DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Dys and sptbn2

DIOPT Version :9

Sequence 1:NP_001036722.1 Gene:Dys / 42327 FlyBaseID:FBgn0260003 Length:3598 Species:Drosophila melanogaster
Sequence 2:XP_012817859.1 Gene:sptbn2 / 100486199 XenbaseID:XB-GENE-1008690 Length:2437 Species:Xenopus tropicalis


Alignment Length:2809 Identity:573/2809 - (20%)
Similarity:1024/2809 - (36%) Gaps:878/2809 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 LIDERQHIQKKTFTKWINSHLIDTQCTPVKDLFLDLRDGHRLLALLSTLTQTNL-KPEKGRMRVH 69
            |.|||:.:||||||||:||||....|. :.||:.|||||..|:.||..|:...| ||.|||||:|
 Frog    87 LQDEREAVQKKTFTKWVNSHLARVTCR-ISDLYNDLRDGRMLIRLLEVLSGEQLPKPTKGRMRIH 150

  Fly    70 HINNLNKVITEIQQHGVKLVNISSDDIVGGNAKLTLGLIWLIALEFNGQHLVKSHSSNGVEKS-- 132
            .:.|::|.:..:::..|.|.|:.|.|||.||.:|||||||.|.|.|..|.:......|..:||  
 Frog   151 CLENVDKALQFLKEQKVHLENMGSHDIVDGNHRLTLGLIWTIILRFQIQDISVETEDNKEKKSAK 215

  Fly   133 --LLAWARQYTEPH-GLQLNDFSSSWSDGRAFLMILDAHVEE-LNLQAALQQHALKRLHLAFDLA 193
              ||.|.:..|..: .:.:::|::||.||.||..|:..|..: ::.....:.:|...|..||::|
 Frog   216 DALLLWCQMKTAGYPNVNVHNFTTSWRDGLAFNAIVHKHRPDIIDFDTLKKSNAHHNLQNAFNVA 280

  Fly   194 HRHFKIEKLLDAEDVHTHKPDNKSIQMYVMCLYHAMESMRTRQQEQEQDEGQDQDPGRVPCTSIT 258
            .|...:.||||.|||:..:||.|||..||...||....|:....|.::       .|:|      
 Frog   281 ERELGLTKLLDPEDVNVDQPDEKSIITYVATFYHYFSKMKALAVEGKR-------IGKV------ 332

  Fly   259 DLDEVPLDNDQ---TSLGLYTSDSAGSMEQRSSGELKTHSMRPLSTATNASVEISGYQSALEAVL 320
             ||:. ::.||   ...||     |..:.|.....:.|.:.|.|:.:      :||.|:.|:|..
 Frog   333 -LDQA-IEADQLIENYEGL-----ASELLQWIEQMIITLNDRKLANS------LSGVQNQLQAFN 384

  Fly   321 TLLLEDEQLLSQNLPDPQDFQTAK-----LQFHENESFMLKLTEHQEYVGEALEEGSNLINESQK 380
            |.         :.:..|..| |.|     |.|    :...|:..:.:.|....|  ..||::   
 Frog   385 TY---------RTVEKPPKF-TEKGNLEVLLF----TIQSKMRANNQKVYTPRE--GKLISD--- 430

  Fly   381 AGAGLSQEDQNEVRQQMVLLNERWETLRLRALDVQAKILMRLAEFQKQKLEQL----------RQ 435
                               :|:.||  ||...:.:.::.:|....:::|||||          |:
 Frog   431 -------------------INKAWE--RLEKAEHERELALRNELIRQEKLEQLAARFDRKAAMRE 474

  Fly   436 FLTSVEDRISHMSDIGPTLEEAEKQLLEAQKLKADLSEQQELVDSLSSMVVIVNDTSGNFNDLED 500
            ...|...|:....:.|..|...|..|.:.:.::.|:....|.|.:::::...:.  :.|::|:..
 Frog   475 TWLSENQRLVAQDNFGVDLTAVEAALRKHEAIETDILAYSERVQAVNAVADELE--AENYHDVRR 537

