Protein Alignment Ino80 and ino80

DIOPT Version :10

• Sequence 1: NP_732413.1
• Gene: Ino80 / 42314
• FlyBaseID: FBgn0289122
• Length: 1638
• Species: Drosophila melanogaster
• Sequence 2: XP_009299103.1
• Gene: ino80 / 566768
• ZFINID: ZDB-GENE-041014-72
• Length: 1558
• Species: Danio rerio
• Alignment Length: 1747
• Identity: 734/1747 - (42%)
• Similarity: 953/1747 - (54%)
• Gaps: 352/1747 - (20%)

  Fly    16 MAEPLHIQRLEAALNMRPFMNMAKRSLRKPLSSDEETDDEH------------VVKREH-----D 63
            :|:|||:|.||.:|.:..|:........:.:|||:..|...            .||::|     :
Zfish    16 LAKPLHLQYLERSLRLDTFLRQTATVFNQNISSDDSDDGLGEGSSLASSNPLLAVKKDHISPEDE 80

  Fly    64 VQDS--DDSSTVGVVRMKQSSKRKSRLLASKEERQSVKAQLYNFNDLTSDREWLYDLLLSD--TE 124
            .:||  |..:..|.:..           |..:|.::.||.||||:.|...|:||..:||||  |:
Zfish    81 TKDSCRDGETECGTLNG-----------AVLQEHKADKASLYNFSRLKKSRKWLKGILLSDDTTD 134

  Fly   125 SD------DPTITEDEYVQQLLREHVREQRQRKNYYKKAANAQYAYYGSGLLSNHDIFAERQLAT 183
            ||      |.|:|.:| :|.:||.|...:..:..::.......|.:|.:||||.||.|.|:|...
Zfish   135 SDSDSDDSDFTMTREE-LQDMLRLHKFTRLHQSKFHSDRELQHYQHYSTGLLSTHDPFYEQQRHL 198

  Fly   184 AGVRKRRRRTKQEILMARLAEAQAGPKPPKQRRRGRKKRDNMGSPESGEVPPSELGKYTFGDTLP 248
            .|::|::.:          .|.:...|..|.:|  :|||....|.|..:.......|::....||
Zfish   199 LGLKKKKIK----------EEKKCKAKLKKMKR--KKKRGEEFSMEGRQHITKTFAKFSHDAPLP 251

  Fly   249 NNEDDDEDGGEVDYKRELASLALDYPEEEEIEEEVDVEGGTEGQVTKVRRKRKNPAALAARRRRI 313
                                                          .:::|......|.||||::
Zfish   252 ----------------------------------------------MIKKKHLTIEQLNARRRKV 270

  Fly   314 WQIMSKKESGRLQRIKSNNHKEMLANCKRVAGMCAKVVRQRAINSQRIMKETVWRAKRLTREMLA 378
            |..::|||..:..:.|.:....:|.|.:::|..|.:.||:.||.:|:..|||:.||:|||:|||.
Zfish   271 WLTIAKKEIPKAFKQKVSARNFVLTNARKLAHQCMREVRRAAIQAQKNCKETLPRARRLTKEMLL 335

  Fly   379 YWKRYERVERDQRRKQEREAEEQRKQDVELIEVKRQQRKLNFLITQTELYAHFMSKKLGQGSEED 443
            |||:||:||::.|::.|:||.||||.|.|:.|.|||||||||||||||||||||..|...|.:..
Zfish   336 YWKKYEKVEKEHRKRAEKEALEQRKLDEEMREAKRQQRKLNFLITQTELYAHFMGGKQNAGGDCT 400

  Fly   444 QLRILSQLDEETNARL----------AAQDDYDAGEMKLLAQENAEAAMQRDLDKTRAFDVFAKK 498
            |..||.:|::.::.|.          .:|:|||:...|..|.:||:.|.|....:||.||..||.
Zfish   401 QEEILRKLEDNSSQRQIDIGGGVMVNVSQEDYDSDYYKSQALKNAKEAYQIHQARTRLFDEEAKD 465

  Fly   499 KEKEEEEQAQ-------ESVEDIKPEPRPEMKDLPQPKMFKGTLKGYQIKGMTWLANIYDQGISG 556
            ........|.       ||.....|..:.. :|:|||.:|.|.|||||:|||.||||:|:|||:|
Zfish   466 SRCASLHAASMSGSGFGESYSLSNPSIQAG-EDIPQPTIFNGKLKGYQLKGMNWLANLYEQGING 529

