Protein Alignment Ino80 and INO80

DIOPT Version :10

• Sequence 1: NP_732413.1
• Gene: Ino80 / 42314
• FlyBaseID: FBgn0289122
• Length: 1638
• Species: Drosophila melanogaster
• Sequence 2: NP_011365.1
• Gene: INO80 / 852728
• SGDID: S000003118
• Length: 1489
• Species: Saccharomyces cerevisiae
• Alignment Length: 1503
• Identity: 536/1503 - (35%)
• Similarity: 794/1503 - (52%)
• Gaps: 285/1503 - (18%)

  Fly    17 AEPLHIQRLEAALNM--------RPFMNMAKRSL--RKPLSSDEETDDEHVVKREHDVQDSDDSS 71
            ::.||.::|...::|        :.|.|.....:  .|....|||.|::.:...|.|::: |::|
Yeast   102 SQDLHFKKLYRDMSMINKEWAEYQSFKNANLSDIINEKDADEDEEDDEDELEDGEEDMEE-DEAS 165

  Fly    72 TVGVVRMK-------QSSKRKSRLLAS------KEERQSVKAQL--------------------- 102
            |......|       |.|::|....|:      |:::......:
Yeast   166 TGRHTNGKSMRGNGIQKSRKKDAAAAAAIGKAIKDDQTHADTVVTVNGDENEDGNNGEDEDNDND 230

  Fly   103 -YNFNDLTSDREWLYDLLLSDTESDDPTIT-----EDEYVQQLLREH---VREQ----------- 147
             .|.||..:|.|...|   :|:::||....     |:|.::.|..|.   ..||
Yeast   231 NENNNDNDNDNENEND---NDSDNDDEEENGEEDEEEEEIEDLDEEDFAAFEEQDDNDDEDFNPD 292

  Fly   148 --RQRKNYYKKAANAQYAYYGSGLLSNHDIFAE-----------RQLAT-------AGVRKRR-- 190
              ::||.....:::.:.:.....|:::..|...           |:|..       ..::|||
Yeast   293 VEKRRKRSSSSSSSTKLSMNSLSLITSKKINKNITINSDRPKIVRELIKMCNKNKHQKIKKRRFT 357

  Fly   191 ----------------RRTKQEILMARLAEAQAGPKPPKQRRRGRKKRDNMGSPESGEVPPSELG 239
                            :.|.::..:.||.:.....|  ::|.|....::|:|
Yeast   358 NCIVTDYNPIDSKLNIKITLKQYHVKRLKKLINDAK--REREREEALKNNVG------------- 407

  Fly   240 KYTFGDTLPNNE-DDDEDGGEVDYKRELASLALDYPEEEEIEEEVDVEGGTEGQVTKVRRKRKNP 303
                   |..|: |:||||.|...:|:|.:...:..::.. :.:.:...|......|:..|.
Yeast   408 -------LDGNDLDNDEDGSESHKRRKLNNNTANGADDAN-KRKFNTRHGLPTYGMKMNAKE--- 461

  Fly   304 AALAARRR------RIWQIMSKKESGRLQRIKSNNHKEMLANCKRVAGMCAKVVRQRAINSQRIM 362
             |.|.:|.      .||:.|::|:|.::.|:..........|.::.:.:||:..::....:.:.:
Yeast   462 -ARAIQRHYDNTYTTIWKDMARKDSTKMSRLVQQIQSIRSTNFRKTSSLCAREAKKWQSKNFKQI 525

  Fly   363 KETVWRAKRLTREMLAYWKRYERVERDQRRKQEREAEEQRKQDVELIEVKRQQRKLNFLITQTEL 427
            |:...||:|..|||..:||:.||.|||.::|.|:||.||.|::.|..|.|||.:|||||:|||||
Yeast   526 KDFQTRARRGIREMSNFWKKNEREERDLKKKIEKEAMEQAKKEEEEKESKRQAKKLNFLLTQTEL 590

  Fly   428 YAHFMSKKLG----QGSEEDQLRILSQLDEETNARLAAQDDYDA--------GEMKLLAQENAEA 480
            |:||:.:|:.    :|:........||.:.:.:|....::|:.|        .:::|.|.|||..
Yeast   591 YSHFIGRKIKTNELEGNNVSSNDSESQKNIDISALAPNKNDFHAIDFDNENDEQLRLRAAENASN 655

  Fly   481 AMQRDLDKTRAFDVFAKKKEKEEEE-----QAQESVEDIKPEPRPEMKDLPQPKMFKGTLKGYQI 540
            |:.....|.:.||..|...|:||||     |...|:.:|..|         |||:...|||.||:
Yeast   656 ALAETRAKAKQFDDHANAHEEEEEEDELNFQNPTSLGEITIE---------QPKILACTLKEYQL 711

  Fly   541 KGMTWLANIYDQGISGILADEMGLGKTVQSIAFLCHIAEHYGVWGPFLVISPASTLHNWQQEMSR 605
            ||:.||||:|||||:||||||||||||||||:.|.|:||::.:||||||::||||||||..|:|:
Yeast   712 KGLNWLANLYDQGINGILADEMGLGKTVQSISVLAHLAENHNIWGPFLVVTPASTLHNWVNEISK 776

  Fly   606 FVPDFKVVPYWGSPAERKILRQFWDQKHL-HTRDASFHVVITSYQLVVSDYKYFNRIKWQYMVLD 669
            |:|.||::||||:..:||:||:|||:|:| :.::|.|||::||||:||:|..|..::|||||:||
Yeast   777 FLPQFKILPYWGNANDRKVLRKFWDRKNLRYNKNAPFHVMVTSYQMVVTDANYLQKMKWQYMILD 841

