DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ino80 and ino80

DIOPT Version :9

Sequence 1:	NP_732413.1	Gene:	Ino80 / 42314	FlyBaseID:	FBgn0086613	Length:	1638	Species:	Drosophila melanogaster
Sequence 2:	NP_001018299.1	Gene:	ino80 / 3361566	PomBaseID:	SPAC29B12.01	Length:	1604	Species:	Schizosaccharomyces pombe

Alignment Length:	1385	Identity:	518/1385 - (37%)
Similarity:	748/1385 - (54%)	Gaps:	236/1385 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEAKPVPAPQPRPRAMAEPLHIQRLEAALNMRPFMNMAKRSLRKPLSSDEETDDEHVV-----KR 60
            :||..:.|.:.:.:...|. .::.|:.:.:....||.|..:    .|.:|:..|:..:     |:
pombe   397 VEAAKIRADEEKKKKEREE-QVRLLQESADKDAEMNEASTA----TSENEDLKDDLSLADLSSKK 456

  Fly    61 EHDVQDSDDSSTVGVVRMKQSSKRKSRLLASKEERQSVKAQLYNFNDLTSDREWLYDLLLSDTES 125
            ..:.|.:::::|....::|..||.:|:   :|.::...|                   |.|||..
pombe   457 TANSQATENNNTPSKAKVKAESKVRSK---AKSDKSRAK-------------------LSSDTNK 499

  Fly   126 DDPTITEDEYVQQLLREHVREQRQRKNYYKKAANAQYAYYGSGLLSNHDIFAERQLATAGVRKRR 190
            |.                           :|..|...:...:|:.|:.:...|..|..|...|:.
pombe   500 DS---------------------------EKNDNNDASLQSAGVASDGESSPETPLTKASKSKKA 537

  Fly   191 RRTKQEILMARLAEAQAGPKPPKQRRRGRKKRDNMGSPESGEVPPSELGKYTF-GDTLPNNEDDD 254
            :.:|.....::.|..:....|.|.:::..|.:....|..:.       ||... ||:.......:
pombe   538 KASKLANDTSKNANGETKSTPKKSKKKTSKAQQEANSTTAE-------GKEKLSGDSTETGNSTN 595

  Fly   255 EDGGEVDYKRELASLALDYPEEEEIEEEVDVEGGTEGQVTKVRRKRKNPAALAARRRRIWQIMSK 319
            ::....|.|....:.|                         ..:|:|....|   ::::.:.:::
pombe   596 KEASTEDTKANATASA-------------------------PNKKKKTVETL---QQQVIKEIAR 632

  Fly   320 KESGRLQRIKSNNHKEMLANCKRVAGMCAKVVRQRAINSQRIMKETVWRAKRLTREMLAYWKRYE 384
            ||..|:.:|...|......|.::.:.:|.:..|:....:.:..|:...:|||..||.:.:|||.|
pombe   633 KEIPRVYKIIQQNQYNRSTNARKTSQLCGREARRWQFRTIKNNKDMQTKAKRAMRETMVFWKRNE 697

  Fly   385 RVERDQRRKQEREAEEQRKQDVELIEVKRQQRKLNFLITQTELYAHFMSKKLGQGSEEDQLRILS 449
            |||||.|:|.||||.::.|::.||.|.:||.|||:|||||||||:||:.:|:.:  |:|
pombe   698 RVERDLRKKAEREALDRAKKEEELRESRRQARKLDFLITQTELYSHFVGRKMDR--EQD------ 754

  Fly   450 QLDEETNARLAAQDDYDAGE---MKLLAQENAEAAMQRDLDKTRAFDVFAKKKEKEEEEQAQESV 511
             |...||....::.::|:.|   ::.||.|:|:.|:|:..:.::.||...::..........|..
pombe   755 -LPSATNTASVSEINFDSDEEEDIRRLAVESAQEAVQKAREHSQLFDANRQQSPNNSSSDMNEGE 818

  Fly   512 EDIKPEPRPEMKDLPQPKMFKGTLKGYQIKGMTWLANIYDQGISGILADEMGLGKTVQSIAFLCH 576
            .:.:........::.||||....||.||:||:.||||:|:|||:||||||||||||||||:.:.:
pombe   819 MNFQNPTLVNAFEVKQPKMLMCKLKEYQLKGLNWLANLYEQGINGILADEMGLGKTVQSISVMAY 883

  Fly   577 IAEHYGVWGPFLVISPASTLHNWQQEMSRFVPDFKVVPYWGSPAERKILRQFWDQKHL-HTRDAS 640
            :||.:.:|||||||:|||||||||||::||||..|.:|||||..:|||||:||.:|:: :..::.
pombe   884 LAETHNIWGPFLVIAPASTLHNWQQEITRFVPKLKCIPYWGSTKDRKILRKFWCRKNMTYDENSP 948

  Fly   641 FHVVITSYQLVVSDYKYFNRIKWQYMVLDEAQAIKSAASQRWKLLLGFSCRNRLLLSGTPIQNSM 705
            ||||:|||||||.|.:||..:|||||:|||||||||::|.|||.||.|.|||||||:||||||:|
pombe   949 FHVVVTSYQLVVLDAQYFQSVKWQYMILDEAQAIKSSSSSRWKSLLAFKCRNRLLLTGTPIQNTM 1013