  Fly   557 ILADEMGLGKTVQSIAFLCHIAEHYGVWGPFLVISPASTLHNWQQEMSRFVPDFKVVPYWGSPAE 621
            ||||||||||||||||.|.|:||...:|||||:|||||||:||.||.|||||.|||:||||:|.:
Zfish   530 ILADEMGLGKTVQSIALLAHLAERENIWGPFLIISPASTLNNWHQEFSRFVPKFKVLPYWGNPHD 594

  Fly   622 RKILRQFWDQKHLHTRDASFHVVITSYQLVVSDYKYFNRIKWQYMVLDEAQAIKSAASQRWKLLL 686
            ||::|:||.||.|:|::|.||||||||||||.|.|||.|:||||||||||||:||:.|.|||:||
Zfish   595 RKVIRKFWSQKTLYTQNAPFHVVITSYQLVVQDVKYFQRVKWQYMVLDEAQALKSSTSVRWKILL 659

  Fly   687 GFSCRNRLLLSGTPIQNSMAELWALLHFIMPTLFDSHDEFNEWFSKDIESHAENKTGIDEKQISR 751
            .|.|||||||:||||||:|||||||||||||||||||:|||||||||||||||||:.|||.|:||
Zfish   660 QFQCRNRLLLTGTPIQNTMAELWALLHFIMPTLFDSHEEFNEWFSKDIESHAENKSAIDENQLSR 724

  Fly   752 LHMILKPFMLRRIKKDVENELSDKIEIMVYCPLTIRQKLLYRALKQKIRIEDLLHLTSGSTTTSS 816
            |||||||||||||||||||||||||||:.||.||.||:|||:|||.||.|||||..:.|| ...:
Zfish   725 LHMILKPFMLRRIKKDVENELSDKIEILTYCQLTSRQRLLYQALKNKISIEDLLQSSMGS-AQQA 788

  Fly   817 SSSASNLMNLVMQFRKVCNHPELFERRDARSPFFMRCAEYTIPRLIHEEGLIHRMLPSRKHLLYN 881
            .|:.|:|||||||||||||||:||||::.||||.|....:.:.:.:....::|.:...:..|...
Zfish   789 HSTTSSLMNLVMQFRKVCNHPDLFERQEIRSPFHMSLKPFIMSKFLFRHAILHTIDHGKTKLKQT 853

  Fly   882 RFNIFKSEYIQRSLFE---DVNVNSCFGFTRLCDLSVGDMVEVTLNG-LIDFLLHYRRVLEKYPL 942
            ..:.|.:::||:|||.   |...:| |.|.|..|:|..:|..|.|.| |:.:|..|......|.|
Zfish   854 LLSPFSAQHIQQSLFHRKTDDEASS-FSFLRFIDVSPAEMSNVMLQGTLVRWLALYLSFKSAYRL 917

  Fly   943 LAYRRFWWKKQPDSRYQ---LLEPMLENKLALDYMP-----------PN----SVLKNFIFTAMT 989
            ...|:  |:::..|..:   .||     ||.|.:..           ||    .||::.:||:.
Zfish   918 HHSRQ--WEEEKMSEVKGRGRLE-----KLCLSHRDLILWLNRPTSFPNVHSSPVLQDLVFTST- 974

  Fly   990 ANESSVYAFGDYFTYNMQETIEHRVIRSKILKKKTSLIEEMEDVSKQKLEIESVEVQTKSNAKSD 1054
                     |.....:....|..|...::.|::
Zfish   975 ---------GSLSICHTDAVIHSRRSSTRTLRQ-------------------------------- 998

  Fly  1055 VKVTTLLLLPEFPHRPRKPRKYVCEPLSMPRILYDLGQKVQAVHRYLYCDSRSA--AWSQIRH-- 1115
                                   |:|...|:.|..:..:|.:|....||..|||  .|..:|.
Zfish   999 -----------------------CQPTQPPKFLLAVTPRVTSVPLERYCADRSAEYEWRLMRDGG 1040

