DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ino80 and SRCAP

DIOPT Version :9

Sequence 1:NP_732413.1 Gene:Ino80 / 42314 FlyBaseID:FBgn0086613 Length:1638 Species:Drosophila melanogaster
Sequence 2:NP_006653.2 Gene:SRCAP / 10847 HGNCID:16974 Length:3230 Species:Homo sapiens


Alignment Length:2549 Identity:511/2549 - (20%)
Similarity:781/2549 - (30%) Gaps:1125/2549 - (44%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 VPAPQPRPRA----MAEPLHIQRLEAALNMRPFMNMAKRSLRKPL-SSDEETDDEHVVKREHDVQ 65
            ||.| |||:.    :.|.:.....:.|...|....:|::.:|..: ..:|:...|...:||...:
Human   127 VPEP-PRPKGHWDYLCEEMQWLSADFAQERRWKRGVARKVVRMVIRHHEEQRQKEERARREEQAK 190

  Fly    66 DSDDSSTVG------------VVRMKQSS----KRKSRL-------LASKEERQSVKAQLYNFND 107
            ....:||:.            ||:.||.|    |||..|       :...|:...:.:|..| ..
Human   191 LRRIASTMAKDVRQFWSNVEKVVQFKQQSRLEEKRKKALDLHLDFIVGQTEKYSDLLSQSLN-QP 254

  Fly   108 LTSDREWLYDLL---------------LSDTESD-DPTITEDEYVQQLLREHVREQRQRKNYYKK 156
            |||.:......|               |.|.:.| .|...|:|..::.:  .|.||::..:    
Human   255 LTSSKAGSSPCLGSSSAASSPPPPASRLDDEDGDFQPQEDEEEDDEETI--EVEEQQEGND---- 313

  Fly   157 AANAQYAYYGSGLLSNHDIFAERQLATAGVRKRRRRTKQEILMARLAEAQAGPKPPKQRRRGRKK 221
             |.||                .|::..  :|:......:|:|.:...:...||..|.|.......
Human   314 -AEAQ----------------RREIEL--LRREGELPLEELLRSLPPQLLEGPSSPSQTPSSHDS 359

  Fly   222 RDNMGSPESG-----------EVPPSELGKYTFGDTLPNNEDDDEDGGEVDYKRELASLALDYPE 275
             |....||.|           :.|||.:.:.......|:.:|::....|.:.:.|..::|    .
Human   360 -DTRDGPEEGAEEEPPQVLEIKPPPSAVTQRNKQPWHPDEDDEEFTANEEEAEDEEDTIA----A 419

  Fly   276 EEEIEEEVD-----VEGGTEGQVTKVRRKRKNPAALAARRRRIWQIMSKKESGRLQRIKSNNHKE 335
            ||::|.|||     .|...||:::.....::...|.|..       ....|......:.:|:   
Human   420 EEQLEGEVDHAMELSELAREGELSMEELLQQYAGAYAPG-------SGSSEDEDEDEVDANS--- 474

  Fly   336 MLANCKRVAGMCAKVVRQRAINSQRIMKETVWRAKRLTREMLAYWKRYERVERDQRRKQEREAEE 400
              ::|:....:.|:...|...:||.                       :.||.....:::..:||
Human   475 --SDCEPEGPVEAEEPPQEDSSSQS-----------------------DSVEDRSEDEEDEHSEE 514

  Fly   401 QRKQDVELIEVKRQQRKLNFLITQTELYAHFMSKKLGQGSEEDQLRILSQLDEETNARLAAQDDY 465
            :........|....:.                       ||:.|.:  ||.|||       ::|.
Human   515 EETSGSSASEESESEE-----------------------SEDAQSQ--SQADEE-------EEDD 547

  Fly   466 DAGEMKLLAQENAEAAMQRDLD-----KTRAFDVFAKKKEKEEEEQAQESVEDIKPEPR------ 519
            |.|...|||::..    |.:.|     .|........|||..:...|.||:     :|:      
Human   548 DFGVEYLLARDEE----QSEADAGSGPPTPGPTTLGPKKEITDIAAAAESL-----QPKGYTLAT 603