  Fly   706 AELWALLHFIMPTLFDSHDEFNEWFSKDIESHAENKTGIDEKQISRLHMILKPFMLRRIKKDVEN 770
            .|||||||||||:|||||:||:|||||||||||::.|.::|:|:.|||||||||||||:||:|::
pombe  1014 QELWALLHFIMPSLFDSHNEFSEWFSKDIESHAQSNTQLNEQQLKRLHMILKPFMLRRVKKNVQS 1078

  Fly   771 ELSDKIEIMVYCPLTIRQKLLYRALKQKIRIEDLLH--LTSGSTTTSSSSSASNLMNLVMQFRKV 833
            ||.:|||..|||.||.|||:||:||:::|.|.:||.  :..|..|.:|      :||||||||||
pombe  1079 ELGEKIEKEVYCDLTQRQKILYQALRRQISIAELLEKAILGGDDTVAS------IMNLVMQFRKV 1137

  Fly   834 CNHPELFERRDARSPFFM-----------------------RCAEYTIPRLIHEEGLIHRMLPS- 874
            ||||:||||.|.|||..:                       ....::||||::|:|.| ..:|.
pombe  1138 CNHPDLFEREDVRSPLSLATWSKSIYINREGNFLDVPYNTRNFITFSIPRLLYEQGGI-LSVPGL 1201

  Fly   875 ------RKHLLYNRFNIFKSEYIQRSLFEDVNVNSCFGFTRLCDLSVGDMVEVTLNGLIDFLLHY 933
                  ....|||..||:..||...|:..:.. .|.|.:.|..|.|...:.:...|.::    ||
pombe  1202 NTSRGFETKYLYNLMNIWNPEYTNDSIKSNPE-GSPFSWLRFVDESPQTLFQTFQNPVV----HY 1261

  Fly   934 RRVLE-----KYPLLAYRRFWWKKQPDSRYQLLEPMLENKLALDYMPPNSVLKNFIFTAMTANES 993
            ....|     |...|..:.|.:.|.    |..:..||        :.|.|:.|..:..:....:|
pombe  1262 LDEAEASSSLKEEQLCRQEFCYGKD----YSNVRKML--------LLPKSITKVDVLGSDFKEDS 1314

  Fly   994 SVYAFGDYFTYNMQETIEHRVIRSKILKKKTSLIEEMEDVSKQKLE---IESVEVQTKSNAKSDV 1055
            ..|..                         |.::||    |..:|:   ::||.||..|....|:
pombe  1315 PFYHL-------------------------THVLEE----SDSQLDLTLLDSVLVQRASAPPIDI 1350

  Fly  1056 KVTTLLLLPEFPHRPRKPRKYVCEPLSMPRILYDLGQKVQAVHRYLYCDSRSAAWSQIRHNQCEN 1120
                                 .|.......:|....|:......|||...:... ..|.:||..:
pombe  1351 ---------------------YCPGSRQFTVLQSRFQRDHLWSHYLYQPLKGEE-DLIINNQAVS 1393

  Fly  1121 S----QGRELVSSGLALCKPHGGWSSIVVPDKETLITDAGKLFVLDNLLTRLKANGHRVLIYSQM 1181
            .    :...|.|.|:|    .|.:|::.:|.....|.|:|||..||.||..||||.||||||.||
pombe  1394 KLPIPRKPLLPSFGIA----KGSYSNVRIPSMLRFIADSGKLSKLDKLLVELKANDHRVLIYFQM 1454

  Fly  1182 TKMIDLLEEYMWHRKHRYMRLDGSSKISARRDMVADFQTRADIFVFLLSTRAGGLGINLTAADTV 1246
            |:||||:|||:..|:::|:|||||||||.|||||.::|||.::||||||||||||||||||||||
pombe  1455 TRMIDLMEEYLTFRQYKYLRLDGSSKISQRRDMVTEWQTRPELFVFLLSTRAGGLGINLTAADTV 1519

  Fly  1247 IFYDSDWNPTVDQQAMDRAHRLGQTKQVTVYRLICKGTIEERILQRAREKSEIQRMVISGGNFKP 1311
            |||||||||::|.||||||||:||.|||||||.|.:|||||||:.||:||.|:|::|||||..:|
pombe  1520 IFYDSDWNPSIDSQAMDRAHRIGQQKQVTVYRFITRGTIEERIVIRAKEKEEVQKVVISGGETRP 1584

  Fly  1312 D---TLK--PKEVVSLLLDD 1326
            .   .||  .:|:||.||::
pombe  1585 TKQMDLKGNSREMVSWLLEE 1604

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ino80	NP_732413.1	DBINO	313..438	CDD:290603	50/124 (40%)
		SNF2_N	538..840	CDD:278600	201/304 (66%)
		DEXDc	555..700	CDD:238005	97/145 (67%)
		Helicase_C	1156..1269	CDD:278689	86/112 (77%)
ino80	NP_001018299.1	DBINO	619..750	CDD:290603	51/133 (38%)
		SNF2_N	845..1144	CDD:278600	201/304 (66%)
		DEXDc	862..1008	CDD:238005	97/145 (67%)
		HELICc	1427..1550	CDD:238034	93/122 (76%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	410	1.000	Domainoid score	I92
eggNOG	1	0.900	-	-		E2759_KOG0388
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	821	1.000	Inparanoid score	I60
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005575
OrthoInspector	1	1.000	-	-		oto100673
orthoMCL	1	0.900	-	-		OOG6_103743
Panther	1	1.100	-	-	LDO	PTHR45685
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R612
SonicParanoid	1	1.000	-	-		X3990
TreeFam	1	0.960	-	-
	12	11.850