Protein Alignment Ino80 and SMARCA5

DIOPT Version :10

• Sequence 1: NP_732413.1
• Gene: Ino80 / 42314
• FlyBaseID: FBgn0289122
• Length: 1638
• Species: Drosophila melanogaster
• Sequence 2: NP_003592.3
• Gene: SMARCA5 / 8467
• HGNCID: 11101
• Length: 1052
• Species: Homo sapiens
• Alignment Length: 1058
• Identity: 267/1058 - (25%)
• Similarity: 403/1058 - (38%)
• Gaps: 412/1058 - (38%)

  Fly   384 ERVERDQRRKQEREAEEQRKQDVELIEVKRQQRKLNFLITQTELYAHFMSKKLGQGSEEDQLRIL 448
            |.:..|....:::|.:|......|.::..|..| ..:|:.||||:|||: :...|.:....|::.
Human    59 EEIFDDASPGKQKEIQEPDPTYEEKMQTDRANR-FEYLLKQTELFAHFI-QPAAQKTPTSPLKMK 121

  Fly   449 S-----QLDEETNARLAAQDDYDAGEMKLLAQENAEAAMQRDLDKTRAFDVFAKKKEKEEEEQAQ 508
            .     :.||:.|  |.:..||.                            ..:.:::|:||...
Human   122 PGRPRIKKDEKQN--LLSVGDYR----------------------------HRRTEQEEDEELLT 156

  Fly   509 ESVEDIKPEPRPEMKDLPQPKMFK-GTLKGYQIKGMTWLANIYDQGISGILADEMGLGKTVQSIA 572
            ||.:......|.|    ..|...| |.|:.||::|:.||.::|:.||:||||||||||||:|:|:
Human   157 ESSKATNVCTRFE----DSPSYVKWGKLRDYQVRGLNWLISLYENGINGILADEMGLGKTLQTIS 217

  Fly   573 FLCHIAEHYGVWGPFLVISPASTLHNWQQEMSRFVPDFKVVPYWGSPAERK------ILRQFWDQ 631
            .|.::..:..:.||.:|:.|.||||||..|..|:||..:.|...|...:|.      :|...||
Human   218 LLGYMKHYRNIPGPHMVLVPKSTLHNWMSEFKRWVPTLRSVCLIGDKEQRAAFVRDVLLPGEWD- 281

  Fly   632 KHLHTRDASFHVVITSYQLVVSDYKYFNRIKWQYMVLDEAQAIKSAASQRWKLLLGFSCRNRLLL 696
                       |.:|||::::.:...|.:..|:|:|:|||..||:..|:..:::..|...|||||
Human   282 -----------VCVTSYEMLIKEKSVFKKFNWRYLVIDEAHRIKNEKSKLSEIVREFKTTNRLLL 335

  Fly   697 SGTPIQNSMAELWALLHFIMPTLFDSHDEFNEWFSKDIESHAENKTGIDEKQISRLHMILKPFML 761
            :|||:||::.|||:||:|::|.:|:|.|:|:.||.      ..|..| |:|.:.||||:|:||:|
Human   336 TGTPLQNNLHELWSLLNFLLPDVFNSADDFDSWFD------TNNCLG-DQKLVERLHMVLRPFLL 393

  Fly   762 RRIKKDVENELSDKIEIMVYCPLTIRQKLLY-RALKQKIRIEDLLHLTSGSTTTSSSSSASNLMN 825
            ||||.|||..|..|.|:.:|..|:..|:..| |.|.:.|   |:|:       ::.......|:|
Human   394 RRIKADVEKSLPPKKEVKIYVGLSKMQREWYTRILMKDI---DILN-------SAGKMDKMRLLN 448

  Fly   826 LVMQFRKVCNHPELFERRDARSPFFMRCAEYTIPRLIHEEGLIHRMLPSRKHLLYNRFNIFKSEY 890
            ::||.||.||||.||   |...|
Human   449 ILMQLRKCCNHPYLF---DGAEP------------------------------------------ 468

  Fly   891 IQRSLFEDVNVNSCFGFTRLCDLSVGDMVEVTLNGLIDFLLHYRRVLEKYPLLAYRRFWWKKQPD 955
                                                                             
Human   469 ----------------------------------------------------------------- 468

  Fly   956 SRYQLLEPMLENKLALDYMPPNSVLKNFIFTAMTANESSVYAFGDYFTYNMQETIEHRVIRSKIL 1020
                                                       |..:|.:|.
Human   469 -------------------------------------------GPPYTTDMH------------- 477

  Fly  1021 KKKTSLIEEMEDVSKQKLEIESVEVQTKSNAKSDVKVTTLLLLPEFPHRPRKPRKYVCEPLSMPR 1085
                                                                             
Human   478 ----------------------------------------------------------------- 477

  Fly  1086 ILYDLGQKVQAVHRYLYCDSRSAAWSQIRHNQCENSQGRELVSSGLALCKPHGGWSSIVVPDKET 1150
                                                                             
Human   478 ----------------------------------------------------------------- 477

  Fly  1151 LITDAGKLFVLDNLLTRLKANGHRVLIYSQMTKMIDLLEEYMWHRKHRYMRLDGSSKISARRDMV 1215
            |:|::||:.|||.||.:||..|.||||:||||:::|:||:|...|.:.|.||||.:....|:|.:
Human   478 LVTNSGKMVVLDKLLPKLKEQGSRVLIFSQMTRVLDILEDYCMWRNYEYCRLDGQTPHDERQDSI 542

  Fly  1216 ADF-QTRADIFVFLLSTRAGGLGINLTAADTVIFYDSDWNPTVDQQAMDRAHRLGQTKQVTVYRL 1279
            ..: :..:..|||:||||||||||||..||.||.|||||||.||.||||||||:||||.|.|:|.
Human   543 NAYNEPNSTKFVFMLSTRAGGLGINLATADVVILYDSDWNPQVDLQAMDRAHRIGQTKTVRVFRF 607

  Fly  1280 ICKGTIEERILQRAREKSEIQRMVISGGNFKPDTLKPKEVVSLLLDDEEIEMKYRQEAKLQSSSP 1344
            |...|:||||::||..|..:..:||..|......|      :.:..||.::|
Human   608 ITDNTVEERIVERAEMKLRLDSIVIQQGRLVDQNL------NKIGKDEMLQM------------- 653

  Fly  1345 IPAATQSERKRRHPQKDVNMGGTTIAATSATQNPDDDVPSCSSAAKRIKLETEEDFIDVGITSSA 1409
                             :..|.|.:.|:..::..|:|:........:...|..|....:|.:|..
Human   654 -----------------IRHGATHVFASKESEITDEDIDGILERGAKKTAEMNEKLSKMGESSLR 701

  Fly  1410 S-SVGTDSNHPTLSQETY 1426
            : ::.|:|:......|.|
Human   702 NFTMDTESSVYNFEGEDY 719

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ino80	NP_732413.1	HepA	364..>855	CDD:440319	160/483 (33%)
		DEXQc_INO80	535..763	CDD:350760	94/233 (40%)
		SF2_C_SNF	1146..1280	CDD:350180	75/134 (56%)
		PHA03247	<1535..1637	CDD:223021
SMARCA5	NP_003592.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..83		4/23 (17%)
		PLN03142	69..1012	CDD:215601	265/1048 (25%)
		DEAH box	308..311		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1015..1052