DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Dys and sptbn4

DIOPT Version :9

Sequence 1:NP_001036722.1 Gene:Dys / 42327 FlyBaseID:FBgn0260003 Length:3598 Species:Drosophila melanogaster
Sequence 2:XP_002938861.2 Gene:sptbn4 / 100488521 XenbaseID:XB-GENE-1013360 Length:2545 Species:Xenopus tropicalis


Alignment Length:2732 Identity:554/2732 - (20%)
Similarity:959/2732 - (35%) Gaps:799/2732 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 LIDERQHIQKKTFTKWINSHLIDTQCTPVKDLFLDLRDGHRLLALLSTLTQTNL-KPEKGRMRVH 69
            |.|||..:|||||||||||||...... |.||:.|||||:.:..||..|:...| ||.:||||:|
 Frog    48 LADERDAVQKKTFTKWINSHLSKVPLR-VNDLYTDLRDGYIITKLLEVLSGEQLPKPTRGRMRIH 111

  Fly    70 HINNLNKVITEIQQHGVKLVNISSDDIVGGNAKLTLGLIWLIALEFNGQ----HLVKSHSSNGVE 130
            ::.|::|.:..:::..|.|.|:.|.|||.||.:|||||||.|.|.|..|    ....|..:...:
 Frog   112 YLENVDKALQFLKEQRVHLENVGSHDIVDGNHRLTLGLIWTIILRFQIQVIRIETEDSRETRSAK 176

  Fly   131 KSLLAWARQYTEPH-GLQLNDFSSSWSDGRAFLMILDAH-VEELNLQAALQQHALKRLHLAFDLA 193
            .:||.|.:..|..: .:.:.:|::||.||.||..::..| .:.::.....:.:|...|..||:.|
 Frog   177 DALLLWCQMKTSGYPEVNIQNFTTSWRDGLAFSALIHRHRPDVIDFNKLTKSNATYNLQHAFNTA 241

  Fly   194 HRHFKIEKLLDAEDVHTHKPDNKSIQMYVMCLYHAMESMRTRQQEQEQDEGQDQDPGRVPCTSIT 258
            .:...:.||||.|||:...||.|||..||:..||....|:....|.::       .|:|      
 Frog   242 EQQLGLTKLLDPEDVNMEHPDEKSIITYVVSFYHYFSKMKALAVEGKR-------IGKV------ 293

  Fly   259 DLDE-VPLDNDQTSLGLYTSDSAGSMEQRSSGELKTHSMRPLSTATNASV--EISGYQSALEAVL 320
             ||: :..:.|.....:..|            ||.....|.::..||...  .:.|.|..|:...
 Frog   294 -LDKAIETEKDIVKYEVLAS------------ELLEWIERTIAIITNQKFANSLLGVQQQLQVFT 345

  Fly   321 TLLLEDEQLLSQNLPDPQDFQ----TAKLQFHENESFMLKLTEH--QEYVGEALEEGSNLINESQ 379
            |....::         |..||    ...|.|    |...|:.|.  :.||.   .||.| |::..
 Frog   346 TYCTTEK---------PCKFQEKGNLEVLLF----SIQSKMREEKCKLYVP---SEGKN-ISDIN 393

  Fly   380 KAGAGLSQEDQNEVRQQMVLLNERWETLRLRALDVQAKILMRLAEFQKQKLEQ---LRQFLTSVE 441
            ||.|.|   ::.|..:::.|.||         |..|.|:     |...|:.:|   :|:...|..
 Frog   394 KAWACL---EKAEHEREVALRNE---------LIRQEKL-----ELLSQRFDQKAAMREAWLSEN 441

  Fly   442 DRISHMSDIGPTLEEAEKQLLEAQKLKADLSEQQELVDSLSSMVVIVNDTSGNFNDLEDRLSALG 506
            .|:....:.|..|...|..:.:.:.::||:|..:|.:..::              ||...|.|.|
 Frog   442 QRLVSQDNFGYDLPAVEAAMKKHEAIEADISSYEERIQVVA--------------DLAQELEAEG 492

