Protein Alignment Dys and atn-1

DIOPT Version :9

• Sequence 1: NP_001036722.1
• Gene: Dys / 42327
• FlyBaseID: FBgn0260003
• Length: 3598
• Species: Drosophila melanogaster
• Sequence 2: NP_506127.1
• Gene: atn-1 / 179709
• WormBaseID: WBGene00000228
• Length: 920
• Species: Caenorhabditis elegans
• Alignment Length: 1057
• Identity: 249/1057 - (23%)
• Similarity: 410/1057 - (38%)
• Gaps: 331/1057 - (31%)

  Fly     6 LID---ERQHIQKKTFTKWINSHL------IDTQCTPVKDLFLDLRDGHRLLALLSTLTQTNL-K 60
            |:|   |:|  ||||||.|.||||      |||    :::   |.|:|.:|:.||..::...| |
 Worm    30 LLDPAWEKQ--QKKTFTAWCNSHLRKAGTSIDT----IEE---DFRNGLKLMLLLEVISGEPLPK 85

  Fly    61 PEKGRMRVHHINNLNKVITEIQQHGVKLVNISSDDIVGGNAKLTLGLIWLIALEFNGQHLVKSHS 125
            |::|:||.|.|.|:||.:..|:..|||||:|.:::||.||.|:||||||.|.|.|..|.:.....
 Worm    86 PDRGKMRFHKIANVNKALEYIESKGVKLVSIGAEEIVDGNVKMTLGLIWTIILRFAIQDINVEEL 150

  Fly   126 SNGVEKSLLAWARQYTEPH-GLQLNDFSSSWSDGRAFLMILDAHVEELNLQAALQQ-HALKRLHL 188
            |  ....||.|.::.|.|: .:.:.:|.:||.||.||..::..|..:|...:.|.: ..:..|:|
 Worm   151 S--ARDGLLLWCQRKTAPYNNVNVQNFHNSWKDGLAFCALIHRHRPDLLDYSQLHKGDPIHNLNL 213

  Fly   189 AFDLAHRHFKIEKLLDAEDVHTHKPDNKSIQMYVMCLYHAMESMR------TRQ---------QE 238
            |||:|.:|..|.|:||||||..| ||.||...||.|.|||..:||      .||         ..
 Worm   214 AFDIAEKHLDIPKMLDAEDVSRH-PDEKSTMTYVSCFYHAFRNMRDPPPPVIRQPPPQRVVVAPP 277

  Fly   239 QEQDEGQDQDPGRVPCTSITDLDEVPLDNDQTSLGLYTSDSAGSME--QRSSGELKTHSMRPLST 301
            .|:|..:|.:   .....|..:.:|..:|::            .||  :..:.:|.....|.:..
 Worm   278 PERDWRKDAE---TAANRICRVLKVNQENEK------------MMEDYENLASDLLAWINRWMPW 327

  Fly   302 ATNASVEISGYQSALEAVLTLLLEDEQLLSQNLPDPQDFQTAKLQ--FHENESFMLKLTEHQEYV 364
            ..|.|.:.:..|:..:      |||.:...:....|:.....:|:  |:..:: .|:|:....:
 Worm   328 LANRSTDDTLQQAQQK------LEDYRNYRRREKPPRIEDKGRLETLFNTLQT-RLRLSNRPAF- 384

  Fly   365 GEALEEGSNLINESQKAGAGLSQEDQNEVRQQMVLLNERWETLRLRALDVQAKILMRLAEFQKQK 429
               |....:||.:...|.|||  ||..:..::. ||:|                :|||
 Worm   385 ---LPRDGHLIKDINAAWAGL--EDSEKGFEEW-LLSE----------------IMRL------- 420

  Fly   430 LEQLRQFLTSVEDRISHMSDIGPTLEEAEKQLLEAQKLKADLSEQQELVDSLSSMVVIVNDTSGN 494
                        :|:.|:                |:|.:
 Worm   421 ------------ERLEHL----------------AEKFR-------------------------- 431

  Fly   495 FNDLEDRLSALGERWSH----VVKWSDLRKEKLQQYKCISRWLDAREQDLKLMESRDVTDVGGIT 555
                  |..||.|.|:|    .::.:|.|...|.:.|.:.:..:|.|.||...:.| |..:..|.
 Worm   432 ------RKCALHEEWAHGKEDALRSNDWRSCGLYKIKALRKRHEAFESDLGAHQDR-VEQIAAIA 489

