Protein Alignment Ino80 and ssl-1

DIOPT Version :10

• Sequence 1: NP_732413.1
• Gene: Ino80 / 42314
• FlyBaseID: FBgn0289122
• Length: 1638
• Species: Drosophila melanogaster
• Sequence 2: NP_001255179.1
• Gene: ssl-1 / 190954
• WormBaseID: WBGene00007027
• Length: 2395
• Species: Caenorhabditis elegans
• Alignment Length: 1684
• Identity: 445/1684 - (26%)
• Similarity: 729/1684 - (43%)
• Gaps: 371/1684 - (22%)

  Fly     1 MEAKPVPAPQPRPRAMAEPLHIQRLEAALNM---RPFMNMAKRSLRKPLSSDEETDDEHVVKREH 62
            |.|.||.|...|         |.|..::.::   :|..:.|......|::.  |||::.||:.|.
 Worm     1 MPATPVRASSTR---------ISRRTSSRSVADDQPSTSSAVAPPPSPIAI--ETDEDAVVEEEK 54

  Fly    63 DVQDSDDSSTVGVVRMKQSSKRKSRLLAS--KEERQSVKAQLYNFNDLTSDREWLYDLLLSDTES 125
            ..:.:.|.  :.::..:....|:...:.|  ..|.:|::.:|                    ..|
 Worm    55 KKKKTSDD--LEIITPRTPVDRRIPYICSILLTENRSIRDKL--------------------VLS 97

  Fly   126 DDPTITEDEYVQQLLR----EHVREQRQRKNYYKKAANAQYAYYGSGLLSNHDIFAERQLATAGV 186
            ..| :.::::.:|:.|    :.|.:|.||..        |....|    |..||..:.:.|
 Worm    98 SGP-VRQEDHEEQIARAQRIQPVVDQIQRVE--------QIILNG----SVEDILKDPRFA---- 145

  Fly   187 RKRRRRTKQEILMARLAE---AQAGPKPPKQRRRGR---KKRDNMGSPESGEVPPSELGKYTFGD 245
                       :||.|.:   ....|.||.|:....   |..|:.|   |....||.|.....|:
 Worm   146 -----------VMADLTKEPPPTPAPPPPIQKTMQPIEVKIEDSEG---SNTAQPSVLPSCGGGE 196

  Fly   246 T-----------------------------LPNNEDDDEDGGEVDY------------------K 263
            |                             ||...:.:.:....||                  |
 Worm   197 TNVERAAKREAHVLARIAELRKNGLWSNSRLPKCVEPERNKTHWDYLLEEVKWMAVDFRTETNTK 261

  Fly   264 RELASLALDYPEEEEIEEEVDVEGGTEGQVTKVRRKRKNPAALAARRRRIWQIMSKKESGRLQ-- 326
            |::|.:......::..::::::|...|   .:::.|||..|.:|...|..|....|....|.:
 Worm   262 RKIAKVIAHAIAKQHRDKQIEIERAAE---REIKEKRKMCAGIAKMVRDFWSSTDKVVDIRAKEV 323

  Fly   327 ---RIKSNNHKEMLANCKRVAGMCAKVVRQ--------RAINSQRIMKETVWRAKRLTREMLAYW 380
               |::...:|.::....:|..| :.:|::        .:|.|.|..|:..::|..
 Worm   324 LESRLRKARNKHLMFVIGQVDEM-SNIVQEGLVSSSKSPSIASDRDDKDEEFKAPG--------- 378

  Fly   381 KRYERVERDQRRKQEREAEEQRKQDVELIEVKRQQRKL-----NFLITQTELYAHFMSKKLGQGS 440
               ...|.|..:......:.|:|:||.. ||...|.:.     :||.|....|.    |..|. :
 Worm   379 ---SDSESDDEQTIANAEKSQKKEDVRQ-EVDALQNEATVDMDDFLYTLPPEYL----KAYGL-T 434

  Fly   441 EEDQLRILSQLDEETNARLAAQDDYDAGEMKLLAQENAEAAMQR------DLDKTRAFDV----- 494
            :||...:..:..||..||..|..|   .|.|:...|:..:..|:      ||...:..|.
 Worm   435 QEDLEEMKREKLEEQKARKEACGD---NEEKMEIDESPSSDAQKPSTSSSDLTAEQLQDPTAEDG 496