  Fly   507 ---------------ERWSHVVKWSDLRKEKLQQYKCISR----------WLDAREQDLK----- 541
                           .:|:.:......|:.:|:|...:.:          |:|..:..|.     
 Frog   493 YYDICRISAQKDNILRQWNLLKDMLSSRRARLEQNLSLQKIFQEMVYMIDWMDEMQVPLSSKDFG 557

  Fly   542 --LMESRDV--------TDVGGITQRINELNYCAKDLLELQRYLIDLRQMVAATLQDGDDKGERV 596
              |:|..|:        .|:...|:|:|.||..|....::..|            |..|.  :.:
 Frog   558 KHLLEVEDLLQKHCLLEADIAAQTERVNSLNQAALKFTQMTDY------------QPCDP--QVI 608

  Fly   597 LIQLESYEDRLDALKQIVEVQTVRIETKGFNFGRDRASYDDSR--------VVRPEGWV-DYQMI 652
            ..::|.....|:.|:|:.|              :.|...::||        |...|||: :.:.|
 Frog   609 CNRVEHVRSCLEGLRQLAE--------------KRRGELEESRRLWCFLQEVEEAEGWIREKEQI 659

  Fly   653 I----RFGEDDSQ-------------EDDDEHDLASKKRKLRNADNFNALENHIMEHFGYVQEVE 700
            :    .:|:|.|.             |....|  |..::.|:..:...|.....|.  |..|.:|
 Frog   660 LSAPQSYGKDLSSVLRLLSKHKILVGELRGRH--AMLQQTLQKGEQVLAKRRKGMS--GLRQRME 720

  Fly   701 Q---KLQQLQR-----QSLRQQCELLKELQAENSRRCGTLPELKKL----------YEVCELEDP 747
            |   |.:.||:     |...|:.....:..|:.....|.|.:..:|          |....|...
 Frog   721 QVRLKWENLQKACDNHQQKLQEASSFYQFSADTMELAGWLQDTYRLVSSDDFGHDEYSTQSLVKK 785

  Fly   748 SRNLLLE-ETH---IKQLEQRYANLSQKLSSQQSESHTLLAKEKYYNSLTGFKLV----LADSRD 804
            .|...:| |.|   :..|.|:.:.|..:...|.....|::..|:.|..:.....:    |.|:.|
 Frog   786 HRAETVEIEKHKVAVLGLRQQLSELGAEYRDQVDVQITIVEVEQLYGEVVEVSALRSQWLQDALD 850

  Fly   805 WYKQHAGSASG-----NELEQRLSHME--SLASEISEAKTATEELDDNLIEWKQDFGLFYDSWHD 862
            .||.. |..:.     :|.||.|..||  ....|:...:...|.||       |:.........|
 Frog   851 VYKMF-GEVNSCEVWIDEKEQWLMKMEIPQRLEEVEVVQHRFESLD-------QEMNSLMGRVLD 907

  Fly   863 MKQALQALIQQRGGESLSRQLKQIQD--------FVTKVSNQKVRVSNLEVMQEQQHFL--NQLL 917
            :.|.:|.|::  ||...|.:::..||        .|..|..:|.::|:  |::.|.:||  |::.
 Frog   908 VNQIVQQLLE--GGHPSSSEVRACQDHLNSRWNRIVELVEQRKEQLSS--VLRLQNYFLECNEVK 968

  Fly   918 DEMESLRLTYDNIPKHLIGE------------ELQTAWNRLPEQL----NERVIKQTT----AIE 962
            .::...|.|.:. |:...||            .::.|...|..:|    .:..|..|:    |:|
 Frog   969 SQIREKRRTMET-PQCGSGELGGVLSLQRKLSSMEAALLALEPKLVQLQQDAEILATSHPSQAME 1032

  Fly   963 NLNHF---AAEYNAIIAMLRSAADS---------------------------------------- 984
            .|.||   :.|::|:...|:...||                                        
 Frog  1033 VLVHFEEISGEWDALKRTLQGCEDSLTVANKLQQFIQDLDNFLTWLVKTQTAVAAEELPSNLAEA 1097

