Protein Alignment Ino80 and Ino80

DIOPT Version :10

• Sequence 1: NP_732413.1
• Gene: Ino80 / 42314
• FlyBaseID: FBgn0289122
• Length: 1638
• Species: Drosophila melanogaster
• Sequence 2: NP_001248333.1
• Gene: Ino80 / 296084
• RGDID: 1310969
• Length: 1559
• Species: Rattus norvegicus
• Alignment Length: 1739
• Identity: 748/1739 - (43%)
• Similarity: 957/1739 - (55%)
• Gaps: 325/1739 - (18%)

  Fly    16 MAEPLHIQRLEAALNMRPFMNMAKRSLRKPLSSDEE---TDDEHVVKREH-----DVQDSDDSST 72
            :|:||::|.||.||.:..|:........:.:|||:.   .||.:.:..|.     .|::...:|.
  Rat    16 LAKPLYLQYLERALRLDHFLRQTSAIFNRNISSDDSEDGLDDNNPLLPESGDPLIQVKEEPPNSL 80

  Fly    73 VGVVRMKQSSKRKSRLL-------ASKEERQSVKAQLYNFNDLTSDREWLYDLLLSDTESDDPTI 130
            :|    :.|....|.||       ..:.|.:|.|..||||:.|...|:||..:||||..|:..:.
  Rat    81 LG----ETSGASSSGLLNPYSLNGVLQSESKSDKGNLYNFSKLKKSRKWLKSILLSDESSEADSQ 141

  Fly   131 TED------------EYVQQLLREHVREQRQRKNYYKKAANAQYAYYGSGLLSNHDIFAERQLAT 183
            :||            |.:..:||.|..::..:..|.|.....||.||.:||||..|.|.|:|...
  Rat   142 SEDNDDEEEELSLSREELHNMLRLHKYKKLHQNKYSKDKELQQYQYYSAGLLSTCDPFYEQQRHL 206

  Fly   184 AGVRKRRRRTKQEILMARLAEAQAGPKPPKQRRRGRKKRDNMGSPESGEVPPSELGKYTFGDTLP 248
            .|.:|::.:..:: |.|:|      .|..|:|||
  Rat   207 LGPKKKKFKEDKK-LKAKL------KKVKKKRRR------------------------------- 233

  Fly   249 NNEDDDEDGGEVDYKRELASLALDYPEEEEIEEEVDVEGGTEGQVTKVRRKRKNPAALAARRRRI 313
                |:|...|            :.|.....:.:|..:...:......::|..:...|.||||::
  Rat   234 ----DEEFSSE------------ESPRHHHHQTKVFAKFSHDAPPPGTKKKHLSIEQLNARRRKV 282

  Fly   314 WQIMSKKESGRLQRIKSNNHKEMLANCKRVAGMCAKVVRQRAINSQRIMKETVWRAKRLTREMLA 378
            |..:.|||..:..:.||:.....|.|.:::|..|.|.||:.|:.:|:..|||:.||:|||:|||.
  Rat   283 WLSIVKKELPKANKQKSSARNLFLTNSRKLAHQCMKEVRRAALQAQKNCKETLPRARRLTKEMLL 347

  Fly   379 YWKRYERVERDQRRKQEREAEEQRKQDVELIEVKRQQRKLNFLITQTELYAHFMSKKLGQGSEED 443
            |||:||:||::.|::.|:||.||||.|.|:.|.||||||||||||||||||||||:|...|.:..
  Rat   348 YWKKYEKVEKEHRKRAEKEALEQRKLDEEMREAKRQQRKLNFLITQTELYAHFMSRKRDMGHDGI 412

  Fly   444 QLRILSQLDEETNARL----------AAQDDYDAGEMKLLAQENAEAAMQRDLDKTRAFDVFAKK 498
            |..||.:|::.:..|.          ..|:|||:...|..|.:|||.|......:||:||..||:
  Rat   413 QEEILRKLEDSSTQRQIDIGGGVVVNITQEDYDSNHFKAQALKNAENAYHIHQARTRSFDEDAKE 477

  Fly   499 KEKEEEEQAQ-------ESVEDIKPEPRPEMKDLPQPKMFKGTLKGYQIKGMTWLANIYDQGISG 556
            ........|.       ||.....|..|.. :|:|||.:|.|.|||||:|||.||||:|:|||:|
  Rat   478 SRAAALRAADKSGSGFGESYSLANPSIRAG-EDIPQPTIFNGKLKGYQLKGMNWLANLYEQGING 541