  Fly   501 RLSALGERWSHVVKWSDLRKEKLQQYKCISRWLDAREQDLKLMESRDVTDVGGITQRINELNYCA 565
            .|:    |..:|::.||..:|          .:.||.|.|.:.                      
 Frog   538 ILA----RKCNVIRLSDYLRE----------LVTARRQRLHMN---------------------- 566

  Fly   566 KDLLELQRYLIDLRQMVAATLQDGDDKGERVLIQLESYEDRLDALKQIVEVQTVRIETKGFNFGR 630
               |||||...||..::..|   .|.||.   :|.|.|...|..::.:::..|:           
 Frog   567 ---LELQRMFQDLHYLMDWT---EDMKGR---LQSEDYGKHLHGVEDLLQTHTL----------- 611

  Fly   631 DRASYDDSRVVRPEGWVDYQMIIRFGEDDSQEDDDEHDLASKKRKLRNADNFNALENHIMEHFGY 695
                                              .|.|:|.:..::::                 
 Frog   612 ----------------------------------VEADIAVQAERVKS----------------- 625

  Fly   696 VQEVEQKLQQLQRQSLRQQCELLKELQAENSRRCGTLPELKKLYEVCELEDPSRNLLLEETHIKQ 760
            |..|.||..                .:.|..:.|                ||  .|:....|:  
 Frog   626 VTAVAQKFM----------------TEDEGYKPC----------------DP--ELVRNRVHL-- 654

  Fly   761 LEQRYA---NLSQKLSSQQSESH--------------------TLLAKEKYYNSLTGFKLVLADS 802
            ||||||   |||....|:..||.                    .||..:.|...||. .|.|...
 Frog   655 LEQRYAELCNLSAARRSKLEESRRLWKFFWDMGEEEAWIREQSRLLLSDDYGKDLTS-SLRLISK 718

  Fly   803 RDWYKQHAGSASGNE--LEQRLSHMESLASEISEAKTATEELDDNLIEWKQDFGLFYDSWHDMKQ 865
            .:.::   |..||:.  |:|.::..|.|   ||:......|:::.:.|.|       ..|.:|  
 Frog   719 HNAFR---GEMSGHRGPLQQTVAEGEEL---ISKGHFGAGEIEERIKEVK-------GQWTEM-- 768

  Fly   866 ALQALIQQRGGESLSRQLKQIQDFVTKVSNQKVRVSNLEVMQEQQHFLNQLLDEMESLRLTYDNI 930
              :||.:.|     .|:|::...:.                                        
 Frog   769 --EALAEDR-----ERRLREAYSYY---------------------------------------- 786

  Fly   931 PKHLIGEELQTAWNRLPEQLNERVIKQTTAIENLNHFAAEYNA----IIAMLRSAADSKLNGSDG 991
                                               .|.|:.|.    |:..||..:.|:: |.|.
 Frog   787 -----------------------------------QFQADANDAEAWILDTLRLVSTSEV-GHDE 815

  Fly   992 ASSQDL----RKLEIDVISARNFSEILIKEAE---PAQKES--LQSQIRALNTLYDQVEQV--HR 1045
            .|:|.|    :::|.:::|.|...:.|.::|.   ||...|  :..::.||...|:::..:  ||
 Frog   816 YSTQTLVKKHKEIEEEILSHRPAIDALHEQARGLPPAYSHSPEVDGRLPALEQRYEELVALAAHR 880

  Fly  1046 EKKEQQTV----LQSHIDLIQLRLKETDQWLTDLESNTPKSGISDIVNSNELFQSKSRFQTLKET 1106
            ::..|.::    :.|..|...|.:.|.:|||...|       |.:.:...|:.|  .||:||:..
 Frog   881 KQALQDSLALHKMFSEADACLLWIDEKEQWLNVTE-------IPEKLEDLEVVQ--QRFETLEAE 936

  Fly  1107 CERETTQFRDLNERGGELLLQMDELQDQDRESRYGSLAKQFTRINARWTEVTELVYAKTALLE-- 1169
            .....::...:||..|:||     ..||..|:   |:.....::|:||.|..:||..|...|:  
 Frog   937 MNNLASRIASVNEVAGQLL-----TTDQRNEN---SIRDMQDQLNSRWNEFRKLVDQKKGALDSA 993