  Fly   985 -KLNGSDGASSQDLRKLEIDVISARNFSEILIKEAEPAQKESLQSQIRALNTLYDQVEQVHREKK 1048
             :|.|..|:..:::.:.|.:....:..:::|..|.......|||..::.|...::::.|:...::
 Frog  1098 ERLLGLHGSLKEEISRYEEEYNKIQAVNDLLSLEEADLPYLSLQQWLQKLEVGWNKLLQMWENRR 1162

  Fly  1049 EQQTVLQSHIDLIQLR-LKETDQWLTDLESNTPKSGISDIVNSNELFQSKSR-FQTLKETCERET 1111
            |  .::|:||..:.|| .|:.:..|...||......:.:.|...|....|.: |.|..|.    .
 Frog  1163 E--VLVQAHIFHLFLRDFKQAEACLNTQESTLAHVELPNTVEGVEAAIKKHKDFVTTMEL----N 1221

  Fly  1112 TQFRDLNERGGELLLQM-----DELQD-----QDRESRYGSLAK----------QFTRINARWTE 1156
            .|...:....||.|:::     |.:|:     |.|..|..:||:          |.........|
 Frog  1222 VQKVSVAVEAGESLIRLGNVFADHVQERISAIQKRSQRNTALAQKWLQRLRDHLQLQHFLQNCNE 1286

  Fly  1157 VTELVYAKTALLEHISTQLGE--FKKFMVSETGYLDKLENKIRNTPENAADAEEIMEELDDLENV 1219
            :...|:.||.:....|..|.:  .||::..:.                      .|.||      
 Frog  1287 LDAWVHEKTLMARDSSRDLSQKPHKKWLKHQA----------------------FMAEL------ 1323

  Fly  1220 LRSHSEEWLDKIQEIGNELI-DNEFMADSIRRDIDETVQRWTQLQQQAKKRTELL------EQKV 1277
              |.::.||:||::.|.:|| :...:|..:::.::|..|.|.:|:...:.:.:.|      :|.|
 Frog  1324 --SQNKGWLEKIEKEGQQLIQEKPELAGVVKKKLEEIRQCWVELESSTQAKAQQLFQATKADQVV 1386

  Fly  1278 SEAEQSEKCIVQFEKWLTRVDDI-----LSDHLDNDVTIVDQPEEFQRLAHEF----------VA 1327
            ....:..|.:...::.|..||.:     ::..|....|:..|.||:.:...|.          ||
 Frog  1387 QNYSELGKRLYHLKEQLQPVDPVPDVSSVNTQLKRLETMESQMEEWYKEVGELQAQIASLPLEVA 1451

  Fly  1328 NEKNFKE--------ISELIDEHTRNGKVGAANRLQEQLNL-MEVRFKYCQAKLSKCTAIQH--- 1380
            ::|..:|        |..||:......::..|::...|:.. :|....:.|.:|...|:.:|   
 Frog  1452 SQKALEEKQNEVGTTIVRLIEPLKERRRILLASKEVHQVTRDLEDEIFWVQERLPLATSKEHGSN 1516

  Fly  1381 ------------------------------------------------SYESRLNRAYTDLRN-V 1396
                                                            .||| |...:..||: .
 Frog  1517 LQIVQQLIKKNQNLRREIQVHSPRVDDILERAGAIASIRTPEAEGVRLGYES-LGEMWNMLRDET 1580

  Fly  1397 ERSTEVVDVASAGPNTVQTQY--------------------------QKCLQIYR---TLSEIKS 1432
            ||..:::|:.    ..||..|                          |..||:.:   .|.:...
 Frog  1581 ERRQQLLDIT----YQVQQYYFDVGEVETWLSEQELLMMNDEKGKDEQSTLQLLKKHLMLEQTIE 1641

