DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ino80 and Marcal1

DIOPT Version :9

Sequence 1:	NP_732413.1	Gene:	Ino80 / 42314	FlyBaseID:	FBgn0086613	Length:	1638	Species:	Drosophila melanogaster
Sequence 2:	NP_608883.1	Gene:	Marcal1 / 33709	FlyBaseID:	FBgn0031655	Length:	755	Species:	Drosophila melanogaster

Alignment Length:	908	Identity:	168/908 - (18%)
Similarity:	262/908 - (28%)	Gaps:	422/908 - (46%)

- Green bases have known domain annotations that are detailed below.

  Fly   504 EEQAQESVEDIKPEPRPEMKDLPQPKMFKGTLKGYQIKGMTWLANIYDQGISGILADEMGLGKTV 568
            |.....|:|       |::.|...|....|.......||..            ::.||||||||.
  Fly   232 ERSVLASIE-------PKLADQLMPFQQDGVCFAIAQKGRI------------MICDEMGLGKTY 277

  Fly   569 QSIAFLCHIAEHYGVWGPFLVISPASTLHNWQQEMSRFVPDFKVVPYWGSPAERKILRQFWDQKH 633
            |::|    :|:::....|.||.:.|||..:|.:.:...:|  ||..::         .|..:...
  Fly   278 QALA----VADYFKDDWPLLVCTTASTRDSWAKHIMDLLP--KVPIHY---------VQVLNNNQ 327

  Fly   634 LHTRDASFHVVITSYQLVVSDYKYFNRIKWQYMVLDEAQAIKSA------ASQRWKLLLGFSCRN 692
            |:..:|.  |:||||.::........:.|:.:::.||:..:|::      .::|    |....:.
  Fly   328 LYVGEAK--VLITSYNMMERHEDKLMQRKFGFIIFDESHTLKNSKAKCTTTAKR----LTDQAKR 386

  Fly   693 RLLLSGTPIQNSMAELWALLHFIMPTLFDSHDEFNEWFSKDIES----HAENKTGIDEKQISRLH 753
            .:||||||..:...||:..|..| ...|.:..||...:....:|    .|..::.::|.::. ||
  Fly   387 VVLLSGTPALSRPLELFTQLQMI-DGKFMNFMEFTTRYCDGKQSTFGWDANGQSNLEELKVI-LH 449

  Fly   754 MILKPFMLRRIKKDVENELSDKIEIMVYCPLTIRQKLLYRALKQKIRIEDLLHLTSGSTTTSSSS 818
            :   .:||||.|.:|..:|::|
  Fly   450 L---KYMLRRTKVEVLPQLAEK------------------------------------------- 468

  Fly   819 SASNLMNLVMQFRKVCNHPELFERRDARSPFFMRCAEYTIPRLIHEEGLIHRMLPSRKHLLYNRF 883
               |...:|:....|..:.|..|..||
  Fly   469 ---NRETVVLDPALVWTNAETKETLDA-------------------------------------- 492

  Fly   884 NIFKSEYIQRSLFEDVNVNSCFGFTRLCDLSVGDMVEVTLNGLIDFLLHYRRVLEKYPLLAYRRF 948
              |..|.                              .|..|         |..|:..|..|.|
  Fly   493 --FNKEL------------------------------KTAKG---------RATEEILLRFYAR- 515

  Fly   949 WWKKQPDSRYQLLEPMLENKLALDYMPPNSVLKNFIFTAMTANESSVYAFGDYFTYNMQETIEHR 1013

  Fly   516 ----------------------------------------------------------------- 515

  Fly  1014 VIRSKILKKKTSLIEEMEDVSKQKLEIESVEVQTKSNAKSDVKVTTLLLLPEFPHRPRKPRKYVC 1078
                                        :.||:|:
  Fly   516 ----------------------------TAEVKTR------------------------------ 522

  Fly  1079 EPLSMPRILYDLGQKVQAVHRYLYCDSRSAAWSQIRHNQCENSQGRELVSSGLALCKPHGGWSSI 1143
                             ||..||
  Fly   523 -----------------AVCAYL------------------------------------------ 528

  Fly  1144 VVPDKETLITDAGKLFVLDNLLTRLKANGHRVLIYSQMTKMIDLLEEYMWHRKHRYMRLDGSSKI 1208
                 :||:.:..|..:..:         |||        |:|.:.:::...|..|:|:||.::.
  Fly   529 -----KTLVKEQKKFIIFAH---------HRV--------MMDAISDFLSGLKVHYIRIDGQTRS 571

  Fly  1209 SARRDMVADFQTRADIFVFLLSTRAGGLGINLTAADTVIFYDSDWNPTVDQQAMDRAHRLGQTKQ 1273
            ..|.|.|..||.::...|.|||.:|...||.||||:.::|.:.||||:...||..||||:||||.
  Fly   572 DHRSDSVDTFQKKSSCKVALLSLKACNSGITLTAAEIIVFAELDWNPSTLAQAESRAHRIGQTKP 636

  Fly  1274 VTVYRLICKGTIEERILQRAREKSEI-QRMVISGGN-------------------FKPDTLKPKE 1318
            |....||...|.::.|....:.|.|: .::.|...|                   |.|.|
  Fly   637 VICRYLIAHNTADDIIWNMLKNKQEVLSKVGIFAENLQKATHTAAPTSSHKIEEYFSPST----- 696

  Fly  1319 VVSLLLDDEEIEMKYRQEAKLQSSSPIPAATQSERKRRHPQKDVNMGGTTIAATSATQNPDDD 1381
              |..|:.|...:|       |..|.|||....|:........||...:.|||..   |.|||
  Fly   697 --STSLEPERNSIK-------QYFSTIPAKEPPEQNNNTEMTKVNKAESDIAAFF---NDDDD 747

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ino80	NP_732413.1	DBINO	313..438	CDD:290603
		SNF2_N	538..840	CDD:278600	67/311 (22%)
		DEXDc	555..700	CDD:238005	39/150 (26%)
		Helicase_C	1156..1269	CDD:278689	38/112 (34%)
Marcal1	NP_608883.1	HARP	160..215	CDD:284784
		DEXDc	239..420	CDD:214692	54/221 (24%)
		DEXDc	265..394	CDD:238005	39/161 (24%)
		Helicase_C	518..632	CDD:278689	47/224 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467200
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930