DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dys and drp2

DIOPT Version :9

Sequence 1:	NP_001036722.1	Gene:	Dys / 42327	FlyBaseID:	FBgn0260003	Length:	3598	Species:	Drosophila melanogaster
Sequence 2:	NP_001096188.1	Gene:	drp2 / 100124737	XenbaseID:	XB-GENE-994502	Length:	930	Species:	Xenopus tropicalis

Alignment Length:	939	Identity:	358/939 - (38%)
Similarity:	523/939 - (55%)	Gaps:	104/939 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly  2508 NPLMFKDLQSEIETHRVVYDR--------LDGTGRKLLGSLTSQEDAVMLQRRLDEMNQRWNNLK 2564
            :|::.:|     ..|.::.|:        .|.|.:  |..:...|::...|.: .|||..||.:|
Frog     2 HPMVMQD-----GAHCLLTDQWHHSSTATSDSTNQ--LSQVPDSEESSASQIQ-PEMNLCWNEIK 58

  Fly  2565 SKSIAIRNRLESNSEHWNALLLSLRELTEWVIRKDTELSTLGLGPVRGDAVSLQKQLDDHKAFRR 2629
            .||.::|.|||:.|:....|...|:|:.:|:.:||.|||  ...|:|||..|:|:..|.|..|..
Frog    59 KKSQSLRARLEAFSDPTLKLHPPLQEIIDWLGQKDEELS--AQLPLRGDLSSVQQAKDKHVTFME 121

  Fly  2630 QLEDKRPIVESNLTSGRQYIANEAAVSDTSDTEANHDSDSRYMSAEEQSRELTRSIRREVGKLSE 2694
            :::.:.|.:.|.|.|.:.::.......:..|.....||..|     .::..|:|.:.::....||
Frog   122 EVKSRGPYIYSVLESAQTFLTQHPFSDEEEDATQGKDSSPR-----SKAETLSRLLWKQASVASE 181

  Fly  2695 QWNNLIDRSDNWKHRLDEYMTKMRQFQKILEDLSSRVALAEQTKTSWLP---------PSSVGEA 2750
            .|:.|..||.:....|:..:.::::....:::....:...|..:.||.|         |..:...
Frog   182 LWDRLTARSLDQHRHLERTLEQIQELGISMKEAGDSIGQGESVQASWEPIGDLFIDSLPDHIQTT 246

  Fly  2751 NEQMQQLQRLRDKMTTASAL---LDDCNEQQSFFTANQVLVPTPCLSKLEDLNTRMKLLQIAMDE 2812
            ....::|..::|.:..|:.|   |..|:...|...|.:          ||::|:|.|.||.::.|
Frog   247 KLFKEELSPIKDMVKLANDLAHQLALCDVHLSMENARE----------LENINSRWKQLQTSVGE 301

  Fly  2813 RQKVLCQAGAQQTHENGDDGRTTSNSGTIGPLPN--LGQSVKPPWERATTAANVPYYIDHERETT 2875
            |.:.|     |..|.:            .||...  |..||:.|||||.:...|||||:|:.:||
Frog   302 RLRQL-----QDAHRD------------FGPESQHFLSSSVQVPWERAISPNKVPYYINHQAQTT 349

  Fly  2876 HWDHPEMIELMKGLADLNEIRFSAYRTAMKLRSVQKRLALDRISMSTACESFDRHGLRAQNDKLI 2940
            .||||:|.||.:.|.|||.|:|||||||||||.|||.|.||.:::....:.|....|::. ::.:
Frog   350 CWDHPKMTELYQALGDLNNIKFSAYRTAMKLRRVQKALRLDLVTLPLLTQIFTCDTLQSP-ERNL 413

  Fly  2941 DIPDMTTVLHSLYVTIDK-----IDLTLMLDLAINWILNVYDSQRTGQIRVLSFKVGLVLLCKGH 3000
            |:.|:...|.|||..:::     :::.|.:||.:||:|||:|..|.|:|||||||.|:|.||...
Frog   414 DVLDVIRCLSSLYERLEEERGLLVNVPLCVDLTLNWLLNVFDGARNGRIRVLSFKAGIVSLCDCD 478