  Fly  1433 EIESTIKTGRRVCE---DRYTKSPKQLSQRIDALKHLYNTLGENVTQSKATLER---LLTLARQL 1491
            ..|.||....|.|.   |......:|:|:|...:..||.:|.:.|.:.|..||:   |..|:|::
 Frog  1642 NYEETIAQLSRQCRTLLDLGHPDSEQISKRQSQIDRLYVSLKDLVDERKGRLEQQYWLFQLSREV 1706

  Fly  1492 EEC-------------------FDSADNLIRRF-ESPQEV----------------------HDR 1514
            :|.                   ::....|..:| |...|.                      |..
 Frog  1707 DELEQWIAEKEVVAGSPELGQDYEHVTLLQEKFTEFATETGSVGQERISAVNQMVDELIDFGHSD 1771

  Fly  1515 NSILLEFED------------------VLRRCEDHYNEYNKSCDQ--SCMVETRQRIDGLKATYH 1559
            .:|:.|::|                  :|....:.|..:| .|.:  |.:.|.:||:..:||...
 Frog  1772 AAIIAEWKDGVNEAWADLLELMETRSQMLAASHELYKFFN-DCKEVLSQVEEKKQRLPEVKAQEA 1835

  Fly  1560 KLTSADIIKRLTEMKTTLQNLDNISLETLRAMEHDLKEINVPSNPEIEKLQQQVIAIVVDVLKTR 1624
            || ||..::|:                 |.:.|||::.:..    ::.:||:....:        
 Frog  1836 KL-SAGSLQRI-----------------LSSFEHDIQVLVT----QVRQLQENAAQL-------- 1870

  Fly  1625 FNEATTLAARNTSSPDNDDTEIV----------------------------VVSDTVRQRRARTP 1661
               .|..|..|.::....:.|::                            :|.|.:....:.|.
 Frog  1871 ---RTVYAGENAAAIVTSEQEVMRAWKELLTSCEDCRLQITSTTDRIKFLNLVRDLISWMESITC 1932

  Fly  1662 QSGESPSSAHTSSSE---SPTKGVENSPGAVGDQVMPDLLPPQTFRLAESSTLFSQISLNPQKVT 1723
            |.|........||.|   |..:|:::.            :..:..|:|:...|...:.||.:   
 Frog  1933 QIGAEEKPRDVSSVEVLMSYHQGLKSE------------IESRNKRIADCVELGKTLVLNKR--- 1982

  Fly  1724 NTPPPKPAKTKRKAPSSPAQVVEIRVKNIQNDKMSVQNIDLE--PQQGEIVDTVNILESVEPFV- 1785
                |...:.|:......|:..|:..|..::.:...|.:::.  .|:..:.|.  .|.:.||.| 
 Frog  1983 ----PSSDEIKQSLDRLMAKKKEMLEKWNKHWEWLQQMLEVHQFAQEAGVADA--WLTAQEPIVK 2041

  Fly  1786 -PEYVETVQIVD--------------LSEDSDSSVRVDSQGKEMRRSKSK--------------- 1820
             ||...:|..|:              :.|:..||:|..:..::::..:||               
 Frog  2042 SPELGNSVDEVEQLIRRHEAFRKTAAVWEERFSSLRRLTTLEKLKAEQSKQPATPLLGRKVFPDT 2106

  Fly  1821 --HSLNETPLPK--VSDNDEDSAEQEEDLLRPSAENTSTPFLRVEKRRISFDEKRKRVANERDIL 1881
              :|...:||.:  |.:|.|...:|:|.|..|..........|.||........|:.:..|| :.
 Frog  2107 TDYSARPSPLSRQTVYENSETKLDQKEALSIPDGGQQEIRRARAEKGETRVGYVRQDIKPER-LQ 2170

  Fly  1882 RDSEEEEPKTPDTPRAAQ--------------------VSKP-------------------KRWR 1907
            ...:..|.|..|.|.|||                    |.||                   :|..
 Frog  2171 PKMDHVETKVADKPLAAQEVERAEKTEIKFAQGMANLTVEKPEIKGSRHTERKRDRHERRLERQE 2235