  Fly   520 PEMKDLPQPKMFKGTLKGYQIKGMTWLANIYDQGISGILADEMGLGKTVQSIAFLCHIAEHYGVW 584
            .::| .|.|.:.:|.|:.||..|:.||..:|::.::||||||||||||:|:|:.|.|:|...|.|
Human   604 TQVK-TPIPLLLRGQLREYQHIGLDWLVTMYEKKLNGILADEMGLGKTIQTISLLAHLACEKGNW 667

  Fly   585 GPFLVISPASTLHNWQQEMSRFVPDFKVVPYWGSPAERKILRQFWDQKHLHTRDASFHVVITSYQ 649
            ||.|:|.|.|.:.||:.|:.|:.|.||::.|:|:..|||:.||.|      |:..:|||.||||:
Human   668 GPHLIIVPTSVMLNWEMELKRWCPSFKILTYYGAQKERKLKRQGW------TKPNAFHVCITSYK 726

  Fly   650 LVVSDYKYFNRIKWQYMVLDEAQAIKSAASQRWKLLLGFSCRNRLLLSGTPIQNSMAELWALLHF 714
            ||:.|::.|.|..|:|::|||||.||:..||||:.||.|:.:.||||:|||:|||:.|||:|:||
Human   727 LVLQDHQAFRRKNWRYLILDEAQNIKNFKSQRWQSLLNFNSQRRLLLTGTPLQNSLMELWSLMHF 791

  Fly   715 IMPTLFDSHDEFNEWFSKDIESHAENKTGIDEKQISRLHMILKPFMLRRIKKDVENELSDKIEIM 779
            :||.:|.||.||.||||..:....|.....:|..:.|||.:|:||:|||:|.|||.::..|.|.:
Human   792 LMPHVFQSHREFKEWFSNPLTGMIEGSQEYNEGLVKRLHKVLRPFLLRRVKVDVEKQMPKKYEHV 856

  Fly   780 VYCPLTIRQKLLYRALKQKIRIEDLLHLTSGSTTTSSSSSASNLM---NLVMQFRKVCNHPELFE 841
            :.|.|:.||:.||         :|.:    ..|||..:.:..:.|   |::||.|||||||.||:
Human   857 IRCRLSKRQRCLY---------DDFM----AQTTTKETLATGHFMSVINILMQLRKVCNHPNLFD 908

  Fly   842 RRDARSPFF------------MRCAE-YTIPR-------LIHEEGLIHR-----MLP----SRKH 877
            .|...|||.            :|..: :.:.|       ||..||.:.|     .||    ||:.
Human   909 PRPVTSPFITPGICFSTASLVLRATDVHPLQRIDMGRFDLIGLEGRVSRYEADTFLPRHRLSRRV 973

  Fly   878 LL------------------YNRF----------------------------------------- 883
            ||                  .||.                                         
Human   974 LLEVATAPDPPPRPKPVKMKVNRMLQPVPKQEGRTVVVVNNPRAPLGPVPVRPPPGPELSAQPTP 1038

  Fly   884 ----NIFKSEYI----------------------------------------------------- 891
                .:..:..:                                                     
Human  1039 GPVPQVLPASLMVSASPAGPPLIPASRPPGPVLLPPLQPNSGSLPQVLPSPLGVLSGTSRPPTPT 1103

  Fly   892 --------------------QRSLFEDVNVNSCFGF----------------------------- 907
                                ..||.:.:.|...:.|                             
Human  1104 LSLKPTPPAPVRLSPAPPPGSSSLLKPLTVPPGYTFPPAAATTTSTTTATATTTAVPAPTPAPQR 1168

  Fly   908 --------TRLCD---LSVGDMV-----------------------EVTLNG------------- 925
                    .||..   :|:|.:.                       ::||.|             
Human  1169 LILSPDMQARLPSGEVVSIGQLASLAQRPVANAGGSKPLTFQIQGNKLTLTGAQVRQLAVGQPRP 1233

  Fly   926 ----------------LIDFLLHYR---------------------------------------- 934
                            ||....|..                                        
Human  1234 LQRNVVHLVSAGGQHHLISQPAHVALIQAVAPTPGPTPVSVLPSSTPSTTPAPTGLSLPLAANQV 1298