  Fly   556 QRINELNY---------CAKDLLELQRYLIDLRQMVAATLQDGDDKGERVLIQLESYEDRLDALK 611
            :.:|.|.|         |.....:..| |..|......||:|    .||:       .:|||:|.
 Worm   490 RELNNLRYPDIGPINARCQAICSQWDR-LGQLSSKRRETLED----AERI-------AERLDSLY 542

  Fly   612 QIVEVQTVRIETKGFNFGRDRASYDDSRVVRPEGWVD------YQMIIRFGEDDSQEDDDEHDLA 670
                          .:|.:..|.:::        |:|      ..::|.....:.:|..:.||
 Worm   543 --------------LDFAKRAAPFNN--------WLDGAREDLADLVIVHEMREIEELVNAHD-- 583

  Fly   671 SKKRKLRNAD----NFNALENHIMEH---------------------------FGYVQ-EVEQKL 703
            ..|..|.:||    :.|.:| |.:||                           :|.|| .|.::.
 Worm   584 QFKSTLGDADREFSSINQIE-HEVEHLVTSHGLDRELLRNPYTDLSASDIRRKWGEVQNSVPRRD 647

  Fly   704 QQLQRQSLRQQ-CELLKELQAENSRRCGTLPELKKLYE----------------VCELEDPSRNL 751
            .|||.:..||| .|.|:.:.||.:.:.|  |.|::..|                :.:|....||:
 Worm   648 SQLQAELKRQQNNERLRTIFAEKANQVG--PWLERELEQVLAIGLGGRGRLEDAIQQLRSIQRNV 710

  Fly   752 LLEETHIKQLEQRYANLSQKLSSQQSESHTLLAKEKYYNSLTGFKLVLADSRDWYKQHAGSASGN 816
            |..:.::.:||:.:..:.:....:..:|...:...:     .|::.:|...         :.:.|
 Worm   711 LGYKPNLDELERVHQEMQENFVFENRKSRYSMESLR-----VGWETLLTSI---------NKTIN 761

  Fly   817 ELEQRLSHMESLA---SEISEAKTATEELDDNLIEWKQDFGLFYDSWHDMKQALQALIQ------ 872
            |.|.::...:|..   .:|:|.:.:....|      |:..||      |.:|....||.
 Worm   762 EFENQVLLRDSKGISEEQIAEFRASFSHFD------KERAGL------DPEQLRSCLISVGYTIR 814

  Fly   873 --QRGGESLSRQLKQIQ-------------DFVTKVSNQKVRVSNLEVMQEQQHFLNQLLDEMES 922
              :.|...|.|.|..:.             ||:||.::             .|..:.|::|....
 Worm   815 PGREGDAELHRVLAHVDPNRMGRVPFEAFLDFMTKENS-------------DQDTVEQMIDSFRI 866

  Fly   923 LR-----LTYDNIPKHL 934
            |.     :|.|.:.:.|
 Worm   867 LASGKTFITADELEREL 883

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dys	NP_001036722.1	CH	13..111	CDD:278723	49/104 (47%)
		CH	129..225	CDD:278723	37/97 (38%)
		SPEC	312..525	CDD:238103	37/218 (17%)
		SbcC	<325..957	CDD:223496	132/709 (19%)
		Smc	<816..1591	CDD:224117	29/148 (20%)
		SPEC	1174..1365	CDD:238103
		SPEC	1289..1485	CDD:295325
		SPEC	2369..2576	CDD:238103
		SPEC	2477..2714	CDD:238103
		WW	2852..2882	CDD:238122
		EF-hand_2	2883..2997	CDD:286194
		EF-hand_3	3001..3100	CDD:286195
		ZZ_dystrophin	3110..3158	CDD:239074
atn-1	NP_506127.1	CH	39..141	CDD:237981	51/108 (47%)
		CH	151..254	CDD:237981	42/105 (40%)
		Spectrin	305..414	CDD:278843	24/134 (18%)
		SPEC	426..654	CDD:238103	59/313 (19%)
		SPEC	667..765	CDD:295325	17/113 (15%)
		EFh	782..848	CDD:238008	15/77 (19%)
		EFhand_Ca_insen	853..919	CDD:285885	7/31 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910