  Fly   670 EAQAIKSAASQRWKLLLGFSCRNRLLLSGTPIQNSMAELWALLHFIMPTLFDSHDEFNEWFSKDI 734
            |||||||:.|.|||.||.|.|||||||:||||||||.|||||||||||:||||||||||||||||
Yeast   842 EAQAIKSSQSSRWKNLLSFHCRNRLLLTGTPIQNSMQELWALLHFIMPSLFDSHDEFNEWFSKDI 906

  Fly   735 ESHAENKTGIDEKQISRLHMILKPFMLRRIKKDVENELSDKIEIMVYCPLTIRQKLLYRALKQKI 799
            |||||..|.::::|:.|||||||||||||:||:|::||.|||||.|.|.||.||..||:.||.:|
Yeast   907 ESHAEANTKLNQQQLRRLHMILKPFMLRRVKKNVQSELGDKIEIDVLCDLTQRQAKLYQVLKSQI 971

  Fly   800 -----RIEDLLHLTSGSTTTSSSSSASNLMNLVMQFRKVCNHPELFERRDARSPFFMRCAEYTIP 859
                 .||:.....|.|.:.|:|.|..||:|.|||||||||||:||||.|..|||.......|..
Yeast   972 STNYDAIENAATNDSTSNSASNSGSDQNLINAVMQFRKVCNHPDLFERADVDSPFSFTTFGKTTS 1036

  Fly   860 RLIHEEGLIHRMLPSRKHLLYNRFNIFKSEYIQRSLFEDVNVNSCFGFTRLCDLSVGDMVEVTLN 924
            .|             ...:..|..::..:..:..|.....|::                     |
Yeast  1037 ML-------------TASVANNNSSVISNSNMNLSSMSSNNIS---------------------N 1067

  Fly   925 GLIDFLLHYRRVLEKY--PLLAYRRFWWKKQPDSRYQLLEPMLENKLALDYMPPNSVLKNF---I 984
            |....|::..|...||  |.|.|.            .|:.|...|.:.:     .:.|||.   |
Yeast  1068 GKFTDLIYSSRNPIKYSLPRLIYE------------DLILPNYNNDVDI-----ANKLKNVKFNI 1115

  Fly   985 FTAMTANESSVY--------AFGDYFTYNMQETIEHRVIRSKILKK---KTSLIEEMEDVSKQKL 1038
            |...|..|..::        :..::|          ||..:.:||:   :|:..:..:.:|.:.:
Yeast  1116 FNPSTNYELCLFLSKLTGEPSLNEFF----------RVSTTPLLKRVIERTNGPKNTDSLSFKTI 1170

  Fly  1039 EIESVEVQTKSNAKSDVKVTTLLLLPEFPHRPRKPRKYV-C-----EP-LSMPRILYD-LGQK-- 1093
            ..|.:||  ..||.|:..:.:||.:.:..:.    |:|: |     .| :|.|.:..: ||..
Yeast  1171 TQELLEV--TRNAPSEGVMASLLNVEKHAYE----REYLNCIQRGYHPNVSAPPVTIEVLGSSHV 1229

  Fly  1094 VQAVHRYLYCDSRSAAWSQI----RHNQCENSQG---RELVSSGL---ALCKPHGGWSSIVVPDK 1148
            ..:::..|:....|.|.|.|    ::|. ...:|   .:...:||   .|.|...  |:|.:|..
Yeast  1230 TNSINNELFDPLISQALSDIPAITQYNM-HVKKGIPVEDFPKTGLFPEPLNKNFS--SNISMPSM 1291

  Fly  1149 ETLITDAGKLFVLDNLLTRLKANGHRVLIYSQMTKMIDLLEEYMWHRKHRYMRLDGSSKISARRD 1213
            :..||::.||..||.||.:||:.|||||||.|||||:||:|||:.:|::.::|||||||:..|||
Yeast  1292 DRFITESAKLRKLDELLVKLKSEGHRVLIYFQMTKMMDLMEEYLTYRQYNHIRLDGSSKLEDRRD 1356

  Fly  1214 MVADFQTRADIFVFLLSTRAGGLGINLTAADTVIFYDSDWNPTVDQQAMDRAHRLGQTKQVTVYR 1278
            :|.|:||..:|||||||||||||||||||||||||||||||||:|.||||||||||||:||||||
Yeast  1357 LVHDWQTNPEIFVFLLSTRAGGLGINLTAADTVIFYDSDWNPTIDSQAMDRAHRLGQTRQVTVYR 1421

  Fly  1279 LICKGTIEERILQRAREKSEIQRMVISGGNFKPDTLKPKEVVSLLLDDEEIEMKYRQEAKLQSSS 1343
            |:.:||||||:..||::|.::|::|:.|      ..:.|.:.::.:.:.:.|:. |:.:|..|..
Yeast  1422 LLVRGTIEERMRDRAKQKEQVQQVVMEG------KTQEKNIKTIEVGENDSEVT-REGSKSISQD 1479

  Fly  1344 PIPAATQS 1351
            .|..|..:
Yeast  1480 GIKEAASA 1487

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ino80	NP_732413.1	HepA	364..>855	CDD:440319	281/513 (55%)
		DEXQc_INO80	535..763	CDD:350760	161/228 (71%)
		SF2_C_SNF	1146..1280	CDD:350180	95/133 (71%)
		PHA03247	<1535..1637	CDD:223021
INO80	NP_011365.1	DBINO	469..602	CDD:464024	49/132 (37%)
		PLN03142	537..>1026	CDD:215601	276/497 (56%)
		DEXQc_INO80	706..935	CDD:350760	161/228 (71%)
		SF2_C_SNF	1295..1423	CDD:350180	94/127 (74%)