Protein Alignment Dys and Actn3

DIOPT Version :10

• Sequence 1: NP_001036722.1
• Gene: Dys / 42327
• FlyBaseID: FBgn0260003
• Length: 3598
• Species: Drosophila melanogaster
• Sequence 2: NP_596915.1
• Gene: Actn3 / 171009
• RGDID: 621792
• Length: 900
• Species: Rattus norvegicus
• Alignment Length: 1122
• Identity: 248/1122 - (22%)
• Similarity: 412/1122 - (36%)
• Gaps: 368/1122 - (32%)

  Fly     5 ILID---ERQHIQKKTFTKWINSHLIDTQCTPVKDLFLDLRDGHRLLALLSTLTQTNL-KPEKGR 65
            :|:|   |:|  |:||||.|.||||.... |.::::..|.|:|.:|:.||..::...| :|:||:
  Rat    36 LLLDPAWEKQ--QRKTFTAWCNSHLRKAG-TQIENIEEDFRNGLKLMLLLEVISGERLPRPDKGK 97

  Fly    66 MRVHHINNLNKVITEIQQHGVKLVNISSDDIVGGNAKLTLGLIWLIALEFNGQHLVKSHSSNGVE 130
            ||.|.|.|:||.:..|...|||||:|.:::||.||.|:|||:||.|.|.|..|.:  |......:
  Rat    98 MRFHKIANVNKALDFIASKGVKLVSIGAEEIVDGNLKMTLGMIWTIILRFAIQDI--SVEETSAK 160

  Fly   131 KSLLAWARQYTEPH-GLQLNDFSSSWSDGRAFLMILDAHVEELNLQAALQQ-HALKRLHLAFDLA 193
            :.||.|.::.|.|: .:.:.:|.:||.||.|...::..|..:|...|.|:: ..:..|:.||::|
  Rat   161 EGLLLWCQRKTAPYRNVNVQNFHTSWKDGLALCALIHRHRPDLIDYAKLRKDDPIGNLNTAFEVA 225

  Fly   194 HRHFKIEKLLDAED-VHTHKPDNKSIQMYVMCLYHAMESMRTRQQEQEQDEGQDQDPGRVPCTSI 257
            .::..|.|:||||| |:|.|||.|:|..||.|.|||...       .||.|
  Rat   226 EKYLDIPKMLDAEDIVNTPKPDEKAIMTYVSCFYHAFAG-------AEQAE-------------- 269

  Fly   258 TDLDEVPLDNDQTSLGLYTSDSAGSMEQRSSGELKTHSMRPLSTATNASVEISGYQSALEAVLTL 322
                                                       ||.|...:          ||.:
  Rat   270 -------------------------------------------TAANRICK----------VLAV 281

  Fly   323 LLEDEQLLSQNLPDPQDFQTAKLQFHENESFMLKLTEHQEYVGEALEEGSNLINESQKAGAGLSQ 387
            ..|:|:|:                    |.:....:|..|::...:....|.:.|...:......
  Rat   282 NQENEKLM--------------------EEYEKLASELLEWIRRTVPWLENRVGEPSMSAMQRKL 326

  Fly   388 EDQNEVR--------QQMVLLNERWETLRLRALDVQAKILMRLAEFQKQKLEQLRQFLTSVEDRI 444
            ||..:.|        |:...|...:.||:                 .|.:|.....|:.|....:
  Rat   327 EDFRDYRRLHKPPRVQEKCQLEINFNTLQ-----------------TKLRLSHRPAFMPSEGKLV 374

  Fly   445 SHMSDIGPTLEEAEK-----QLLEAQKLKADLSEQQELVDSLSSMVVIVNDTSGNFNDLEDRLSA 504
            |.:::....||:.||     .|.|.::|:    ..|.|.:..                  .:.::
  Rat   375 SDIANAWRGLEQVEKGYEDWLLSEIRRLQ----RLQHLAEKF------------------QQKAS 417

  Fly   505 LGERWS----HVVKWSDLRKEKLQQYKCISRWLDAREQDLKLMESRDVTDVGGITQRINELNYCA 565
            |.|.|:    .::...|.....||:.:.:.|..:|.|.||...:.| |..:..:.|.:|||:|
  Rat   418 LHEAWTRGKEEMLNQHDYESASLQEVRALLRRHEAFESDLAAHQDR-VEHIAALAQELNELDY-- 479

  Fly   566 KDLLELQRYLIDLRQMVAATLQDGDDKGERVLIQLESYEDRLDALKQIVEVQTVRIETKGFNFGR 630
                   .....:.....|.....|:.|...    :...|.|:.:::::|.    |:.....|.|
  Rat   480 -------HEAASVNSRCQAICDQWDNLGTLT----QKRRDALERMEKLLET----IDQLQLEFAR 529