  Fly  1116 ----NQC-------------ENSQGRELVSSG--LALCKPHGGWSSIVVPDKETLITDAGKLFVL 1161
                .||             :.||.....:.|  :||.:.| |||.|.:||||:||||:|||..|
Zfish  1041 SLIAKQCFLYGSPELACAWAQRSQSFLPPNPGGVMALQQRH-GWSFIRIPDKESLITDSGKLHTL 1104

  Fly  1162 DNLLTRLKANGHRVLIYSQMTKMIDLLEEYMWHRKHRYMRLDGSSKISARRDMVADFQTRADIFV 1226
            |.||||||:.|||||||||||:|||||||||.:|||.|||||||||||.|||||||||:|.||||
Zfish  1105 DLLLTRLKSQGHRVLIYSQMTRMIDLLEEYMVYRKHTYMRLDGSSKISERRDMVADFQSRTDIFV 1169

  Fly  1227 FLLSTRAGGLGINLTAADTVIFYDSDWNPTVDQQAMDRAHRLGQTKQVTVYRLICKGTIEERILQ 1291
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish  1170 FLLSTRAGGLGINLTAADTVIFYDSDWNPTVDQQAMDRAHRLGQTKQVTVYRLICKGTIEERILQ 1234

  Fly  1292 RAREKSEIQRMVISGGNFKPDTLKPKEVVSLLLDDEEIE--MKYRQEAK--LQSSSPIPAATQ-- 1350
            ||:||||||||||||||||||||||||||||||||||:|  ::.|||.|  |:.||.:....:
Zfish  1235 RAKEKSEIQRMVISGGNFKPDTLKPKEVVSLLLDDEELEKKLRLRQEEKRQLEESSKVKERKRKR 1299

  Fly  1351 ---SERKRRH--PQKDVNMGGTTIAATSATQNPDDDVPSCSSAAKRIKLETEEDFIDVGITSSAS 1410
               :||||:.  |:......|..:....        |||..::  .:..:.|:.||
Zfish  1300 EKYAERKRKEDDPESKRKKEGVNMVIPY--------VPSADNS--NLSADGEDSFI--------- 1345

  Fly  1411 SVGTDSNHPTLSQETYV----PGATCVQQTEI---DSENEALVVDGDSPTMLGQNESMN------ 1462
            ||..||..|:...|.||    ..::.:|.:.|   :|.::.||:..:..:...|:.:.|
Zfish  1346 SVDMDSAIPSPFSENYVSLQISLSSELQPSSIPADESSSDMLVIVDEPVSSAQQSRATNSPASIA 1410

  Fly  1463 --FLDDLSGI------SPMRRRHHPRGTRRGRPRG-------STRRGGGHGSIPRVLTPTQAATP 1512
              ..|.::|:      ||.|.|.:   ..||||:|       |.|:|.|..|     |...||..
Zfish  1411 GSVSDTMNGVSSQDISSPGRGRSN---RSRGRPKGSGGAGKSSVRKGRGRKS-----TAGSAAAM 1467

  Fly  1513 AVPATASQAAAAGTGAAAGTSSPLPQQEVSGGGDNAGVPLHEEEYRTSPSGQSPGVSCKRGPGRP 1577
            |.....:.||:|...||.|.|.            :.|:|         .||..|....
Zfish  1468 AGAMAGAAAASAAAYAAYGYSV------------SKGIP---------ASGSLPTALI------- 1504

  Fly  1578 RSKTATPISRGTRGAPRARRPMGPLLVPLGRSPDDTPPSSSPATSRAPSPLSGSHGA 1634
            ||.|.                  |..||.|.|   :|.:.|.|.:.....|  :||:
Zfish  1505 RSSTT------------------PTFVPAGTS---SPQAKSSAVATNSQTL--AHGS 1538

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ino80	NP_732413.1	HepA	364..>855	CDD:440319	325/507 (64%)
		DEXQc_INO80	535..763	CDD:350760	179/227 (79%)
		SF2_C_SNF	1146..1280	CDD:350180	119/133 (89%)
		PHA03247	<1535..1637	CDD:223021	19/100 (19%)
ino80	XP_009299103.1	DBINO	263..392	CDD:464024	69/128 (54%)
		DEXQc_INO80	508..736	CDD:350760	179/227 (79%)
		SF2_C_SNF	1088..1223	CDD:350180	119/134 (89%)
		PTZ00121	<1229..>1321	CDD:173412	55/91 (60%)