  Fly  1170 ------HISTQLGEFKKFMVSETGYLDKLENKIRNTPENAADAEEIMEELDDLENVLRSHSEEWL 1228
                  |:  :..|...:|..:|    |:....::...:.|....:..:|..:|..|::      
 Frog   994 LDIQNYHL--ECNETVCWMREKT----KVIESTQSLGNDLAGVTALQRKLTGMERDLKA------ 1046

  Fly  1229 DKIQ-EIGNELIDNEFMADS--------IRR--DIDETVQRWTQLQQQAKKRTELLEQKVSEAEQ 1282
              || ::|:...:.|.:||.        |.|  |||||   |.:|:...|:|.|.|.: .|:.:.
 Frog  1047 --IQGKVGDLRSEAEKLADGHPQKAPAIIGRLSDIDET---WGELKDTMKRREETLGE-ASKLQG 1105

  Fly  1283 SEKCIVQFEKWLTRVDD-ILSDHLDNDVTIVDQPEEFQRL--AHEFVANE-----KNFKEISELI 1339
            ..:.:..|:.||:|... :.|:.:..|:.      |.:||  .||.:.||     .::..:.::.
 Frog  1106 FLRDLDDFQSWLSRAQTAVASEDVPADLA------EAERLLAQHEGIKNEIDHYGADYHRVRDVG 1164

  Fly  1340 DEHTRNGKVGAANRLQEQLNLMEVRFKYCQAKLSKCTAIQHSYESR---LNRAYTDLRNVE---R 1398
            :|.||.........||::|..::..:.    :|.:....:|...|:   ..:...|.:.||   .
 Frog  1165 EEVTRGQTDAQYMFLQQRLKALDTGWN----ELGQMWENRHQLLSQGHSFQQFLKDTKQVEGFLN 1225

  Fly  1399 STEVVDVASAGPNTVQ---TQYQKCLQIYRTLSEIKSEIESTIKTGRRVCEDRYTKSPKQLSQRI 1460
            :.|.|...:..|:|:|   ...::......|:...:.:|:..:::||::.|::...|.| :.:::
 Frog  1226 NQEYVLSHTEMPSTLQAAEAAIKRHEDFLTTMDANEEKIQGLVESGRKLIEEQNVNSEK-IQEKV 1289

  Fly  1461 DAL--KHLYN--TLGENVTQSKATLERLLTLARQLEEC------------------FDSADNLIR 1503
            .::  :|..|  |..|.:|:.|...:    |...|::|                  :|.|.||..
 Frog  1290 TSIDERHKKNQKTASEVLTRLKDNRD----LQHFLQDCQELTLWINEKMLTAQDVSYDEARNLHS 1350

  Fly  1504 RFESPQEVHDRNSILLEFEDVLRRCEDHYNEYNKSCDQSCMVE-------TRQRIDGLKATYHKL 1561
            :::..|          .|...|...:|..::.:|. .|..|.|       .|:::|.|...::.|
 Frog  1351 KWQKHQ----------AFMAELASNKDWLDKIDKE-GQQLMSEKPELEPVVREKLDTLHKLWNDL 1404

  Fly  1562 TS--------------ADII-KRLTEMKTTLQNLDNISLETLRAMEH---DLKEINVPSNPEIEK 1608
            .|              |::. :..:.:::.||||:: .|::    :|   ||..:|:..|.: :.
 Frog  1405 ESTTQSKAQCLFDANRAELFTQSCSALESWLQNLES-QLQS----DHYGKDLTSVNILLNKQ-QM 1463

  Fly  1609 LQQQVIAIVVDVLKTRFNEATTLAARNTSSPDNDDTEIVVVSDTVRQ-----RRARTPQSGESPS 1668
            |:.|        ::.|..|...:.:: ..:...:|..||.|....:.     .:.|.|.:.....
 Frog  1464 LENQ--------MEVREKELEAIQSQ-AQALGQEDANIVEVDSKHKDVADKFSKLRAPLNKRRKL 1519

