DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ino80 and okr

DIOPT Version :9

Sequence 1:	NP_732413.1	Gene:	Ino80 / 42314	FlyBaseID:	FBgn0086613	Length:	1638	Species:	Drosophila melanogaster
Sequence 2:	NP_476661.1	Gene:	okr / 33507	FlyBaseID:	FBgn0002989	Length:	784	Species:	Drosophila melanogaster

Alignment Length:	983	Identity:	195/983 - (19%)
Similarity:	334/983 - (33%)	Gaps:	384/983 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   434 KKLGQGSEEDQLRILSQLDEETNA-------RLAAQDDYDAGEMKLLAQE--------------N 477
            ::|.:..|.|:.| |..|.:.:|.       |..|..:|:....|:||::              .
  Fly    35 QELEREQELDRRR-LGALRDASNTSELPLPIRFTANSEYELAIAKVLARKFKVPMDNYVPDYGGK 98

  Fly   478 AEAAMQRDLDKTRAFDVFAKKKEKEEEEQAQESVEDIKPEPRPEMKDLPQPKMFKGTLKGYQIKG 542
            ....::|.:.:....|..|..........|....|.:..:|...:..:....:....|:.:|.:|
  Fly    99 RVLGVRRCISRRPLHDPMACNALVLFHPPAYTEHERMGMDPTKVLVHVVVDPLLSNILRPHQREG 163

  Fly   543 MTWLANIYD--QGISG-----ILADEMGLGKTVQSIAFLCHIAEHYGVW-----GP--------F 587
            :.::   |:  :|..|     |:|||||||||:|.:..         ||     ||        .
  Fly   164 VRFM---YECVEGKRGNFNGCIMADEMGLGKTLQCVTL---------VWTLLRQGPECKPTINKA 216

  Fly   588 LVISPASTLHNWQQEMSRFVPD-FKVVPYWGSPAERKI--LRQFWDQKHLHTRDASFHVVITSYQ 649
            :|:||:|.:.||::|.::::.. ...:|..|...|..|  |.||    .:.:......|::.||:
  Fly   217 IVVSPSSLVKNWEKEFTKWLHGRLLCLPMEGGTKENTIRALEQF----SMTSARLGTPVLLISYE 277

  Fly   650 LVVSDYKYFNRIKWQY----MVLDEAQAIKSAASQRWKLLLGFSCRNRLLLSGTPIQNSMAELWA 710
                .::.:..|..:|    ::.||...:|::.:..::.|:|...:.|:|||||||||.:.|.::
  Fly   278 ----TFRIYAEILCKYEVGMVICDEGHRLKNSDNLTYQALMGLKTKRRVLLSGTPIQNDLTEYYS 338

  Fly   711 LLHFIMPTLFDSHDEFNEWFSKDI-------ESHAENKTGIDEKQISRLHMILKPFMLRRIKKDV 768
            |::|:.|.:..:...|...|...|       .:..|.:..|::.|  .|..::...::||..:.:
  Fly   339 LVNFVNPEMLGTAAVFKRNFESAILRGQNTDSTEQERQRAIEKTQ--ELIGLVDQCIIRRTNQIL 401

  Fly   769 ENELSDKIEIMVYCPLTIRQKLLYRALKQKIRIEDLLHLTSGSTTTSSSSSASNLMNLVMQFRKV 833
            ...|..|.|:::...||..|..||.
  Fly   402 TKYLPVKFEMVICAKLTAIQLELYT---------------------------------------- 426

  Fly   834 CNHPELFERRDARSPFFMRCAEYTIPRLIHEEGLIHRMLPSRKHLLYNRFNIFKSEYIQRSLFED 898
                                                              |..||:.::|||.:
  Fly   427 --------------------------------------------------NFLKSDQVRRSLAD- 440

  Fly   899 VNVNSCFGFTRLCDLSVGDMVEVTLNGLIDFLLHYRRVLEKYPLLAYRRFWWKKQPDSRYQLLEP 963
                        |:
  Fly   441 ------------CN--------------------------------------------------- 442

  Fly   964 MLENKLALDYMPPNSVLKNFIFTAMTANESSVYAFGDYFTYNMQETIEHRVIRSKILKKKTSLIE 1028
                                       .::|:.|..|
  Fly   443 ---------------------------EKASLTALAD---------------------------- 452

  Fly  1029 EMEDVSKQKLEIESVEVQTKSNAKSDVKVTTLLLLPEFPHRPRKPRKYVCEPLSMPRILYDLGQK 1093
                                        :|||              |.:|   |.|.::|   :|
  Fly   453 ----------------------------ITTL--------------KKIC---SHPDLIY---EK 469

  Fly  1094 VQAVHRYLYCDSRSAAWSQIRHNQCENSQGRELVSSGLALCKPHGGWSSIVVPD----KETLITD 1154
            :.|                 |....||||.                    |:|.    |:.....
  Fly   470 LTA-----------------REKGFENSQN--------------------VLPSNYKPKDLNPEL 497

  Fly  1155 AGKLFVLDNLLTRLKANGH-RVLIYSQMTKMIDLLEEYMWHRKHRYMRLDGSSKISARRDMVADF 1218
            :||..:||.:|..::|.|: :|::.|..|:.:||.|:....||:.::||||:..|..|..:|..|
  Fly   498 SGKFMLLDFMLAAIRAEGNDKVVLISNYTQTLDLFEQLARKRKYGFVRLDGTMSIKKRSKVVDRF 562

  Fly  1219 -QTRADIFVFLLSTRAGGLGINLTAADTVIFYDSDWNPTVDQQAMDRAHRLGQTKQVTVYRLICK 1282
             ...:|.|:|:||::|||.|:||..|:.:..:|.||||..|:|||.|..|.||.|...:|||:..
  Fly   563 NDPESDSFLFMLSSKAGGCGLNLIGANRLFMFDPDWNPANDEQAMARVWRDGQKKPCYIYRLVAS 627

  Fly  1283 GTIEERILQRAREKSEIQRMVISGG-----NFKPDTLKPKEVVSL-LLDDEEIEMKYRQEAKLQS 1341
            |:|||:||||...|..:...:|...     :|..|.||....... :|.|...::|.::..:...
  Fly   628 GSIEEKILQRQTHKKSLSSTIIDNNESAEKHFTRDDLKDLFTFDANILSDTHDKLKCKRCVQNIQ 692

  Fly  1342 SSPIPAAT 1349
            ..|.|..|
  Fly   693 MKPPPEDT 700

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ino80	NP_732413.1	DBINO	313..438	CDD:290603	1/3 (33%)
		SNF2_N	538..840	CDD:278600	75/335 (22%)
		DEXDc	555..700	CDD:238005	45/169 (27%)
		Helicase_C	1156..1269	CDD:278689	46/114 (40%)
okr	NP_476661.1	SNF2_N	159..466	CDD:278600	92/582 (16%)
		DEXDc	179..328	CDD:238005	44/165 (27%)
		HELICc	493..622	CDD:238034	49/128 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467199
Domainoid	1	1.000	47	1.000	Domainoid score	I705
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.930