  Fly  3001 LEEKYRYLFRLVADTDRRADQRRLGLLLHDCIQVPRQLGEVAAFGGSNIEPSVRSCLEQAGISQE 3065
            ::.|.:|||..||......|||:||||||:.||:||||||||||||||:|||||||..
Frog   479 VKGKLQYLFSQVASPGNTCDQRQLGLLLHEAIQIPRQLGEVAAFGGSNVEPSVRSCFR------- 536

  Fly  3066 AIDGNQDISIELQHFLGWLQHEPQSLVWLPVLHRLAAAEAAKHQAKCNICKEYPIVGFRYRCLKC 3130
              .||....:||..||.|...||||:||||||||:..||..||||||::||:.|:.|||||.||.
Frog   537 --FGNGTAHLELAQFLEWGCLEPQSMVWLPVLHRVTLAETVKHQAKCSVCKQCPMKGFRYRSLKQ 599

  Fly  3131 FNFDMCQKCFFFGRNAKNHKLTHPMHEYCTTTTSTEDVRDFTRALKNKFKSRKYFKKHPRVGYLP 3195
            |..|:||.||..|:..|.:||.:|:.||.|.|||.|.:|||...|||||::|:||.:||:.||||
Frog   600 FGVDICQSCFLTGQAGKVNKLHYPIMEYYTPTTSGEKMRDFATTLKNKFRTRQYFSRHPQRGYLP 664

  Fly  3196 VQSVLEGDALESPAPSPQ--HTTHQLQNDMHSRLEMYASRLAQVEYGG----TGSNSTPDSDDEH 3254
            ||||||.:..::||.||.  |.      |.|||:|.:|||||::|...    |.|.|..||.||.
Frog   665 VQSVLEAEVADTPASSPMLPHA------DTHSRIEHFASRLAEMESQNCSFFTDSLSPDDSLDED 723

  Fly  3255 QLIAQYCQALPGTSNGSAPKSPVQVMAAMDAEQREELEAIIRDLEEENANLQAEYQQLCSKEQSG 3319
            |.:.::...:......:.|:.|..:   ...|::.|||.|:..||.||..||.|.::|  |.|..
Frog   724 QYLLRHSSPITDRDPSNTPQIPGNL---NPEEEQGELEKILAHLEHENRILQGELKRL--KWQHA 783

  Fly  3320 MPEDSNGMQHSSSSMTGLSGQGE-QGQDMMAEAKLLRQHKGRLEARMQILEDHNRQLEAQLQRLR 3383
            ...:.:.:...|..:.| :|.|| |.:::::||::||.||.|||.|||||||||:|||:||:|||
Frog   784 EAGEVSALGEVSPDVGG-NGVGEAQSEELLSEARILRHHKNRLETRMQILEDHNKQLESQLRRLR 847

  Fly  3384 QLLDEPNGGGSSATSSGLPSAPGSALNSK 3412
            :||.:||      |..|.||:..|:.:|:
Frog   848 ELLLQPN------TDEGKPSSSSSSPDSQ 870

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dys	NP_001036722.1	CH	13..111	CDD:278723
		CH	129..225	CDD:278723
		SPEC	312..525	CDD:238103
		SbcC	<325..957	CDD:223496
		Smc	<816..1591	CDD:224117
		SPEC	1174..1365	CDD:238103
		SPEC	1289..1485	CDD:295325
		SPEC	2369..2576	CDD:238103	20/75 (27%)
		SPEC	2477..2714	CDD:238103	57/213 (27%)
		WW	2852..2882	CDD:238122	17/29 (59%)
		EF-hand_2	2883..2997	CDD:286194	52/118 (44%)
		EF-hand_3	3001..3100	CDD:286195	56/98 (57%)
		ZZ_dystrophin	3110..3158	CDD:239074	24/47 (51%)
drp2	NP_001096188.1	SPEC	82..310	CDD:238103	58/249 (23%)
		WW	328..356	CDD:238122	17/27 (63%)
		EFh_DRP-2	393..554	CDD:320006	75/170 (44%)
		EF-hand-like motif	393..431	CDD:320006	8/38 (21%)
		EF-hand-like motif	439..473	CDD:320006	19/33 (58%)
		EF-hand-like motif	479..515	CDD:320006	18/35 (51%)
		EF-hand-like motif	528..554	CDD:320006	14/34 (41%)
		ZZ	579..627	CDD:294208	24/47 (51%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	126	1.000	Domainoid score	I5336
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D46278at33208
OrthoFinder	1	1.000	-	-		FOG0001792
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4540
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.040