DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ino80 and brm

DIOPT Version :9

Sequence 1:	NP_732413.1	Gene:	Ino80 / 42314	FlyBaseID:	FBgn0086613	Length:	1638	Species:	Drosophila melanogaster
Sequence 2:	NP_001261906.1	Gene:	brm / 39744	FlyBaseID:	FBgn0000212	Length:	1658	Species:	Drosophila melanogaster

Alignment Length:	1457	Identity:	341/1457 - (23%)
Similarity:	560/1457 - (38%)	Gaps:	531/1457 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   204 EAQAGPKPPK----QRRRGRKKRDNMGSPESGE--VPPSELGKYTFGDTL----PNNEDDDEDGG 258
            :.|:.|.||:    |...|.|.. :|| |..|:  :|.|.:.....| ||    |.::.....||
  Fly   314 QQQSQPPPPEPHQHQLPNGGKPL-SMG-PSGGQPLIPSSPMQPQVRG-TLPGMPPGSQVPQPGGG 375

  Fly   259 EVDYKRELASLALDYPEEEEIE--------EEVDVEGGTEGQVT-----KVRRKRKNPAAL---- 306
            .   :|::....:..|:...|.        :.:.:....|.::.     :::..::.||.:
  Fly   376 P---QRQVPPAGMPMPKPNRITTVAKPVGLDPITLLQERENRIAARISLRMQELQRLPATMSEDL 437

  Fly   307 ---AARRRRIWQIMSKKESGRLQRIKSNNHK---EMLANCK----------RVAGMCAKVVRQRA 355
               ||...|..::::.:...|::.::.....   |...|.|          |.|....|:.:|:.
  Fly   438 RLQAAIELRALRVLNFQRQLRMEFVQCTRRDTTLETALNIKLYKRTKRQGLREARATEKLEKQQK 502

  Fly   356 INSQR--------IMKETVWRAK-----------RLTREMLAYWKRYERVERDQRRKQER-EAEE 400
            :.::|        .:...:...|           :|.|...|....:...||:|:::||| |.|.
  Fly   503 LEAERKRRQKHLEFLAAVLQHGKDLREFHRNNKAQLARMNKAVMNHHANAEREQKKEQERIEKER 567

  Fly   401 QRK---QDVE----LIEVKRQQRKLNFLITQTELYAHFMSKKLGQGSEEDQLR------------ 446
            .|:   :|.|    ||:.|:.:| |.||::||:.|...:::.:.| .::||::
  Fly   568 MRRLMAEDEEGYRKLIDQKKDKR-LAFLLSQTDEYISNLTQMVKQ-HKDDQMKKKEEEGKRLIQF 630

  Fly   447 -------------------------ILSQ-----------------------------LDEETNA 457
                                     ::.|                             :|:|.::
  Fly   631 KKELLMSGEYIGIDEGSIVADMRVHVVEQCTGKKLTGDDAPMLKHLHRWLNMHPGWDWIDDEEDS 695

  Fly   458 RLAAQDDYDAGEMKLLAQENAEAAMQRDLDKTRAFDVFAKKKEKEE----EEQAQESVEDIKPEP 518
            ..:..|.....|.:..|.|:|....|...:...|.|:..|.|.:::    |||...|:.....|.
  Fly   696 CGSNDDHKPKVEEQPTATEDATDKAQATGNDEDAKDLITKAKVEDDEYRTEEQTYYSIAHTIHEK 760

  Fly   519 RPEMKDLPQPKMFKGTLKGYQIKGMTWLANIYDQGISGILADEMGLGKTVQSIAFLCHIAEHYGV 583
            ..|...:    |..||||.|||||:.||.::|:..::||||||||||||:|:|:.:.::.:...|
  Fly   761 VVEQASI----MVNGTLKEYQIKGLEWLVSLYNNNLNGILADEMGLGKTIQTISLVTYLMDRKKV 821

  Fly   584 WGPFLVISPASTLHNWQQEMSRFVPDFKVVPYWGSPAERKILRQFWDQKHLHTRDASFHVVITSY 648
            .||:|:|.|.|||.||..|..::.|...||.|.|||..|::|:.       ..|...|:|::|:|
  Fly   822 MGPYLIIVPLSTLPNWVLEFEKWAPAVGVVSYKGSPQGRRLLQN-------QMRATKFNVLLTTY 879

  Fly   649 QLVVSDYKYFNRIKWQYMVLDEAQAIKSAASQRWKLL-LGFSCRNRLLLSGTPIQNSMAELWALL 712
            :.|:.|.....:|:|:||::||...:|:...:..::| ..:....||||:|||:||.:.||||||
  Fly   880 EYVIKDKAVLAKIQWKYMIIDEGHRMKNHHCKLTQVLNTHYIAPYRLLLTGTPLQNKLPELWALL 944

  Fly   713 HFIMPTLFDSHDEFNEWFSKDIESHAENKTGIDEKQ----ISRLHMILKPFMLRRIKKDVENELS 773
            :|::|::|.|...|.:||:....:..| |..::|::    |.|||.:|:||:|||:||:||::|.
  Fly   945 NFLLPSIFKSCSTFEQWFNAPFATTGE-KVELNEEETILIIRRLHKVLRPFLLRRLKKEVEHQLP 1008

