Protein Alignment Dys and Dytn

DIOPT Version :10

• Sequence 1: NP_001036722.1
• Gene: Dys / 42327
• FlyBaseID: FBgn0260003
• Length: 3598
• Species: Drosophila melanogaster
• Sequence 2: XP_003750755.3
• Gene: Dytn / 100361043
• RGDID: 2320917
• Length: 648
• Species: Rattus norvegicus
• Alignment Length: 684
• Identity: 170/684 - (24%)
• Similarity: 275/684 - (40%)
• Gaps: 169/684 - (24%)

  Fly  2892 LNEIRFSAYRTAMKLRSVQKRLALDRISMSTACESFDRHGLRAQNDKLIDIPDMTTVLHSLY--- 2953
            ||.|..|.||||.||||:|....||.:|.|...:......|.......|.:..:...|..|:
  Rat     9 LNRIENSVYRTAFKLRSIQTLCQLDLMSSSLIQQVLWHEHLGEVTVTSISVQQLFQELRELFQRT 73

  Fly  2954 -------VTIDKIDLTLMLDLAINWILNVYDSQRTGQIRVLSFKVGLVLLCKGHLEEKYRYLFRL 3011
                   |.....:|||.|      ::.::|...:|.:::......||.|.......|||.||:|
  Rat    74 GMGSPVQVHPRAPELTLSL------LMAMFDRTGSGILKLQPVAAALVALSGDSPLTKYRALFQL 132

  Fly  3012 VADTDRRADQ-------RRLGLLLHDCIQVPRQLGEVAAFGGSNIEPSVRSCLEQAGISQEAIDG 3069
            .|:.:||.|:       |.|..||.|..|:|..:||..:.  ..:|.::.||..          |
  Rat   133 YAENNRRGDESQARMTRRVLRALLTDLQQIPTVVGESCSL--CPVESAIHSCFR----------G 185

  Fly  3070 NQDISIELQHFLGWLQHEPQSLVWLPVLHRLAAAEAAKHQAKCNICKEYPIVGFRYRCLKCFNFD 3134
            .....|:.:.||.|.|.||...:|||..:||:|:|...|..:|::|:.:||:|.|||||||.:||
  Rat   186 VLSFGIKEEKFLSWAQSEPLVFLWLPTCYRLSASETVTHPVRCSVCRSFPIIGLRYRCLKCLDFD 250

  Fly  3135 MCQKCFFFGRNAKNHKLTHPMHEYCTTTTSTEDVRDFTRALKNKFKSRKYFKKHPRVGYLPVQSV 3199
            :|:.||..|.:.|:|:.:|.:.|.|...::||:.:...|:|:|....|     |.|.|.:..|.:
  Rat   251 ICELCFLSGLHKKSHQKSHTVMEDCVQMSATENTKLLFRSLRNNLPLR-----HHRAGAVGRQWL 310

  Fly  3200 LEGDALESPAPSPQHTTHQLQNDMHSRLEMYASRLAQVEYGGTGSNSTPDSDDEHQLIAQYCQAL 3264
            |:                                  |:..|.:||     |..:.:|..||
  Rat   311 LD----------------------------------QLASGDSGS-----SHGQARLCIQY---- 332

  Fly  3265 PGTSNGSAPKSPVQVMAAMDAEQREELEAIIRDLEEENANLQAEYQQLCSKEQSGMPEDSNGMQH 3329
                  ..||:||...:|              ...|..|..:..:  ||.:....:....:..:|
  Rat   333 ------KGPKTPVYASSA--------------GAVETAATERTRF--LCQRSSPALQAIDSPHRH 375

  Fly  3330 SSSSMTGLSGQGEQGQD----MMAEAKLLR----QHKGRLEARMQILEDHNRQLE---------- 3376
             .|::..:..:..:.:|    :..|.:.||    ::|.:|:....:.|:.|.:.|
  Rat   376 -GSTVVNIKNELWRTRDSVNALHRERRFLRKQLQRYKHKLQGTYTLQENQNCRFETKIRELTINQ 439

  Fly  3377 ----AQLQRLRQ----LLDEPNGGGSSATSSGL-PSAPGSALNSKPNTLQTRSVTASQLNTDSP- 3431
                .:||::|:    :|..|.......|...: .|.|...|....|:...:|||     .|||
  Rat   440 DNLWTKLQQMRRDLQAMLQPPRPSSPQTTVLKIVHSLPDDGLWRGGNSSHIKSVT-----RDSPE 499

  Fly  3432 -------AKMNQQNGHYEHNSKGIMLPGMNS-EIQQQHAQLASLAAKHHQHQLSGALNALHQQQQ 3488
                   ||:|::  |....|.|.:.|...| ||..|     |.:.:.|..::...:::....:|
  Rat   500 WEPLPNSAKVNRK--HKCQASSGKVPPDSESPEIIFQ-----STSKQSHPQKMPREVHSSPSARQ 557

  Fly  3489 QQLQ---QQPPQQQRSMMTGNGGMDISGGMQTSG 3519
            ::||   |.||            .::|...||.|
  Rat   558 EELQDSLQIPP------------TEVSSPTQTPG 579

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dys	NP_001036722.1	CH_DMD-like_rpt1	12..118	CDD:409035
		CH_SF	129..229	CDD:469584
		SPEC	312..525	CDD:238103
		PRK03918	<716..1238	CDD:235175
		SMC_prok_B	<995..1279	CDD:274008
		SPEC	1174..1365	CDD:238103
		SPEC	1289..1485	CDD:413338
		SPEC	2369..2576	CDD:238103
		SPEC	2477..2714	CDD:238103
		WW	2852..2882	CDD:238122
		EFh_DMD_like	2919..3085	CDD:320000	43/182 (24%)
		EF-hand-like motif	2919..2958	CDD:320000	7/48 (15%)
		EF-hand-like motif	2961..2995	CDD:320000	7/33 (21%)
		EF-hand-like motif	3001..3037	CDD:320000	17/42 (40%)
		EF-hand-like motif	3050..3085	CDD:320000	8/34 (24%)
		ZZ_dystrophin	3110..3158	CDD:239074	21/47 (45%)
Dytn	XP_003750755.3	EFh_DMD_DYTN_DTN	36..201	CDD:352774	43/182 (24%)
		EF-hand-like motif	36..75	CDD:320001	6/38 (16%)
		EF-hand-like motif	82..116	CDD:320001	7/39 (18%)
		EF-hand-like motif	122..165	CDD:320001	17/42 (40%)
		EF-hand-like motif	176..201	CDD:320001	8/34 (24%)
		ZZ	226..273	CDD:412288	21/46 (46%)