DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ino80 and Chd3

DIOPT Version :9

Sequence 1:	NP_732413.1	Gene:	Ino80 / 42314	FlyBaseID:	FBgn0086613	Length:	1638	Species:	Drosophila melanogaster
Sequence 2:	NP_649111.1	Gene:	Chd3 / 40111	FlyBaseID:	FBgn0023395	Length:	892	Species:	Drosophila melanogaster

Alignment Length:	1242	Identity:	281/1242 - (22%)
Similarity:	425/1242 - (34%)	Gaps:	504/1242 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   284 DVEGGTEGQVTKVRRKRKNPAALAARRRRIWQIMSKKESGRL---QRIKSNNHKEMLA------- 338
            |.:..|.|:.:|.:|.:.|......|.....::.|  :.|.|   ....|..|:..|:
  Fly     8 DPDWKTPGKASKDKRPKTNAKKQKFRDEEYCKVCS--DGGDLLCCDSCPSVYHRTCLSPPLKSIP 70

  Fly   339 -------NCKRVAGMCAKVVRQRAINSQRIMKETVWRAKRLTREM------LAYW---------- 380
                   .|..:.|...|::..|....:.:...|....||  ||.      ::||
  Fly    71 KGDWICPRCIPLPGKAEKILSWRWALDRSVELRTSKGEKR--REYFIKWHGMSYWHCEWIPEGQM 133

  Fly   381 --KRYERVERDQRRK--QEREAEEQRKQDVELIE-VKRQQRKLNFLITQTELYAHFMSKKLGQGS 440
              .....|...|||.  :|...||...||..|.| ..|...|..:|:.|
  Fly   134 LLHHASMVASFQRRSDMEEPSLEELDDQDGNLHERFYRYGIKPEWLLVQ---------------- 182

  Fly   441 EEDQLRILSQLDEETNARLAAQDDYDAGEMKLLAQENA---EAAMQRDLDK----TRAFDVFAKK 498
                 |:::. .||.|          .|.|.|:.....   :::.:|:.|.    .:|..::.|.
  Fly   183 -----RVINH-SEEPN----------GGTMYLVKWRELSYNDSSWERESDSIPGLNQAIALYKKL 231

  Fly   499 KEKEEEEQAQESVEDIKPEPRPEM--KDLPQPKMFKGT---LKGYQIKGMTWLANIYDQGISGIL 558
            :...:..|..      :|.|..::  |...||...|..   |..:||:|::||...:.|||..||
  Fly   232 RSSNKGRQRD------RPAPTIDLNKKYEDQPVFLKEAGLKLHPFQIEGVSWLRYSWGQGIPTIL 290

  Fly   559 ADEMGLGKTVQSIAFLCHIAEHYGVWGPFLVISPASTLHNWQQEMSRFVPDFKVVPYWGSPAERK 623
            |||||||||:|::.||..:.:.....||||:..|.|||.||::|:..:.|:...|.|.|....|.
  Fly   291 ADEMGLGKTIQTVVFLYSLFKEGHCRGPFLISVPLSTLTNWERELELWAPELYCVTYVGGKTARA 355

  Fly   624 ILRQFWDQKH------LHTR-------DASFHVVITSYQLVVSDYKYFNRIKWQYMVLDEAQAIK 675
            ::|     ||      :.|:       ...|:|::|||:.:..|..:...|.|..:|:|||..::
  Fly   356 VIR-----KHEISFEEVTTKTMRENQTQYKFNVMLTSYEFISVDAAFLGCIDWAALVVDEAHRLR 415

  Fly   676 SAASQRWKLLLGFSCRNRLLLSGTPIQNSMAELWALLHFIMPTLFDSHDEFNEWFSKDIESHAEN 740
            |..|:.:::|..:....:|||:|||:||::.||:.||:|:      |..:||     |:::....
  Fly   416 SNQSKFFRILSKYRIGYKLLLTGTPLQNNLEELFHLLNFL------SSGKFN-----DLQTFQAE 469

  Fly   741 KTGID-EKQISRLHMILKPFMLRRIKKDVENELSDKIEIMVYCPLTIRQKLLY--------RALK 796
            .|.:. |:|:.|||.||:|.||||:|.||...:..|.|.:|...|:..||..|        :||.
  Fly   470 FTDVSKEEQVKRLHEILEPHMLRRLKADVLKSMPPKSEFIVRVELSSMQKKFYKHILTKNFKALN 534