  Fly  1669 SAHTSSSESPTKGVENS--------PGAVGDQVMPDLLPPQTFRLAESSTLFSQISLNPQKVTNT 1725
            ...:.......:.:|:.        |.|:......| ||.....:.::.||..:|..:..::.:.
 Frog  1520 LLASKEGHQFNRDLEDEILWVKEKMPMAISTDHGKD-LPTVQLLIKKNQTLQKEILGHQPRIDDI 1583

  Fly  1726 PPPKPAKTKRKAPSSPAQVVEIRVKNIQNDKMSVQNIDLEPQQGEIVDTVNILESV-EPFVPE-- 1787
                                      ::..|..:|:..|:||  ||.:.:.:|:|. |....|  
 Frog  1584 --------------------------LERGKSMIQDSSLDPQ--EIEERLGLLKSTWEELAAEGG 1620

  Fly  1788 ---------------YVETVQIVDLSEDSDSSVRVDSQGKE---MRRSKSKHSLNETPLPKVSDN 1834
                           |.:..:......:.:..:..:.:.|:   .:....||.:.|..|...:||
 Frog  1621 KRHARLEESLAAQQFYADAAEAEAWMGEQELHMMSEEKAKDEIGAQAMLKKHLVMEQALDDYADN 1685

  Fly  1835 DEDSAEQEEDLL---RPSAENTSTPFLRVEKRRISFDEKRKRVANERDILRDSEEEEPKTPDTPR 1896
            ....|....|::   .|.::..:....:|:|...|              |:|..||        |
 Frog  1686 IHQLANSSRDMVSRGHPESDRITLRQGQVDKLYAS--------------LKDLAEE--------R 1728

  Fly  1897 AAQVSKPKRWRQLQPEMDALEPESPGRDSFYSPDKESGFDAEPLVFSDDEDIPRFSLEMTSTIDS 1961
            ..::.:..|..||:.:::.||.....|: ..:...|.|.|.|.:....|: ...||.: ||.|..
 Frog  1729 QGKLQEHHRLCQLKRDVEDLEHWISERE-VVAASHELGQDYEHVTMLRDK-FREFSRD-TSNIGQ 1790

  Fly  1962 DS-DTSRIMTPSTKNPNPFLSKVLESLSSPVDDSNVTL---KSPISE---EQPQNLDDR------ 2013
            :. |...:|.              :.|.|.....|.|:   |..::|   :..:.:|.|      
 Frog  1791 ERVDAVNLMA--------------DDLISSGHSENATVADWKDQLNEAWADLLEMIDTRSQMLAA 1841

  Fly  2014 ---VREFDKQAKQMIYKLKLTKAKIEQCHESEAEDLRLLIAPDAATLISQGDSLVLETHGRQGSI 2075
               :..|.:.||:.:.::   :.|.:|..|....||....|........:.|...|..       
 Frog  1842 SYELHRFYQDAKETLGQI---QDKQKQIPEETGRDLNTAEAMQRMHTAFEHDIQALSA------- 1896

  Fly  2076 SRLVMRTQIILREQFREVQQARSKTSGSGAPAPPLDSVNIEELVTK---------GLRRINVL-- 2129
                         |.::||:..|:...:.|.....|....|:.|::         |.||..:|  
 Frog  1897 -------------QVKQVQEDASRLQKAYAGEKAADIHRHEQAVSEAWGELQNASGARRQLLLDT 1948

  Fly  2130 IEKTVDLKSSTDLEKRMEDINERHDDLQVIVSAIGKNAQMPKVTPLMMNEIEKTKNNLIAHADS- 2193
            :||....:...||...|:|||       :::.|..|...:.....::.|.: ..|..:.|.||| 
 Frog  1949 VEKFRFFRMVRDLMLWMDDIN-------LLIDAQEKPRDVSSADLVIQNHL-GIKAEVDARADSF 2005

  Fly  2194 ---IEL--SLTELRN--GPRISNGKERPDASSAATMSCRSEYNNEPSGTGALAGSFDKSVLQISD 2251
               |:|  ||.|..:  ..:||...|:       ....|.|..|:                    
 Frog  2006 TTCIDLGNSLLEKNHYASDKISEKLEQ-------LQERRQETENK-------------------- 2043

