQFSLAPHCSADL 2331
            .||..:...|.|:|::: .:||:    :..|::..:.:|.::                   .|..
Mouse  1919 MVRDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEI-------------------DARN 1964

  Fly  2332 DYMRCCLKVTR---LREHW--DETSQCVLQRAAQLKNMLSD-SQRFEAKRLEL------------ 2378
            |....|:::.:   .|:|:  :|..:.:||...:.|.|:.. ..|:|..||.|            
Mouse  1965 DSFTACIELGKSLLARKHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVA 2029

  Fly  2379 EKWLARMEQRAERMGTIATTADILEAQQKEQKSFHAELHQNKQHFDIFNELTQ-KLIAVY----- 2437
            |.||...|...... .|..:.|.:|...|..::|........:.|.....||. :|:.|.     
Mouse  2030 EAWLLGQEPYLSSR-EIGQSVDEVEKLIKRHEAFEKSAATWDERFSALERLTTLELLEVRRQQEE 2093

  Fly  2438 -------PN-DDTTRIKKMTEVINQRYANLNSGVINRGKQL-HAAVHSLQSFDRAMDQFLAFLSE 2493
                   |: |..|::.:..|  :|::..      ::|.|: ...:.:.|...|     :|...|
Mouse  2094 EERKRRPPSPDPNTKVSEEAE--SQQWDT------SKGDQVSQNGLPAEQGSPR-----MAGTME 2145

  Fly  2494 TETLCENAESDIERNPLMFKDLQSEIETHRVVYDRLDGTGRKLLGSLTSQEDAVMLQRRLD---E 2555
            |..:...|.          :...|..|:..|....||   ||...:|.:|..|.:..|.|:   .
Mouse  2146 TSEMVNGAA----------EQRTSSKESSPVPSPTLD---RKAKSALPAQSAATLPARTLETPAA 2197

  Fly  2556 MNQRWNNLKSKSIAIRNRLESNSEHWNALLLSLRELTEWVIRKDTELSTLGLGPVRGDA-VSLQK 2619
            ..:.:.|.|.:..|...:..|.|.|....:::.:|:..:   ||.:.:..|: |...:. |||::
Mouse  2198 QMEGFLNRKHEWEAHNKKASSRSWHNVYCVINNQEMGFY---KDAKSAASGI-PYHSEVPVSLKE 2258

  Fly  2620 QLD----DHKAFRRQLEDKRPIVESNLTSGRQYI---------------ANEAAVSDTSDTEANH 2665
            .:.    |:|       .|:.:.:..|:.|.:|:               .:.|..||..||.|:.
Mouse  2259 AICEVALDYK-------KKKHVFKLRLSDGNEYLFQAKDDEEMNTWIQAISSAISSDKHDTSAST 2316

  Fly  2666 DSDSRYMSAEEQSRELTRSIRREVGKLSEQWNNLIDRSDNWKHRLDEYMTKMRQF 2720
            .|    ..|..:::.|..|:           ..:...|...|...|:...|.::|
Mouse  2317 QS----TPASSRAQTLPTSV-----------VTITSESSPGKREKDKEKDKEKRF 2356

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DysNP_001036722.1 CH 13..111 CDD:278723 51/98 (52%)
CH 129..225 CDD:278723 35/101 (35%)
SPEC 312..525 CDD:238103 46/245 (19%)
SbcC <325..957 CDD:223496 116/672 (17%)
Smc <816..1591 CDD:224117 162/888 (18%)
SPEC 1174..1365 CDD:238103 45/230 (20%)
SPEC 1289..1485 CDD:295325 46/223 (21%)
SPEC 2369..2576 CDD:238103 47/236 (20%)
SPEC 2477..2714 CDD:238103 51/259 (20%)
WW 2852..2882 CDD:238122
EF-hand_2 2883..2997 CDD:286194
EF-hand_3 3001..3100 CDD:286195
ZZ_dystrophin 3110..3158 CDD:239074
Sptbn1NP_787030.2 Actin-binding 2..275 95/227 (42%)
SAC6 48..>530 CDD:227401 163/598 (27%)
Spectrin 1. /evidence=ECO:0000255 303..411 24/143 (17%)
Spectrin 2. /evidence=ECO:0000255 423..525 27/140 (19%)
SPEC 530..743 CDD:238103 65/408 (16%)
Spectrin 3. /evidence=ECO:0000255 530..636 30/172 (17%)
Spectrin 4. /evidence=ECO:0000255 639..742 32/231 (14%)
SPEC 642..849 CDD:238103 52/331 (16%)
Spectrin 5. /evidence=ECO:0000255 745..847 20/102 (20%)
Spectrin 6. /evidence=ECO:0000255 850..952 27/118 (23%)
SPEC 851..1061 CDD:238103 51/244 (21%)
Spectrin 7. /evidence=ECO:0000255 957..1060 21/119 (18%)
SPEC 958..1169 CDD:238103 48/245 (20%)
Spectrin 8. /evidence=ECO:0000255 1063..1166 24/115 (21%)
Spectrin 9. /evidence=ECO:0000255 1170..1259 18/93 (19%)
SPEC 1171..1380 CDD:238103 33/217 (15%)
Spectrin 10. /evidence=ECO:0000255 1276..1376 12/103 (12%)
SPEC 1381..1592 CDD:238103 52/352 (15%)
Spectrin 11. /evidence=ECO:0000255 1381..1482 33/205 (16%)
Spectrin 12. /evidence=ECO:0000255 1486..1590 18/140 (13%)
Interaction with ANK2. /evidence=ECO:0000250 1563..2093 123/631 (19%)
SPEC 1593..1805 CDD:238103 56/266 (21%)
SPEC 1806..2027 CDD:238103 48/266 (18%)
Spectrin 2017..>2075 CDD:334073 11/58 (19%)
Spectrin 17. /evidence=ECO:0000255 2018..2097 14/79 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2089..2193 24/129 (19%)
Mediates interaction with CAMSAP1. /evidence=ECO:0000250 2148..2176 8/40 (20%)
PH_beta_spectrin 2199..2304 CDD:269975 20/115 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2308..2363 13/64 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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