DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Dys and Actn3

DIOPT Version :9

Sequence 1:NP_001036722.1 Gene:Dys / 42327 FlyBaseID:FBgn0260003 Length:3598 Species:Drosophila melanogaster
Sequence 2:NP_596915.1 Gene:Actn3 / 171009 RGDID:621792 Length:900 Species:Rattus norvegicus


Alignment Length:1122 Identity:248/1122 - (22%)
Similarity:412/1122 - (36%) Gaps:368/1122 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 ILID---ERQHIQKKTFTKWINSHLIDTQCTPVKDLFLDLRDGHRLLALLSTLTQTNL-KPEKGR 65
            :|:|   |:|  |:||||.|.||||.... |.::::..|.|:|.:|:.||..::...| :|:||:
  Rat    36 LLLDPAWEKQ--QRKTFTAWCNSHLRKAG-TQIENIEEDFRNGLKLMLLLEVISGERLPRPDKGK 97

  Fly    66 MRVHHINNLNKVITEIQQHGVKLVNISSDDIVGGNAKLTLGLIWLIALEFNGQHLVKSHSSNGVE 130
            ||.|.|.|:||.:..|...|||||:|.:::||.||.|:|||:||.|.|.|..|.:  |......:
  Rat    98 MRFHKIANVNKALDFIASKGVKLVSIGAEEIVDGNLKMTLGMIWTIILRFAIQDI--SVEETSAK 160

  Fly   131 KSLLAWARQYTEPH-GLQLNDFSSSWSDGRAFLMILDAHVEELNLQAALQQ-HALKRLHLAFDLA 193
            :.||.|.::.|.|: .:.:.:|.:||.||.|...::..|..:|...|.|:: ..:..|:.||::|
  Rat   161 EGLLLWCQRKTAPYRNVNVQNFHTSWKDGLALCALIHRHRPDLIDYAKLRKDDPIGNLNTAFEVA 225

  Fly   194 HRHFKIEKLLDAED-VHTHKPDNKSIQMYVMCLYHAMESMRTRQQEQEQDEGQDQDPGRVPCTSI 257
            .::..|.|:||||| |:|.|||.|:|..||.|.|||...       .||.|              
  Rat   226 EKYLDIPKMLDAEDIVNTPKPDEKAIMTYVSCFYHAFAG-------AEQAE-------------- 269

  Fly   258 TDLDEVPLDNDQTSLGLYTSDSAGSMEQRSSGELKTHSMRPLSTATNASVEISGYQSALEAVLTL 322
                                                       ||.|...:          ||.:
  Rat   270 -------------------------------------------TAANRICK----------VLAV 281

  Fly   323 LLEDEQLLSQNLPDPQDFQTAKLQFHENESFMLKLTEHQEYVGEALEEGSNLINESQKAGAGLSQ 387
            ..|:|:|:                    |.:....:|..|::...:....|.:.|...:......
  Rat   282 NQENEKLM--------------------EEYEKLASELLEWIRRTVPWLENRVGEPSMSAMQRKL 326

  Fly   388 EDQNEVR--------QQMVLLNERWETLRLRALDVQAKILMRLAEFQKQKLEQLRQFLTSVEDRI 444
            ||..:.|        |:...|...:.||:                 .|.:|.....|:.|....:
  Rat   327 EDFRDYRRLHKPPRVQEKCQLEINFNTLQ-----------------TKLRLSHRPAFMPSEGKLV 374

  Fly   445 SHMSDIGPTLEEAEK-----QLLEAQKLKADLSEQQELVDSLSSMVVIVNDTSGNFNDLEDRLSA 504
            |.:::....||:.||     .|.|.::|:    ..|.|.:..                  .:.::
  Rat   375 SDIANAWRGLEQVEKGYEDWLLSEIRRLQ----RLQHLAEKF------------------QQKAS 417

  Fly   505 LGERWS----HVVKWSDLRKEKLQQYKCISRWLDAREQDLKLMESRDVTDVGGITQRINELNYCA 565
            |.|.|:    .::...|.....||:.:.:.|..:|.|.||...:.| |..:..:.|.:|||:|  
  Rat   418 LHEAWTRGKEEMLNQHDYESASLQEVRALLRRHEAFESDLAAHQDR-VEHIAALAQELNELDY-- 479