  Fly   495 ------------FAKKKEKEEEEQAQE----SVEDIKPEPR------PEMKDLPQPKMFKGTLKG 537
                        :.|...::.:|:.||    :.|.:|.:|:      .::| .|.|.:.:|.|:.
 Worm   497 NGDGHGVLENVDYVKLNSQDSDERQQELANIAEEALKFQPKGYTLETTQVK-TPVPFLIRGQLRE 560

  Fly   538 YQIKGMTWLANIYDQGISGILADEMGLGKTVQSIAFLCHIAEHYGVWGPFLVISPASTLHNWQQE 602
            ||:.|:.|:..:|::.::||||||||||||:|:|:.|.|:|....:|||.|::.|.|.:.||:.|
 Worm   561 YQMVGLDWMVTLYEKNLNGILADEMGLGKTIQTISLLAHMACSESIWGPHLIVVPTSVILNWEME 625

  Fly   603 MSRFVPDFKVVPYWGSPAERKILRQFWDQKHLHTRDASFHVVITSYQLVVSDYKYFNRIKWQYMV 667
            ..::.|..|::.|:|:..||...|:.|      .:...|||.||||:.|..|.:.|.:..|||::
 Worm   626 FKKWCPALKILTYFGTAKERAEKRKGW------MKPNCFHVCITSYKTVTQDIRAFKQRAWQYLI 684

  Fly   668 LDEAQAIKSAASQRWKLLLGFSCRNRLLLSGTPIQNSMAELWALLHFIMPTLFDSHDEFNEWFSK 732
            |||||.||:..||||:.||....|.||||:|||:|||:.|||:|:||:|||:|.|||:|.:|||.
 Worm   685 LDEAQNIKNWKSQRWQALLNVRARRRLLLTGTPLQNSLMELWSLMHFLMPTIFSSHDDFKDWFSN 749

  Fly   733 DIESHAENKTGIDEKQISRLHMILKPFMLRRIKKDVENELSDKIEIMVYCPLTIRQKLLY----- 792
            .:....|.....:...|.|||.:|:||:|||:||:||.:|.:|.|.:|.|.|:.||:.||
 Worm   750 PLTGMMEGNMEFNAPLIGRLHKVLRPFILRRLKKEVEKQLPEKTEHIVNCSLSKRQRYLYDDFMS 814

  Fly   793 -RALKQKIRIEDLLHLTSGSTTTSSSSSASNLMNLVMQFRKVCNHPELFERRDARSPFFMRCAEY 856
             |:.|:.::                |.:..:::|:|||.||.||||.|||.|...:||.:...:.
 Worm   815 RRSTKENLK----------------SGNMMSVLNIVMQLRKCCNHPNLFEPRPVVAPFVVEKLQL 863

  Fly   857 TIPRLIHEEGLIHRMLPSRKHL--LYNRFNIFKSEY-----IQRSLFEDVNVNSC---------- 904
            .:|..:.|   |.:..||....  :...||:.|..|     ..:.|.|::...|.
 Worm   864 DVPARLFE---ISQQDPSSSSASQIPEIFNLSKIGYQSSVRSAKPLIEELEAMSTYPEPRAPEVG 925

  Fly   905 -FGFTRLCDLSVGDMVEVTLN-GLIDFLLHYRRVLEKYPLLAYRRFWWKKQPDSRYQLLEPMLEN 967
             |.|.|...::.....|.:.: |::     ..|||.| |:..      ..||          |:|
 Worm   926 GFRFNRTAFVAKNPHTEESEDEGVM-----RSRVLPK-PING------TAQP----------LQN 968

  Fly   968 KLALDYMPPNSVLKNFIFTAMTANESSVYAFGDY--FTYNMQETIEHRVIR-------SKILKKK 1023
            ..::....||....:.|.:....|...:....|.  |.:|| ..:...|:|       |..||::
 Worm   969 GNSIPQNAPNRPQTSCIRSKTVVNTVPLTISTDRSGFHFNM-ANVGRGVVRLDDSARMSPPLKRQ 1032