  Fly   557 ILADEMGLGKTVQSIAFLCHIAEHYGVWGPFLVISPASTLHNWQQEMSRFVPDFKVVPYWGSPAE 621
            ||||||||||||||||.|.|:||...:|||||:|||||||:||.||.:||||.|||:||||:|.:
  Rat   542 ILADEMGLGKTVQSIALLAHLAERENIWGPFLIISPASTLNNWHQEFTRFVPKFKVLPYWGNPHD 606

  Fly   622 RKILRQFWDQKHLHTRDASFHVVITSYQLVVSDYKYFNRIKWQYMVLDEAQAIKSAASQRWKLLL 686
            ||::|:||.||.|:|:||.||||||||||||.|.|||.|:||||||||||||:||::|.|||:||
  Rat   607 RKVIRRFWSQKTLYTQDAPFHVVITSYQLVVQDVKYFQRVKWQYMVLDEAQALKSSSSVRWKILL 671

  Fly   687 GFSCRNRLLLSGTPIQNSMAELWALLHFIMPTLFDSHDEFNEWFSKDIESHAENKTGIDEKQISR 751
            .|.|||||||:||||||:|||||||||||||||||||:|||||||||||||||||:.|||.|:||
  Rat   672 QFQCRNRLLLTGTPIQNTMAELWALLHFIMPTLFDSHEEFNEWFSKDIESHAENKSAIDENQLSR 736

  Fly   752 LHMILKPFMLRRIKKDVENELSDKIEIMVYCPLTIRQKLLYRALKQKIRIEDLLHLTSGSTTTSS 816
            |||||||||||||||||||||||||||::||.||.||||||:|||.||.|||||..:.|| |..:
  Rat   737 LHMILKPFMLRRIKKDVENELSDKIEILMYCQLTSRQKLLYQALKNKISIEDLLQSSMGS-TQQA 800

  Fly   817 SSSASNLMNLVMQFRKVCNHPELFERRDARSPFFMRCAEYTIPRLIHEEGLIHRMLPSRKHLLYN 881
            .::.|:||||||||||||||||||||::..|||.:....|.|.:.|:..|.|.....||...|..
  Rat   801 QNTTSSLMNLVMQFRKVCNHPELFERQETWSPFHISLKPYEISKFIYRHGQIRVFNHSRDRWLKV 865

  Fly   882 RFNIFKSEYIQRSLF--EDVNVNSCFGFTRLCDLSVGDMVEVTLNGLIDFLLHYRRVLEKYPLLA 944
            ..:.|..:|||:|||  :.:|..|||.|.|..|:|..:|..:.|.||:...|.....|:....|.
  Rat   866 LLSPFAPDYIQQSLFHRKGINEGSCFSFLRFIDVSPAEMANLMLQGLLARWLALFLSLKASYRLH 930

  Fly   945 YRRFWWKKQPDS--RYQLLEPMLENK---LALDYMP---PN----SVLKNFIFTAMTANESSVYA 997
            ..|.|.:...:|  ||      |.||   |.:|: |   ||    .:||:.:|   :::..:|..
  Rat   931 QLRSWGEPDGESHQRY------LRNKDFLLGVDF-PLSFPNLCSCPLLKSLVF---SSHCKAVSG 985

  Fly   998 FGDYFTYNMQETIEHRVIRSKILKKKTSLIEEMEDVSKQKLEIESVEVQTKSNAKSDVKVTTLLL 1062
            :.|...:..:                                          :|.|.::...|..
  Rat   986 YSDQVVHQWR------------------------------------------SATSSLRCCLLTE 1008

  Fly  1063 LPEFPHRPRKPRKYVCEPLSMPRILYDLGQKVQAVHRYLYCDSRSAAWSQ--------IRHNQCE 1119
            ||.|          :|  ::.||        |.||....||:.|||.:.:        :...||.
  Rat  1009 LPSF----------LC--VASPR--------VTAVPLDSYCNDRSAEYERGVLKEGGSLAAKQCL 1053