  Fly   566 KDLLELQRYLIDLRQMVAATLQDGDDKGERVLIQLESYEDRLDALKQIVEVQTVRIETKGFNFGR 630
                   .....:.....|.....|:.|...    :...|.|:.:::::|.    |:.....|.|
  Rat   480 -------HEAASVNSRCQAICDQWDNLGTLT----QKRRDALERMEKLLET----IDQLQLEFAR 529

  Fly   631 DRASYDDSRVVRPEGWVDYQMIIRFGEDDSQEDDDEHDLASKKRKLRNADNFNALENHIMEHFGY 695
            ..|.:::        |:|                                  .|:|:  ::....
  Rat   530 RAAPFNN--------WLD----------------------------------GAIED--LQDVWL 550

  Fly   696 VQEVEQKLQQLQRQSLRQQCELLKELQAENSRRCGTLPELKKLYEVCELEDPSRNLLLE-ETHIK 759
            |..||      :.|||....|..|          .||||          .|..|..:|. :..|:
  Rat   551 VHSVE------ETQSLLTAHEQFK----------ATLPE----------ADRERGAILGIQGEIQ 589

  Fly   760 QLEQRYANLSQKLSSQQSESHTLLAKEKYYNSL-TGFKLVLADSRDWYKQHAGSASGNELEQRLS 823
            ::.|.|.     |..:....:..|:.:...|.. |..|||  .|||                   
  Rat   590 KICQTYG-----LRPKSGNPYITLSSQDINNKWDTVRKLV--PSRD------------------- 628

  Fly   824 HMESLASEISEAKTATEELDDNLIEWKQDFGLFYDS---WHDMKQALQALIQQRG------GESL 879
              ::|..|:     |.:::::.|   ::.|....::   |      :|..:::.|      ..||
  Rat   629 --QTLQEEL-----ARQQVNERL---RRQFAAQANAIGPW------IQGKVEEVGRLAAGLAGSL 677

  Fly   880 SRQLKQIQDFVTKVSNQKVRVSNLEVMQEQQHFLNQLLDEMESLRLTYDNIPKHLI--GEELQTA 942
            ..|:..::.....:.|.|..:..|    |..|   |||.|    .|.:||  ||.:  .|.::..
  Rat   678 EEQMAGLRQQEQNIINYKSNIDRL----EGDH---QLLQE----GLVFDN--KHTVYSMEHIRVG 729

  Fly   943 WNRLPEQLNERVIKQTTAIEN--------------LNHFAAEYNAIIAMLRSAADSKLNG---SD 990
            |    |||...:.:....:||              ||.|.|.:|..        |.|.||   .|
  Rat   730 W----EQLLTSIARTINEVENQVLTRDAKGLSQEQLNEFRASFNHF--------DRKRNGMMEPD 782

  Fly   991 G------ASSQDLRKLE-------ID-----VISARNFSEILIKE-AEPAQKESLQSQIRAL--N 1034
            .      :...||.::|       :|     |::.:.|.:.:.:| ||....|.:.:..:.|  :
  Rat   783 DFRACLISMGYDLGEVEFARIMTMVDPNAAGVVTFQAFIDFMTRETAETDTAEQVVASFKILAGD 847

  Fly  1035 TLYDQVEQVHREKKEQQ 1051
            ..|...|::.||...:|
  Rat   848 KNYITPEELRRELPAEQ 864

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DysNP_001036722.1 CH 13..111 CDD:278723 45/98 (46%)
CH 129..225 CDD:278723 35/98 (36%)
SPEC 312..525 CDD:238103 36/229 (16%)
SbcC <325..957 CDD:223496 119/661 (18%)
Smc <816..1591 CDD:224117 58/285 (20%)
SPEC 1174..1365 CDD:238103
SPEC 1289..1485 CDD:295325
SPEC 2369..2576 CDD:238103
SPEC 2477..2714 CDD:238103
WW 2852..2882 CDD:238122
EF-hand_2 2883..2997 CDD:286194
EF-hand_3 3001..3100 CDD:286195
ZZ_dystrophin 3110..3158 CDD:239074
Actn3NP_596915.1 CH 45..143 CDD:278723 46/100 (46%)
CH 158..263 CDD:237981 39/104 (38%)
SPEC 290..513 CDD:238103 49/275 (18%)
SPEC 408..635 CDD:238103 62/360 (17%)
SPEC 526..746 CDD:238103 65/348 (19%)
EFh 763..825 CDD:238008 14/69 (20%)
EF-hand_7 765..824 CDD:290234 13/66 (20%)
EFhand_Ca_insen 830..896 CDD:285885 8/35 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
11.000

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