Protein Alignment Dys and actn3

DIOPT Version :10

• Sequence 1: NP_001036722.1
• Gene: Dys / 42327
• FlyBaseID: FBgn0260003
• Length: 3598
• Species: Drosophila melanogaster
• Sequence 2: NP_001135513.1
• Gene: actn3 / 100216053
• XenbaseID: XB-GENE-920242
• Length: 896
• Species: Xenopus tropicalis
• Alignment Length: 1113
• Identity: 236/1113 - (21%)
• Similarity: 419/1113 - (37%)
• Gaps: 350/1113 - (31%)

  Fly     5 ILID---ERQHIQKKTFTKWINSHLIDTQCTPVKDLFLDLRDGHRLLALLSTLTQTNL-KPEKGR 65
            :|:|   |:|  |:||||.|.||||.... |.::::..|.|:|.:|:.||..::...| ||:||:
 Frog    32 LLLDPAWEKQ--QRKTFTAWCNSHLRKAG-TQIENIEEDFRNGLKLMLLLEVISGERLPKPDKGK 93

  Fly    66 MRVHHINNLNKVITEIQQHGVKLVNISSDDIVGGNAKLTLGLIWLIALEFNGQHLVKSHSSNGVE 130
            ||.|.|.|:||.:..|...|||||:|.:::||.||.|:|||:||.|.|.|..|.:  |......:
 Frog    94 MRFHKIANVNKALDFIASKGVKLVSIGAEEIVDGNLKMTLGMIWTIILRFAIQDI--SVEETSAK 156

  Fly   131 KSLLAWARQYTEPH-GLQLNDFSSSWSDGRAFLMILDAHVEELNLQAALQQ-HALKRLHLAFDLA 193
            :.||.|.::.|.|: .:.:.:|..||.||.|...::..|..:|...:.|:: ..:..|:.|||:|
 Frog   157 EGLLLWCQRKTAPYRNVNVQNFHISWKDGLALCALIHRHRPDLIDYSKLRKDDPIGNLNTAFDVA 221

  Fly   194 HRHFKIEKLLDAED-VHTHKPDNKSIQMYVMCLYHAMESMRTRQQEQEQDEGQDQDPGRVPCTSI 257
            .::..|.|:||||| |:|.|||.|:|..||.|.|||.             .|.:|  .......|
 Frog   222 EKYLDIPKMLDAEDIVNTPKPDEKAIMTYVSCFYHAF-------------AGAEQ--AETAANRI 271

  Fly   258 TDLDEVPLDNDQTSLGLYTSDSAGSME--QRSSGELKTHSMRPLSTATNASVEISGYQSALEAVL 320
            ..:..|..:|::.            ||  ::.:.||.....|.:....|.:.|
 Frog   272 CKVLAVNQENEKL------------MEEYEKLASELLEWIRRTIPWLENRTPE------------ 312

  Fly   321 TLLLEDEQLLSQNLPDPQDFQTA--------KLQFHENESFM---LKLTEHQEYVGEALEEGSNL 374
                ::...:.:.|.|.:|::..        |.|...|.:.:   |:|:....::.   .|| .:
 Frog   313 ----KNMGAMQKKLEDFRDYRRVHKPPRVQEKCQLEINFNTLQTKLRLSNRPAFMP---SEG-KM 369

  Fly   375 INESQKAGAGLSQEDQNEVRQQMVLLNERWETLRLRALDVQAKILMRLAEFQKQKLEQLRQFLTS 439
            :::...|..||.|.::.         .|.|..|.:|.|:    .|..|||..|||......:...
 Frog   370 VSDIANAWKGLEQVEKG---------YEEWLLLEIRRLE----RLEHLAEKFKQKASLHESWTRG 421

  Fly   440 VEDRISHMSDIGPTLEEAEKQLLEAQKLKADLSEQQELVDSLSSMVVIVNDTSGNFND---LEDR 501
            .|:.::.......:|.|....:.:.:..::||:..|:.|:.::::...:|:.  :::|   :..|
 Frog   422 KEELLTQRDYESASLMEIRALVRKHEAFESDLAAHQDRVEQIAAIAQELNEL--DYHDAASVNSR 484

  Fly   502 LSALGERWSHVVKWSDLRKEKLQQYKCI------------------SRWLDAREQDLKLMESRDV 548
            ..|:.::|.::...:..|::.|::.:.:                  :.|:|...:||:.|
 Frog   485 CQAICDQWDNLGTLTQKRRDALERVEKLLETIDQLYLEFAKRAAPFNNWMDGAVEDLQDM----- 544