  Fly   774 DKIEIMVYCPLTIRQKLLYRALKQKIRIEDLLHLTSGSTT-TSSSSSASNLMNLVMQFRKVCNHP 837
            ||:|.::.|.::..|::||:.::.|..:     ||.||.. ......|..|||.::|.||:||||
  Fly  1009 DKVEYIIKCDMSALQRVLYKHMQSKGVL-----LTDGSEKGKHGKGGAKALMNTIVQLRKLCNHP 1068

  Fly   838 ELFERRDARSPFFMRCAEYTIPRLIHEEGLIHRMLPSRKHLLYNRFNIFKSEYIQRSLFEDVNVN 902
            .:|:                     |.|
  Fly  1069 FMFQ---------------------HIE------------------------------------- 1075

  Fly   903 SCFGFTRLCDLSVGDMVEVTLNGLIDFLLHYRRVLEKYPLLAYRRFWWKKQPDSRYQLLEPMLEN 967
                                               |||
  Fly  1076 -----------------------------------EKY--------------------------- 1078

  Fly   968 KLALDYMPPNSVLKNFIFTAMTANESSVYAFGDYFTYNMQETIEHRVIRSKILKKKTSLIEEMED 1032

  Fly  1079 ----------------------------------------------------------------- 1078

  Fly  1033 VSKQKLEIESVEVQTKSNAKSDVKVTTLLLLPEFPHRPRKPRKYVCEPLSMPRILYDLGQKVQAV 1097

  Fly  1079 ----------------------------------------------------------------- 1078

  Fly  1098 HRYLYCDSRSAAWSQIRHNQCENSQGRELVSSGLALCKPHGGWSSIVVPDKETLITDAGKLFVLD 1162
                                |:::.|..:||.                ||   |...:||..:||
  Fly  1079 --------------------CDHTGGHGVVSG----------------PD---LYRVSGKFELLD 1104

  Fly  1163 NLLTRLKANGHRVLIYSQMTKMIDLLEEYMWHRKHRYMRLDGSSKISARRDMVADFQTR-ADIFV 1226
            .:|.:|||..||||::.|||:.:.::|:|:..|:..|:||||::|...|.:::..|..: :|:||
  Fly  1105 RILPKLKATNHRVLLFCQMTQCMTIIEDYLGWRQFGYLRLDGTTKAEDRGELLRKFNAKGSDVFV 1169

  Fly  1227 FLLSTRAGGLGINLTAADTVIFYDSDWNPTVDQQAMDRAHRLGQTKQVTVYRLICKGTIEERILQ 1291
            |||||||||||:||..||||:.:||||||..|.||.|||||:||..:|.|.||:...::|||||.
  Fly  1170 FLLSTRAGGLGLNLQTADTVVIFDSDWNPHQDLQAQDRAHRIGQRNEVRVLRLMTVNSVEERILA 1234

  Fly  1292 RAREKSEIQRMVISGGNF--KPDTLKPKEVVSLLL--------------DDEEIEMKY-RQEAKL 1339
            .||.|..:...||..|.|  |....:.::.:..:|              |||.|.|.. |.|.::
  Fly  1235 AARYKLNMDEKVIQAGMFDQKSTGSERQQFLQTILHQDDNEEEEENEVPDDEMINMMIARSEEEI 1299

  Fly  1340 QSSSPIPAATQSERKRRHPQKDVNMGGTTIAATSATQNPD----DDVPSCSSAAKRIKLETEEDF 1400
            :....:.|..:.|.:..||.::        .....::.||    ||     ...:|...:.:||.
  Fly  1300 EIFKRMDAERKKEDEEIHPGRE--------RLIDESELPDWLTKDD-----DEVERFHYQYDEDT 1351

  Fly  1401 I---------DVGITSSASSVGTDSNHPTLSQETYV----PGATCVQQTEIDSENEALVVDGDSP 1452
            |         :|..|.|            |:::.::    .||      |.|.|.|    :.||.
  Fly  1352 ILGRGSRQRKEVDYTDS------------LTEKEWLKAIDDGA------EFDEEEE----EDDSK 1394

  Fly  1453 TMLGQNES-MNFLDDLSGISPMRRRHH 1478
            ....:.:: ....||.|.|...|||.:
  Fly  1395 RKRRKRKNRKEESDDDSLILKRRRRQN 1421

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ino80	NP_732413.1	DBINO	313..438	CDD:290603	34/164 (21%)
		SNF2_N	538..840	CDD:278600	121/307 (39%)
		DEXDc	555..700	CDD:238005	55/145 (38%)
		Helicase_C	1156..1269	CDD:278689	60/113 (53%)
brm	NP_001261906.1	QLQ	172..202	CDD:214931
		Drf_FH1	251..390	CDD:283903	21/81 (26%)
		HSA	501..573	CDD:214727	14/71 (20%)
		BRK	649..693	CDD:197800	2/43 (5%)
		PHA02934	687..>824	CDD:165245	46/140 (33%)
		SNF2_N	776..1071	CDD:278600	121/307 (39%)
		DEXDc	793..932	CDD:238005	55/145 (38%)
		Helicase_C	1097..1212	CDD:278689	60/114 (53%)
		SnAC	1304..1375	CDD:291293	16/95 (17%)
		Bromo_SNF2L2	1425..1530	CDD:99947
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467180
Domainoid	1	1.000	47	1.000	Domainoid score	I705
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.930