Protein Alignment Ino80 and ino80

DIOPT Version :10

• Sequence 1: NP_732413.1
• Gene: Ino80 / 42314
• FlyBaseID: FBgn0289122
• Length: 1638
• Species: Drosophila melanogaster
• Sequence 2: XP_004917366.1
• Gene: ino80 / 100127778
• XenbaseID: XB-GENE-957629
• Length: 1547
• Species: Xenopus tropicalis
• Alignment Length: 1729
• Identity: 743/1729 - (42%)
• Similarity: 958/1729 - (55%)
• Gaps: 313/1729 - (18%)

  Fly    16 MAEPLHIQRLEAALNMRPFMNMAKRSLRKPLSSDEETD--DEHVVKREHD-----VQDSDDSSTV 73
            :|:||::|.||.||.:..|:........:.:||||..|  ||..:..|.:     |::...|..:
 Frog    16 LAKPLYLQYLERALRLDQFLRQTSAVFNRSISSDESEDGLDETPLLPEAEDPSLQVKEEPMSPLL 80

  Fly    74 GVVRMKQSSKRKSRLLA-------SKEERQSVKAQLYNFNDLTSDREWLYDLLLSDTESDDPTIT 131
            |    :.|....:.||:       .|.|.:|.:...|||:.|...|:||.::|||:..||..:::
 Frog    81 G----EPSGDGSTDLLSVHALNGILKPEPKSERGSFYNFSKLKKSRKWLKNILLSEDSSDTDSLS 141

  Fly   132 ED---------EYVQQLLREHVREQRQRKNYYKKAANAQYAYYGSGLLSNHDIFAERQLATAGVR 187
            |:         |.:..:||.|..::..:..|.|.....||.||.:||||.||.|.|:|....|.|
 Frog   142 EEDEEEFSLSKEELHDMLRIHKYKKLHQSKYLKDKELHQYQYYSAGLLSTHDPFYEQQRHFLGPR 206

  Fly   188 KRRRRTKQEILMARLAEAQAGPKPPKQRRRGRKKRDNMGSPESGEVPPSELGKYTFGDTLPNNED 252
            |::.:.::: ..|:|      .|..|:|||              |...||       |.||...
 Frog   207 KKKIKEEKK-FKAKL------KKVKKKRRR--------------EEDLSE-------DELPRRH- 242

  Fly   253 DDEDGGEVDYKRELASLALDYPEEEEIEEEVDVEGGTEGQVTKV-RRKRKNPAALAARRRRIWQI 316
                    .:.:..|..:.|.|                   |.| ::|......|.||||::||:
 Frog   243 --------HHTKVFAKFSHDAP-------------------TPVGKKKHLTLEQLNARRRKVWQM 280

  Fly   317 MSKKESGRLQRIKSNNHKEMLANCKRVAGMCAKVVRQRAINSQRIMKETVWRAKRLTREMLAYWK 381
            :.|||..:..:.|.:....:|.|.|::|..|.:.||:.||.:|:..|||:.||:|||:||..|||
 Frog   281 IVKKELPKAYKQKVSARNLLLTNSKKLAHQCMREVRRAAIQAQKNCKETLPRARRLTKEMSLYWK 345

  Fly   382 RYERVERDQRRKQEREAEEQRKQDVELIEVKRQQRKLNFLITQTELYAHFMSKKLGQGSEEDQLR 446
            :|::||::.|::.|:||.||||.|.|:.|.||||||||||||||||||||:|:|...|.:..|..
 Frog   346 KYDKVEKEHRKRAEKEALEQRKLDEEMREAKRQQRKLNFLITQTELYAHFVSRKRESGPDGIQEE 410

  Fly   447 ILSQLDEETNARLA---------AQDDYDAGEMKLLAQENAEAAMQRDLDKTRAFDVFAKKKEKE 502
            ||.:|::.::....         :|.|||:...|..|.:|||.|.:....:||:||..||:....
 Frog   411 ILRKLEDSSSQEQVGAGGSYLHLSQMDYDSDYYKSQALKNAEEAFRIHQAQTRSFDEDAKESRAA 475