  Fly   549 TDVGGITQRINELNYCAKDLLELQRYLIDLRQMVAATLQDGDDKGERVL-IQLESYEDRLDALKQ 612
                          :....:.|:|. ||...:...|||.:.|.:...:| ||.|        :::
 Frog   545 --------------FIVHSIEEIQS-LITAHEQFKATLPEADKEKMSILGIQAE--------IQK 586

  Fly   613 IVEVQTVRIETKGFNFGRDRASYDDSRVVRPEGWVDYQMIIRFGEDDSQEDDDEHDLASKKRKLR 677
            |  .||..|:..|.|...:....|.|     ..|...:.::...:...||     :||.::...|
 Frog   587 I--AQTYGIKLSGINPYTNLTHLDIS-----NKWETVKQLVPHRDQTLQE-----ELARQQANER 639

  Fly   678 NADNFNALENHIMEHFGYVQEVEQKLQQLQRQSLRQQCELLKELQAENSRRCGTLPELKKLYEVC 742
            ....|.|..|.|...      ::.|::::.|.|:
 Frog   640 LRRQFAAQANVIGPW------IQSKMEEIGRISV------------------------------- 667

  Fly   743 ELEDPSRNLLLEETHIKQLEQRYANLSQKLSSQQSESHTLLAKEKYYNSLTGFKLVLADSRDWYK 807
               |.|.:|..:..|:||.||...:                                      ||
 Frog   668 ---DISASLEDQMNHLKQYEQNIIS--------------------------------------YK 691

  Fly   808 QHAGSASGNELEQRLSHMESLASEISEAKTATEELDDNLIEWKQDFGLFYDSWHDMKQALQALIQ 872
            .:.....|                           |..||:    ..|.:|:.|
 Frog   692 SNIDKLEG---------------------------DHQLIQ----ESLIFDNKH----------- 714

  Fly   873 QRGGESLSRQLKQIQDFVTKVSNQKVRVSNLEVMQEQQHFLNQLLDEMESLRLTYDNIPKHLIGE 937
                              |..|.:.:||...:::..    :.:.::|:|:..||.|
 Frog   715 ------------------TNYSMEHIRVGWEQLLTT----IARTINEVENQILTRD--------- 748

  Fly   938 ELQTAWNRLPEQLNERVIKQTTAIENLNHFAAEYNAIIAMLRSAADSKLNGSDG---------AS 993
                          .:.|.|    |.:|.|.|.:|..        |.|.||...         :.
 Frog   749 --------------AKGISQ----EQMNEFRASFNHF--------DRKRNGMMDPDDFRACLISM 787

  Fly   994 SQDLRKLE-------ID-----VISARNFSEILIK---EAEPAQKESLQSQIRALNTLYDQVEQV 1043
            ..||.::|       :|     |::.:.|.:.:.:   |.:.|::.....:|.|.:..|..:|::
 Frog   788 GYDLGEVEFARIMTLVDPNNTGVVTFQAFIDFMTRETAETDTAEQVMASFKILASDKSYITIEEL 852

  Fly  1044 HREKKEQQ 1051
            .||...:|
 Frog   853 RRELPPEQ 860

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dys	NP_001036722.1	CH_DMD-like_rpt1	12..118	CDD:409035	49/106 (46%)
		CH_SF	129..229	CDD:469584	38/102 (37%)
		SPEC	312..525	CDD:238103	40/226 (18%)
		PRK03918	<716..1238	CDD:235175	52/360 (14%)
		SMC_prok_B	<995..1279	CDD:274008	15/72 (21%)
		SPEC	1174..1365	CDD:238103
		SPEC	1289..1485	CDD:413338
		SPEC	2369..2576	CDD:238103
		SPEC	2477..2714	CDD:238103
		WW	2852..2882	CDD:238122
		EFh_DMD_like	2919..3085	CDD:320000
		EF-hand-like motif	2919..2958	CDD:320000
		EF-hand-like motif	2961..2995	CDD:320000
		EF-hand-like motif	3001..3037	CDD:320000
		EF-hand-like motif	3050..3085	CDD:320000
		ZZ_dystrophin	3110..3158	CDD:239074
actn3	NP_001135513.1	CH_ACTN_rpt1	37..141	CDD:409063	49/106 (46%)
		CH_ACTN_rpt2	145..259	CDD:409065	41/128 (32%)
		Spectrin	283..392	CDD:395348	23/149 (15%)
		SPEC	404..631	CDD:238103	48/268 (18%)
		Spectrin	639..742	CDD:395348	30/244 (12%)
		EFh	759..821	CDD:238008	13/69 (19%)
		EFhand_Ca_insen	826..892	CDD:430177	9/35 (26%)