  Fly   797 QKIRIEDLLHLTSGSTTTSSSSSASNLMNLVMQFRKVCNHPELFERRDARSPFFMRCAEYTIPRL 861
            ||                 ......:|:|::|..||.||||.||
  Fly   535 QK-----------------GGGRVCSLLNIMMDLRKCCNHPYLF--------------------- 561

  Fly   862 IHEEGLIHRMLPSRKHLLYNRFNIFKSEYIQRSLFEDVNVNSCFGFTRLCDLSVGDMVEVTLNGL 926
                       ||
  Fly   562 -----------PS---------------------------------------------------- 563

  Fly   927 IDFLLHYRRVLEKYPLLAYRRFWWKKQPDSRYQLLEPMLENKLALDYMPPNSVLKNFIFTAMTAN 991
                                                                          .|.
  Fly   564 --------------------------------------------------------------AAE 566

  Fly   992 ESSVYAFGDYFTYNMQETIEHRVIRSKILKKKTSLIEEMEDVSKQKLEIESVEVQTKSNAKSDVK 1056
            |:::...|.|                           ||..::|.
  Fly   567 EATISPSGLY---------------------------EMSSLTKA-------------------- 584

  Fly  1057 VTTLLLLPEFPHRPRKPRKYVCEPLSMPRILYDLGQKVQAVHRYLYCDSRSAAWSQIRHNQCENS 1121

  Fly   585 ----------------------------------------------------------------- 584

  Fly  1122 QGRELVSSGLALCKPHGGWSSIVVPDKETLITDAGKLFVLDNLLTRLKANGHRVLIYSQMTKMID 1186
                                             :|||.:|..:|.:|||:.||||::||||||::
  Fly   585 ---------------------------------SGKLDLLSKMLKQLKADNHRVLLFSQMTKMLN 616

  Fly  1187 LLEEYMWHRKHRYMRLDGSSKISARRDMVADFQTR-ADIFVFLLSTRAGGLGINLTAADTVIFYD 1250
            :||.::....::|.|:|||.|...|:..:..|... ::.||||||||||||||||..|||||.:|
  Fly   617 VLEHFLEGEGYQYDRIDGSIKGDLRQKAIDRFNDPVSEHFVFLLSTRAGGLGINLATADTVIIFD 681

  Fly  1251 SDWNPTVDQQAMDRAHRLGQTKQVTVYRLICKGTIEERILQRAREKSEIQRMVISGG------NF 1309
            |||||..|.||..||||:||.|:|.:||.:...::||||:|.|:.|..:..:|:..|      ||
  Fly   682 SDWNPHNDVQAFSRAHRMGQKKKVMIYRFVTHNSVEERIMQVAKHKMMLTHLVVRPGMGGMTTNF 746

  Fly  1310 KPDTLK---------------------PKEVVSLLLD--DEEIEMKYRQEAKLQSSSPIPAATQS 1351
            ..|.|:                     ..:.|:.|||  :..||.|.....:..||..:.:....
  Fly   747 SKDELEDILRFGTEDLFKDGKSEAIHYDDKAVADLLDRTNRGIEEKESWANEYLSSFKVASYATK 811

  Fly  1352 ERKRRH--------------------------PQKDVNMGGTTIAATSATQNPDDDVPSCSSAAK 1390
            |....|                          |:|.          ...:|....||.|.....|
  Fly   812 EDHEEHDDYNNDAENTDPFYWENLMGKSQPKLPKKQ----------KKQSQQSQVDVESIMGKGK 866

  Fly  1391 RIKLETE 1397
            ||:.|.:
  Fly   867 RIRKEID 873

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ino80	NP_732413.1	DBINO	313..438	CDD:290603	32/162 (20%)
		SNF2_N	538..840	CDD:278600	110/323 (34%)
		DEXDc	555..700	CDD:238005	53/157 (34%)
		Helicase_C	1156..1269	CDD:278689	62/113 (55%)
Chd3	NP_649111.1	PHD2_CHD_II	37..79	CDD:277007	6/43 (14%)
		CHROMO	85..147	CDD:237991	11/63 (17%)
		CHROMO	181..233	CDD:214605	12/83 (14%)
		SNF2_N	270..561	CDD:278600	110/323 (34%)
		DEXDc	288..440	CDD:238005	53/156 (34%)
		Helicase_C	585..700	CDD:278689	62/114 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467192
Domainoid	1	1.000	47	1.000	Domainoid score	I705
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.930