  Fly   631 DRASYDDSRVVRPEGWVDYQMIIRFGEDDSQEDDDEHDLASKKRKLRNADNFNALENHIMEHFGY 695
            ..|.:::        |:|                                  .|:|:  ::....
  Rat   530 RAAPFNN--------WLD----------------------------------GAIED--LQDVWL 550

  Fly   696 VQEVEQKLQQLQRQSLRQQCELLKELQAENSRRCGTLPELKKLYEVCELEDPSRNLLLE-ETHIK 759
            |..||      :.|||....|..|          .||||          .|..|..:|. :..|:
  Rat   551 VHSVE------ETQSLLTAHEQFK----------ATLPE----------ADRERGAILGIQGEIQ 589

  Fly   760 QLEQRYANLSQKLSSQQSESHTLLAKEKYYNSL-TGFKLVLADSRDWYKQHAGSASGNELEQRLS 823
            ::.|.|.     |..:....:..|:.:...|.. |..|||  .|||
  Rat   590 KICQTYG-----LRPKSGNPYITLSSQDINNKWDTVRKLV--PSRD------------------- 628

  Fly   824 HMESLASEISEAKTATEELDDNLIEWKQDFGLFYDS---WHDMKQALQALIQQRG------GESL 879
              ::|..|:     |.:::::.|   ::.|....::   |      :|..:::.|      ..||
  Rat   629 --QTLQEEL-----ARQQVNERL---RRQFAAQANAIGPW------IQGKVEEVGRLAAGLAGSL 677

  Fly   880 SRQLKQIQDFVTKVSNQKVRVSNLEVMQEQQHFLNQLLDEMESLRLTYDNIPKHLI--GEELQTA 942
            ..|:..::.....:.|.|..:..|    |..|   |||.|    .|.:||  ||.:  .|.::..
  Rat   678 EEQMAGLRQQEQNIINYKSNIDRL----EGDH---QLLQE----GLVFDN--KHTVYSMEHIRVG 729

  Fly   943 WNRLPEQLNERVIKQTTAIEN--------------LNHFAAEYNAIIAMLRSAADSKLNG---SD 990
            |    |||...:.:....:||              ||.|.|.:|..        |.|.||   .|
  Rat   730 W----EQLLTSIARTINEVENQVLTRDAKGLSQEQLNEFRASFNHF--------DRKRNGMMEPD 782

  Fly   991 G------ASSQDLRKLE-------ID-----VISARNFSEILIKE-AEPAQKESLQSQIRAL--N 1034
            .      :...||.::|       :|     |::.:.|.:.:.:| ||....|.:.:..:.|  :
  Rat   783 DFRACLISMGYDLGEVEFARIMTMVDPNAAGVVTFQAFIDFMTRETAETDTAEQVVASFKILAGD 847

  Fly  1035 TLYDQVEQVHREKKEQQ 1051
            ..|...|::.||...:|
  Rat   848 KNYITPEELRRELPAEQ 864

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dys	NP_001036722.1	CH_DMD-like_rpt1	12..118	CDD:409035	48/106 (45%)
		CH_SF	129..229	CDD:469584	38/102 (37%)
		SPEC	312..525	CDD:238103	36/229 (16%)
		PRK03918	<716..1238	CDD:235175	80/387 (21%)
		SMC_prok_B	<995..1279	CDD:274008	16/72 (22%)
		SPEC	1174..1365	CDD:238103
		SPEC	1289..1485	CDD:413338
		SPEC	2369..2576	CDD:238103
		SPEC	2477..2714	CDD:238103
		WW	2852..2882	CDD:238122
		EFh_DMD_like	2919..3085	CDD:320000
		EF-hand-like motif	2919..2958	CDD:320000
		EF-hand-like motif	2961..2995	CDD:320000
		EF-hand-like motif	3001..3037	CDD:320000
		EF-hand-like motif	3050..3085	CDD:320000
		ZZ_dystrophin	3110..3158	CDD:239074
Actn3	NP_596915.1	CH_ACTN_rpt1	41..145	CDD:409063	48/106 (45%)
		CH_ACTN_rpt2	149..263	CDD:409065	41/115 (36%)
		SPEC	290..513	CDD:238103	49/275 (18%)
		SPEC	408..635	CDD:238103	62/360 (17%)
		SPEC	526..746	CDD:238103	65/348 (19%)
		PTZ00184	753..>857	CDD:185504	23/111 (21%)
		EFhand_Ca_insen	830..896	CDD:430177	8/35 (23%)