DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Dys and unc-70

DIOPT Version :9

Sequence 1:NP_001036722.1 Gene:Dys / 42327 FlyBaseID:FBgn0260003 Length:3598 Species:Drosophila melanogaster
Sequence 2:NP_001256073.1 Gene:unc-70 / 179077 WormBaseID:WBGene00006803 Length:2326 Species:Caenorhabditis elegans


Alignment Length:2696 Identity:537/2696 - (19%)
Similarity:999/2696 - (37%) Gaps:785/2696 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 LIDERQHIQKKTFTKWINSHLIDTQCTPVKDLFLDLRDGHRLLALLSTLTQTNL-KPEKGRMRVH 69
            |.|||:.:||||||||:||||:...| .|:||::|:|||..||.||:.|:...| ||..|:||:|
 Worm   103 LRDERELVQKKTFTKWVNSHLVRVSC-KVQDLYMDMRDGKMLLRLLAVLSGERLPKPTPGKMRIH 166

  Fly    70 HINNLNKVITEIQQHGVKLVNISSDDIVGGNAKLTLGLIWLIALEFNGQHL----VKSHSSNGVE 130
            .:.|:.|.:..::...|.|.|:.|.|||.||::|||||||.|.|.|..|.:    ..:|.:...:
 Worm   167 CLENVEKGLQFLRNQHVHLENLGSHDIVDGNSRLTLGLIWTIILRFQIQDITFEDADNHETRSAK 231

  Fly   131 KSLLAWARQYTEPH-GLQLNDFSSSWSDGRAFLMILDAHVEEL----NLQAALQQHALKRLHLAF 190
            ::||.|.:..|..: .:.:.:||:||.||.||..::..|..:|    |||   :.:||..|..||
 Worm   232 EALLLWCQMKTAGYPNVNVKNFSTSWRDGLAFNALIHKHRPDLVDYDNLQ---KSNALYNLQSAF 293

  Fly   191 DLAHRHFKIEKLLDAEDVHTHKPDNKSIQMYVMCLYHAMESMRTRQQEQEQDEGQDQDPGRVPCT 255
            |.|.....:.|.||||||:..:||.|||..||:..||....::       ||..|.:..|:|   
 Worm   294 DTAENQLGLAKFLDAEDVNVDQPDEKSIITYVVTYYHYFNKLK-------QDNIQGKRIGKV--- 348

  Fly   256 SITDLDEVPLDNDQTSLGLYTSDSAGSMEQRSSGELKTHSMRPLSTATNASVEISG---YQSALE 317
             |.:|    ::||: .:..|.:.|:..:|.                 .||.:::..   :::.||
 Worm   349 -INEL----MENDK-MINRYETLSSDLLEW-----------------INAKIQLLNERHFENNLE 390

  Fly   318 AVLTLLLEDEQLLSQNLPDPQDFQTAKLQ--FHENESFMLKLTEHQEYVGEALEEGSNLINESQK 380
            .|...|.|.....:|..| |:..:..:|:  ....:|.| :....:.:|.   .|| .||.:..:
 Worm   391 GVQRQLTEFNDYRTQEKP-PKFDEKGELEVLLFTLQSAM-RANNQRPFVP---REG-KLIADINR 449

  Fly   381 AGAGLSQEDQNEVRQQMVLLNERWETLRLRALDVQAKILMRLAEFQKQKLEQLRQFLTSVEDRIS 445
            |...|   ::.|..:::||..|         |..|.|:....|.|.: |.|....:||. ..|:.
 Worm   450 AWQSL---EKAEHERELVLKEE---------LIRQEKLEQLAARFNR-KAEMRETWLTE-NQRLV 500

  Fly   446 HMSDIGPTLEEAEKQLLEAQKLKADLSEQQELVDSLSSMVVIVNDTSG-NFND---LEDRLSALG 506
            ...:.|..|...|....:.:.::.|:...:|.|   .::|.:..:... |::|   :.:|...:.
 Worm   501 SQDNFGNDLSSVEAATKKHEAIETDIFAYEERV---QAVVAVAGELEAENYHDQAKINERKENVL 562

