DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ino80 and dom

DIOPT Version :9

Sequence 1:	NP_732413.1	Gene:	Ino80 / 42314	FlyBaseID:	FBgn0086613	Length:	1638	Species:	Drosophila melanogaster
Sequence 2:	NP_001286676.1	Gene:	dom / 45655	FlyBaseID:	FBgn0020306	Length:	3233	Species:	Drosophila melanogaster

Alignment Length:	1600	Identity:	417/1600 - (26%)
Similarity:	643/1600 - (40%)	Gaps:	499/1600 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   226 GSPESGEVPPSELGKYTFGDTLPNNEDDDEDGGEVDYKRELASLALDYPEEEEIE-----EEVDV 285
            |:|.||.:....||.   |...||:                |:....:..::|:.     .|:..
  Fly   488 GTPTSGSLLSPALGG---GSGTPNS----------------AAQEFSFKAKQEVYVMQRISELQR 533

  Fly   286 EG-GTEGQVTKVRRKRKNPAA-----------LAA--RRRRIWQIMSKKESGRLQRIKSNNHKEM 336
            || .||.::.|::...: |.|           |||  .:.|.|:
  Fly   534 EGLWTERRLPKLQEPSR-PKAHWDYLLEEMVWLAADFAQERKWK--------------------- 576

  Fly   337 LANCKRVAGMCAKVVRQ----RAINSQRIMKETVWRAKR----LTREMLAYWKRYERVERDQRRK 393
                |..|..|||:|::    :|..:||..|....:.||    :.||:.::|   ..||:....|
  Fly   577 ----KNAAKKCAKMVQKYFQDKATAAQRAEKAQELQLKRVASFIAREVKSFW---SNVEKLVEYK 634

  Fly   394 QEREAEEQRKQDVELIEVKRQQRKLNFLITQTELYA----HFMSKKLG----------------- 437
            .:.:.||:|||.::        :.|:|::.|||.::    ..|:|.:.
  Fly   635 HQTKIEEKRKQALD--------QHLSFIVDQTEKFSQQLVEGMNKSVADTPSLNSSRLTSPKRES 691

  Fly   438 -------QGSEEDQLRIL-------------------SQLD---------------------EET 455
                   .|||:|:..|.                   |::|                     ||.
  Fly   692 DDDFRPESGSEDDEETIAKAEEDAADVKEEVTALAKESEMDFDDFLNDLPPGYLENRDKLMKEEQ 756

  Fly   456 NARLAAQ--DDYDAGEMK-----------LLAQENAEAAM--QRDLDKTRAFD------VFAKKK 499
            ::.:..:  ||.|..|.:           :..||.||..:  ::::|:..|.:      :.||.|
  Fly   757 SSAIKTETPDDSDDSEFEAKEASDDDENTISKQEEAEQEIDHKKEIDELEADNDLSVEQLLAKYK 821

  Fly   500 E------------------------------KEEEEQAQESVEDIKP-------EPRPEMKD--- 524
            .                              :|.|:.|.|..||:..       |.:.|.:|
  Fly   822 SEQPPSPKRRKLAPRDPELDSDDDSTAVDSTEESEDAATEDEEDLSTVKTDTDMEEQDEQEDGLK 886

  Fly   525 ----------------------------------------------------LPQPKMFKGTLKG 537
                                                                .|.|.:.|.:|:.
  Fly   887 SLMADADATSGAAGSGSTAGASGNKDDMLNDAAALAESLQPKGNTLSSTNVVTPVPFLLKHSLRE 951

  Fly   538 YQIKGMTWLANIYDQGISGILADEMGLGKTVQSIAFLCHIAEHYGVWGPFLVISPASTLHNWQQE 602
            ||..|:.||..:.::.::||||||||||||:|:||.|.|:|...|.|||.|::.|:|.:.||:.|
  Fly   952 YQHIGLDWLVTMNERKLNGILADEMGLGKTIQTIALLAHLACAKGNWGPHLIVVPSSVMLNWEME 1016

