DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dl and DLK2

DIOPT Version :9

Sequence 1:	NP_001247193.1	Gene:	Dl / 42313	FlyBaseID:	FBgn0000463	Length:	833	Species:	Drosophila melanogaster
Sequence 2:	XP_005249365.1	Gene:	DLK2 / 65989	HGNCID:	21113	Length:	476	Species:	Homo sapiens

Alignment Length:	465	Identity:	128/465 - (27%)
Similarity:	180/465 - (38%)	Gaps:	164/465 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   191 SGCAKFCRPRDDSFGHSTCSETGEIICLTGWQGDYCHIPKCAKGCE--HGHCDKPNQCVCQLGWK 253
            |||.  |.       |..|     ::|:.|..|.......|:..|:  ||.|.....|.|..||:
Human    96 SGCR--CL-------HLVC-----LLCILGAPGQPVRADDCSSHCDLAHGCCAPDGSCRCDPGWE 146

  Fly   254 GALCNECVLEPNCIHGTCNKPWTCICNEGWGGLYCNQDLNYCTNHRPCKNGGTCFNTGEGLYTCK 318
            |..|..||..|.|.||||::||.|||:.||.|.:|::|.:.||...||:|||.|...|.|.|.|.
Human   147 GLHCERCVRMPGCQHGTCHQPWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCV 211

  Fly   319 CAPGYSGDDCENEIYSCDADVNPCQNGGTCIDEPHTKTGYKCHCANGWSGKMCEEKVLTCSDKPC 383
            |.||:.|.|||.:...|:...:||:|||.|.|:
Human   212 CLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDD-------------------------------- 244

  Fly   384 HQGICRNVRPGLGSKGQGYQCECPIGYSGPNCDLQLDNCSPNPCINGGSCQPSGKCICPAGFSGT 448
             ||...|           :.|.|.:                                   ||.|.
Human   245 -QGFALN-----------FTCRCLV-----------------------------------GFVGA 262

  Fly   449 RCETNIDDCLGHQCENGGTCIDMVNQYRCQCVPGFHGTHCSSKVDLCLIRPCANGGTCLNLNNDY 513
            |||.|:||                                      ||:||||||.|||:..|.:
Human   263 RCEVNVDD--------------------------------------CLMRPCANGATCLDGINRF 289

  Fly   514 QCTCRAGFTGKDCSVDIDECSSGPCHNGGTCMNRVNSFECVCANGFRGKQCD--------EESYD 570
            .|.|..||.|:.|::::|:|:|.||..|..|.:||:.|:|:|.:|:.||.|:        ..:.|
Human   290 SCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCELVLPVPDPPTTVD 354

  Fly   571 -------SVTFDA-----HQYGA---------TTQARADGLTNAQVVLIAVFSVAMPLVAVIAAC 614
                   :|...|     |..||         ..:.:..||....:|.:.||...  ..|::.|.
Human   355 TPLGPTSAVVVPATGPAPHSAGAGLLRISVKEVVRRQEAGLGEPSLVALVVFGAL--TAALVLAT 417

  Fly   615 VVFCMKRKRK 624
            |:..::..|:
Human   418 VLLTLRAWRR 427

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dl	NP_001247193.1	MNNL	23..96	CDD:284966
		DSL	164..226	CDD:279722	9/34 (26%)
		EGF_CA	291..329	CDD:238011	18/37 (49%)
		EGF_CA	337..372	CDD:238011	7/34 (21%)
		EGF_CA	453..488	CDD:238011	3/34 (9%)
		EGF_CA	492..526	CDD:238011	17/33 (52%)
		EGF_CA	529..564	CDD:238011	15/34 (44%)
DLK2	XP_005249365.1	EGF_CA	182..222	CDD:238011	18/39 (46%)
		EGF_CA	267..303	CDD:238011	20/73 (27%)
		EGF_CA	305..341	CDD:238011	15/35 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24044
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010