  Fly   507 ERWSHVVKWSDLRKEKLQQYKCISR-------WLDAREQDLK-----------LMESRDV----- 548
            :.|:::.:....|:.:|:....|.:       .||..: |:|           ||:..|:     
 Worm   563 QLWNYLFQLLLARRVRLELSMAIQKIFHDMLLTLDLMD-DIKSRLLSEDLGAHLMDVEDLLQKHA 626

  Fly   549 ---TDVGGITQRINELNYCAKDLLELQRYLIDLRQMVAATLQDGDDKGERVLIQLESYEDRLDAL 610
               :|:..|.:|:|      ..:.:.||:          ...||.|......::..:.::|.|.|
 Worm   627 LLESDINIIGERVN------NSIAQAQRF----------RNPDGPDGSGYKPVEPGTIDERSDVL 675

  Fly   611 -KQIVEVQTVRIETKGFNFGRDRASYDDSRVVRPEGWVDYQMI---IRFGEDDSQEDDDEHDLAS 671
             |:..|:..:..|       |.|...|:.|:.  :.|.|...:   |:..|......|...|:.:
 Worm   676 QKRYKELLDLAAE-------RKRRLEDNKRLC--QFWWDVAELEHGIKEQEQVLSSTDTGRDIVT 731

  Fly   672 KKR---KLRNADNFNALENHIMEHFGYVQEVEQKLQQLQRQSLRQQCELLKELQAENSRRCGTLP 733
            ...   |.:||:|             .::::|:.|.:|....        ||||.|:......:|
 Worm   732 VSHLLAKHKNAEN-------------NLRDLEKYLDRLDVSG--------KELQDESIPGSDNIP 775

  Fly   734 ELKKLYEVCELEDPSRNLLLEETHIKQLEQRYANLSQKLSSQQSESHTLLAKEKYYNSLTGFKLV 798
            .     .:.|:.|                  |.|..::||:.:.|  .|....:||...|.    
 Worm   776 P-----RLAEIRD------------------YINKLKELSASRKE--RLAGGVEYYQFFTD---- 811

  Fly   799 LADSRDWYKQHAGSASGNELEQRLSHMESLASEISEAKTATEELDDNLIEWKQDFGLFYDSWHDM 863
             ||..|.|....         .|:...|.:..:....:...::.||           .:|...:.
 Worm   812 -ADDVDRYLYDT---------LRVMSSEDVGKDEGTVQLLLKKHDD-----------VHDELQNF 855

  Fly   864 KQALQALIQQRGGESLSRQLKQIQDFVTKVS---NQKVRVSNLEVMQEQQHFLNQLLDEMESLRL 925
            .|.::.|  ....|||.::.::..|...::.   .||..:.||..:::|     :|:|.:...:|
 Worm   856 DQHIKVL--HAKAESLPQEAREHPDIRQRLDTTLKQKAELENLSQLRKQ-----RLIDALSLYKL 913

  Fly   926 TYDNIPKHLIGEELQTAWNRLPEQLNERVIKQTTAIENLNHFAAEYNAIIAMLRSAADSK----L 986
            ..|                                .:::..:..|...::|.|....|.:    :
 Worm   914 YSD--------------------------------ADSVESWIDEKGKLLATLVPGRDIEEVEIM 946

  Fly   987 NGSDGASSQDLRKLEIDVISARNFSEILIKEAEPAQKESLQSQIRALNTLYDQVEQVHREKKEQQ 1051
            ........||::..|..|.:..:.:..|:....|...:.|..| ..||..:.|:..:..:|:.: 
 Worm   947 KHRFDTLEQDMKNQEAKVTNVNDLARQLLNVEHPNSDDILHRQ-NKLNARWAQLRDMVDQKRNE- 1009

