DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ino80 and INO80

DIOPT Version :9

Sequence 1:	NP_732413.1	Gene:	Ino80 / 42314	FlyBaseID:	FBgn0086613	Length:	1638	Species:	Drosophila melanogaster
Sequence 2:	NP_001190117.1	Gene:	INO80 / 824897	AraportID:	AT3G57300	Length:	1540	Species:	Arabidopsis thaliana

Alignment Length:	1647	Identity:	549/1647 - (33%)
Similarity:	799/1647 - (48%)	Gaps:	393/1647 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 NMRPFMNMAKRSLRKPLSSDEETDDEHVVKREHDVQDSDDS-STVGVVRMKQSSKRKSRLLASKE 93
            ::.|.|   |..:.||   ::|.|       .:.....|:| ||.|.|....|:..|||:.||.:
plant    18 DLEPLM---KFRIPKP---EDEVD-------YYGSSSQDESRSTQGGVVANYSNGSKSRMNASSK 69

  Fly    94 ERQSVKAQLYNFNDLTSDREWLYDLLLSDTESDDPT----ITEDEYVQQLLREHVREQRQRK--- 151
            :|                :.|..   ..|.|.||..    :||:.| :.:|.|||::.:.|.
plant    70 KR----------------KRWTE---AEDAEDDDDLYNQHVTEEHY-RSMLGEHVQKFKNRSKET 114

  Fly   152 ----------------------------------------------------NYYKKAANAQYAY 164
                                                                :|:.:....:.||
plant   115 QGNPPHLMGFPVLKSNVGSYRGRKPGNDYHGRFYDMDNSPNFAADVTPHRRGSYHDRDITPKIAY 179

  Fly   165 ------YGSGLL-----SNHDIFAERQLAT-AGVRKRRRRTKQEILMARLAEAQAGPKPPKQRRR 217
                  .|.|::     |...:.|...|.: :.:.......|..:.:..|||..|..|     |.
plant   180 EPSYLDIGDGVIYKIPPSYDKLVASLNLPSFSDIHVEEFYLKGTLDLRSLAELMASDK-----RS 239

  Fly   218 GRKKRDNMGSPE---------------SGEVPPSEL--GKYTFGDTLPNNEDDDEDGGEVDYKRE 265
            |.:.|:.||.|.               |...|...|  .:......:|       :|......|.
plant   240 GVRSRNGMGEPRPQYESLQARMKALSPSNSTPNFSLKVSEAAMNSAIP-------EGSAGSTART 297

  Fly   266 LAS----LALDYPEEEEIEEEVDVEGGTEGQVTKVRRKRKNPAALAA----RRRRIWQIMSKKES 322
            :.|    |.:.|   .:|.|:.|.....:..:.|..:.:.:||.:..    :.|:.|..:.:::.
plant   298 ILSEGGVLQVHY---VKILEKGDTYEIVKRSLPKKLKAKNDPAVIEKTERDKIRKAWINIVRRDI 359

  Fly   323 GRLQRIKSNNHKEMLANCKRVAGMCAKVVRQRAINSQRIMKETVWRAKRLTREMLAYWKRYERVE 387
            .:..||.:..|:::..:.||.|..|.:.||.:...|.:|.:....|.::::|:||.:||||::..
plant   360 AKHHRIFTTFHRKLSIDAKRFADGCQREVRMKVGRSYKIPRTAPIRTRKISRDMLLFWKRYDKQM 424

  Fly   388 RDQRRKQEREAEEQRKQDVELIEVKRQQRKLNFLITQTELYAHFMSKKLGQGSEE-----DQLRI 447
            .::|:|||:||.|..|::.|..|.||||::|||||.|||||:|||..|......|     |:..|
plant   425 AEERKKQEKEAAEAFKREQEQRESKRQQQRLNFLIKQTELYSHFMQNKTDSNPSEALPIGDENPI 489

  Fly   448 LSQLDEETNARLAAQDDYDAGEMKLLAQENAEAAMQRDLDKTRAFDV-FAKKKEKEEEE------ 505
            ...|.|.:.|..:..:|.:..|:|......|:.|:.:....|.|||. :.|.::..|.|
plant   490 DEVLPETSAAEPSEVEDPEEAELKEKVLRAAQDAVSKQKQITDAFDTEYMKLRQTSEMEGPLNDI 554

