DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Scsalpha2 and LSC1

DIOPT Version :9

Sequence 1:	NP_650809.1	Gene:	Scsalpha2 / 42326	FlyBaseID:	FBgn0038708	Length:	342	Species:	Drosophila melanogaster
Sequence 2:	NP_014785.3	Gene:	LSC1 / 854310	SGDID:	S000005668	Length:	329	Species:	Saccharomyces cerevisiae

Alignment Length:	311	Identity:	169/311 - (54%)
Similarity:	216/311 - (69%)	Gaps:	4/311 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 RGKADYGKTVCNLKINKATKVLVQGFTGKQATFHSEESIKYGTNIVGGVNPKKGGTEHLGKPVFK 85
            |....|.||:.||.:.|.|||:.|||||||.|||:..|.:||||:|||.||||.|..|||:|||.
Yeast    19 RESIPYDKTIKNLLLPKDTKVIFQGFTGKQGTFHASISQEYGTNVVGGTNPKKAGQTHLGQPVFA 83

  Fly    86 SVAEAVEKAKPDATVIFIPPPSAAEGICAAIESEIGLIVAITEGIPQADMVRISQMLNCQEKSRL 150
            ||.:|:::....|:.||:|||.||..|..:||:||.|.|.|||||||.||:.|::||..|:|:||
Yeast    84 SVKDAIKETGATASAIFVPPPIAAAAIKESIEAEIPLAVCITEGIPQHDMLYIAEMLQTQDKTRL 148

  Fly   151 LGPNCPGIISP-DQCKIGIMPGDIHKRGVVGIVSRSGTLTYESVHQTTNVGLGQALCVGLGGDPF 214
            :||||||||:| .:.:|||.|..|.:.|.:||:|||||||||:|.|||...|||:|.:|:|||.|
Yeast   149 VGPNCPGIINPATKVRIGIQPPKIFQAGKIGIISRSGTLTYEAVQQTTKTDLGQSLVIGMGGDAF 213

  Fly   215 NGTSFIDALKVFLSDKEIKGIVMIGEIGGSAEEEAADFLKEKN-TGCEAKPVVGFIAGQTA--PP 276
            .||.||||||:||.|:..:||:|:|||||.||.|||.||||.| :..:..||..||||..|  ..
Yeast   214 PGTDFIDALKLFLEDETTEGIIMLGEIGGKAEIEAAQFLKEYNFSRSKPMPVASFIAGTVAGQMK 278

  Fly   277 GRRMGHAGAIISGGKGAAKDKVAALEKAGVRMTANPCHLGSTLLEEMIRLK 327
            |.||||:|||:.|....|:.|..||...||.:..:|.:||..||::..:.|
Yeast   279 GVRMGHSGAIVEGSGTDAESKKQALRDVGVAVVESPGYLGQALLDQFAKFK 329

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Scsalpha2	NP_650809.1	PTZ00187	16..327	CDD:240307	168/309 (54%)
		CoA_binding	36..129	CDD:280747	53/92 (58%)
		Ligase_CoA	182..306	CDD:278948	71/126 (56%)
LSC1	NP_014785.3	PTZ00187	24..327	CDD:240307	167/302 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344859
Domainoid	1	1.000	137	1.000	Domainoid score	I1063
eggNOG	1	0.900	-	-		E1_COG0074
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	330	1.000	Inparanoid score	I426
Isobase	1	0.950	-	0	Normalized mean entropy	S294
OMA	1	1.010	-	-		QHG60703
OrthoFinder	1	1.000	-	-		FOG0002539
OrthoInspector	1	1.000	-	-		otm46914
orthoMCL	1	0.900	-	-		OOG6_100834
Panther	1	1.100	-	-	O	PTHR11117
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1662
TreeFam	1	0.960	-	-
	14	13.710