  Fly  1052 TVLQSH-IDLIQLRLKETDQWLTDLESNTPKSGISDIVNSNELFQSKSRFQTLKETCERETTQFR 1115
             :.::| ::..::..:||..|:.|      |:.:  :.:|:.|....|....|:   .|.:...|
 Worm  1010 -LERAHRLETFRIDCQETVTWIED------KTRV--LEDSDALTNDLSGVMKLQ---RRLSMMER 1062

  Fly  1116 DLNERGGELLLQMDELQ------DQDRESRYGSLAKQFTRINARWTEVTELVYAKTALLEHISTQ 1174
            ||    |.:..::|.|.      :::|.....::.:...||:..|..:.:.|....|.|:    :
 Worm  1063 DL----GAIQAKLDSLHKEADDIERERPQEAQAIREDIKRIHQVWDILNKKVREHEAKLD----E 1119

  Fly  1175 LGEFKKFMVSETGYLDKLENKIRNT---------PENAADAEEIMEELDDLENVLRSHSEEWLDK 1230
            .|:.::|:..    ||..:..:..|         |::.|:||:::.:...:...:..::|:: .|
 Worm  1120 AGDLQRFLRD----LDHFQAWLTATQRQVASEEEPQSLAEAEQLLNQHAAIREEIDGYAEDY-KK 1179

  Fly  1231 IQEIGNEL----IDNEFMADSIRRDIDETVQRWTQLQQQAKKRTELLEQKVS------EAEQSEK 1285
            ::.:|:.:    .|.::|  .:|:.:....:.|.:||:....|..||.|.::      :|:|:|.
 Worm  1180 MRAMGDRVTQDQTDPQYM--FLRQRLAGLQEGWEELQRMWDNRQHLLSQGLNLQMFLRDAKQAEV 1242

  Fly  1286 CIVQFEKWLTRVDDILSDHLDNDVTIVDQPEEFQRLAHEFV----ANEKNFKEISELIDEHTRNG 1346
            .:.|.|.:|.: |||...        ::|.|...:...:|:    ||::..:.:....|:..::|
 Worm  1243 MLSQQENYLAK-DDIPQS--------LEQAENQLKRHQDFITTMDANDEKIRAVGMFGDQLCQDG 1298

  Fly  1347 KVGA---------------ANR---------LQEQLNLMEVRFKYCQAKLSKCTAIQHSYESRLN 1387
            ...|               |||         |::.|:|        |..||.|..::...|.::.
 Worm  1299 HYAADKIHKKARNIDERRGANREKAQEVLKKLKDALSL--------QQFLSDCDELREWIEEKMI 1355

  Fly  1388 RAYTDLRNVERSTEVVDVASAGPNTVQTQYQKCLQIYRTLSEIKSEIESTIKTGRRVCEDRYTKS 1452
            ||..                              :.||....|.|:..            |:...
 Worm  1356 RAQD------------------------------ETYRDAKTITSKFV------------RHQAF 1378

  Fly  1453 PKQLS---QRIDALKHLYNTLGENVTQSKATLERLLTLARQLEECFDSADNLIRRFESP------ 1508
            ..:|:   :|:|.|||....||::..:...|::      .|:||.....|.|.:..|..      
 Worm  1379 QSELAANKERLDQLKHAAINLGDDKPEYHGTID------PQIEELATQWDELEKTTEEKGQKLFD 1437

  Fly  1509 --------QEVHDRNSILLEFEDVLRRCEDHYNE---YNKSCDQSCMVETRQRIDGLKATYHKLT 1562
                    |.:.|......:.|:.:.| ||...:   .|.:..:..::||..    :|...|   
 Worm  1438 ANRQQLYVQSIADMKEWATQLENEMTR-EDQPGDLTTVNVAMQKQHLIETEM----IKKAQH--- 1494

  Fly  1563 SADIIKRLTEMKTTLQNLDNISLETLR----AMEHDLKEINVPSNPEIEKLQQQVIAIVVDVLKT 1623
                |.:|.||:..|:.|....||.::    |::..|:.:..|.:...:.|:::..|.       
 Worm  1495 ----IDQLMEMEPQLEELHPDELENIKAHRLAVQEQLQRLQAPLDDRRKALERKKAAF------- 1548