  Fly   506 --QAQESVEDIKPEPRPEMKDLPQPKMFKGTLKGYQIKGMTWLANIYDQGISGILADEMGLGKTV 568
              ....:::...|...|....:..|::||||||.||:||:.||.|.|:||::||||||||||||:
plant   555 SVSGSSNIDLHNPSTMPVTSTVQTPELFKGTLKEYQMKGLQWLVNCYEQGLNGILADEMGLGKTI 619

  Fly   569 QSIAFLCHIAEHYGVWGPFLVISPASTLHNWQQEMSRFVPDFKVVPYWGSPAERKILRQFWDQKH 633
            |::|||.|:||...:||||||::|||.|:||..|:|||.||.|.:||||...||.|||:..:.|.
plant   620 QAMAFLAHLAEEKNIWGPFLVVAPASVLNNWADEISRFCPDLKTLPYWGGLQERTILRKNINPKR 684

  Fly   634 ---------------------------------LHTRDASFHVVITSYQLVVSDYKYFNRIKWQY 665
                                             |...||.||::||||||:|:|.|||.|:||||
plant   685 VMFFSTWIISFDPWAVRQICICKRACNVVRFQTLSDMDAGFHILITSYQLLVTDEKYFRRVKWQY 749

  Fly   666 MVLDEAQAIKSAASQRWKLLLGFSCRNRLLLSGTPIQNSMAELWALLHFIMPTLFDSHDEFNEWF 730
            |||||||||||::|.|||.||.|:|||||||:||||||:|||||||||||||.|||:||:|||||
plant   750 MVLDEAQAIKSSSSIRWKTLLSFNCRNRLLLTGTPIQNNMAELWALLHFIMPMLFDNHDQFNEWF 814

  Fly   731 SKDIESHAENKTGIDEKQISRLHMILKPFMLRRIKKDVENELSDKIEIMVYCPLTIRQKLLYRAL 795
            ||.||:|||:...::|.|::|||.|||||||||:||||.:||:.|.|:.|:|.|:.||:..|:|:
plant   815 SKGIENHAEHGGTLNEHQLNRLHAILKPFMLRRVKKDVVSELTTKTEVTVHCKLSSRQQAFYQAI 879

  Fly   796 KQKIRIEDLLHLTSGSTTTSSSSSASNLMNLVMQFRKVCNHPELFERRDARSPFFMRCAE----- 855
            |.||.:.:|.....|..|   .....||||:|:|.||||||||||||.:..|..:.....
plant   880 KNKISLAELFDSNRGQFT---DKKVLNLMNIVIQLRKVCNHPELFERNEGSSYLYFGVTSNSLLP 941

  Fly   856 -------------------YTIPRLIHEEGL---------IHRMLPSRKHLLYNRFNIFKSEYIQ 892
                               |.||:|:|:|.|         :.|.: ||:..| ..|||:..|||.
plant   942 HPFGELEDVHYSGGQNPIIYKIPKLLHQEVLQNSETFCSSVGRGI-SRESFL-KHFNIYSPEYIL 1004

  Fly   893 RSLF-------EDVNVNSCFGFTRLCDLSVGDMVEVTLNGLIDFLLHYRRVLEKYPLLAYRRFWW 950
            :|:|       :.|:.:..|||:||.|||..::..:.|..:.:.||        :.:|.:.|
plant  1005 KSIFPSDSGVDQVVSGSGAFGFSRLMDLSPSEVGYLALCSVAERLL--------FSILRWER--- 1058

  Fly   951 KKQPDSRYQLLEPMLENKLALDYMPPNSVLKNFIFTAMTANESSVYAFGDYFTYNMQETIEHRVI 1015
                    |.|:.::           ||::::              ..||....|::......|.
plant  1059 --------QFLDELV-----------NSLMES--------------KDGDLSDNNIERVKTKAVT 1090

