Protein Alignment Delta and dll4

DIOPT Version :10

• Sequence 1: NP_477264.1
• Gene: Delta / 42313
• FlyBaseID: FBgn0000463
• Length: 833
• Species: Drosophila melanogaster
• Sequence 2: NP_001073304.1
• Gene: dll4 / 563920
• ZFINID: ZDB-GENE-041014-73
• Length: 683
• Species: Danio rerio
• Alignment Length: 671
• Identity: 264/671 - (39%)
• Similarity: 354/671 - (52%)
• Gaps: 99/671 - (14%)

  Fly     3 WIKCLLTAFICFTVIVQVHSSGSFELRLKYFSNDHGRDNEGRCCSGESDGATGKCLGSCKTRFRV 67
            |:..|:..|.  ||:.|:..||.|||.|..|.|..|....|..|:.:           |:|.|||
Zfish     4 WLTFLIAFFT--TVLTQIFGSGVFELDLHEFKNFKGLLANGNSCTPD-----------CRTFFRV 55

  Fly    68 CLKHYQATIDTTSQCTYGDVITPILGENSVNLTDAQRFQNKG-FTNPIQFPFSFSWPGTFSLIVE 131
            |||:||..: :...|.:|..:||:||.||.      |....| |:.||:.||:|.|||:||||:|
Zfish    56 CLKNYQVVV-SPGDCIFGSALTPVLGTNSF------RIMGGGSFSTPIRLPFNFGWPGSFSLIIE 113

  Fly   132 AWHD--TNNSGNARTNKLLIQRLLVQQVLEVSSEWKTNKSESQYTSLEYDFRVTCDLNYYGSGCA 194
            |||.  ::...:|....:.|....:|:.|||.:||..:....:.|.|.|.:|..|:.||||..|:
Zfish   114 AWHSPYSDLPVDAYNPNMQISFFAIQRKLEVGAEWSQDVQSGKQTELRYSYRFICNENYYGDSCS 178

  Fly   195 KFCRPRDDSFGHSTCSETGEIICLTGWQGDYCHIPKCAKGCE--HGHCDKPNQCVCQLGWKGALC 257
            |.|.||||.|||.||:..|::.||.||:|:||..|.|.:||.  :|:|.||.:|||:.||:|..|
Zfish   179 KKCTPRDDRFGHYTCNPDGQLSCLPGWKGEYCEEPICLEGCSEANGNCSKPGECVCREGWQGKFC 243

  Fly   258 NECVLEPNCIHGTCNKPWTCICNEGWGGLYCNQDLNYCTNHRPCKNGGTCFNTGEGLYTCKCAPG 322
            .||...|.|.||||:.|..|.|.||||||:|:||||:||:|:||.||.||.|||:|.|||.|.||
Zfish   244 TECKTYPACKHGTCHLPGQCNCKEGWGGLFCDQDLNFCTHHKPCVNGATCMNTGQGSYTCICRPG 308

  Fly   323 YSGDDCENEIYSCDADVNPCQNGGTCIDEPHTKTGYKCHCANGWSGKMCEEKVLTCSDKPC-HQG 386
            |:|.:||.::..||:  :|.:|||.|.|  |.|: |.|.|...:.|..||..:|||:|.|| |:|
Zfish   309 YTGVNCELQVRECDS--SPRKNGGLCTD--HDKS-YTCTCLPDFEGTHCEHSLLTCADSPCFHKG 368

  Fly   387 ICRNVRPGLGSKGQGYQCECPIGYSGPNCDLQLDNCSPNPCINGGSCQPSGK---CICPAGFSGT 448
            .|..     ...|:.|.||||:||:|.||:.::|.|:...|.|.|.|...|.   |.|.|||:|.
Zfish   369 RCHE-----KDNGRSYACECPLGYTGLNCERRMDKCTSMLCANDGLCLILGGKRICSCRAGFTGQ 428

  Fly   449 RCETNIDDCLGHQCENGGTCIDMVNQYRCQCVPGFHGTHCSSKVDLCLIRPCANGGTCLNLNNDY 513
            |||.||:||..:.|.|||||.|.:|:|.|.|.||:.|.:|..  ..||..||.|||:|:
Zfish   429 RCEININDCANNPCANGGTCYDRINEYVCSCPPGYKGRNCDR--PSCLSTPCLNGGSCV------ 485

  Fly   514 QCTCRAGFTGKDCSVDIDECSSGPCHNGGTCMNRVNSFECVCANGFRGKQCDEESYDSVTFDAHQ 578
                  |.||                         |...|.|.:||.|..|             :
Zfish   486 ------GITG-------------------------NPPACFCPSGFTGPLC-------------E 506

  Fly   579 YGATTQARADGLTNAQVVLIAVFSVAMPLVA-VIAACVVFCMKR--KRKRAQEKDDAEA----RK 636
            |.|.|.....|.|..:....|| |:|:.||| |:..|:|....|  .|:.:.|:...||    .:
Zfish   507 YYAVTAPVTRGETQDRFQWAAV-SLAVGLVALVVLLCMVVIALRHIHRQASGERTRGEAMNNLSE 570

  Fly   637 QNEQNAVATMHHNGSGVGVAL 657
            ....|.:.|.....:...|:|
Zfish   571 SQRDNLIPTSQLKNTNKQVSL 591

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Delta	NP_477264.1	MNNL	23..182	CDD:462222	59/161 (37%)
		DSL	164..226	CDD:128366	28/61 (46%)
		EGF_CA	291..329	CDD:238011	24/37 (65%)
		EGF_CA	337..372	CDD:238011	12/34 (35%)
		EGF_CA	453..488	CDD:238011	18/34 (53%)
		EGF_CA	492..526	CDD:238011	11/33 (33%)
		EGF_CA	529..564	CDD:238011	6/34 (18%)
dll4	NP_001073304.1	MNNL	22..166	CDD:462222	59/161 (37%)
		DSL	148..210	CDD:128366	28/61 (46%)
		EGF_CA	277..315	CDD:238011	24/37 (65%)
		EGF_CA	320..353	CDD:238011	14/37 (38%)
		EGF_CA	433..468	CDD:238011	18/34 (53%)