  Fly  2252 WLTWEQNMI---KIQSVLV--DDGDAVRLAIEKQEKVLRELKMKKPQLNELVHTAEVLKGDVKRQ 2311
               |:..|.   .:..||:  .|.......:..||.::|.        :||....:.::..:||.
 Frog  2044 ---WKDKMAWLRVVHEVLMFGRDASVAEAWLASQEPIVRS--------SELGGNVDEVESLIKRH 2097

  Fly  2312 QLQEKELKQFSLAPHCSADLDYMRCCLKVTRLREHWDETSQCVLQRAAQLKNMLSDSQRFEAKR- 2375
            :..:|.:..                          |||.. .:|::...|:.:....:|.|.:| 
 Frog  2098 EAFQKAVST--------------------------WDERF-VLLEKLTTLEEIEMRRKREEEERK 2135

  Fly  2376 -------LELEKWLARMEQRAERMGT-IATT-------ADILEAQ-QKEQKSFHAELHQNKQHFD 2424
                   |.:|      |.|.|.:.| ::.|       |:||:.: ...|.||..::.       
 Frog  2136 KRPPTPPLPVE------EPREEVVKTQVSQTIEGQTDPANILQERINGMQNSFQEQVS------- 2187

  Fly  2425 IFNELTQKLIAVYPNDDTTRIK-----------------KMTEV--------------------- 2451
             .|.|..:..:..|:.||.|::                 ..|||                     
 Frog  2188 -VNGLCTESDSPQPSSDTQRLEDSISENQGPEQSDVTNGARTEVITKDGSPTPSPQLVARPTFSP 2251

  Fly  2452 INQRYANLNS------------GVINRGKQLHAAVHSLQSFDRAMDQFLAFLSETETLCENAESD 2504
            ||.:|:.|.|            |:::|.:::.:  |:.::.:|:.              :|....
 Frog  2252 INLQYSTLPSSPTEPLASEQMEGMLHRKQEMDS--HNKKAANRSW--------------QNVYCA 2300

  Fly  2505 IERNPL-MFKDLQS 2517
            ::|..| .:||.:|
 Frog  2301 LKRGSLGFYKDAKS 2314

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DysNP_001036722.1 CH 13..111 CDD:278723 51/98 (52%)
CH 129..225 CDD:278723 35/101 (35%)
SPEC 312..525 CDD:238103 44/227 (19%)
SbcC <325..957 CDD:223496 111/671 (17%)
Smc <816..1591 CDD:224117 172/875 (20%)
SPEC 1174..1365 CDD:238103 47/209 (22%)
SPEC 1289..1485 CDD:295325 43/216 (20%)
SPEC 2369..2576 CDD:238103 40/217 (18%)
SPEC 2477..2714 CDD:238103 7/42 (17%)
WW 2852..2882 CDD:238122
EF-hand_2 2883..2997 CDD:286194
EF-hand_3 3001..3100 CDD:286195
ZZ_dystrophin 3110..3158 CDD:239074
sptbn2XP_012817859.1 CH 94..197 CDD:237981 53/103 (51%)
CH 213..316 CDD:237981 36/102 (35%)
Spectrin 341..451 CDD:278843 30/160 (19%)
SPEC 465..563 CDD:197544 21/113 (19%)
SPEC 568..783 CDD:238103 66/341 (19%)
SPEC 681..888 CDD:238103 52/305 (17%)
SPEC 785..994 CDD:238103 58/301 (19%)
SPEC 997..1206 CDD:238103 50/236 (21%)
SPEC 1210..1419 CDD:238103 41/224 (18%)
SPEC 1420..1630 CDD:238103 41/253 (16%)
SPEC 1527..1734 CDD:238103 39/257 (15%)
SPEC 1632..1843 CDD:238103 45/249 (18%)
SPEC 1844..2051 CDD:238103 52/267 (19%)
SPEC 2060..>2117 CDD:197544 13/91 (14%)
PH 2272..2378 CDD:278594 10/59 (17%)
PH_beta_spectrin 2272..2377 CDD:269975 10/59 (17%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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