  Fly  1016 RSKIL--KKKTSLIEEMEDVSKQKLEIESVEVQTKSNAKSDVKVTTLLLLPEFPHRP--RKPRKY 1076
            |..::  |.:|:..:........:...|::.:..:....|.:|    ||...:.:.|  |.|
plant  1091 RMLLMPSKVETNFQKRRLSTGPTRPSFEALVISHQDRFLSSIK----LLHSAYTYIPKARAP--- 1148

  Fly  1077 VCEPLSMPRILYDLGQKVQAVHRYLYCDSRSAAW---------------------SQIRHNQCEN 1120
               |:|                  ::|..|::|:                     |:....:..|
plant  1149 ---PVS------------------IHCSDRNSAYRVTEELHQPWLKRLLIGFARTSEANGPRKPN 1192

  Fly  1121 SQGREL---VSSGLALCKP--------HGGWSSIVVPDKETLITDAGKLFVLDNLLTRLKANGHR 1174
            |....|   :.|.|.:.:|        .|....:...|...|:||:|||..||.||.||:|..||
plant  1193 SFPHPLIQEIDSELPVVQPALQLTHRIFGSCPPMQSFDPAKLLTDSGKLQTLDILLKRLRAGNHR 1257

  Fly  1175 VLIYSQMTKMIDLLEEYMWHRKHRYMRLDGSSKISARRDMVADFQTRADIFVFLLSTRAGGLGIN 1239
            ||:::|||||:::||:||.:||::|:||||||.|..|||||.|||.|:|||||||||||||||||
plant  1258 VLLFAQMTKMLNILEDYMNYRKYKYLRLDGSSTIMDRRDMVRDFQHRSDIFVFLLSTRAGGLGIN 1322

  Fly  1240 LTAADTVIFYDSDWNPTVDQQAMDRAHRLGQTKQVTVYRLICKGTIEERILQRAREKSEIQRMVI 1304
            ||||||||||:||||||:|.|||||||||||||.|||||||||.|:||:||.||.:|:.:|::|:
plant  1323 LTAADTVIFYESDWNPTLDLQAMDRAHRLGQTKDVTVYRLICKETVEEKILHRASQKNTVQQLVM 1387

  Fly  1305 SGGNFK-PDTLKPKEVVSLLLDDEE---IEMKYRQ----------------------EAKLQSSS 1343
            :||:.: .|.|...:|||||:||.|   :|.|:|:                      :|.|:...
plant  1388 TGGHVQGDDFLGAADVVSLLMDDAEAAQLEQKFRELPLQVKDRQKKKTKRIRIDAEGDATLEELE 1452

  Fly  1344 PIPAATQSERKRRHPQKDVNMGGTTIAATSATQNP-------------DDDVPSCSSAAKRIKLE 1395
            .:......:.....|:|..:......||:    ||             .:|.|   ...||:|.:
plant  1453 DVDRQDNGQEPLEEPEKPKSSNKKRRAAS----NPKARAPQKAKEEANGEDTP---QRTKRVKRQ 1510

  Fly  1396 TEEDFIDVGITSSASSVGTDSN 1417
            |:.  |:..:....|:..|:||
plant  1511 TKS--INESLEPVFSASVTESN 1530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ino80	NP_732413.1	DBINO	313..438	CDD:290603	48/124 (39%)
		SNF2_N	538..840	CDD:278600	189/334 (57%)
		DEXDc	555..700	CDD:238005	95/177 (54%)
		Helicase_C	1156..1269	CDD:278689	84/112 (75%)
INO80	NP_001190117.1	DBINO	345..476	CDD:290603	49/130 (38%)
		Med21	452..>530	CDD:288119	26/77 (34%)
		SNF2_N	589..921	CDD:278600	189/334 (57%)
		DEXDc	606..784	CDD:238005	95/177 (54%)
		CBS_pair	873..>922	CDD:301603	23/51 (45%)
		Helicase_C	1238..1352	CDD:278689	84/113 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	392	1.000	Domainoid score	I144
eggNOG	1	0.900	-	-		E2759_KOG0388
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	809	1.000	Inparanoid score	I86
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D188211at2759
OrthoFinder	1	1.000	-	-		FOG0005575
OrthoInspector	1	1.000	-	-		oto3527
orthoMCL	1	0.900	-	-		OOG6_103743
Panther	1	1.100	-	-	LDO	PTHR45685
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3990
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.830