  Fly   603 MSRFVPDFKVVPYWGSPAERKILRQFWDQKHLHTRDASFHVVITSYQLVVSDYKYFNRIKWQYMV 667
            ..::.|.||::.|:||..|||:.|..|      |:..:|||.||||:|||.|.:.|.|.||:|::
  Fly  1017 FKKWCPGFKILTYYGSQKERKLKRVGW------TKPNAFHVCITSYKLVVQDQQSFRRKKWKYLI 1075

  Fly   668 LDEAQAIKSAASQRWKLLLGFSCRNRLLLSGTPIQNSMAELWALLHFIMPTLFDSHDEFNEWFSK 732
            |||||.||:..||||:|||.||...||||:|||:||.:.|||:|:||:||.:|.||.||.||||.
  Fly  1076 LDEAQNIKNFKSQRWQLLLNFSTERRLLLTGTPLQNDLMELWSLMHFLMPYVFSSHREFKEWFSN 1140

  Fly   733 DIESHAENKTGIDEKQISRLHMILKPFMLRRIKKDVENELSDKIEIMVYCPLTIRQKLLYRALKQ 797
            .:....|.....:|..|:|||.:::||:|||:||:||.::..|.|.::.|.|:.||:.||.....
  Fly  1141 PMTGMIEGNMEYNETLITRLHKVIRPFLLRRLKKEVEKQMPKKYEHVITCRLSNRQRYLYEDFMS 1205

  Fly   798 KIRIEDLLHLTSGSTTTSSSSSASNLMNLVMQFRKVCNHPELFERRDARSPFFMRCAEYTIPRLI 862
            :.:..:          |..:.:..:::|::||.|||||||.:||.|...|||.|....:..|||:
  Fly  1206 RAKTRE----------TLQTGNLLSVINVLMQLRKVCNHPNMFEARPTISPFQMDGITFHTPRLV 1260

  Fly   863 ----------------------HEEGLIHRMLPSRKHLLYNRFNIFKSEYIQRSLFEDVNV---- 901
                                  |.|..:...:..:..||..          .|.|.||::.
  Fly  1261 CDIMEYDPFTQINLETLNLLLLHLEQTMTAYVSHKSRLLAP----------PRKLIEDIDTAPLP 1315

  Fly   902 -----NSCFGF------------TRLCDLSVGDMVEVTLNGL----IDFLLHYRRVLEKY----- 940
                 |..:.|            .:|..:.||....:.|.|.    :..||...|||::.
  Fly  1316 APRCPNGKYRFHIRVRSAELAQRIKLNAVKVGASPAMRLEGSKIMPMRNLLPSGRVLKRVSASIN 1380

  Fly   941 --------------------------PLLAYRRFWWKKQPDSRYQLLEP-------MLENKLALD 972
                                      |..|.......|...:|.|:..|       .:::.....
  Fly  1381 PVNMALKPVVINSVVTTTSSSTTASSPTGALSVLSNSKLLGARSQINAPTPAKVAKTMQDGKPFF 1445

  Fly   973 YMPP--NSVLKNFIFTAMTANESSVYAFGDYFTYNMQETIEHRVIRSKILKKKTSLIEEMEDVSK 1035
            |:.|  ||.......|..:...:|........|.....|...::||..|:|...:.::  ..|.|
  Fly  1446 YLTPATNSGAAGARLTLTSKTTASASTTTSRTTVTASTTSGQQLIRDPIVKDLATHVK--STVQK 1508

  Fly  1036 QKLEIESVEVQTKSNAKSDVKVTTLL--------------------------------------- 1061
            |.:.....|.:.::.|:...||..|:
  Fly  1509 QSIANGKTEPEEETEAEDPYKVQELIQMRKEQRLAALKRMAMINRRRTDATPIYGEDCREAIQRC 1573