  Fly  1624 RFNEATTLAARNTSSPDNDDTEIVVVSDTVRQRRARTPQSGESPSSAHTSSSESPTKGVENSPGA 1688
            :|..            |.||.::.:   :.|...|:....|||....|                 
 Worm  1549 QFGR------------DVDDEKLWI---SERLVLAKAQNLGESLPDCH----------------- 1581

  Fly  1689 VGDQVMPDLLPPQTFRLAESSTLFS-----------QISLNPQKVTNTPPPKPAKTKRKAPSSPA 1742
                           ||.::..|.|           ||..|.|::.:       :.....|:...
 Worm  1582 ---------------RLQKNLQLLSNEIDNHEPWINQICNNGQELID-------EGHANGPAFEK 1624

  Fly  1743 QVVEIRVKNIQNDKMSVQNIDLEPQQGEIVDTVNILESVEPFVPEYVETVQIVDLSE------DS 1801
            ::.|:| ...|..|.:|::     ::|::.::    |....|         :.|..|      :.
 Worm  1625 KIQELR-SAWQELKEAVKD-----RKGDLGES----EKAHQF---------LYDCGEAEAWMSEQ 1670

  Fly  1802 DSSVRVDSQGKEMRRSKS---KHSLNETPLPKVSDNDEDSAEQEEDLLR---PSAENTSTPFLRV 1860
            :..:..|.:||:...:|:   ||...::.:.|.:|.....|.:....:.   |..|.......::
 Worm  1671 ELYMMQDERGKDEFSTKNQIKKHERLQSDIDKFADTIRALATKAHKFVEEKSPLTEQIQVRQAQI 1735

  Fly  1861 EKRRISFD----EKRKRV-------ANERDI------LRDSE-----EEEPKTPDTPRAAQVSKP 1903
            ||......    |:|||:       |..|:|      :.|.|     :|..:..:..:..|    
 Worm  1736 EKLYAGLQDLSKERRKRLEETLELYALHREIDDLLQWIADKEVVAGSQENGQDYEHVQMLQ---- 1796

  Fly  1904 KRWRQLQPEMDALEPESPGRDSFYSPDKESGFDAEPLVFSDDEDIPRFS-------------LEM 1955
            :|::|.     |.:.|:.|.:..  .:...|.|.  |:.....|.|..:             ||:
 Worm  1797 ERFQQF-----ARDTENIGSERV--ANANDGCDT--LIGHGHTDAPTIALWKDSLNEAWENLLEL 1852

  Fly  1956 TSTIDSDSDTSRIMTPSTKNPNPFLSKVLESLSSPVDD-----SNVTLKSPISEEQPQNLDDRVR 2015
            ..|.....:.||::.....:....||:::|...:..||     |:|   ..:|.:....|.| :.
 Worm  1853 MDTRAQILEASRLLHKFYHDCRDCLSRIMEKTHAMPDDLGRDSSSV---GALSRKHQNYLKD-IA 1913

  Fly  2016 EFDKQAKQMIYKLKLTKAKIEQCHESEAEDLRLLIAPDAATLISQGDSLVLET--HGR---QGSI 2075
            ...:|..|:               |.:|.:||...|.|.|..|...:|.|::.  |.|   ....
 Worm  1914 AIGEQVAQI---------------ERDAAELRDGYAGDKALDIGSRESEVVKAWRHLRGLCDART 1963

  Fly  2076 SRL-----------VMRTQIILREQFREVQQARSKTSGSGAPAPPLDSVNIEELVT--KGLR--- 2124
            |||           ::|..::..::.:....::.:         |.|...:|.|:.  :.|:   
 Worm  1964 SRLMDTSDLFKFMNMVRDLLLWMDEVKREMNSQER---------PKDVSGVELLMNNHQSLKAEI 2019