  Fly   935 -----------------------------------------RVLEKYPLLAYRR-----FWWKKQ 953
                                                     .||...|.|...|     ....:.
Human  1299 PPTMVNNTGVVKIVVRQAPRDGLTPVPPLAPAPRPPSSGLPAVLNPRPTLTPGRLPTPTLGTARA 1363

  Fly   954 PDSRYQLLEPMLENKL---------------------------------ALDYMP-PN------- 977
            |.....|:.|:|  ||                                 |...|| ||       
Human  1364 PMPTPTLVRPLL--KLVHSPSPEVSASAPGAAPLTISSPLHVPSSLPGPASSPMPIPNSSPLASP 1426

  Fly   978 ----------------------------------------------------------------- 977
                                                                             
Human  1427 VSSTVSVPLSSSLPISVPTTLPAPASAPLTIPISAPLTVSASGPALLTSVTPPLAPVVPAAPGPP 1491

  Fly   978 -----------SVLKNFIFTA-------------------------------------------- 987
                       |.|...:.||                                            
Human  1492 SLAPSGASPSASALTLGLATAPSLSSSQTPGHPLLLAPTSSHVPGLNSTVAPACSPVLVPASALA 1556

  Fly   988 ---------------------------------MTANESSVYA---------------------- 997
                                             |.|.::::.|                      
Human  1557 SPFPSAPNPAPAQASLLAPASSASQALATPLAPMAAPQTAILAPSPAPPLAPLPVLAPSPGAAPV 1621

  Fly   998 ----------------------------------------------------------------- 997
                                                                             
Human  1622 LASSQTPVPVMAPSSTPGTSLASASPVPAPTPVLAPSSTQTMLPAPVPSPLPSPASTQTLALAPA 1686

  Fly   998 ---------------------FGDYFTYNMQETIEHRVI-------------------------- 1015
                                 .|.:.|..:..|....::                          
Human  1687 LAPTLGGSSPSQTLSLGTGNPQGPFPTQTLSLTPASSLVPTPAQTLSLAPGPPLGPTQTLSLAPA 1751

  Fly  1016 --------------RSKILKKKTSLIEEMEDVSKQKLEIESVEVQT------------------- 1047
                          .:..|...:|....:...|.|.|.:....|.|                   
Human  1752 PPLAPASPVGPAPAHTLTLAPASSSASLLAPASVQTLTLSPAPVPTLGPAAAQTLALAPASTQSP 1816

  Fly  1048 ---------KSNAKSDVKVTTLLLLPEFPHRP---------------------RKPRKYVCEPLS 1082
                     .::..:.:.||.:..||.....|                     .:||:....|..
Human  1817 ASQASSLVVSASGAAPLPVTMVSRLPVSKDEPDTLTLRSGPPSPPSTATSFGGPRPRRQPPPPPR 1881

  Fly  1083 MPRILYDLGQK--------------VQAVHRYL----------YCD------------------- 1104
            .|..|..|.:|              :...|..|          :|.                   
Human  1882 SPFYLDSLEEKRKRQRSERLERIFQLSEAHGALAPVYGTEVLDFCTLPQPVASPIGPRSPGPSHP 1946

  Fly  1105 ---------SRSAAWSQIRHNQCENSQGR--------ELVSSGLALCKPHGGWSS---------- 1142
                     .|:..:.|.|.:|......|        |.....|..|.| ..|.:          
Human  1947 TFWTYTEAAHRAVLFPQQRLDQLSEIIERFIFVMPPVEAPPPSLHACHP-PPWLAPRQAAFQEQL 2010

  Fly  1143 -------------IV------VPDKETLITDAGKLFVLDNLLTRLKANGHRVLIYSQMTKMIDLL 1188
                         ||      .||...:..|.|||..|..||.:|||.||||||::|||:|:|:|
Human  2011 ASELWPRARPLHRIVCNMRTQFPDLRLIQYDCGKLQTLAVLLRQLKAEGHRVLIFTQMTRMLDVL 2075

  Fly  1189 EEYMWHRKHRYMRLDGSSKISARRDMVADFQTRADIFVFLLSTRAGGLGINLTAADTVIFYDSDW 1253
            |:::.:..|.|:|||||:::..|:.::..|.....||.|:||||:||:|:|||.||||:||||||
Human  2076 EQFLTYHGHLYLRLDGSTRVEQRQALMERFNADKRIFCFILSTRSGGVGVNLTGADTVVFYDSDW 2140

