DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dys and Dytn

DIOPT Version :9

Sequence 1:	NP_001036722.1	Gene:	Dys / 42327	FlyBaseID:	FBgn0260003	Length:	3598	Species:	Drosophila melanogaster
Sequence 2:	XP_003750755.3	Gene:	Dytn / 100361043	RGDID:	2320917	Length:	648	Species:	Rattus norvegicus

Alignment Length:	684	Identity:	170/684 - (24%)
Similarity:	275/684 - (40%)	Gaps:	169/684 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly  2892 LNEIRFSAYRTAMKLRSVQKRLALDRISMSTACESFDRHGLRAQNDKLIDIPDMTTVLHSLY--- 2953
            ||.|..|.||||.||||:|....||.:|.|...:......|.......|.:..:...|..|:
  Rat     9 LNRIENSVYRTAFKLRSIQTLCQLDLMSSSLIQQVLWHEHLGEVTVTSISVQQLFQELRELFQRT 73

  Fly  2954 -------VTIDKIDLTLMLDLAINWILNVYDSQRTGQIRVLSFKVGLVLLCKGHLEEKYRYLFRL 3011
                   |.....:|||.|      ::.::|...:|.:::......||.|.......|||.||:|
  Rat    74 GMGSPVQVHPRAPELTLSL------LMAMFDRTGSGILKLQPVAAALVALSGDSPLTKYRALFQL 132

  Fly  3012 VADTDRRADQ-------RRLGLLLHDCIQVPRQLGEVAAFGGSNIEPSVRSCLEQAGISQEAIDG 3069
            .|:.:||.|:       |.|..||.|..|:|..:||..:.  ..:|.::.||..          |
  Rat   133 YAENNRRGDESQARMTRRVLRALLTDLQQIPTVVGESCSL--CPVESAIHSCFR----------G 185

  Fly  3070 NQDISIELQHFLGWLQHEPQSLVWLPVLHRLAAAEAAKHQAKCNICKEYPIVGFRYRCLKCFNFD 3134
            .....|:.:.||.|.|.||...:|||..:||:|:|...|..:|::|:.:||:|.|||||||.:||
  Rat   186 VLSFGIKEEKFLSWAQSEPLVFLWLPTCYRLSASETVTHPVRCSVCRSFPIIGLRYRCLKCLDFD 250

  Fly  3135 MCQKCFFFGRNAKNHKLTHPMHEYCTTTTSTEDVRDFTRALKNKFKSRKYFKKHPRVGYLPVQSV 3199
            :|:.||..|.:.|:|:.:|.:.|.|...::||:.:...|:|:|....|     |.|.|.:..|.:
  Rat   251 ICELCFLSGLHKKSHQKSHTVMEDCVQMSATENTKLLFRSLRNNLPLR-----HHRAGAVGRQWL 310

  Fly  3200 LEGDALESPAPSPQHTTHQLQNDMHSRLEMYASRLAQVEYGGTGSNSTPDSDDEHQLIAQYCQAL 3264
            |:                                  |:..|.:||     |..:.:|..||
  Rat   311 LD----------------------------------QLASGDSGS-----SHGQARLCIQY---- 332

  Fly  3265 PGTSNGSAPKSPVQVMAAMDAEQREELEAIIRDLEEENANLQAEYQQLCSKEQSGMPEDSNGMQH 3329
                  ..||:||...:|              ...|..|..:..:  ||.:....:....:..:|
  Rat   333 ------KGPKTPVYASSA--------------GAVETAATERTRF--LCQRSSPALQAIDSPHRH 375

  Fly  3330 SSSSMTGLSGQGEQGQD----MMAEAKLLR----QHKGRLEARMQILEDHNRQLE---------- 3376
             .|::..:..:..:.:|    :..|.:.||    ::|.:|:....:.|:.|.:.|
  Rat   376 -GSTVVNIKNELWRTRDSVNALHRERRFLRKQLQRYKHKLQGTYTLQENQNCRFETKIRELTINQ 439

  Fly  3377 ----AQLQRLRQ----LLDEPNGGGSSATSSGL-PSAPGSALNSKPNTLQTRSVTASQLNTDSP- 3431
                .:||::|:    :|..|.......|...: .|.|...|....|:...:|||     .|||
  Rat   440 DNLWTKLQQMRRDLQAMLQPPRPSSPQTTVLKIVHSLPDDGLWRGGNSSHIKSVT-----RDSPE 499

  Fly  3432 -------AKMNQQNGHYEHNSKGIMLPGMNS-EIQQQHAQLASLAAKHHQHQLSGALNALHQQQQ 3488
                   ||:|::  |....|.|.:.|...| ||..|     |.:.:.|..::...:::....:|
  Rat   500 WEPLPNSAKVNRK--HKCQASSGKVPPDSESPEIIFQ-----STSKQSHPQKMPREVHSSPSARQ 557

  Fly  3489 QQLQ---QQPPQQQRSMMTGNGGMDISGGMQTSG 3519
            ::||   |.||            .::|...||.|
  Rat   558 EELQDSLQIPP------------TEVSSPTQTPG 579

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dys	NP_001036722.1	CH	13..111	CDD:278723
		CH	129..225	CDD:278723
		SPEC	312..525	CDD:238103
		SbcC	<325..957	CDD:223496
		Smc	<816..1591	CDD:224117
		SPEC	1174..1365	CDD:238103
		SPEC	1289..1485	CDD:295325
		SPEC	2369..2576	CDD:238103
		SPEC	2477..2714	CDD:238103
		WW	2852..2882	CDD:238122
		EF-hand_2	2883..2997	CDD:286194	30/114 (26%)
		EF-hand_3	3001..3100	CDD:286195	33/105 (31%)
		ZZ_dystrophin	3110..3158	CDD:239074	21/47 (45%)
Dytn	XP_003750755.3	EFh_DMD_DYTN_DTN	36..201	CDD:352774	43/182 (24%)
		EF-hand-like motif	36..76	CDD:319999	6/39 (15%)
		EF-hand-like motif	82..116	CDD:319999	7/39 (18%)
		EF-hand-like motif	122..165	CDD:319999	17/42 (40%)
		EF-hand-like motif	176..201	CDD:319999	8/34 (24%)
		ZZ	226..273	CDD:412288	21/46 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910