  Fly  1024 --------------TSLIEEMEDVSKQKLEIESVEVQTKSNAKSDVKVTTLL---LLPEFPHRPR 1071
                          ..::|:||:..|.:|||.....:........:::..|:   ::.|||....
 Worm  1033 KLTGTATNWSDYVPRHVVEKMEESRKNQLEIVRRRFEMIRAPIIPLEMVALVREEIIAEFPRLAV 1097

  Fly  1072 KPRKYVCEPLSMPRILYDLGQKVQAVHRYL--------YC-DSRSAAWSQIRHNQCE---NSQGR 1124
            :..:.|.|     |:|......||....|:        .| .|.|...|.||:|...   ||:..
 Worm  1098 EEDEVVQE-----RLLEYCELLVQRFGMYVEPVLTDAWQCRPSSSGLPSYIRNNLSNIELNSRSL 1157

  Fly  1125 ELVSS-----GLALCKPHGGWSSIVVPDKETLITDAGKLFVLDNLLTRLKANGHRVLIYSQMTKM 1184
            .|.:|     .:::.:      ::..|:...:..|.|||..|..||.:|....||.||::||:||
 Worm  1158 LLNTSTNFDTRMSISR------ALQFPELRLIEYDCGKLQTLAVLLRQLYLYKHRCLIFTQMSKM 1216

  Fly  1185 IDLLEEYMWHRKHRYMRLDGSSKISARRDMVADFQTRADIFVFLLSTRAGGLGINLTAADTVIFY 1249
            :|:|:.::.|..::|.||||::.:..|:.|:..|.....:|.|:||||:||:|:|||.|||||||
 Worm  1217 LDVLQTFLSHHGYQYFRLDGTTGVEQRQAMMERFNADPKVFCFILSTRSGGVGVNLTGADTVIFY 1281

  Fly  1250 DSDWNPTVDQQAMDRAHRLGQTKQVTVYRLICKGTIEERILQRAREKSEIQRMVISGGNFKPDTL 1314
            |||||||:|.||.||.||:|||:.|::||||.:.||||.||::|.:|..:..:.|....|.|:..
 Worm  1282 DSDWNPTMDAQAQDRCHRIGQTRNVSIYRLISERTIEENILRKATQKRRLGELAIDEAGFTPEFF 1346

  Fly  1315 KPKEVVSLLLDDEEIEMKYRQEAKLQSSSPIPAATQSERK------RRHPQKDVNMGGTTIAATS 1373
            |..:.:..|.|.|.:|:....:.         |.|.||::      :...:.|||.....:|..:
 Worm  1347 KQSDSIRDLFDGENVEVTAVADV---------ATTMSEKEMEVAMAKCEDEADVNAAKIAVAEAN 1402

  Fly  1374 ATQNPDDD--VPSCSSAAKRIKLETEEDFIDV-----GITSSASSVGTDSNHPTLSQETYVPGAT 1431
            ......|:  :|..|:.  :...|.:|.::::     .|...|.:.......|...:|.....|.
 Worm  1403 VDNAEFDEKSLPPMSNL--QGDEEADEKYMELIQQLKPIERYAINFLETQYKPEFEEECKEAEAL 1465

  Fly  1432 CVQQTE--IDSENEALVVD-GDSPTMLGQNES--------------MNFLDDLSGISPM 1473
            ..|:.|  ..:.|:..|:| .||.::|..:.|              :.|.|:|..|.|:
 Worm  1466 IDQKREEWDKNLNDTAVIDLDDSDSLLLNDPSTSADFYQSSSLLDEIKFYDELDDIMPI 1524

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ino80	NP_732413.1	HepA	364..>855	CDD:440319	180/534 (34%)
		DEXQc_INO80	535..763	CDD:350760	103/227 (45%)
		SF2_C_SNF	1146..1280	CDD:350180	67/133 (50%)
		PHA03247	<1535..1637	CDD:223021
ssl-1	NP_001255179.1	HSA	231..295	CDD:462194	7/66 (11%)
		PLN03142	372..>851	CDD:215601	177/522 (34%)
		DEXQc_SRCAP	558..780	CDD:350761	103/227 (45%)
		SF2_C_SNF	1183..1312	CDD:350180	66/128 (52%)
		Med15	1978..>2359	CDD:312941