  Fly  1908 QLQPEMDALEPESPGRDSFYSPDKESGFDAEPLVFSDDEDIPRFS------------LEMTSTID 1960
            ..:.|....||....||......:..|        |.:::.|:..            .|...||:
 Frog  2236 SSEQETPKQEPPERRRDRHEKRLERQG--------SSEQETPKQEQSERRRDRHERRTERQDTIE 2292

  Fly  1961 SDSDTSRIMTPSTKNPNPFLSKVLESL-------------SSPVDDSNVTLKSPISEEQPQNLDD 2012
            .|...:.   |..:.....|:.::|.|             .||....|...|.|....:|    |
 Frog  2293 QDKPRTE---PEKQAGKATLADIVEQLQEKEAFQNSSGGQDSPARVPNGVDKLPERTTRP----D 2350

  Fly  2013 RVREFDKQAKQMIYKLKLTKAKIEQCHESEAEDLRLLIA------PDAATLISQGDSLVLETHGR 2071
            |.|..|:...:     :..:.|.......||...|...|      |...|...|.:..:...|..
 Frog  2351 RPRARDRPKPR-----RRPRPKDPNQPPGEARRSRSAPAQSSAPPPPPPTHTIQQEGYLFRKHEL 2410

  Fly  2072 QGSISRLVMRTQIIL-----REQFREVQQARSKTSGSGAPAPPLDSVNIEELVTKGLRRINVLIE 2131
            .|...:...|:.|.|     :......:.|:|::||:.....||            |..:....|
 Frog  2411 DGPSKKASNRSWINLYCVLNKGDLGVYKDAKSQSSGATHGGEPL------------LNLLGASCE 2463

  Fly  2132 KTVDLKS--------STDLEK---RMEDINERHDDLQVIVSAIGKNAQMPKVTPLMMNEIEKTKN 2185
            ...:.|.        |||..:   :.:|..|..:.:..|.:.:.::|::.:.:..::......:.
 Frog  2464 VASEYKKKKFVFKLRSTDGREFLFQAKDEEEMKNWITAITTCVSQHAEIARWSQSLLTTSSTDEG 2528

  Fly  2186 NL 2187
            |:
 Frog  2529 NI 2530

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DysNP_001036722.1 CH 13..111 CDD:278723 50/98 (51%)
CH 129..225 CDD:278723 31/97 (32%)
SPEC 312..525 CDD:238103 49/236 (21%)
SbcC <325..957 CDD:223496 155/765 (20%)
Smc <816..1591 CDD:224117 199/1054 (19%)
SPEC 1174..1365 CDD:238103 42/223 (19%)
SPEC 1289..1485 CDD:295325 55/306 (18%)
SPEC 2369..2576 CDD:238103
SPEC 2477..2714 CDD:238103
WW 2852..2882 CDD:238122
EF-hand_2 2883..2997 CDD:286194
EF-hand_3 3001..3100 CDD:286195
ZZ_dystrophin 3110..3158 CDD:239074
sptbn4XP_002938861.2 SAC6 48..>454 CDD:227401 141/466 (30%)
SPEC 425..637 CDD:238103 43/253 (17%)
SPEC 642..849 CDD:238103 42/210 (20%)
SPEC 746..955 CDD:238103 47/220 (21%)
SPEC 956..1169 CDD:238103 37/215 (17%)
SPEC 1171..1379 CDD:238103 49/241 (20%)
SPEC 1276..1484 CDD:238103 45/237 (19%)
SPEC 1488..1588 CDD:197544 14/100 (14%)
SPEC 1592..1804 CDD:238103 36/211 (17%)
SPEC 1804..1906 CDD:351773 24/135 (18%)
SPEC 1915..>2079 CDD:238103 35/184 (19%)
PTZ00121 <1985..2345 CDD:173412 69/373 (18%)
PH_beta_spectrin 2401..2505 CDD:269975 20/115 (17%)
DUF5069 <2473..2540 CDD:374811 8/58 (14%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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