  Fly   503 EEEQA-------QESVEDIKPEPRPEMKDLPQPKMFKGTLKGYQIKGMTWLANIYDQGISGILAD 560
            .:..|       .||.....|..|.. :|:|||.:|.|.|||||:|||.||||:|:|||:|||||
 Frog   476 AQRVAIKLESGFGESYSLANPSIRAG-EDIPQPTIFNGKLKGYQLKGMNWLANLYEQGINGILAD 539

  Fly   561 EMGLGKTVQSIAFLCHIAEHYGVWGPFLVISPASTLHNWQQEMSRFVPDFKVVPYWGSPAERKIL 625
            ||||||||||||.|.|:||...:|||||:|||||||:||.||.|||||.|||:||||||.|||::
 Frog   540 EMGLGKTVQSIALLAHLAERENIWGPFLIISPASTLNNWHQEFSRFVPKFKVLPYWGSPHERKVI 604

  Fly   626 RQFWDQKHLHTRDASFHVVITSYQLVVSDYKYFNRIKWQYMVLDEAQAIKSAASQRWKLLLGFSC 690
            |:||.||.|:|::|.||||||||||||.|.|||.|:||||||||||||:||::|.|||:||.|.|
 Frog   605 RKFWGQKTLYTQEAPFHVVITSYQLVVQDVKYFQRVKWQYMVLDEAQALKSSSSVRWKILLQFQC 669

  Fly   691 RNRLLLSGTPIQNSMAELWALLHFIMPTLFDSHDEFNEWFSKDIESHAENKTGIDEKQISRLHMI 755
            ||||||:||||||:||||||||||||||||||||||:||||||||||||||:.|||.|:||||||
 Frog   670 RNRLLLTGTPIQNTMAELWALLHFIMPTLFDSHDEFSEWFSKDIESHAENKSAIDENQLSRLHMI 734

  Fly   756 LKPFMLRRIKKDVENELSDKIEIMVYCPLTIRQKLLYRALKQKIRIEDLLHLTSGSTTTSSSSSA 820
            |||||||||||||||||||||||::||.||.||||||:|||.||.|:|||..:.| |...:.::.
 Frog   735 LKPFMLRRIKKDVENELSDKIEILMYCSLTTRQKLLYQALKNKISIDDLLQSSMG-TAQQAQNTT 798

  Fly   821 SNLMNLVMQFRKVCNHPELFERRDARSPFFMRCAEYTIPRLIHEEGLIHRMLPSRKHLLYNRFNI 885
            |:||||||||||||||.|||||::..|||......|.|.:.:...|.|:.:..||...|....:.
 Frog   799 SSLMNLVMQFRKVCNHSELFERQETWSPFHFSLRPYQISKFLFRHGNINCLNWSRNRWLRVMLSP 863

  Fly   886 FKSEYIQRSLF--EDVNVNSCFGFTRLCDLSVGDMVEVTLNGLIDFLLHYRRVLEKYPLL--AYR 946
            |..::||:|||  ...:..|||.|.|..|:...::..:.|.|      |..|.|..:..|  |||
 Frog   864 FAPDHIQQSLFHRNGSDKESCFSFLRFIDVCPAEIGNLMLRG------HLARWLALFLSLKAAYR 922

  Fly   947 ----RFWWK-KQPDSRYQLLEPMLENK-------LALDYMPPN----SVLKNFIFTAMTANESSV 995
                |.|.: .|.||    |...|.|:       .||.:  ||    |.|:..:|   |::...:
 Frog   923 LHNARVWDEGSQSDS----LNSYLTNRSLILWVNFALSF--PNLHSSSTLQELVF---TSHCRPI 978

  Fly   996 YAFGDYFTYNMQETIEHRVIRSKILKKKTSLIEEMEDVSKQKLEIESVEVQTKSNAKSDVKVTTL 1060
            ...|||..:.                                          :.:.:|.|....:
 Frog   979 SGRGDYVLHG------------------------------------------RKSGQSQVLHCQI 1001

  Fly  1061 LLLPEFPHRPRKPRKYVCEPLSMPRILYDLGQKVQAVHRYLYCDSRSAAWS--QIRH------NQ 1117
            ...|.|        .||..||            |.|....:||:.|||.:.  :.|.      .|
 Frog  1002 TQFPSF--------LYVASPL------------VTASPIDIYCNDRSAEYERREFREGGGPVSRQ 1046