  Fly  2125 -----RINVLIEKTVDL-----KSSTDLEKR-----------MEDINERHDDLQVIV-------- 2160
                 ..|..|....||     .:|:::||:           |....:|.:.||:|:        
 Worm  2020 DAREENFNACISLGRDLLNRKHYASSEIEKKLIKLTTERAEMMRRWEDRWEYLQLILEVYQFARD 2084

  Fly  2161 SAIGKN---AQMP-----------KVTPLMMNEIEKTKNNLIAHAD---------SIELSLTE-- 2200
            :|:.::   ||.|           :.|..::.:.|..:.:..|..:         :.||..|:  
 Worm  2085 AAVAESWLFAQEPYLISKEYGRNLEETIKLIKKHEAFEKSAFAQEERFLALEKLTTFELKETQHR 2149

  Fly  2201 -----LRNGPRISNGKERPDASSAATMSCRSEYNNEPSGTGALAGSFDKSVLQISDWLTWEQNMI 2260
                 .|.||.......|...::..:...:.:        ||..|.            .:|..:|
 Worm  2150 EEETAKRRGPAHIGSPSRSTPAAETSFGAQDD--------GAKQGE------------AFEGTLI 2194

  Fly  2261 KIQSVLVDDGDAVRLAIEKQEKVLRELKM---KKPQLNELVHTAEVLKGDVKRQQLQEKELKQFS 2322
            :..:....|..|...:.||...|||:.::   |.|:     |..|.:.|:..            .
 Worm  2195 RKHTYESLDRKAANRSWEKLYAVLRQNELSFYKDPK-----HRDESVHGEPP------------M 2242

  Fly  2323 LAPHCSADL--DYMRCCLKVTRLREHWDETSQCVLQRAAQLKNMLSDSQRFEAKRL-------EL 2378
            ..|.||.::  ||.:                         .||:||......|:.|       ::
 Worm  2243 ALPGCSVNVASDYQK-------------------------KKNVLSLRLPIGAEYLFQCGSEEDM 2282

  Fly  2379 EKWLARMEQRAERMGTIATTADILEAQQKEQ 2409
            ::||..::        :||....||...:.|
 Worm  2283 QRWLTELQ--------VATGQAQLEEASRSQ 2305

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DysNP_001036722.1 CH 13..111 CDD:278723 50/98 (51%)
CH 129..225 CDD:278723 38/100 (38%)
SPEC 312..525 CDD:238103 45/218 (21%)
SbcC <325..957 CDD:223496 122/673 (18%)
Smc <816..1591 CDD:224117 151/859 (18%)
SPEC 1174..1365 CDD:238103 45/237 (19%)
SPEC 1289..1485 CDD:295325 41/226 (18%)
SPEC 2369..2576 CDD:238103 9/48 (19%)
SPEC 2477..2714 CDD:238103
WW 2852..2882 CDD:238122
EF-hand_2 2883..2997 CDD:286194
EF-hand_3 3001..3100 CDD:286195
ZZ_dystrophin 3110..3158 CDD:239074
unc-70NP_001256073.1 CH 110..208 CDD:278723 50/98 (51%)
CH 229..333 CDD:237981 40/106 (38%)
SPEC 368..580 CDD:238103 47/251 (19%)
SPEC 481..695 CDD:238103 44/242 (18%)
SPEC 698..908 CDD:238103 53/289 (18%)
SPEC 804..1014 CDD:238103 43/276 (16%)
SPEC 910..1120 CDD:238103 42/263 (16%)
SPEC 1122..1334 CDD:238103 42/227 (19%)
SPEC 1230..1439 CDD:238103 50/273 (18%)
SPEC 1440..1650 CDD:238103 49/288 (17%)
SPEC 1652..1864 CDD:238103 40/233 (17%)
SPEC 1865..2073 CDD:238103 42/235 (18%)
SPEC 2079..>2157 CDD:197544 10/77 (13%)
PH_beta_spectrin 2189..2290 CDD:269975 27/142 (19%)
PH 2190..2290 CDD:278594 27/141 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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