  Fly  1062 ----------------------------------LLPEFPHRPRKPRKYVC---EPLSMPRILYD 1089
                                              ||..|..|        |   :|:....::|.
  Fly  1574 MQATRSLKRSTWQTRGYANCCTAMAHRNGWSLNHLLKSFEER--------CADLKPVFANFVIYV 1630

  Fly  1090 LGQKVQAVHRYLYCDSRSAAWSQIRHNQCENSQGRELVSSGLALCKPHGGWSSIVVPDKETLITD 1154
            .......:.||:. :..|..|   :|.|...:...:.:...|||..|.....:...||...:..|
  Fly  1631 PSVCAPRIRRYVQ-NLSSTHW---QHEQRIENIVDQALRPKLALLHPIISEMTTKFPDPRLIQYD 1691

  Fly  1155 AGKLFVLDNLLTRLKANGHRVLIYSQMTKMIDLLEEYMWHRKHRYMRLDGSSKISARRDMVADFQ 1219
            .|||..:|.||.:||.|||||||::|||||:|:||.::.:..|.|:|||||:::..|:.::..|.
  Fly  1692 CGKLQTMDRLLRQLKVNGHRVLIFTQMTKMLDVLEAFLNYHGHIYLRLDGSTRVEQRQILMERFN 1756

  Fly  1220 TRADIFVFLLSTRAGGLGINLTAADTVIFYDSDWNPTVDQQAMDRAHRLGQTKQVTVYRLICKGT 1284
            ....||.|:||||:||:|||||.||||||||||||||:|.||.||.||:|||:.|.:|||:.:.|
  Fly  1757 GDKRIFCFILSTRSGGVGINLTGADTVIFYDSDWNPTMDAQAQDRCHRIGQTRDVHIYRLVSERT 1821

  Fly  1285 IEERILQRAREKSEIQRMVISGGNFKPDTLKPKEVVSLLLDDEEIEMKYRQEAKLQSSSPIPAAT 1349
            ||..||::|.:|..:..|.|.||||.....|...:..|...::..:.:..||
  Fly  1822 IEVNILKKANQKRMLSDMAIEGGNFTTTYFKSSTIKDLFTMEQSEQDESSQE------------- 1873

  Fly  1350 QSERKRRHPQKDVNMGGTTIAATSATQNPDDDVPSCSSAAKRIK--LETEEDFIDVGITSSASS- 1411
            :||.|.|           .:|.|:.:..|...|.:...:.:..:  |...||..||..|.:|.:
  Fly  1874 KSENKDR-----------IVATTTLSDTPSTVVETEKQSLRAFEHALAAAEDEQDVQATKTAKAE 1927

  Fly  1412 -----VGTDSNHPTLSQETYVPGATCVQQTEIDSENEALV 1446
                 ...|.|.|..:::....|...|:.::.|.|.:.||
  Fly  1928 VAADLAEFDENIPIATEDPNAEGGPQVELSKADLEMQNLV 1967

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ino80	NP_732413.1	DBINO	313..438	CDD:290603	31/160 (19%)
		SNF2_N	538..840	CDD:278600	137/301 (46%)
		DEXDc	555..700	CDD:238005	77/144 (53%)
		Helicase_C	1156..1269	CDD:278689	67/112 (60%)
dom	NP_001286676.1	HSA	543..614	CDD:214727	20/96 (21%)
		ASF1_hist_chap	<674..831	CDD:304562	22/156 (14%)
		FAM176	<824..>868	CDD:291517	6/43 (14%)
		SNF2_N	952..1238	CDD:278600	137/301 (46%)
		DEXDc	969..1108	CDD:238005	77/144 (53%)
		Helicase_C	1692..1806	CDD:278689	67/113 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467169
Domainoid	1	1.000	47	1.000	Domainoid score	I705
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D11283at33392
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45685
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	4.040