  Fly  1118 CENSQGRELVS--------------SGLALCKPHGGWSSIVVPDKETLITDAGKLFVLDNLLTRL 1168
            |......||.:              .||...||..|||.|.:||||:||||:|||:.||.|||||
 Frog  1047 CLMFGAPELYADWPKRQLQFFPASPGGLMTIKPCNGWSYIKIPDKESLITDSGKLYALDLLLTRL 1111

  Fly  1169 KANGHRVLIYSQMTKMIDLLEEYMWHRKHRYMRLDGSSKISARRDMVADFQTRADIFVFLLSTRA 1233
            |::|||||||||||:|||||||||.:|||.|||||||||||.|||||||||:|.|||||||||||
 Frog  1112 KSHGHRVLIYSQMTRMIDLLEEYMVYRKHTYMRLDGSSKISERRDMVADFQSRTDIFVFLLSTRA 1176

  Fly  1234 GGLGINLTAADTVIFYDSDWNPTVDQQAMDRAHRLGQTKQVTVYRLICKGTIEERILQRAREKSE 1298
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||:||||
 Frog  1177 GGLGINLTAADTVIFYDSDWNPTVDQQAMDRAHRLGQTKQVTVYRLICKGTIEERILQRAKEKSE 1241

  Fly  1299 IQRMVISGGNFKPDTLKPKEVVSLLLDDEEIE--MKYRQEAKLQSSSPIPAATQSERKRRHPQKD 1361
            |||:||||||||||||||||||||||||||:|  ::.|||.|.|.........:..::.::.:|
 Frog  1242 IQRVVISGGNFKPDTLKPKEVVSLLLDDEELEKKLRQRQEEKRQQEETNKVKERKRKREKYAEK- 1305

  Fly  1362 VNMGGTTIAATSATQNPDDDV----------------PSCSSAAKRIKLETEEDFIDVGITSSAS 1410
                          :..:|:|                ||..::  .:..:.|:.||.|.     |
 Frog  1306 --------------KKKEDEVDGRRKKDGGNLVIPFLPSADNS--NLSADGEDSFISVD-----S 1349

  Fly  1411 SVGTDSNHPTLSQETYVPGATCVQQTEIDSENEALVVDGDSPTMLGQNESMN--------FLDDL 1467
            ::.:..:..::|.|.:. |:....    :|.|:.||:..|..:...|:...|        ..::|
 Frog  1350 AMPSPFSEISISSELHT-GSIAPD----ESSNDMLVIVDDPSSSAQQSRGTNSPASITGSVSENL 1409

  Fly  1468 SGISPMRRRHHPRGTR------RGRPRGSTRRGGGHGSIPRVLTPTQAATPAVPATASQAAAAGT 1526
            :|||   .:..|...|      |||.:.......|..|..|..|...||..|.....:.||:|..
 Frog  1410 NGIS---NQETPNSARVNSSRNRGRAKAGANSSKGGKSRSRKSTAGSAAAIAGAMAGAAAASAAA 1471

  Fly  1527 GAAAG--TSSPLPQQEVSGGGDNAGVPLHEEEYRTSPSGQSPGVSCKRGPGRPRSKTATPISRGT 1589
            .||.|  .|..||          |..||.....|||      |:| ..||....|...:|:|:||
 Frog  1472 YAAYGYNVSKGLP----------ASSPLQTSLLRTS------GIS-DFGPINTSSPINSPLSKGT 1519

  Fly  1590 RGAPRARRPMGPLLVPLGRSPDDTPPSSSPATSRAPSPL 1628
               |:...|:|  |.|      :||......||..|..|
 Frog  1520 ---PKINNPIG--LAP------ETPTRRHGKTSSTPGGL 1547

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ino80	NP_732413.1	HepA	364..>855	CDD:440319	322/506 (64%)
		DEXQc_INO80	535..763	CDD:350760	181/227 (80%)
		SF2_C_SNF	1146..1280	CDD:350180	119/133 (89%)
		PHA03247	<1535..1637	CDD:223021	28/94 (30%)
ino80	XP_004917366.1	HepA	330..>826	CDD:440319	317/497 (64%)
		DEXQc_INO80	514..742	CDD:350760	181/227 (80%)
		SF2_C_SNF	1088..1223	CDD:350180	119/134 (89%)