  Fly  1254 NPTVDQQAMDRAHRLGQTKQVTVYRLICKGTIEERILQRAREKSEIQRMVISGGN-----FKPDT 1313
            |||:|.||.||.||:|||:.|.:||||.:.|:||.||::|.:|..:..|.|.|||     ||..|
Human  2141 NPTMDAQAQDRCHRIGQTRDVHIYRLISERTVEENILKKANQKRMLGDMAIEGGNFTTAYFKQQT 2205

  Fly  1314 LKPKEVVSLLLDDEEIEMKYRQEAKLQSSSPIPAATQSERKRRHPQKDVNMGGTTIAATSATQNP 1378
            :  :|:..:.|::             .|||.:|:|.:.|      ::.|....|.|...:..:..
Human  2206 I--RELFDMPLEE-------------PSSSSVPSAPEEE------EETVASKQTHILEQALCRAE 2249

  Fly  1379 DDDVPSCSSAAKRIKLETEEDFIDVGITSSASSVGTDSNHPTLSQETYVPGATCVQQTEIDSENE 1443
            |::....::.||..::....:|.:           .|.......:|...|||...:.:..:.|..
Human  2250 DEEDIRAATQAKAEQVAELAEFNE-----------NDGFPAGEGEEAGRPGAEDEEMSRAEQEIA 2303

  Fly  1444 ALVVDGDSPTMLGQNESMNFLD-DLSGISPMRRRHH---------------------PRGTRRGR 1486
            |||   :..|.: :..:|.||: .|..:|....:..                     |:....|.
Human  2304 ALV---EQLTPI-ERYAMKFLEASLEEVSREELKQAEEQVEAARKDLDQAKEEVFRLPQEEEEGP 2364

  Fly  1487 PRGSTRRGGGHGSIPRVLTPTQAATPAVPATASQAAAAGTGAAAGTSSPLPQQEVSGGGDNAGVP 1551
            ..|.....|..|...|  ...:|..|..|.|.......|..|           |..|......:.
Human  2365 GAGDESSCGTGGGTHR--RSKKAKAPERPGTRVSERLRGARA-----------ETQGANHTPVIS 2416

  Fly  1552 LHEEEYRTSPSGQSPG-VSCKRGPGRPRSKTATPISRGTRGAPRARRPMGPLLVPLGRSPDDTPP 1615
            .|:....|:|...||. ....|...|||   .||.|     ||.|.    |.|||:        |
Human  2417 AHQTRSTTTPPRCSPARERVPRPAPRPR---PTPAS-----APAAI----PALVPV--------P 2461

  Fly  1616 SSSPATSRAPSPLS 1629
            .|:|....||:|::
Human  2462 VSAPVPISAPNPIT 2475

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ino80NP_732413.1 DBINO 313..438 CDD:290603 12/124 (10%)
SNF2_N 538..840 CDD:278600 140/304 (46%)
DEXDc 555..700 CDD:238005 74/144 (51%)
Helicase_C 1156..1269 CDD:278689 64/112 (57%)
SRCAPNP_006653.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..71
HSA 127..196 CDD:400077 15/69 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 253..547 67/390 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 559..581 3/25 (12%)
DEXQc_SRCAP 618..840 CDD:350761 112/227 (49%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1017..1045 0/27 (0%)
PHA03247 <1031..1592 CDD:223021 35/562 (6%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1058..1125 0/66 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1138..1166 1/27 (4%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1320..1366 6/45 (13%)
PHA03247 <1366..1834 CDD:223021 27/469 (6%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1406..1425 5/18 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1629..1760 3/130 (2%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1839..1893 9/53 (17%)
SF2_C_SNF 2032..2167 CDD:350180 73/134 (54%)
PTZ00121 <2170..2362 CDD:173412 46/227 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2214..2233 7/37 (19%)
mukB <2253..>2344 CDD:235316 18/105 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2271..2298 6/37 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2327..2453 29/146 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2564..2583
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2598..3081
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3095..3230
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D188211at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.010

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