  Fly  1120 NSQGRELV--------------SSGLALCKPHGGWSSIVVPDKETLITDAGKLFVLDNLLTRLKA 1170
            .:...||.              :.||...:|..|||.|.:|.||:||||:|||:.||.||||||:
  Rat  1054 LNGAPELATDWLNRRSQFFPEPAGGLLSIRPQNGWSFIRIPGKESLITDSGKLYALDILLTRLKS 1118

  Fly  1171 NGHRVLIYSQMTKMIDLLEEYMWHRKHRYMRLDGSSKISARRDMVADFQTRADIFVFLLSTRAGG 1235
            .|||||||||||:|||||||||.:|||.|||||||||||.|||||||||||.|||||||||||||
  Rat  1119 QGHRVLIYSQMTRMIDLLEEYMVYRKHTYMRLDGSSKISERRDMVADFQTRNDIFVFLLSTRAGG 1183

  Fly  1236 LGINLTAADTVIFYDSDWNPTVDQQAMDRAHRLGQTKQVTVYRLICKGTIEERILQRAREKSEIQ 1300
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||:||||||
  Rat  1184 LGINLTAADTVIFYDSDWNPTVDQQAMDRAHRLGQTKQVTVYRLICKGTIEERILQRAKEKSEIQ 1248

  Fly  1301 RMVISGGNFKPDTLKPKEVVSLLLDDEEIE--MKYRQEAKLQSSSPIPAATQSERKRRHPQKDVN 1363
            ||||||||||||||||||||||||||||:|  ::.|||.|.|...   :....||||:.
  Rat  1249 RMVISGGNFKPDTLKPKEVVSLLLDDEELEKKLRLRQEEKRQQEE---SNRVKERKRKR------ 1304

  Fly  1364 MGGTTIAATSATQNPDDDVPSCSSAAKRIKLETEED-------------FIDVGITSSASSVGTD 1415
                                  ...|::.|.|.|.|             |:.....|:.|:.|.|
  Rat  1305 ----------------------EKYAEKKKKEDELDGKRRKEGVNLVIPFVPAADNSNLSADGDD 1347

  Fly  1416 SNHPTLSQETYVPGATCVQQTEIDSE------------NEALVVDGDSPTMLGQNESMN------ 1462
            |   .:|.::.:|..  ..:..|.||            ::.||:..|..:...|:.:.|
  Rat  1348 S---FISVDSAMPSP--FSEISISSELHTGSIPPDESSSDMLVIVDDPASSAPQSRATNSPASIT 1407

  Fly  1463 --FLDDLSGIS----PMRRRHHPRGTRRGRPR--GSTRRGGGHGSIPRVLTPTQAATPAVPATAS 1519
              ..|.::|||    |...|.| ....||||:  |||.:|.|.|. .|..|...||..|.....:
  Rat  1408 GSVSDTVNGISIQEVPAAGRGH-SARSRGRPKGSGSTAKGAGKGR-SRKSTAGSAAAMAGAKAGA 1470

  Fly  1520 QAAAAGTGAAAGTSSPLPQQEVSGGGDNAGVPLHEEEYRTSPSGQSPGVSCKRGPGRPRSKTATP 1584
            .||:|...||.|       ..|| .|.:|..||.....|  |:|.:     ..||....|..::|
  Rat  1471 AAASAAAYAAYG-------YNVS-KGISASSPLQTSIVR--PAGLA-----DFGPSSASSPLSSP 1520

  Fly  1585 ISRGTRGAPRARRPMGPLLVPLGRSPDDTPPSSSPATSRAPSPLSGSHG 1633
            :::|..             :|      .||.|....:|.|..||....|
  Rat  1521 LNKGNN-------------IP------GTPKSLHMTSSLASDPLIRKQG 1550

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ino80	NP_732413.1	HepA	364..>855	CDD:440319	327/507 (64%)
		DEXQc_INO80	535..763	CDD:350760	179/227 (79%)
		SF2_C_SNF	1146..1280	CDD:350180	119/133 (89%)
		PHA03247	<1535..1637	CDD:223021	23/99 (23%)
Ino80	NP_001248333.1	HepA	300..>832	CDD:440319	333/548 (61%)
		DEXQc_INO80	520..748	CDD:350760	172/227 (76%)
		SF2_C_SNF	1093..1228	CDD:350180	86/156 (55%)